This paper is concerned with the existence of traveling wave solutions in a reaction-diffusion predator-prey system with Beddington-DeAngelis functional response and a discrete time delay. By introducing a partial qua...This paper is concerned with the existence of traveling wave solutions in a reaction-diffusion predator-prey system with Beddington-DeAngelis functional response and a discrete time delay. By introducing a partial quasi-monotonicity condition and constructing a pair of upper-lower solutions, we establish the existence of traveling wave solutions. Moreover, a numerical simulation is carried out to illustrate the theoretical results.展开更多
This paper deals with the blow-up properties of the solution to a semilinear parabolic system with localized nonlinear reaction terms, subject to the null Dirichlet boundary condition. We first give sufficient conditi...This paper deals with the blow-up properties of the solution to a semilinear parabolic system with localized nonlinear reaction terms, subject to the null Dirichlet boundary condition. We first give sufficient conditions for that the classical solution blows up in the finite time, secondly give necessary conditions and a sufficient condition for that two components blow up simultaneously, and then obtain the uniform blow-up profiles in the interior. Finally we describe the asymptotic behavior of the blow-up solution in the boundary layer.展开更多
Background: Venom allergy is significantly underestimated in China. Venom-specific IgE may not provide accurate clinical reactions. Our conducted retrospective analysis observes alternative diagnostic considerations ...Background: Venom allergy is significantly underestimated in China. Venom-specific IgE may not provide accurate clinical reactions. Our conducted retrospective analysis observes alternative diagnostic considerations in assessing confirmation and severity of honeybee veuom allergy, Methods: Retrospective review of honeybee venom allergy versus nonallergy patients presenled v,ith positive honeybee venom (iI) sIgE results. According to clinically observed reactions caused by a honeybee sting, patients were divided into three groups. Patient residence and exposure types were analyzed. The slgE/T-IgE among allergy and control groups was compared, Results: Gender ratio male:female was 32:22: median age was 39 years (31. 50). 48% (26/54) of patients live in urban areas. 52% (28/54) in rural areas. Based on bee sting reactions, patients were divided into common localized reactions (32/54). large localized reactions (7/54), and systemic reactions (15/54), In the systemic reaction group, patients presented as Type Ⅱ (6/15), Type Ⅲ (6/15). There is significant difference (P 〈 0,001 ) between the three groups in regards to exposure types. In the systemic reaction group. 8.7% (13/15) of patients are beekeepers. A significant difference (P 〈 0.001 ) was observed between allergic and control groups based on slgE/T-lgE results. As well as significant difference observed between the systemic reaction group to the other two reaction groups in regards to slgE/T-IgE results. Six systemic reaction patients presented with large localized reactions before onset of system symptoms 1 month to 1year of being stung. Conclusions: Occupational exposure is the most common cause in honeybee venom allergy induced systemic reactions. The use of sIgE/T-IgE results is a useful diagnostic parameter in determining honeybee venom allergy,展开更多
