Ambroxol,the cough expectorant with neuroprotective effects

Ambroxol hydrochloride(2-amino-3,5-dibromo-N-methylbenzylamine hydrochloride)has been used as a mucolytic agent in the treatment of respiratory diseases since the late 1970s.Its effects on mucus membranes such as mucus disruption,increased mucus production,and low toxicity profile were addressed in its original German patent in 1966.These first described properties have kept Ambroxol available worldwide and over the counter in the pharmaceutical market to this day.

Optimizing the Chemical Compositions of Protective Agents for Freeze-drying Bifidobacterium longum BIOMA 5920

Freeze drying has a deleterious effect on the viability of microorganisms. In front of this difficulty, the present study adopts response surface methodology to optimize the chemical compositions of protective agents to seek for maximum viability of Bifidobacterium longum BIOMA 5920 during freeze-drying. Through the compara- tive analysis of single protectant, the complex protective agents show better effect on the Bifidobacterium viability. Human-like collagen (HLC), trehalose and glycerol are confirmed as significant factors by Box-Behnken Design. The optimized formula for these three variables is tested as follows: HLC 1.23%, trehalose 11.50% and glycerol 4.65%. Under this formula, the viability is 88.23%, 39.67% higher in comparison to the control. The viable count is 1.07×10 9 cfu·g-1 , greatly exceeding the minimum viable count requirement (10 6 cfu·g-1 ).

Effect of Isobutyl-triethoxy-silane Penetrative Protective Agent on the Carbonation Resistance of Concrete

Effect of isobutyl-triethoxy-silane penetrative protective agent on the carbonation resistance of the concrete was studied.The concrete specimens for the 28 d accelerated carbonation process were manufactured with w/c of 0.49 and 0.64,both in the presence and absence of silane and mineral admixture.The penetration of isobutyl-triethoxy-silane and the carbonation of concrete were investigated by penetration depth,carbonation depth,XRD,SEM,and pore size distribution.The results showed that concrete compactness played an important role in the silane penetration and carbonation resistance.Penetration depth of silane-treated concrete mainly depended on the compactness of the concrete,and could not remarkably change through the accelerated carbonation process.In the accelerated carbonation process,penetrative protective agent improved the carbonation resistance of the higher compactness concretes but accelerated the carbonization process of the lower compactness concretes.As penetrative protective agent penetrated along the external connectivity pores into concrete not filling the entire surface area,the inorganic film could not fully protect the Ca（OH）_2 phase from carbonation.After 28 d accelerated carbonation,fibrous hydration products disappeared and the surface holes decreased.Due to the formation of carbonized products,the porosity of the concrete surface decreased,especially in high-strength concrete.

Optimization of Freeze-drying Protective Agents for Lactobacillus plantarum KLDS1.0391 by Response Surface Methodology

In this study, the Single Factor Test（SFT） was used to optimize the pre-freezing conditions of L. plantarum KLDS1.0391（KLDS1.0391）. Further, the Freeze-Drying Protective Agents（FDPA） of KLDS1.0391 was optimized by Response Surface Methodology（RSM）. The optimum pretreatment conditions were as the follows： initial concentration of KLDS1.0391 was 1011 CFU · m L-1 and KLDS1.0391 was pre-freezed at –80℃ for 8 h to achieve the survival rate of 46.21%. The main components of FDPA were skim milk, sucrose, sodium glutamate and Tween-80. And the influence of four factors on the survival rate of KLDS1.0391 in freeze-drying was in order as the follows： skim milk〉sucrose〉Tween-80〉sodium glutamate. The optimal FDPA composition was skim milk 11.3%, sucrose 9.8%, sodium glutamate 5.1% and Tween-80 0.2%. Under the above conditions, the survival rate of the cells was 82.98%. Comparing the predicted values, the relative error was 0.37% and the difference was not significant, which indicated that the established model could effectively reflect the actual protection of FDPA to KLDS1.0391.

