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Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease 被引量:1
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作者 Bo Li Yujie Chen +10 位作者 Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao Cheng Yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1593-1601,共9页
Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheime... Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis. 展开更多
关键词 Alzheimer’s disease mitochondrial biogenesis neural stem cell-derived exosome sIRT1-PGC1α regional brain distribution whole brain clearing and imaging
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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles
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作者 Yanting Liu Wei Huang +8 位作者 Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang 《Neural Regeneration Research》 SCIE CAS 2025年第4期1124-1134,共11页
The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin a... The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage. 展开更多
关键词 NEURODEGENERATION PARKIN Parkinson’s disease PINK1 subcellular distribution
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Spatiotemporal Distributions of Bacterioplankton Communities in the Qiantang River(Hangzhou Section),China
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作者 XU Jiaojiao ZHAO Li +4 位作者 LUKWAMBE Betina NICHOLAUS Regan ZHU Jinyong YANG Wen ZHENG Zhongming 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第4期1102-1114,共13页
The spatial and temporal distribution of bacterioplankton communities plays a vital role in understanding the ecological dynamics and health of aquatic ecosystems.In this study,we conducted a comprehensive investigati... The spatial and temporal distribution of bacterioplankton communities plays a vital role in understanding the ecological dynamics and health of aquatic ecosystems.In this study,we conducted a comprehensive investigation of the bacterioplankton communities in the Qiantang River(Hangzhou section).Water samples were collected quarterly from seven sites over a one-year period.Physical and chemical parameters,including dissolved oxygen(DO),water temperature(WT),chemical oxygen demand(COD),nitrite(NO_(2)^(-)),active phosphate(PO_(4)^(3-))and other indices were determined.In this study,theαdiversity,βdiversity and abundance differences of bacterial communities were investigated using 16S rRNA high-throughput sequencing analysis.The spatial and temporal distribution characteristics and main driving factors of the bacterioplankton community structure and diversity were discussed.The results showed that a total of 57 phyla were detected in the bacterioplankton community,among which Proteobacteria and Actinomycetes were the two dominant groups with the highest relative abundance.The results of PCoA based on Bray-Curtis distance showed that the sampling season had a slightly greater effect on the changes in bacterioplankton community structure in the Qiantang River.Mantel and partial Mantel test showed that environmental variables(Mantel r=0.6739,P<0.0001;partial Mantel r=0.507,P=0.0001)were more important than geographical distance(Mantel r=0.5322,P<0.001;partial Mantel r=0.1563,P=0.001).The distance attenuation model showed that there was significant distance attenuation in all four seasons,and the maximum limit of bacterial community diffusion was found in spring.RDA analysis showed that nine environmental factors,including COD,WT and DO,significantly affected community distribution(P<0.05).This study provides valuable insights into the spatial and temporal distribution characteristics of bacterioplankton communities,shedding light on their ecological roles in the Qiantang River.The information obtained can guide future research on the interactions between bacterioplankton and their environment,enabling the development of effective conservation strategies and sustainable management practices for aquatic ecosystems. 展开更多
关键词 Qiantang River bacterioplankton community spatial and temporal distribution 16s rRNA range attenuation
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Natural variations and geographical distributions of seed carotenoids and chlorophylls in 1167 Chinese soybean accessions 被引量:1