目的探讨蜜蜂蜂毒过敏的临床特点。方法回顾2002年6月至2012年2月到北京协和医院就诊并确诊的蜜蜂蜂毒过敏患者及同时期因过敏性疾病在北京协和医院变态反应科就诊,无蜜蜂蛰刺过敏反应的相关临床病史,但蜜蜂蜂毒血清sIgE检测阳性的对照...目的探讨蜜蜂蜂毒过敏的临床特点。方法回顾2002年6月至2012年2月到北京协和医院就诊并确诊的蜜蜂蜂毒过敏患者及同时期因过敏性疾病在北京协和医院变态反应科就诊,无蜜蜂蛰刺过敏反应的相关临床病史,但蜜蜂蜂毒血清sIgE检测阳性的对照组患者资料;根据蜜蜂蜇刺后的过敏反应类型将研究组分为局部反应组、大局部反应组和全身反应组。分析蜜蜂蜂毒过敏患者生活地域、暴露类型等特点,比较各研究组和对照组之间的IgE比活性(IgE specific activity,sIgE/T-IgE)。结果研究组44例,男女之比为31:13,平均年龄37(29,48)岁,48%(21/44)生活在市区,52%(23/44)生活在郊区。局部反应组30例、大局部反应组6例、全身反应组8例。全身反应组中II级1例、III级7例。蜂毒暴露类型构成比的研究组间差异有统计学意义(P=0.0085),全身反应组中50%(4/8)为养蜂者。局部反应组、大局部反应组、全身反应组及对照组sIgE/T-IgE组间差异有统计学意义(P=0.001),全身反应组与对照组sIgE/T-IgE差异有统计学意义[3.51%(1.19%,8.84%)vs.0.16%(0.09%,0.49%),P=0.001]。全身反应组中1例在首次蜜蜂蜇刺时为大局部反应,3个月后再次蜜蜂蜇刺出现II级全身性严重过敏反应。结论蜜蜂蜂毒导致全身性严重过敏反应以职业性暴露最为常见,使用sIgE/T-IgE有助于正确诊断蜜蜂蜂毒过敏。展开更多
目的探讨结缔组织生长因子(CTGF)在硬皮病(SD)发病机制中的作用及其与SD分型、分期的关系。方法分别采用原位RT-PCR和免疫组化SABC法检测36例SD〔其中系统性硬化症(SSc)29例,局限性SD 7例;水肿硬化期28例,萎缩期8例〕皮损中CTGF mRNA与...目的探讨结缔组织生长因子(CTGF)在硬皮病(SD)发病机制中的作用及其与SD分型、分期的关系。方法分别采用原位RT-PCR和免疫组化SABC法检测36例SD〔其中系统性硬化症(SSc)29例,局限性SD 7例;水肿硬化期28例,萎缩期8例〕皮损中CTGF mRNA与蛋白的表达,并以20例正常皮肤组织作为对照。结果SD组CTGF mRNA(阳性表达率:80.6%vs 40.0%,P=0.002;范围强度积分:2.67±1.33 vs 1.30±1.03,P<0.01)与蛋白(阳性表达率:88.9%vs 45.0%,P<0.001;范围强度积分:2.83±1.06 vs 1.40±1.10,P=0.001)表达阳性率和范围强度均高于正常对照组。SSc组CTGF mRNA与蛋白表达阳性率和范围强度与局限性SD组间差异均无统计学意义。SD水肿硬化期皮损中CTGF mRNA(阳性表达率:89.3%vs 50.0%,P=0.030;范围强度积分:2.89±0.99 vs 2.00±1.20,P=0.039)与蛋白(阳性表达率:96.4%vs 62.5%,P=0.028;范围强度积分:3.07±0.86 vs 2.00±1.31,P=0.009)表达阳性率和范围强度均高于萎缩期皮损。结论CTGF在SD发病机制中起重要作用,与皮肤纤维化的发展密切相关,局限性SD和SSc发病机制可能相似。展开更多
摘要:目的分析应用标准化屋尘螨变应原对变应性哮喘和(或)变应性鼻炎进行皮下特异性免疫治疗(subcutaneous specific immunotherapy,SCIT)的速发不良反应。方法回顾性记录广州医科大学附属第一医院变态反应科2004年11月至2012年5...摘要:目的分析应用标准化屋尘螨变应原对变应性哮喘和(或)变应性鼻炎进行皮下特异性免疫治疗(subcutaneous specific immunotherapy,SCIT)的速发不良反应。方法回顾性记录广州医科大学附属第一医院变态反应科2004年11月至2012年5月对屋尘螨过敏的哮喘和(或)变应性鼻炎患者接受SCIT过程中出现的速发不良反应,并分析速发不良反应与注射剂量、患者年龄、性别、患病种类和变态反应程度的关系。结果研究共纳入462例患者,其中452例(97.8%)出现速发局部不良反应,153例(33.1%)出现速发全身不良反应;所有患者共接受15645针次皮下注射,其中8523针次(54.5%)出现速发局部不良反应,397针次(2.5%)出现速发全身不良反应。速发局部不良反应发生率随剂量增加而增高,而速发全身不良反应主要分布在剂量上升阶段(2000~80000 SQU)。单纯哮喘及哮喘合并变应性鼻炎的速发不良反应(局部和全身)的发生率高于单纯变应性鼻炎(P〈0.01)。儿童速发局部不良反应发生率高于成人(P〈0.001),但速发全身不良反应的发生率在儿童及成人患者间差异无统计学意义(P〉0.05)。儿童患者中,男性速发不良反应发生率高于女性(P〈0.01);而在成人患者中,女性速发不良反应发生率高于男性(P〈0.01)。速发不良反应(局部和全身)的发生率随着屋尘螨特异性IgE级别的增高而升高(P〈0.001);在皮下注射过程中出现速发全身不良反应者治疗前总IgE[(634.24±883.91)U/ml]与未发生速发全身不良反应者治疗前总IgE[(416.60±438.59)U/ml]比较,差异有统计学意义(t=2.008,P=0.048)。结论对屋尘螨过敏的哮喘和(或)变应性鼻炎患者进行标准化屋尘螨变应原的SCIT时,速发局部不良反应常见,而速发全身不良反应少见,哮喘和鼻炎合并哮喘、少年男性、成年女性及屋尘螨特异性IgE和总IgE水平较高时,速发不良反应的发生率增高,且随注射变应原剂量递增而存在增高趋势,剂量快速上升阶段应警惕严重不良反应的发生。展开更多
文摘This paper is concerned with the existence of traveling wave solutions in a reaction-diffusion predator-prey system with Beddington-DeAngelis functional response and a discrete time delay. By introducing a partial quasi-monotonicity condition and constructing a pair of upper-lower solutions, we establish the existence of traveling wave solutions. Moreover, a numerical simulation is carried out to illustrate the theoretical results.
