Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative disorder.The Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain unclear.In this st...Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative disorder.The Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain unclear.In this study,we gathered 794 constituents,1249 drug targets,1654 disease genes and 129 intersection genes.GO and KEGG were used to analyze the function of these genes.Compatibility of prescription study showed that monarch drug,minister drug,assistant and guide drug played a synergistic role in the treatment of CML.In addition,we obtained 20 hub genes and 12 key components.Molecular docking indicated that the main compounds and core proteins had good binding ability.The results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK,PI3K/AKT,FoxO and p53 signaling pathways.展开更多
Background:To preliminary the feasibility and the potential mechanism of classic ancient prescription of Chinese medicine Danggui Longhui pill in the treatment of COVID-19 based on network pharmacology.Methods:The act...Background:To preliminary the feasibility and the potential mechanism of classic ancient prescription of Chinese medicine Danggui Longhui pill in the treatment of COVID-19 based on network pharmacology.Methods:The active constituents and acting targets of classic ancient prescription of Chinese medicine Danggui Longhui pill were collected and screen out by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platformand Genecard databases.Cytoscape-v3.7.2 software and Search Tool for the Retrieval of Interacting Genes databases were used to construct and analyze networks and protein-protein interaction network.The R programming language software combined with Bioconductor were used to analyze gene function(the gene oncology)and gene pathway(Kyoto Encyclopedia of Genes and Genomes)enrichment of the targets.Results:Seventy-three active constituents of classic ancient prescription of Chinese medicine classic ancient prescription of Chinese medicine Danggui Longhui pill played its effect on 48 targets through 83 signal pathway were effected,including advanced glycation end products/receptor for advanced glycation end products,interleukin-17,tumorecrosis factor,NOD-like receptor and cytokine-cytokine receptor interaction.Conclusion:Classic ancient prescription of Chinese medicine Danggui Longhui pill has certain feasibility in the treatment of COVID-19.To predict the potential mechanism of classic ancient prescription of Chinese medicine Danggui Longhui pill in the treatment of COVID-19 may be related to the regulate inflammation and immune system.展开更多
Indirubin,indigo and isoindigo are the core representatives of a rather small category of bisindole alkaloids referred to as indigoids.These compounds are the coloured constituents of the natural dyes Indigo and the f...Indirubin,indigo and isoindigo are the core representatives of a rather small category of bisindole alkaloids referred to as indigoids.These compounds are the coloured constituents of the natural dyes Indigo and the famous molluscan Tyrian purple,used throughout the centuries for textile dying.In contrast with Indigo dyes,the major constituents of molluscan purple dyes are展开更多
文摘Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative disorder.The Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain unclear.In this study,we gathered 794 constituents,1249 drug targets,1654 disease genes and 129 intersection genes.GO and KEGG were used to analyze the function of these genes.Compatibility of prescription study showed that monarch drug,minister drug,assistant and guide drug played a synergistic role in the treatment of CML.In addition,we obtained 20 hub genes and 12 key components.Molecular docking indicated that the main compounds and core proteins had good binding ability.The results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK,PI3K/AKT,FoxO and p53 signaling pathways.
基金supported by Scientific Research Youth Fund of Health Department of Fujian Province(2018-1-90)Educational and Scientific Research Fund for Young and Middle-aged Teachers of Fujian Province(JAT191299)Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology,Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety(FS1809).
文摘Background:To preliminary the feasibility and the potential mechanism of classic ancient prescription of Chinese medicine Danggui Longhui pill in the treatment of COVID-19 based on network pharmacology.Methods:The active constituents and acting targets of classic ancient prescription of Chinese medicine Danggui Longhui pill were collected and screen out by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platformand Genecard databases.Cytoscape-v3.7.2 software and Search Tool for the Retrieval of Interacting Genes databases were used to construct and analyze networks and protein-protein interaction network.The R programming language software combined with Bioconductor were used to analyze gene function(the gene oncology)and gene pathway(Kyoto Encyclopedia of Genes and Genomes)enrichment of the targets.Results:Seventy-three active constituents of classic ancient prescription of Chinese medicine classic ancient prescription of Chinese medicine Danggui Longhui pill played its effect on 48 targets through 83 signal pathway were effected,including advanced glycation end products/receptor for advanced glycation end products,interleukin-17,tumorecrosis factor,NOD-like receptor and cytokine-cytokine receptor interaction.Conclusion:Classic ancient prescription of Chinese medicine Danggui Longhui pill has certain feasibility in the treatment of COVID-19.To predict the potential mechanism of classic ancient prescription of Chinese medicine Danggui Longhui pill in the treatment of COVID-19 may be related to the regulate inflammation and immune system.
文摘Indirubin,indigo and isoindigo are the core representatives of a rather small category of bisindole alkaloids referred to as indigoids.These compounds are the coloured constituents of the natural dyes Indigo and the famous molluscan Tyrian purple,used throughout the centuries for textile dying.In contrast with Indigo dyes,the major constituents of molluscan purple dyes are