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作者 Berhane S.GEBREGZIABHER ZHANG Sheng-rui +7 位作者 Muhammad AZAM QI Jie Kwadwo G.AGYENIM-BOATENG FENG Yue LIU Yi-tian LI Jing LI Bin SUN Jun-ming 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2023年第9期2632-2647,共16页
Understanding the composition and contents of carotenoids in various soybean seed accessions is important for their nutritional assessment.This study investigated the variability in the concentrations of carotenoids a... Understanding the composition and contents of carotenoids in various soybean seed accessions is important for their nutritional assessment.This study investigated the variability in the concentrations of carotenoids and chlorophylls and revealed their associations with other nutritional quality traits in a genetically diverse set of Chinese soybean accessions comprised of cultivars and landraces.Genotype,planting year,accession type,seed cotyledon color,and ecoregion of origin significantly influenced the accumulation of carotenoids and chlorophylls.The mean total carotenoid content was in the range of 8.15–14.72μg g–1 across the ecoregions.The total carotenoid content was 1.2-fold higher in the landraces than in the cultivars.Soybeans with green cotyledons had higher contents of carotenoids and chlorophylls than those with yellow cotyledons.Remarkably,lutein was the most abundant carotenoid in all the germplasms,ranging from 1.35–37.44μg g–1.Carotenoids and chlorophylls showed significant correlations with other quality traits,which will help to set breeding strategies for enhancing soybean carotenoids without affecting the other components.Collectively,our results demonstrate that carotenoids are adequately accumulated in soybean seeds,however,they are strongly influenced by genetic factors,accession type,and germplasm origin.We identified novel germplasms with the highest total carotenoid contents across the various ecoregions of China that could serve as the genetic materials for soybean carotenoid breeding programs,and thereby as the raw materials for food sectors,pharmaceuticals,and the cosmetic industry. 展开更多
关键词 accession type carotenoid CHLOROPHYLL ECOREGION geographical distribution Pearson’s correlation soybean(Glycine max L.Merrill)
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Designing Bayesian Two-Sided Group Chain Sampling Plan for Gamma Prior Distribution
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作者 Waqar Hafeez Nazrina Aziz 《Computer Systems Science & Engineering》 SCIE EI 2023年第2期1069-1079,共11页
Acceptance sampling is used to decide either the whole lot will be accepted or rejected,based on inspection of randomly sampled items from the same lot.As an alternative to traditional sampling plans,it is possible to... Acceptance sampling is used to decide either the whole lot will be accepted or rejected,based on inspection of randomly sampled items from the same lot.As an alternative to traditional sampling plans,it is possible to use Baye-sian approaches using previous knowledge on process variation.This study pre-sents a Bayesian two-sided group chain sampling plan(BTSGChSP)by using various combinations of design parameters.In BTSGChSP,inspection is based on preceding as well as succeeding lots.Poisson function is used to derive the probability of lot acceptance based on defective and non-defective products.Gamma distribution is considered as a suitable prior for Poisson distribution.Four quality regions are found,namely:(i)quality decision region(QDR),(ii)probabil-istic quality region(PQR),(iii)limiting quality region(LQR)and(iv)indifference quality region(IQR).Producer’s risk and consumer’s risk are considered to esti-mate the quality regions,where acceptable quality level(AQL)is associated with producer’s risk and limiting quality level(LQL)is associated with consumer’s risk.Moreover,AQL and LQL are used in the selection of design parameters for BTSGChSP.The values based on all possible combinations of design parameters for BTSGChSP are presented and inflection points’values are found.Thefinding exposes that BTSGChSP is a better substitute for the existing plan for industrial practitioners. 展开更多
关键词 Bayesian acceptance sampling poisson distribution gamma distribution producer’s risk consumer’s risk
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Diameter distributions in Pinus sylvestris L.stands:evaluating modelling approaches including a machine learning technique
