This paper takes the long-term mechanism exploration of the construction of teachers’ethics in the new era under the concept of“Sanquan education,”aiming to explore how to establish a long-term mechanism of the con...This paper takes the long-term mechanism exploration of the construction of teachers’ethics in the new era under the concept of“Sanquan education,”aiming to explore how to establish a long-term mechanism of the construction to meet the needs of college education development under the background of the new era.A series of targeted measures and suggestions are put forward,including improving the system and mechanism,strengthening the education and training of teachers’ethics,and establishing the evaluation and assessment mechanism.The implementation of these measures can promote the formation of the long-term mechanism of the construction of teachers’ethics in colleges and universities,improve teachers’ethics and behavior quality,and provide strong support for the development of education in colleges and universities.展开更多
Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain- containing 5 (FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates brow...Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain- containing 5 (FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue (WAT) and uncoupling protein I (UCP1) expression, leading to an increase in total body energy expenditure by augmented UCPl-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones, including growth plate, trabecular bone, cortical bone, articular cartilage, and bone-tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal (IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-kB ligand (RANKL)- induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice.展开更多
In the process of urbanization,farmers will inevitably lose their land,which is resulted from the large-scale requisition of rural collective land.The imperfect social security system in rural areas has resulted in a ...In the process of urbanization,farmers will inevitably lose their land,which is resulted from the large-scale requisition of rural collective land.The imperfect social security system in rural areas has resulted in a large number of landless farmers being transformed into urban poor people.Therefore,proper resettlement of landless farmers and the establishment of a long-term security mechanism for ensuring the basic livelihood of landless farmers are important issues that need to be resolved in the process of China’s social and economic development.展开更多
Based on the literature review of environmental anti-pollution researches, this paper analyzes the administra- tive mechanism of Huaihe River anti-pollution with game theory. Based on the quantitative analysis on thre...Based on the literature review of environmental anti-pollution researches, this paper analyzes the administra- tive mechanism of Huaihe River anti-pollution with game theory. Based on the quantitative analysis on three correspond- ing game models with four players including local residents, enterprises, local governments and competent authorities at higher levels, this paper demonstrates four main shortcomings of current administrative mechanism of Huaihe River anti-pollution system, including low emission cost, low connivance cost, overemphasis on heavy fine of the enterprises, neglect of the punishment on the local departments and intersected administrative mechanism. This paper sets up anti- pollution administrative mechanism, combining economic method with noneconomic method, government control with market mechanism, and introducing public participation. At last, this paper proposes policies, such as implementing emissions trading system, reforming public participation system, and reforming government’s environmental protection mechanism to promote law enforcement.展开更多
Thermal stabilities of microstructure and mechanical property have been investigated on superalloy U720Li, which is of great interest of application for jet engine and land-based turbine disc. The results showed that,...Thermal stabilities of microstructure and mechanical property have been investigated on superalloy U720Li, which is of great interest of application for jet engine and land-based turbine disc. The results showed that, the primary and secondary gamma' particles maintain good thermal stability at 650 and 700 degreesC with aging time up to 3000 h, while the tertiary gamma' is apparently dependent on aging temperature and time. The tertiary gamma' particles undergo a procedure of coarsening, dissolution and eventually complete disappearance with the increasing of aging time and temperature. They exhibit unusual high sensibility upon aging temperature, which is attributed to the lattice misfit between the gamma' precipitates and the matrix in the alloy. The grain boundary phase M23C6 remains stable without forming of sigma phase even with aging time up to 3000 h at 700 degreesC. Microhardness decreases apparently with increasing aging time and aging temperature. Theoretical analysis based on dislocation mechanism indicates that the change of microhardness should be attributed to the evolution of the tertiary gamma' during aging.展开更多
The failure of the 2017 Xinmo catastrophic rockslide in Maoxian County, Sichuan, Southwest China was a combined effect of long-term and shortterm triggering factors. Field investigation, historical data collection, la...The failure of the 2017 Xinmo catastrophic rockslide in Maoxian County, Sichuan, Southwest China was a combined effect of long-term and shortterm triggering factors. Field investigation, historical data collection, laboratory tests, chemical and microstructure analysis and numerical simulations were adopted herein to reveal the initiation and failure mechanism of the Xinmo rockslide. The analytical results showed that this failure involved the coupling of several triggering factors. The initial cracks in the rock mass were induced by historical earthquakes due to the convex topography and the direction effect. Rock masses from the source area of the Xinmo rockslide contain water-sensitive minerals, i.e., albite and chamosite, and the easily oxidized chemical element Fe, resulting in obvious strength deterioration under the action of water. The scanning electron microscopy(SEM) experimental results indicated that the internal structure of the rock mass is conducive to weathering. The compressive and shear strengths of the rock mass were reduced due to freeze-thaw cycles and weathering. The antecedent rainfall further deteriorated the stability of the slope, and stress and deformation accumulated continually in the locked section. Finally, the locked section sheared out, and the slope failed. An entrainment effect was observed in the Xinmo rockslide due to the presence of old landslide deposits and the antecedent rainfall, resulting in an amplification of the catastrophic rockslide. A simplified three dimensional analysis model was established in this study to reveal the influence of the triggering factors on the failure mechanism of the Xinmo rockslide.展开更多
