基于“Lock-in”化学传递系统的脑靶向性前药研究进展

血脑屏障的存在,可使95%以上的药物不能有效地进入脑组织发挥作用.因此,基于提高血脑屏障透过能力,改善脑摄取特性的药物传递系统已经成为当前医药界最为关注的问题之一.自1958年Albert首次提出＂前药＂概念以来,前药修饰在提高口服药物生物利用度、改善组织分布、降低不良反应等方面均有着良好的应用,大约5%~7%的上市药物可以定义为前药.＂Lock-in＂化学传递系统是一种前药载体,能生成极性较大的中间体将药物＂Lock＂在脑内,从而可实现药物的脑靶向.本文综述了基于＂Lock-in＂化学传递系统的脑靶向性前药,包括二氢吡啶型、（酰氧基）烷基-磷酸酯型、硫胺素-二硫化物型等化学传递系统.

Empirical Study of Brand-Customer Relationship Based on Customer Lock-In in Chinese Banking

The central construct of customer lock-in （CL） is measured and its role along with that of consumer loyalty in influencing the brand-customer relationship is tested. Using data collected from focus groups, a measurement model for CL is developed, and a structural equation model consisted based on literature review and our own theory is established. Moreover, the moderating effects of CL on the relationship between perceived value （PV） and brand relationship quality （BRQ） , as well as that between BRQ and brand loyalty （BL） based on data collected through a survey have been tested. Results indicate that consumer satisfaction is a critical factor in establishing brand-customer relationship, and the attitudinal brand loyalty is the key to obtain brand behavioral loyalty. Furthermore, CL tactics, such as decreasing consumers＇ learning cost and transactional cost facilitate the relationship building between customer and brand, while involuntary lock-in may have an adverse effect in the relationship building process. In addition, involuntary lock-in and loyalty program help in obtaining consumers＇ behavioral brand loyalty but not their attitudinal loyalty.

Capacitance Sensing and Software-Realized Lock-in Amplifier for the Electromagnetically Levitated Micro Gyroscope

In the novel prototype of micro-gyroscope structure,the new configured capacitance sensing scheme for the micro gyroscope was analyzed and the virtual instrument based detection scheme was implemented.The digital lock-in amplifier was employed in the capacitance detection to restrain the noise interference.The capacitance analysis shows that 1 fF capacitance variation corresponds to 0.1 degree of the turn angle.The differential capacitance bridge and the charge integral amplifier were used as the front signal input interface.In the implementation of digital lock-in amplifier,a new routine which warranted the exactly matching of the reference phase to signal phase was proposed.The result of the experiment shows that digital lock-in amplifier can greatly eliminate the noise in the output signal.The non linearity of the turn angle output is 2.3% and the minimum resolution of turn angle is 0.04 degrees.The application of the software demodulation in the signal detection of micro-electro-mechanical-system(MEMS)device is a new attempt,and it shows the prospective for a high-performance application.

A virtual lock-in amplifier,spectrum analyzer,impedance meter and semiconductor analyzer implemented on an SR7265 hardware target

Lock-in amplifiers are used to detect and measure very small alternating current(AC)signals down to the range of nVs.Accurate measurements can be made even when the small signals are buried by noise thousands of times larger.With the digital signal processing(DSP)technology involved in modern instrumentation,a lock-in amplifier is more versatile in sensing and recovering small signals.Combining the virtual instrumentation technology,we reorganize the functional blocks of a programmable lock-in amplifier and build it as a virtual spectrum analyzer,virtual impedance meter,virtual network analyzer,virtual semiconductor parameter analyzer,signal generator,etc.A 4 layer model is used to implement these virtual instruments.The same virtual instrument can also be implemented on a general purpose FPGA developing board.

“Lock-in Effect” to Be Blamed for Regional Development Imbalances

Reform and opening up has made China’s economy develop faster than ever. But it has not succeeded in changing the regional disparity in China. In this article, we establish a model factor input called the "lock-in effect" and analyze the channel of the lock-in effect and how it influences the regional economy. On the analyses of thirty provinces’ panel data in China from 1990 to 2005, we find that the lock-in effect of factor inputs further exacerbates the developmental imbalance among regions.

