AIM To observe the ultrastructural changes of liver tissues on normal rabbit ablated by high intensity focused ultrasound (HIFU). METHODS A single shot of 1 1MHz focused ultrasound at an intensity of 500W/cm 2 w...AIM To observe the ultrastructural changes of liver tissues on normal rabbit ablated by high intensity focused ultrasound (HIFU). METHODS A single shot of 1 1MHz focused ultrasound at an intensity of 500W/cm 2 with continuous exposure duration of 20s was applied intraoperatively in normal rabbit livers. Ultrastructural changes of the sonoablated lesion, as viewed by light and electron microscopy were observed. RESULTS Liver cells at the center of the sonoablated lesion were irreversible degeneration immediately after HIFU treatment observed by electron microscopy, although it appeared normal histologically, irregularly shaped cavities of about 0 3μm～0 5μm in diameter were found in its cytoplasm. CONCLUSION Thermal damages may be the main mechanism of HIFU ablating liver tissues and cavitation effect also plays a role in it.展开更多
文摘AIM To observe the ultrastructural changes of liver tissues on normal rabbit ablated by high intensity focused ultrasound (HIFU). METHODS A single shot of 1 1MHz focused ultrasound at an intensity of 500W/cm 2 with continuous exposure duration of 20s was applied intraoperatively in normal rabbit livers. Ultrastructural changes of the sonoablated lesion, as viewed by light and electron microscopy were observed. RESULTS Liver cells at the center of the sonoablated lesion were irreversible degeneration immediately after HIFU treatment observed by electron microscopy, although it appeared normal histologically, irregularly shaped cavities of about 0 3μm～0 5μm in diameter were found in its cytoplasm. CONCLUSION Thermal damages may be the main mechanism of HIFU ablating liver tissues and cavitation effect also plays a role in it.