OBJECTIVE: To calculate and compare the cost of Port and PICC's application in long-term intravenous administration, and to support the decision making of hospital manager. METHODS: Literature review and patient s...OBJECTIVE: To calculate and compare the cost of Port and PICC's application in long-term intravenous administration, and to support the decision making of hospital manager. METHODS: Literature review and patient survey in 2 oncology centers in China were carried out to investigate the cost and impact of Port and PICC for patients. The cost at different time of intravenous administration was calculated and compared. One-way sensitivity analysis was performed and tornado graph was drawn. RESULTS: Direct cost of Port at 0.5, 1, 1.5, and 2 years were7442, 8005, 8553, and 9131 CNY, and 4700, 9399, 14032, 18799 CNY for PICC respectively. Direct & indirect cost at 0.5, 1, 1.5, and 2 years were 9291, 11704, 14101, 16529 CNY for Port and 9697, 19393, 29023, 38787 CNY for PICC. Sensitivity analysis showed that productivity loss and device maintenance cost were the most in?uential factors to the result. CONCLUSION: Port had higher cost in short term and less in long term compared with PICC. Patients expected to get intravenous administration more than 0.5 year should use Port if both direct and indirect costs were included.展开更多
The Measures for the Administration of the Import of Mechanical and Electronic' Products co-formulated by the Ministry of Commerce,the General Administration of Customs and the General Administration of Quality Su...The Measures for the Administration of the Import of Mechanical and Electronic' Products co-formulated by the Ministry of Commerce,the General Administration of Customs and the General Administration of Quality Supervision,Inspection and Quarantine,was hereby promul- gated,which entered into force as of May 1,2008.展开更多
The subject of the present paper is to prove that the recently introduced conjecture of boundedness puts a ban over the view of stability as asymptotic property. This result comes in sharp contrast with the prescripti...The subject of the present paper is to prove that the recently introduced conjecture of boundedness puts a ban over the view of stability as asymptotic property. This result comes in sharp contrast with the prescription of the traditional thermodynamics and statistical physics which consider the existence of equilibrium as asymptotic property of all systems. The difference commences from the use of infinitesimal calculus as the basic implement for modelling by the latter while the primary premise of the conjecture of boundedness is sustaining the energy/matter/information permanently bounded and finite. The latter property overrules the infinitesimal calculus as the major implement of modelling because, among all, it is proven that the traditional one suffers unsoluble difficulties.展开更多
基金Central University of Finance and Economics Theoretical Research Project on Party Building and Ideological and Political Work(Project number:DJW23002)。
文摘This paper takes the long-term mechanism exploration of the construction of teachers’ethics in the new era under the concept of“Sanquan education,”aiming to explore how to establish a long-term mechanism of the construction to meet the needs of college education development under the background of the new era.A series of targeted measures and suggestions are put forward,including improving the system and mechanism,strengthening the education and training of teachers’ethics,and establishing the evaluation and assessment mechanism.The implementation of these measures can promote the formation of the long-term mechanism of the construction of teachers’ethics in colleges and universities,improve teachers’ethics and behavior quality,and provide strong support for the development of education in colleges and universities.
基金supported by a R01DE21464 through the National Institutes of Healthan Innovation in Oral Care Award through International Association for Dental Research and Glaxo Smith Kline Consumer Healthcare+2 种基金an Award through International Team of Implantology to JCby GZUCM Science Fund for Creative Research Groups(2016KYTD10)GZUCM Torch Program(A1-AFD015142Z08)to JZ
文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain- containing 5 (FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue (WAT) and uncoupling protein I (UCP1) expression, leading to an increase in total body energy expenditure by augmented UCPl-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones, including growth plate, trabecular bone, cortical bone, articular cartilage, and bone-tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal (IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-kB ligand (RANKL)- induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice.
文摘In the process of urbanization,farmers will inevitably lose their land,which is resulted from the large-scale requisition of rural collective land.The imperfect social security system in rural areas has resulted in a large number of landless farmers being transformed into urban poor people.Therefore,proper resettlement of landless farmers and the establishment of a long-term security mechanism for ensuring the basic livelihood of landless farmers are important issues that need to be resolved in the process of China’s social and economic development.