NDI of Rail Squats and Estimating Defect Size and Location Using Lock-In Thermography

Rail squats are a form of near surface rolling contact fatigue damage found in rail heads. Currently, the most popular method to detect the rail squats is utilizing ultrasonic techniques to determine their presence and measure their depths. This technique needs to be direct contact between the probe and the rail head, with a coupling fluid in at the interface. Other weaknesses of these ultrasonic techniques include false detections as well as missed detections. Infrared thermography is a relatively new non-destructive inspection technique used for a wide range of applications but is not used for rail squat detection. Lock-in thermography is a non-destructive inspection technique that can be used for the detection of near surface defects. It utilizes an infrared camera to detect the thermal waves and then produces a thermal image, which displays the local thermal wave variation in phase or amplitude. In inhomogeneous materials, the amplitude and phase of the thermal wave carries information related to both the local thermal properties and the nature of the structure being inspected. This comparison is then used to determine the phase angle difference (Δf) between the input and the thermal response of the object. The aim of this paper is to determine whether lock-in thermography can be used to firstly locate squats in rails, and secondly measure their depths. It has demonstrated the feasibility for using such a technique in generating thermal responses that could be adequately utilized for the purpose of defect characterization.

An Approximate Method for Calculation of Fluid Force and Response of A Circular Cylinder at Lock-in

In this paper, equations calculating lift force of a rigid circular cylinder at lock-in in uniform flow are deduced in detail. Besides, equations calculating the lift force on a long flexible circular cylinder at lock-in are deduced based on mode analysis of a multi-degree freedom system. The simplified forms of these equations are also given. Furthemore, an approximate method to predict the forces and response of rigid circular cylinders and long flexible circular cylinders at lock-in is introduced in the case of low mass-damping ratio. A method to eliminate one deficiency of these equations is introduced. Comparison with experimental results shows the effectiveness of this approximate method.

Networking Intelligent Pressure Sensor Using Digital Lock-in Amplification Technology

Introducing a System-on-Chip （SoC） microcontroller （C8051F350） into a ceramic pressure sensor has resulted in the design of a intelligent sensor. An improved algorithm for digital phassensitive detection is used to perform lock-in amplification of the sensor signal. The compensation for the sensor error is realized by the detection of the sensor＇s supply voltage and working temperature. The system also has the function of short/open circuit fault detection and can ommamicate with other digital equipment through an RS-485 communication interface. In the design, full utilization of the SoC microcontroller＇ s internal resource results in the simple hardware structure. Experimental results show that the error of the sensor is less than 0.5% at range ratio 1 ： 10. Employing the microcontroller and using lock-in amplification algorithm are an effective method for achieving an intelligent sensor of slowly-varying physical quantities, thereby improving the measuring accuracy and performance.

Digital Lock-in Amplifier Based on Microcontroller

A method of implementing high cost-effective and highly integrated digital lock-in amplifier with microcontroller is discussed. And the digital lock-in amplifier is more suitable for meastwing lowfrequency weak signal. Digital signal sequence is obtained through sampling signal measured over an integer number of signal periods, but digital reference sequence is acquired through mathematical operation, then digital phase sensitive detection can be implemented by calculating the cross-correlation function of digital signal sequence and digital reference sequence. In addition, the frequency response and phase character of the digital lock-in amplifier is analyzed. Finally, the designed digital lock-in amplifier is achieved. Expermental results show that the digital lock-in amplifier can be used for measuring weak signal with low ignal-to-noise ratio.

Erratum to:“An Approximate Method for Calculating the Fluid Force and Response of A Circular Cylinder at Lock-in” [China Ocean Engineering,22(3),2008,371-384]

Because of my carelessness,Eq.（1）in the paper "An approximate method for calculating the fluid force and response of a circular cylinder at lock-in"(China Ocean Engineering,22（3）,2008,pp.373)should be f’-1.0/U’-5.0=f’;-1.0/5.75f’;-5.0,not f’=U’/5.75. My apology is hereby given.

Lightweight Virtualization Cluster How to Overcome Cloud Vendor Lock-In

To overcome vendor lock-in obstacles in public cloud computing, the capability to define transferable cloud-based services is crucial but has not yet been solved satisfactorily. This is especially true for small and medium sized enterprises being typically not able to operate a vast staff of cloud service and IT experts. Actual state of the art cloud service design does not systematically deal with how to define, deploy and operate cross-platform capable cloud services. This is mainly due to inherent complexity of the field and differences in details between a plenty of existing public and private cloud infrastructures. One way to handle this complexity is to restrict cloud service design to a common subset of commodity features provided by existing public and private cloud infrastructures. Nevertheless these restrictions raise new service design questions and have to be answered in ongoing research in a pragmatic manner regarding the limited IT-operation capabilities of small and medium sized enterprises. By simplifying and harmonizing the use of cloud infrastructures using lightweight virtualization approaches, the transfer of cloud deployments between a variety of cloud service providers will become possible. This article will discuss several aspects like high availability, secure communication, elastic service design, transferability of services and formal descriptions of service deployments which have to be addressed and are investigated by our ongoing research.