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作者 Şükrü Teoman Güner Maria J.Diamantopoulou Ramazan Özçelik 《Journal of Forestry Research》 SCIE CAS CSCD 2023年第6期1829-1842,共14页
The diameter distribution of trees in a stand provides the basis for determining the stand’s ecological and economic value,its structure and stability and appropriate management practices.Scots pine(Pinus sylvestris ... The diameter distribution of trees in a stand provides the basis for determining the stand’s ecological and economic value,its structure and stability and appropriate management practices.Scots pine(Pinus sylvestris L.)is one of the most common and important conifers in Turkey,so a well-planned management schedule is critical.Diameter distribution models to accurately describe the stand structure help improve management strategies,but developing reliable models requires a deep understanding of the growth,output and constraints of the forests.The most important information derived by diameter distribution models is primary data on horizontal stand structure for each diameter class of trees:basal area and volume per unit area.These predictions are required to estimate the range of products and predicted volume and yield from a forest stand.Here,to construct an accurate,reliable diameter distribution model for natural Scots pine stands in the Türkmen Mountain region,we used Johnson’s SBdistribution to represent the empirical diameter distributions of the stands using ground-based measurements from 55 sample plots that included1219 trees in natural distribution zones of the forests.As an alternative,nonparametric approach,which does not require any predefined function,an artificial intelligence model was constructed based on support vector machine methodology.An error index was calculated to evaluate the results.Overall,both Johnson’s SB probability density function with a three-parameter recovery approach and the support vector regression methodology provided reliable estimates of the diameter distribution of these stands. 展开更多
关键词 Diameter distribution Johnson’s s_(B) support vector regression scots pine Türkmen mountains
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A Model of the Fatigue Life Distribution of Composite Laminates Based on Their Static Strength Distribution 被引量:7
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作者 吴富强 姚卫星 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2008年第3期241-246,共6页
The reasons of the static strength dispersion and the fatigue life dispersion of composite laminates are analyzed in this article. It is concluded that the inner original defects, which derived from the manufacturing ... The reasons of the static strength dispersion and the fatigue life dispersion of composite laminates are analyzed in this article. It is concluded that the inner original defects, which derived from the manufacturing process of composite laminates, are the common and major reason of causing the random distributions of the static strength and the fatigue life. And there is a correlative relation between the two distributions. With the study of statistical relationship between the fatigue loading and the fatigue life in the uniform confidence level and the same survival rate S-N curves of material, the relationship between the static strength distribution and the fatigue life distribution through a material S-N curve model has been obtained. And then the model which is used to describe the distributions of fatigue life of composites, based on their distributions of static strength, is set up. This model reasonably reflects the effects of the inner original defects on the static strength dispersion and on the fatigue life dispersion of composite laminates. The experimental data of three kinds of composite laminates are employed to verify this model, and the results show that this model can predict the random distributions of fatigue life for composites under any fatigue loads fairly well. 展开更多
关键词 COMPOsITE static strength fatigue life s-N curve random distribution
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高压管汇材料疲劳性能测试及P-S-N模型曲线的拟合 被引量:1
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作者 黄艳娟 周思柱 李宁 《长江大学学报(自然科学版)》 2024年第3期55-61,共7页