Optimization of Protective Agent Formulation for Soybean Rhizobium Strain HW-05 by Response Surface Methodology

[Objective] This study aimed to investigate the protective effects of proteins, salts, sugars and trace elements on soybean rhizobium strain HW-05 by response surface methodology. [Method] Different types, combinations, ratios and concentrations of protective agents were designed. Under simulated conditions, the optimal protective agent formulation was screened for improving the survival rate and survival time of soybean rhizobium strain HW-05. The optimal combination of significant factors was determined by Box-Behnken central composite design. [Result] Three significant factors affecting effective number of viable cells were screened, including peptone, xanthan gum and NaCl. The final concentration of each compound was optimized 0. 13% peptone, 0.011% xanthan gum, 0.30% NaCl. [Conclusion] After addition of protective agent and preservation at room temperature for six months, effective number of viable cells of soybean rhizobium strain HW-05 reached 3.185 ×10^8 CFU/ml. The survival rate of HW-05 cells was improved by more than 25% compared with the control group （2.458×10^8 CFU /ml）.

基于多Agent的含DG智能配电网差动保护自愈方法

含DG智能配电网中的潮流方向随分布式发电的变化而变化,导致配电网故障自愈的效果难以保障,因此,提出基于多Agent的含DG智能配电网差动保护自愈方法。通过构建基于多Agent的MAS体系结构,将其应用于含DG智能配电网差动保护和自愈的控制,在MAS体系结构的数据处理层完成差动保护,并在MAS体系结构的协调控制层实现故障自愈。结果表明,该设计方法不仅可以恢复配电网故障区域的电力,而且在操作次数、线损及功率因数方面可达到较理想的效果。

Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms:A narrative review

T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed.It can cause gastrointestinal toxicity,hepatotoxicity,immunotoxicity,reproductive toxicity,neurotoxicity,and nephrotoxicity in humans and animals.T-2 toxin is physicochemically stable and does not readily degrade during food and feed processing.Therefore,suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent issue.Protective agents against the organ toxicity of T-2 toxin have been recorded widely in the literature,but these protective agents and their molecular mechanisms of detoxification have not been comprehensively summarized.In this review,we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification effects.Targeting appropriate targets to antagonize T-2 toxin toxicity is also an important option.This review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future.

Magnesium acethyltaurate as a potential agent for retinal and optic nerve protection in glaucoma

Glaucoma is the second leading cause of irreversible vision impairment affecting more than 70 million people worldwide with approximately 10%suffering from glaucoma-related bilateral blind（Quigley and Broman,2006）.It is a multi-factorial disease that is characterized by optic nerve damage and visual field loss.Progressive loss of retinal ganglion cells（RGCs）resulting in visual field deficits is the hallmark of glaucoma.

Protection and Treatment of Landscape Plant Secondary Disasters (Deicing Agent Damage) Caused by Extreme Weather

Deicing agent is always applied to alleviate urban traffic pressure after snowing in winter,however,such a snow melting agent is extremely harmful for landscape plants.To eliminate or avoid such damages,we have been actively exploring protection and treatment means.By analyzing the protection of landscape plants before using the deicing agent and the treatment after being damaged by the salt,the paper described how landscaping industry of Beijing handled extreme weather and influence of certain urban environment on landscape plants in a high-efficiency and low-cost way,and then figured out the balance point of normal social life and healthy development of ecological environment.

Multi-agent Based Protection on Highly Dominated Distributed Energy Resources

Highly penetration of Distributed Energy Resources (DER) on the grid systems nowadays makes the systems grow dynamically. The system become more complex and the protection system become more complicated. The protection relay should accommodate the system changes according to the system conditions and topologies. As part of developmental aspect of Distributed Artificial Intelligent, Multi Agent System (MAS) is a challenging method for improving the intelligent properties of relay protection. This paper introduces the use of MAS approach on radial distribution system protection dominated with DER using dispersed adaptive rule-based protection supported by distributed database agent. The simulation results confirmed that the proposed algorithm can respond within 15.05 ms.