文摘Based on the literature review of environmental anti-pollution researches, this paper analyzes the administra- tive mechanism of Huaihe River anti-pollution with game theory. Based on the quantitative analysis on three correspond- ing game models with four players including local residents, enterprises, local governments and competent authorities at higher levels, this paper demonstrates four main shortcomings of current administrative mechanism of Huaihe River anti-pollution system, including low emission cost, low connivance cost, overemphasis on heavy fine of the enterprises, neglect of the punishment on the local departments and intersected administrative mechanism. This paper sets up anti- pollution administrative mechanism, combining economic method with noneconomic method, government control with market mechanism, and introducing public participation. At last, this paper proposes policies, such as implementing emissions trading system, reforming public participation system, and reforming government’s environmental protection mechanism to promote law enforcement.
文摘Thermal stabilities of microstructure and mechanical property have been investigated on superalloy U720Li, which is of great interest of application for jet engine and land-based turbine disc. The results showed that, the primary and secondary gamma' particles maintain good thermal stability at 650 and 700 degreesC with aging time up to 3000 h, while the tertiary gamma' is apparently dependent on aging temperature and time. The tertiary gamma' particles undergo a procedure of coarsening, dissolution and eventually complete disappearance with the increasing of aging time and temperature. They exhibit unusual high sensibility upon aging temperature, which is attributed to the lattice misfit between the gamma' precipitates and the matrix in the alloy. The grain boundary phase M23C6 remains stable without forming of sigma phase even with aging time up to 3000 h at 700 degreesC. Microhardness decreases apparently with increasing aging time and aging temperature. Theoretical analysis based on dislocation mechanism indicates that the change of microhardness should be attributed to the evolution of the tertiary gamma' during aging.
基金financially supported by the Open Fund of State Key Laboratory of Geohazard Prevention and Geoenvironment(No.SKLGP2021K008)the National Natural Science Foundation of China(41907247)。
文摘The failure of the 2017 Xinmo catastrophic rockslide in Maoxian County, Sichuan, Southwest China was a combined effect of long-term and shortterm triggering factors. Field investigation, historical data collection, laboratory tests, chemical and microstructure analysis and numerical simulations were adopted herein to reveal the initiation and failure mechanism of the Xinmo rockslide. The analytical results showed that this failure involved the coupling of several triggering factors. The initial cracks in the rock mass were induced by historical earthquakes due to the convex topography and the direction effect. Rock masses from the source area of the Xinmo rockslide contain water-sensitive minerals, i.e., albite and chamosite, and the easily oxidized chemical element Fe, resulting in obvious strength deterioration under the action of water. The scanning electron microscopy(SEM) experimental results indicated that the internal structure of the rock mass is conducive to weathering. The compressive and shear strengths of the rock mass were reduced due to freeze-thaw cycles and weathering. The antecedent rainfall further deteriorated the stability of the slope, and stress and deformation accumulated continually in the locked section. Finally, the locked section sheared out, and the slope failed. An entrainment effect was observed in the Xinmo rockslide due to the presence of old landslide deposits and the antecedent rainfall, resulting in an amplification of the catastrophic rockslide. A simplified three dimensional analysis model was established in this study to reveal the influence of the triggering factors on the failure mechanism of the Xinmo rockslide.
文摘OBJECTIVE: To calculate and compare the cost of Port and PICC's application in long-term intravenous administration, and to support the decision making of hospital manager. METHODS: Literature review and patient survey in 2 oncology centers in China were carried out to investigate the cost and impact of Port and PICC for patients. The cost at different time of intravenous administration was calculated and compared. One-way sensitivity analysis was performed and tornado graph was drawn. RESULTS: Direct cost of Port at 0.5, 1, 1.5, and 2 years were7442, 8005, 8553, and 9131 CNY, and 4700, 9399, 14032, 18799 CNY for PICC respectively. Direct & indirect cost at 0.5, 1, 1.5, and 2 years were 9291, 11704, 14101, 16529 CNY for Port and 9697, 19393, 29023, 38787 CNY for PICC. Sensitivity analysis showed that productivity loss and device maintenance cost were the most in?uential factors to the result. CONCLUSION: Port had higher cost in short term and less in long term compared with PICC. Patients expected to get intravenous administration more than 0.5 year should use Port if both direct and indirect costs were included.
文摘The Measures for the Administration of the Import of Mechanical and Electronic' Products co-formulated by the Ministry of Commerce,the General Administration of Customs and the General Administration of Quality Supervision,Inspection and Quarantine,was hereby promul- gated,which entered into force as of May 1,2008.
文摘The subject of the present paper is to prove that the recently introduced conjecture of boundedness puts a ban over the view of stability as asymptotic property. This result comes in sharp contrast with the prescription of the traditional thermodynamics and statistical physics which consider the existence of equilibrium as asymptotic property of all systems. The difference commences from the use of infinitesimal calculus as the basic implement for modelling by the latter while the primary premise of the conjecture of boundedness is sustaining the energy/matter/information permanently bounded and finite. The latter property overrules the infinitesimal calculus as the major implement of modelling because, among all, it is proven that the traditional one suffers unsoluble difficulties.