Vortex Shedding Lock-in on Tapered Poles with Polygonal Cross-Section

A study to investigate the effects of taper on vortex shedding coherence on High Mast Lighting Towers (HMLT) with models of eight-, twelve-, and sixteen-sided polygonal cross-section was performed in Purdue’s Boeing Low-Speed Wind Tunnel. Partial tower models were mounted on springs to recreate a flutter phenomenon seen on high mast lighting towers and data was taken using a stationary configuration within the wind tunnel. The model was later oscillated at specified frequencies and amplitudes and the resulting wake and surface pressures were recorded and compared to the stationary cases. The researchers aim to study the characteristics of a “lock-in” phenomenon, that is, a region of pole height where there is a vortex cell with a single shedding frequency, instead of different shedding frequencies for different diameters as Strouhal theory dictates. Results show the existence of vortex cell shedding for clamped models. Using a motor and a forcing cam to recreate the elastic movement of the HMLT in ambient conditions has yielded a specific range of diameters to determine the size of the locked in vortex cells. According to standard Department of Transportation manufacturing standards for tapered HMLT, the lock in distance for small excitations (0.254 cm) would be approximately 305 cm in tower height.

Enhanced imaging through turbid water based on quadrature lock-in discrimination and retinex aided by adaptive gamma function for illumination correction

This paper presents an improved method for imaging in turbid water by using the individual strengths of the quadrature lock-in discrimination(QLD)method and the retinex method.At first,the high-speed QLD is performed on images,aiming at capturing the ballistic photons.Then,we perform the retinex image enhancement on the QLD-processed images to enhance the contrast of the image.Next,the effect of uneven illumination is suppressed by using the bilateral gamma function for adaptive illumination correction.The experimental results depict that the proposed approach achieves better enhancement than the existing approaches,even in a high-turbidity environment.

马兰黄土剩磁不存在显著Lock-in效应:来自Laschamp地磁漂移的证据

中国黄土-古土壤序列的年代框架主要是基于磁性地层所建立的．然而，黄土剩磁是否存在显著的lock—in效应，目前仍存在很大争议．通过比较黄土高原洛川剖面记录的地磁异常和大西洋Heinrich冰筏事件在马兰黄土地层中的位置，揭示了Laschamp地磁漂移被记录在两次寒冷事件（距今～39ka的H4及～48ka的H5）之间，估算的Laschamp地磁漂移相应的年代大约为41．7～43．7ka，与该地磁事件的年龄（大约40～41ka）相近．这说明，马兰黄土的剩磁不存在显著的Lock-in效应．

No apparent lock-in depth of the Laschamp geomagnetic excursion: Evidence from the Malan loess

The first-order chronological framework of the long-term Chinese loess/paleosol sequences was based mainly on magnetostratigraphy. However, there remain arguments on the lock-in ages of the major geomagnetic reversals. This study systematically compared the stratigraphic locations of the Laschamp excursion and Henrich events (H4 at～39 ka and H5 at～48 ka) recorded by the Luochuan loess profile in the central Chinese Loess Plateau. Results show that the Lascchamp excursion is bracketed well by these two cold events, and the corresponding estimated age is between about 41.7-43.7 ka, which is close to the widely accepted age of ～40-41 ka for the excursion.Therefore, our new results do not suggest apparent lock-in effects in the last glacial Malan loess.

Characteristic analysis of lock-in for an elastically suspended airfoil in transonic buffet flow

Numerical simulations are performed to study the aeroelastic responses of an elastically suspended airfoil in transonic buffet flow, by coupling the unsteady Reynolds-averaged Navier- Stokes （RANS） equations and structural motion equation. The current work focuses on the char- acteristic analysis of the lock-in phenomenon. Great attentions are paid to studying the frequency range of lock-in and the effects of the three parameters, namely the structural natural frequency, mass ratio and structural damping, on lock-in characteristic of the elastic system in detail. It is found that when the structural natural frequency is close to the buffet frequency, the coupling fre- quency of the elastic system is no longer equal to the buffet frequency, but keeps the same value as the structural natural frequency. The frequency lock-in occurs and stays present until the structural nature frequency is near the double buffet frequency. It means that the lock-in presents within a broad range, of which the lower threshold is near the buffet frequency, while the upper threshold is near the double buffet frequency. Moreover, the frequency range of lock-in is affected by mass ratio and structural damping. The lower the mass ratio and structural damping are, the wider the range of lock-in will be. The upper threshold of lock-in grows with the mass ratio and structural damping decreasing, but the lower threshold always keeps the same.