文摘This paper deals with the blow-up properties of the solution to a semilinear parabolic system with localized nonlinear reaction terms, subject to the null Dirichlet boundary condition. We first give sufficient conditions for that the classical solution blows up in the finite time, secondly give necessary conditions and a sufficient condition for that two components blow up simultaneously, and then obtain the uniform blow-up profiles in the interior. Finally we describe the asymptotic behavior of the blow-up solution in the boundary layer.
文摘Background: Venom allergy is significantly underestimated in China. Venom-specific IgE may not provide accurate clinical reactions. Our conducted retrospective analysis observes alternative diagnostic considerations in assessing confirmation and severity of honeybee veuom allergy, Methods: Retrospective review of honeybee venom allergy versus nonallergy patients presenled v,ith positive honeybee venom (iI) sIgE results. According to clinically observed reactions caused by a honeybee sting, patients were divided into three groups. Patient residence and exposure types were analyzed. The slgE/T-IgE among allergy and control groups was compared, Results: Gender ratio male:female was 32:22: median age was 39 years (31. 50). 48% (26/54) of patients live in urban areas. 52% (28/54) in rural areas. Based on bee sting reactions, patients were divided into common localized reactions (32/54). large localized reactions (7/54), and systemic reactions (15/54), In the systemic reaction group, patients presented as Type Ⅱ (6/15), Type Ⅲ (6/15). There is significant difference (P 〈 0,001 ) between the three groups in regards to exposure types. In the systemic reaction group. 8.7% (13/15) of patients are beekeepers. A significant difference (P 〈 0.001 ) was observed between allergic and control groups based on slgE/T-lgE results. As well as significant difference observed between the systemic reaction group to the other two reaction groups in regards to slgE/T-IgE results. Six systemic reaction patients presented with large localized reactions before onset of system symptoms 1 month to 1year of being stung. Conclusions: Occupational exposure is the most common cause in honeybee venom allergy induced systemic reactions. The use of sIgE/T-IgE results is a useful diagnostic parameter in determining honeybee venom allergy,