Design and implementation of self-protection agent for network-based intrusion detection system

Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection agents were designed, which have the distributed architecture,cooperate with the agents in intrusion detection in a loose-coupled manner, protect the security of intrusion detection system, and respond to the intrusion actively. A prototype self-protection agent was implemented by using the packet filter in operation system kernel. The results show that all the hosts with the part of network-based intrusion detection system and the whole intrusion detection system are invisible from the outside and network scanning, and cannot apperceive the existence of network-based intrusion detection system. The communication between every part is secure. In the low layer, the packet streams are controlled to avoid the buffer leaks exist ing in some system service process and back-door programs, so as to prevent users from misusing and vicious attack like Trojan Horse effectively.

Performance Analysis of a Profile Control Agent for Waste Drilling Fluid Treatment

A method for the treatment of hazardous waste drilling fluids,potentially leading to environmental pollution,is considered.The waste drilling fluid is treated with an inorganic flocculant,an organic flocculant,and a pH regulator.The profile control agent consists of partially hydrolyzed polyacrylamide,formaldehyde,hexamethylenetetramine,resorcinol,phenol,and the treated waste drilling fluid itself.For a waste drilling fluid concentration of 2500 mg/L,the gelling time of the profile control agent is 25 h,and the gelling strength is 32,000 mPa.s.Compared with the profile control agent prepared by recirculated water under the same conditions,the present profile control agent displays better stability,salt-resistance,and performance.

The study of protection coordination technology in power system based on Multi-Agent

This paper studies mainly how to make use of Multi- Agent technology to solve the complex problems which are caused by unsuitable coordination between protection and untimely action and protection fault activity in large power system, and realizes timely the coordination among protections effectively in when losing some or all information. Thus it overcomes the difficult of solving single or shore range information, enhances correspond and coordination among the intelligent protect Agent, raises the stable and reliable property, and promotes the process of power network for large area.

低压气井修井用压井液体系研制与现场应用

通过对自生气试剂、起泡剂以及稳定剂的种类与用量进行优选,形成自生气体系,并应用于膨胀微球压井液,最终形成一套低压气井修井用压井液体系。该体系配方为0.25%~0.5%自生气试剂SJ-4+0.5%~0.75%复合起泡剂+0.5%~0.75%稳泡剂YH-15+膨胀微球压井液,体系密度在0.6~0.8 g/cm 3范围内可调,该压井液体系具有良好的稳定性、储层保护性能。现场试验结果表明:该压井液体系在长庆油田苏东44-62A井和榆46-15井的压井作业中均可实现有效压井作业,且与地层配伍性良好。

页岩储层防水锁聚合物水基钻井液体系研究

开发一种适用于页岩储层的水基钻井液体系,以优化钻井过程中的页岩稳定性和防水锁效果。通过页岩滚动回收率、线性膨胀率测试以评价不同处理剂的效果。结果表明:0.5%WEDM+1.5%SFTH复配体系可显著提高页岩的回收率,同时最大线性膨胀率由37.6%降至16.80%。封堵剂CMS在控制滤失量方面表现出色,包被剂KPAM在提高钻井液稳定性和降低滤失量方面具有显著效果。防水锁水基钻井液配方为:4%基浆+1.0%WEDM+1.5%SFTH+1.5%CMS+0.3%KPAM+2.0%op-10。该体系在高温高压条件下展现出了优异的流变特性和滤失控制能力,特别是在抗温性和抗污染性方面表现卓越。该体系在150℃高温下保持了良好的稳定性,且对NaCl和CaCl_(2)的抗污染能力强。在储层保护方面,该体系能有效减少钻井液对储层的伤害,实现高达85.69%的渗透率恢复率,同时形成的泥饼质量良好。研究成果对于页岩气开采具有重要意义。