Lock-in phenomenon of tip clearance flow and its influence on aerodynamic damping under specified vibration on an axial transonic compressor rotor

In this study,the lock-in phenomenon of Tip Clearance Flow(TCF)instabilities and their relationship to blade vibration are investigated numerically on an axial transonic rotor with a large tip clearance.The capabilities of simulating instability flow and lock-in phenomenon are verified on a transonic rotor and a NACA0012 airfoil by comparing with the test data,respectively.The lock-in phenomenon is first numerically confirmed that may occur to TCF instabilities when its frequency is close to the blade vibration frequency.The lock-in region becomes wider with the vibration amplitude increasing,and it is also affected by modal shapes.For the rotor at the simulation conditions in this study,the bending mode results in a wider lock-in region than the torsional mode.In the lock-in region,the phase difference between the Tip Clearance Vortex(TCV)and the blade vibration changes with the flow condition and the frequency ratio of the blade vibration and the TCV instabilities.The frequency of the TCV instabilities reduces with the mass flow decreasing.Therefore,reducing mass flow and increasing frequency ratio have similar effects on the TCV phase,which causes a significant variation on the unsteady pressure amplitude in the blade tip area.Thus,the aerodynamic damping changes significantly with the TCV phase.The aerodynamic damping displays a nonlinear relationship with the vibration amplitude,and it changes from negative to positive with the vibration amplitude increasing at the same frequency ratio.The negative damping is mainly provided by the tip area of the blade.For unlocked conditions,the period of the TCF instabilities fluctuates over time,and it cannot be directly separated by their frequency features.Inter Blade Phase Angle(IBPA)also has an important influence on the feature of the TCV instabilities.The occurrence of frequency lock-in also requires“appropriate”IBPA.For the examined working conditions,the frequency lock-in occurs under 0 ND(Nodal Diameter),but not under 8 ND.However,no matter 0 ND or 8 ND,the phase of TCV always locks onto the IBPA at the examined conditions.

Influence of fluid-structure interaction on vortex induced vibration and lock-in phenomena in long span bridges

In this paper, deck models of a cable stayed bridge are generated in ABAQUS-finite element program once using only CFD model （one-way fluid-structure interaction） and another by using both the CFD model and the CSD model together （two-way fluid-structure interaction） in a co-simulation. Shedding frequencies for the associated wind velocities in the lock-in region are calculated in both approaches. The results are validated with Simiu and Scanlan results. The lift and drag coefficients are determined for the two approaches and the latter results are validated with the flat plate theory results by Munson and coauthors. A decrease in the critical wind velocity and the shedding frequencies considering two-way approach was determined compared to those obtained in the one-way approach. The results of the lift and drag forces in the two-way approach showed appreciable decrease in their values. It was concluded that the two-way approach predicts earlier vortex induced vibration for lower critical wind velocities and lock-in phenomena will appear at lower natural frequencies of the long span bridges. This helps the designers to efficiently plan and consider for the design and safety of the long span bridge against this type of vibration.

Resonator integrated optic gyro based on multilevel laser frequency lock-in technique

The resonator integrated optic gyros（RIOGs） based on the Sagnac effect have gained extensive attention in navigation and guidance systems due to their predominant advantages： high theoretical accuracy and simple integration. However, the problems of losing lock and low lock-in accuracy are the bottlenecks, which restrict the development of digital RIOGs. Therefore, a multilevel laser frequency lock-in technique has been proposed in this Letter to address these problems. The experimental results show that lock-in accuracy can be improved one order higher and without losing lock in a variable temperature environment. Then, a digital miniaturized RIOG prototype（18 cm × 18 cm × 20 cm） has been produced, and long-term（1 h） bias stability of 26.6 deg/h is successfully demonstrated.

A Portable Analog Lock-In Amplifier for Accurate Phase Measurement and Application in High-Precision Optical Oxygen Concentration Detection

A portable analog lock-in amplifier capable of accurate phase detection is proposed in this paper. The proposed lock-in amplifier, which uses the dual-channel orthometric signals as the references to build the xy coordinate system, can detect the relative phase between the input and x-axis based on trigonometric function. The sensitivity of the phase measurement reaches 0.014degree, and a detection precision of 0.1 degree is achieved. At the same time, the performance of the lock-in amplifier is verified in the high precision optical oxygen concentration detection. Experimental results reveal that the portable analog lock-in amplifier is accurate for phase detection applications. In the oxygen sensing experiments, 0.058% oxygen concentration resulted in 0.1 degree phase shift detected by the lock-in amplifier precisely. In addition, the lock-in amplifier is small and economical compared with the commercial lock-in equipments, so it can be easily integrated in many portable devices for industrial applications.