Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases. Reactive oxygen species(ROS) are pri...Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases. Reactive oxygen species(ROS) are primarily produced in the mitochondria and in the endoplasmic reticulum of hepatocytes via the cytochrome P450 enzymes. Under the proper conditions, cells are equipped with special molecular strategies that control the level of oxidative stress and maintain a balance between oxidant and antioxidant particles. Oxidative stress represents an imbalance between oxidant and antioxidant agents. Hepatocytic proteins, lipids and DNA are among the cellular structures that are primarily affected by ROS and reactive nitrogen species. The process results in structural and functional abnormalities in the liver. Thus, the phenomenon of oxidative stress should be investigated for several reasons. First, it may explain the pathogenesis of various liver disorders. Moreover, monitoring oxidative markers among hepatocytes offers the potential to diagnose the degree of liver damage and ultimately to observe the response to pharmacological therapies. The present report focuses on the role of oxidative stress in selected liver diseases.展开更多
美国胃肠病学会于2024年1月在American Journal of Gastroenterology发表了酒精相关性肝病(ALD)的临床指南。该指南对ALD和酒精使用障碍的流行病学及疾病负担、ALD危险因素、酒精使用障碍的诊断与治疗、ALD疾病谱、ALD处理及公共政策与...美国胃肠病学会于2024年1月在American Journal of Gastroenterology发表了酒精相关性肝病(ALD)的临床指南。该指南对ALD和酒精使用障碍的流行病学及疾病负担、ALD危险因素、酒精使用障碍的诊断与治疗、ALD疾病谱、ALD处理及公共政策与预防等方面进行了详细地阐述。本文对其推荐意见和关键概念/陈述进行摘译。展开更多
文摘Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases. Reactive oxygen species(ROS) are primarily produced in the mitochondria and in the endoplasmic reticulum of hepatocytes via the cytochrome P450 enzymes. Under the proper conditions, cells are equipped with special molecular strategies that control the level of oxidative stress and maintain a balance between oxidant and antioxidant particles. Oxidative stress represents an imbalance between oxidant and antioxidant agents. Hepatocytic proteins, lipids and DNA are among the cellular structures that are primarily affected by ROS and reactive nitrogen species. The process results in structural and functional abnormalities in the liver. Thus, the phenomenon of oxidative stress should be investigated for several reasons. First, it may explain the pathogenesis of various liver disorders. Moreover, monitoring oxidative markers among hepatocytes offers the potential to diagnose the degree of liver damage and ultimately to observe the response to pharmacological therapies. The present report focuses on the role of oxidative stress in selected liver diseases.
文摘美国胃肠病学会于2024年1月在American Journal of Gastroenterology发表了酒精相关性肝病(ALD)的临床指南。该指南对ALD和酒精使用障碍的流行病学及疾病负担、ALD危险因素、酒精使用障碍的诊断与治疗、ALD疾病谱、ALD处理及公共政策与预防等方面进行了详细地阐述。本文对其推荐意见和关键概念/陈述进行摘译。