基于全同态加密优化的云数据隐私保护方法

为了提升云数据的安全性,改善数据加密时间长以及加密效果较差等问题,提出一种基于全同态加密优化的云数据隐私保护方法。通过生成对抗网络模型学习原始数据中的重要特征,确保合成的数据和初始数据之间具有较高的相似度,使其能够满足差分隐私特征。引入PKI对数据所有者和用户身份认证处理,完成密钥的产生和分发,根据差分隐私特征将用户所有者的数据划分为不同类型,获取用户访问特征向量。构建全同态加密机制,同时引入代理重加密机制,通过密钥转换完成数据加密处理,最终实现云数据全同态加密优化。实验对比结果表明,上述加密方案能够快速完成数据加密处理,有效确保数据的安全性。

基于多Agent技术的继电保护系统

在综述Agent技术及其国外的研究进展和对保护之间的配合考虑不足的研究现状的基础上 ,从不同角度讨论了Agent技术在继电保护中的应用 ,阐述了基于多Agent系统 (MAS)的继电保护系统的特点、结构、模型及决策过程 ,并就其系统构架、通信、可靠性和应用范围等问题进行了讨论。提出了Agent技术在后备保护中的应用方案 ,可以有效地缩短后备保护的动作时间。

基于多Agent的继电保护研究

为了满足大规模互联电网对电网运行安全性及可靠性的要求,在分析了一些传统继电保护及智能技术的基础上,提出了基于多Agent的继电保护。文章综述了Agent及多Agent系统的特点及国内外的研究现状,从不同角度讨论了MAS在继电保护中的作用,对多Agent系统的结构模型进行构建,提出了多Agent系统的协作、通信的方法。这样的保护可以利用相邻线路甚至整个网络的信息,使原有的保护不再独立运行。仿真实验证明,该保护在系统的稳定性、可靠性及快速性等方面较传统保护都有很大提高。

多Agent技术在继电保护中的应用

介绍了多Agent技术及其在继电保护领域中的应用情况,从横向和纵向2个角度研究了多Agent技术应用于继电保护的前景。横向应用提出了集合保护的概念,把每个微机保护装置看作一个Agent,与和它有信息共享和协作关系的其他保护装置一起组成保护集合,这些集合构成了系统保护的保护单元。集合保护能在不损害保护独立性的前提下提高保护系统的性能,并区分故障和过载,防止连锁跳闸事故发生。重点研究了纵向应用,把一个微机保护装置看成由多个Agent组织而成的智能保护,通过对各种保护原理的动作结果进行综合,以提高保护的可靠性;根据故障类型和保护背侧系统阻抗值来切换保护定值使保护定值最佳;利用对采集数据的谐波计算提高故障区域的判断准确性。并给出了智能保护的实现方案。

高活性天然酵母发酵剂的优化

目的:研究标准化稳定天然酵母发酵剂的制备工艺,探究干燥工艺及保护剂对天然酵母活性的影响,并研究其贮藏活性。方法:选用多种水果制备天然酵母,研究其发酵过程并分离菌株通过ITs和16s基因测序在数据库中比对鉴定优势菌株。以干燥工艺处理后的存活率和贮藏活性为指标,通过选择干燥工艺、样品状态和保护剂配方来获得最佳方案。结果:葡萄天然酵母制备的面包具有最好的比容、孔隙度和硬度。在此基础上,以干燥存活率和贮藏活性为指标得到两种保护效果较好的配方:①冷冻干燥优势菌种菌液,脱脂乳粉35%、麦芽糊精7.5%和海藻糖25%,干燥存活率约为93%;②天然酵母整体喷雾干燥,脱脂乳粉35%、麦芽糊精10%和海藻糖15%,干燥存活率约为90%。结论:喷雾干燥的发酵剂贮藏活性下降较快,而冷冻干燥的发酵剂贮藏活性较强。