高压管汇作为压裂设备中的主要易损件之一,其失效危害较大。它的失效原因主要是疲劳、冲蚀、腐蚀或者材料缺陷引起的刺漏和爆裂,其中尤以疲劳失效最不可预估。目前,对于高压管汇材料的疲劳性能研究不够深入,为解决高压管汇材料疲劳寿命... 高压管汇作为压裂设备中的主要易损件之一,其失效危害较大。它的失效原因主要是疲劳、冲蚀、腐蚀或者材料缺陷引起的刺漏和爆裂,其中尤以疲劳失效最不可预估。目前,对于高压管汇材料的疲劳性能研究不够深入,为解决高压管汇材料疲劳寿命的准确描述问题,以某国产高压管汇材料为例,进行了一系列疲劳试验,并基于试验数据,采用多种分布模型和不同S-N模型进行拟合分析,得出综合评价拟合能力最强的P-S-N模型。结果表明,该材料在中长疲劳寿命区,Weibull三参数模型在7级应力水平下综合评价能力最好;在存活率分别为50%、90%、99%、99.9%时,指数S-N模型的拟合系数均大于0.98,拟合能力最好。得出的P-S-N模型曲线可以为高压管汇的疲劳寿命以及安全设计提供依据。 展开更多
关键词 高压管汇材料 正态分布模型 Weibull分布模型 P-s-N模型 幂函数s-N模型 指数s-N模型
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采用非稳相偏振滤波的DAS-VSP数据P/S波分离方法及其应用
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作者 王腾飞 程玖兵 +3 位作者 孟涛 曹中林 胡善政 段鹏飞 《地球物理学报》 SCIE EI CAS CSCD 北大核心 2024年第7期2761-2772,共12页
分布式光纤声学传感(DAS)因成本低、易布设以及高密度采样等优势正成为重要的地震观测技术,尤其是越来越多地与垂直地震剖面(VSP)结合,用于主动地震勘探或被动地震监测.DAS传感器通过感知弹性波场产生的轴向应变或应变速率来观测地震波... 分布式光纤声学传感(DAS)因成本低、易布设以及高密度采样等优势正成为重要的地震观测技术,尤其是越来越多地与垂直地震剖面(VSP)结合,用于主动地震勘探或被动地震监测.DAS传感器通过感知弹性波场产生的轴向应变或应变速率来观测地震波场振动.然而,目前单分量DAS-VSP数据未完整地记录地下弹性波场的三维矢量振动信号,因此如何从中分离出P波或S波用于后续地震成像与参数反演是重要且很有挑战的课题.以弹性波传播理论为基础,本文根据P波和S波的频散关系估算接收点处各自的偏振方向,通过随频率和空间位置变化的偏振滤波实现DAS-VSP数据的P/S波分离.理论模型合成数据与东海实际DAS-VSP数据实验结果表明,该方法能有效地将P波和S波信号从单分量DAS-VSP数据中分离出来,可为后续纵横波速度反演、PP与PS波成像提供关键的数据预条件处理. 展开更多
关键词 分布式光纤声学传感(DAs) VsP P/s波分离 偏振投影 非稳相滤波
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宽负荷下切圆燃煤锅炉H_(2)S分布特性的数值模拟
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作者 邓磊 袁茂博 +3 位作者 杨家辉 韩磊 姜家豪 车得福 《煤炭学报》 EI CAS CSCD 北大核心 2024年第6期2887-2895,共9页
锅炉采用空气分级燃烧降低NO_(x)排放的同时也提高了主燃区H_(2)S体积分数。炉墙壁面过高的H_(2)S体积分数是加剧水冷壁高温腐蚀的重要因素。为保障新能源并网发电,大型燃煤机组灵活调峰的需求增加,不同负荷下的水冷壁近壁面H_(2)S分布... 锅炉采用空气分级燃烧降低NO_(x)排放的同时也提高了主燃区H_(2)S体积分数。炉墙壁面过高的H_(2)S体积分数是加剧水冷壁高温腐蚀的重要因素。为保障新能源并网发电,大型燃煤机组灵活调峰的需求增加,不同负荷下的水冷壁近壁面H_(2)S分布特性值得关注。通过正交试验分析了切圆燃煤锅炉运行参数对水冷壁近壁面H_(2)S体积分数分布的影响。选取一台超临界600 MW切圆燃煤锅炉建立数值模型,设计L_(16)(4^(5))正交工况,覆盖100%BMCR、75%THA,50%THA以及35%BMCR四种负荷。建立了自定义SO_(x)生成模型以确定燃料硫的析出和转化路径,模型包含多表面反应子模型以描述焦炭与O_(2)/CO_(2)/H_(2)O等3种气体的异相反应,并确定焦炭气化反应消耗量占总消耗量的比例,进而对炉膛H_(2)S空间分布进行了模拟计算。研究表明,近壁面高体积分数H_(2)S区域主要位于投运燃烧器层中最下层燃烧器以下以及最上层燃烧器以上至SOFA层之间,烟气切圆沿炉膛高度增加逐渐增大是造成后一区域H_(2)S体积分数较高的重要原因。35%BMCR负荷下水冷壁重点区域的H_(2)S平均体积分数为364μL/L,明显低于其他负荷。锅炉运行参数对重点区域H_(2)S体积分数影响程度的排序为:锅炉负荷>一次风率>主燃区空气过量系数>假想切圆直径>燃烧器竖直摆角。 展开更多
关键词 切圆燃煤锅炉 宽负荷 H2s分布 正交分析 数值模拟
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Origin and Distribution of Hydrogen Sulfide in Oil-Bearing Basins,China 被引量:9
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作者 ZHU Guangyou ZHANG Shuichang LIANG Yingbo 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2009年第6期1188-1201,共14页
The concentration of hydrogen sulfide gas (H2S) varies greatly in the oil-bearing basins of China, from zero to 90%. At present, oil and gas reservoirs with high H2S concentration have been discovered in three basin... The concentration of hydrogen sulfide gas (H2S) varies greatly in the oil-bearing basins of China, from zero to 90%. At present, oil and gas reservoirs with high H2S concentration have been discovered in three basins, viz. the Bohai Bay Basin, Sichuan Basin and the Tarim Basin, whereas natural gas with low H2S concentration has been found in the Ordos Basin, the Songliao Basin and the Junggar Basin. Studies suggest that in China H2S origin types are very complex. In the carbonate reservoir of the Sichuan Basin, the Ordos Basin and the Tarim Basin, as well as the carbonatedominated reservoir in the Luojia area of the Jiyang depression in the Bohai Bay Basin, Wumaying areas of the Huanghua depression, and Zhaolanzhuang areas of the Jizhong depression, the H2S is of Thermochemical Sulfate Reduction (TSR) origin. The H2S is of Bacterial Sulphate Reduction (BSR) origin deduced from the waterflooding operation in the Changheng Oilfield (placanticline oil fields) in the Songliao Basin. H2S originates from thermal decomposition of sulfur-bearing crude oil in the heavy oil area in the Junggar Basin and in the Liaohe heavy oil steam pilot area in the western depression of the Bohai Bay Basin. The origin types are most complex, including TSR and thermal decomposition of sulfcompounds among other combinations of causes. Various methods have been tried to identify the origin mechanism and to predict the distribution of H2S. The origin identification methods for H2S mainly comprise sulfur and carbon isotopes, reservoir petrology, particular biomarkers, and petroleum geology integrated technologies; using a combination of these applications can allow the accurate identification of the origins of H2S. The prediction technologies for primary and secondary origin of H2S have been set up separately. 展开更多
