Objective: To assess the efficacy of Lishen injection (LSI) in treating coronary heart disease (CHD). Methods: The effect of LSI on serum estradiol (E2) testosterone (T) and E2/T ratio in 30 postmenopausal patients wi...Objective: To assess the efficacy of Lishen injection (LSI) in treating coronary heart disease (CHD). Methods: The effect of LSI on serum estradiol (E2) testosterone (T) and E2/T ratio in 30 postmenopausal patients with CHD of Kidney Deficiency (KD) were observed. Results: (1 ) Serum E2 and the E2/Tratio were lower (P ＜ 0. 01 ) in the group of Kidney Yang Deficiency type (KYaDT) and higher (P ＜ 0. 01 ) in the group of Kidney Yin Deficiency type (KYiDT) as compared with normal control. (2) After treatment with LSI the levels of serum E2 and the E2/T ratio were elevated in the KYaDT group (P ＜ 0. 01 ) and lowered in the KYiDT group (P ＜ 0. 01 ). Both approached the normal level (P ＞ 0. 05 ). (3) The levels of T in both groupswere unaffected (P ＞0. 05) before and after treatment. Conclusion: The imbalance of Kidney-Yin and KidneyYang is correlated to the disturbance of sex hormones and LSI could not only regulate the Kidney-Yin and Kidney-Yang, improve the symptoms of KD, but also reverse the disturbance of sex hormone. With a good bidirectional regulatory effect on E2, it is beneficial on balance of sex hormones of both sexes in the inner environment of human body.展开更多
文摘Objective: To assess the efficacy of Lishen injection (LSI) in treating coronary heart disease (CHD). Methods: The effect of LSI on serum estradiol (E2) testosterone (T) and E2/T ratio in 30 postmenopausal patients with CHD of Kidney Deficiency (KD) were observed. Results: (1 ) Serum E2 and the E2/Tratio were lower (P ＜ 0. 01 ) in the group of Kidney Yang Deficiency type (KYaDT) and higher (P ＜ 0. 01 ) in the group of Kidney Yin Deficiency type (KYiDT) as compared with normal control. (2) After treatment with LSI the levels of serum E2 and the E2/T ratio were elevated in the KYaDT group (P ＜ 0. 01 ) and lowered in the KYiDT group (P ＜ 0. 01 ). Both approached the normal level (P ＞ 0. 05 ). (3) The levels of T in both groupswere unaffected (P ＞0. 05) before and after treatment. Conclusion: The imbalance of Kidney-Yin and KidneyYang is correlated to the disturbance of sex hormones and LSI could not only regulate the Kidney-Yin and Kidney-Yang, improve the symptoms of KD, but also reverse the disturbance of sex hormone. With a good bidirectional regulatory effect on E2, it is beneficial on balance of sex hormones of both sexes in the inner environment of human body.