文摘目的探讨蜜蜂蜂毒过敏的临床特点。方法回顾2002年6月至2012年2月到北京协和医院就诊并确诊的蜜蜂蜂毒过敏患者及同时期因过敏性疾病在北京协和医院变态反应科就诊,无蜜蜂蛰刺过敏反应的相关临床病史,但蜜蜂蜂毒血清sIgE检测阳性的对照组患者资料;根据蜜蜂蜇刺后的过敏反应类型将研究组分为局部反应组、大局部反应组和全身反应组。分析蜜蜂蜂毒过敏患者生活地域、暴露类型等特点,比较各研究组和对照组之间的IgE比活性(IgE specific activity,sIgE/T-IgE)。结果研究组44例,男女之比为31:13,平均年龄37(29,48)岁,48%(21/44)生活在市区,52%(23/44)生活在郊区。局部反应组30例、大局部反应组6例、全身反应组8例。全身反应组中II级1例、III级7例。蜂毒暴露类型构成比的研究组间差异有统计学意义(P=0.0085),全身反应组中50%(4/8)为养蜂者。局部反应组、大局部反应组、全身反应组及对照组sIgE/T-IgE组间差异有统计学意义(P=0.001),全身反应组与对照组sIgE/T-IgE差异有统计学意义[3.51%(1.19%,8.84%)vs.0.16%(0.09%,0.49%),P=0.001]。全身反应组中1例在首次蜜蜂蜇刺时为大局部反应,3个月后再次蜜蜂蜇刺出现II级全身性严重过敏反应。结论蜜蜂蜂毒导致全身性严重过敏反应以职业性暴露最为常见,使用sIgE/T-IgE有助于正确诊断蜜蜂蜂毒过敏。
文摘目的探讨结缔组织生长因子(CTGF)在硬皮病(SD)发病机制中的作用及其与SD分型、分期的关系。方法分别采用原位RT-PCR和免疫组化SABC法检测36例SD〔其中系统性硬化症(SSc)29例,局限性SD 7例;水肿硬化期28例,萎缩期8例〕皮损中CTGF mRNA与蛋白的表达,并以20例正常皮肤组织作为对照。结果SD组CTGF mRNA(阳性表达率:80.6%vs 40.0%,P=0.002;范围强度积分:2.67±1.33 vs 1.30±1.03,P<0.01)与蛋白(阳性表达率:88.9%vs 45.0%,P<0.001;范围强度积分:2.83±1.06 vs 1.40±1.10,P=0.001)表达阳性率和范围强度均高于正常对照组。SSc组CTGF mRNA与蛋白表达阳性率和范围强度与局限性SD组间差异均无统计学意义。SD水肿硬化期皮损中CTGF mRNA(阳性表达率:89.3%vs 50.0%,P=0.030;范围强度积分:2.89±0.99 vs 2.00±1.20,P=0.039)与蛋白(阳性表达率:96.4%vs 62.5%,P=0.028;范围强度积分:3.07±0.86 vs 2.00±1.31,P=0.009)表达阳性率和范围强度均高于萎缩期皮损。结论CTGF在SD发病机制中起重要作用,与皮肤纤维化的发展密切相关,局限性SD和SSc发病机制可能相似。
文摘摘要:目的分析应用标准化屋尘螨变应原对变应性哮喘和(或)变应性鼻炎进行皮下特异性免疫治疗(subcutaneous specific immunotherapy,SCIT)的速发不良反应。方法回顾性记录广州医科大学附属第一医院变态反应科2004年11月至2012年5月对屋尘螨过敏的哮喘和(或)变应性鼻炎患者接受SCIT过程中出现的速发不良反应,并分析速发不良反应与注射剂量、患者年龄、性别、患病种类和变态反应程度的关系。结果研究共纳入462例患者,其中452例(97.8%)出现速发局部不良反应,153例(33.1%)出现速发全身不良反应;所有患者共接受15645针次皮下注射,其中8523针次(54.5%)出现速发局部不良反应,397针次(2.5%)出现速发全身不良反应。速发局部不良反应发生率随剂量增加而增高,而速发全身不良反应主要分布在剂量上升阶段(2000~80000 SQU)。单纯哮喘及哮喘合并变应性鼻炎的速发不良反应(局部和全身)的发生率高于单纯变应性鼻炎(P〈0.01)。儿童速发局部不良反应发生率高于成人(P〈0.001),但速发全身不良反应的发生率在儿童及成人患者间差异无统计学意义(P〉0.05)。儿童患者中,男性速发不良反应发生率高于女性(P〈0.01);而在成人患者中,女性速发不良反应发生率高于男性(P〈0.01)。速发不良反应(局部和全身)的发生率随着屋尘螨特异性IgE级别的增高而升高(P〈0.001);在皮下注射过程中出现速发全身不良反应者治疗前总IgE[(634.24±883.91)U/ml]与未发生速发全身不良反应者治疗前总IgE[(416.60±438.59)U/ml]比较,差异有统计学意义(t=2.008,P=0.048)。结论对屋尘螨过敏的哮喘和(或)变应性鼻炎患者进行标准化屋尘螨变应原的SCIT时,速发局部不良反应常见,而速发全身不良反应少见,哮喘和鼻炎合并哮喘、少年男性、成年女性及屋尘螨特异性IgE和总IgE水平较高时,速发不良反应的发生率增高,且随注射变应原剂量递增而存在增高趋势,剂量快速上升阶段应警惕严重不良反应的发生。