关键词 H2s TsR BsR distribution origin mechanism oil-bearing basins
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Spatial Distribution of Mulberry Thrips,Pseudodendrothrips mori Niwa (Thysanoptera:Thripidae) 被引量:5
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作者 Shahram Hesami Kayvan Etebari +1 位作者 Hassan Pourbabaei Mohammad Mojtaba Kamelmanesh 《Zoological Research》 CAS CSCD 北大核心 2007年第3期265-270,共6页
Pseudodendrothrips mori is a serious pest to mulberry trees and its infestation affects the qualitative and quantitative characteristics of mulberry leaves consumed by silkworm. The spatial distribution of mulberry th... Pseudodendrothrips mori is a serious pest to mulberry trees and its infestation affects the qualitative and quantitative characteristics of mulberry leaves consumed by silkworm. The spatial distribution of mulberry thrips within plant and orchard was assessed using Taylor's power law and Morisita's index of dispersion. The results showed that P.mori populations were localized in certain parts of the trees and fields. Distribution of thrips within plant showed that the larval instars were located on lower canopy (leaves 5-10 from top) of trees but adults preferred the upper canopy (leaves 1-5 from top). The thrips density did not vary significantly among the leaf direction inside the trees. The thrips tended to be more accumulated on the trees located in East, South and North than in Center and West of orchard. The distributions of P.mori adults and larvae on the leaves were aggregated. 展开更多
关键词 Mulberry thrips Pseudodendrothrips mori spatial distribution Taylor's power law Iran
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Prognostic significance of red blood cell distribution width in gastrointestinal disorders 被引量:21
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作者 Hemant Goyal Giuseppe Lippi +3 位作者 Altin Gjymishka Bijo John Rajiv Chhabra Elizabeth May 《World Journal of Gastroenterology》 SCIE CAS 2017年第27期4879-4891,共13页
The red blood cell distribution width(RDW) is a routinely measured and automatically reported blood parameter,which reflects the degree of anisocytosis. Recently,the baseline RDW was found to have clinical significanc... The red blood cell distribution width(RDW) is a routinely measured and automatically reported blood parameter,which reflects the degree of anisocytosis. Recently,the baseline RDW was found to have clinical significance for assessing clinical outcome and severity of various pathological conditions including cardiovascular diseases,sepsis,cancers,leukemia,renal dysfunction and respiratory diseases. A myriad of factors,most of which ill-defined,have an impact on the red cell population dynamics(i.e.,production,maturation and turnover). A delay in the red blood cell clearance in pathological conditions represents one of the leading determinants of increased anisocytosis. Further study of RDW may reveal new insight into inflammation mechanisms. In this review,we specifically discuss the current literature about the association of RDW in various disease conditions involving the gastrointestinal and hepatobiliary systems. We also present some of the related measurements for their value in predicting clinical outcomes in such conditions. According to our data,RDW was found to be a valuable prognostic index in gastrointestinal disorders along with additional inflammatory biomarkers(i.e.,C reactive protein,erythrocyte sedimentation rate,and platelet count) and current disease severity indices used in clinical practice. 展开更多
关键词 Red blood cell distribution width HEPATITIs PANCREATITIs Inflammatory bowel diseases Crohn’s disease Ulcerative colitis Colon cancer Hepatocellular carcinoma Acute mesenteric ischemia Gastrointestinal diseases
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R/S ratio in lead Ⅱ, and the prognostic significance of red cell distribution width in acute coronary syndrome 被引量:1
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作者 Abuzer Coskun Sevki Hakan Eren 《World Journal of Clinical Cases》 SCIE 2019年第16期2217-2226,共10页
BACKGROUND In spite of developing medical technologies to discover the etiopathogenesis of diseases and developments in the treatment of coronary artery disease, acute coronary syndromes(ACS) continue to be the main c... BACKGROUND In spite of developing medical technologies to discover the etiopathogenesis of diseases and developments in the treatment of coronary artery disease, acute coronary syndromes(ACS) continue to be the main cause of mortality and morbidity worldwide. New cardiac biomarkers and techniques are needed to help provide rapid diagnosis in order to evaluate risk in coronary artery patients.AIM To evaluate the effects of R to S ratio(RSR) in the electrocardiograph of patients with ACS, from the point of the arising complication after myocardial infarction(MI), to three-vessel disease(TVD) and mortality.METHODS The data of 1,296 patients with ACS, who presented to the emergency department of our hospital with chest pain between January 2014 and December2018 and were admitted to the cardiology clinic, were retrospectively included in this cross-sectional cohort study. Patients with an RSR value less than I were assigned to group Ⅰ, while those with an RSR value greater than Ⅰ were assigned to group Ⅱ.RESULTS In our study, 466(35.9%) of the 1,296 patients, 357(38.3%) in group 1 and 109(29.9%) in group 2, were female, with a mean age of 61.56 ± 9.42. ST-elevation MI 573(44.2%), unstable angina(UA) 502(38.7%) and non ST-elevation MI 220(17%)were more prevalent in group Ⅰ. Acute anterior MI 263(20.3) in group Ⅰ, and acute inferior MI 184(14.2) in group Ⅱ was higher. Ischemic heart failure was the most common complication. In group Ⅱ, the red cell distribution width(RDW) was 15.42 ± 1.82, the gensini score was 48.39 ± 36.44, the left ventricular ejection fraction was 41.17 ± 10.41, the TVD was 111(8.5), and the mortality rate was 72(5.6), which was significantly higher than group Ⅰ RDW; in MI with ST and nonST-elevation, in TVD, mortality and complications were high and low in UA. In single and multivariate regression analyses, the variables were associated with ACS risk.CONCLUSION RSR levels may be an auxiliary predictive value in ACS in terms of complications developing after MI, TVD, and mortality. 展开更多
关键词 Acute CORONARY sYNDROME EMERGENCY DEPARTMENT R/s RATIO Red cell distribution WIDTH
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Species Diversity and Elevational Distribution of Amphibians in the Xianxialing and Wuyishan Mountain Ranges,Southeastern China 被引量:2
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作者 Zhiqiang CHEN Yun TANG +3 位作者 Yingying WANG Yindie LI Longhui LIN Guohua DING 《Asian Herpetological Research》 SCIE CSCD 2020年第1期44-55,共12页
The species diversity and altitudinal distribution of amphibians along an eleva tional gradient of 200-1600 m in the Xianxialing and Wuyishan Mountain Ranges in Southeastern China were investiga ted through time-const... The species diversity and altitudinal distribution of amphibians along an eleva tional gradient of 200-1600 m in the Xianxialing and Wuyishan Mountain Ranges in Southeastern China were investiga ted through time-constra ined visual surveys along 32 transect lines in 9 survey areas,in which the ha bitat types were also recorded.A total of 27 amphibian species belonging to 19 genera,7 families,and 2 orders were found.The species diversity of the amphibians plateaued at low elevation,and the altitudinal boundary of their distribution was at 800 m.Their species compositions were dissimilar in the two mountain ranges probably beca use the annual average temperature and annual rainfall were different in both areas.The eleva tional Rapoport's rule demonstrated that the species range size of the amphibians expanded as the elevation increased in both mountain ranges.The results of the cross species method supported the rule only when the influence of the low-frequency occurrence proba bility of an investigated species was excluded,whereas those of the Steven's method strongly corroborated the rule rega rdless of the incidental occurrence or absence of the species. 展开更多
关键词 AMPHIBIAN diversity altitudinal distribution Rapoport’s rule CROss-sPECIEs METHOD steven’s METHOD
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Distribution of ^3H—nicotine in Rat Tissues Under the Influence of Simulated Microgravity 被引量:6
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作者 PARIMAL CHOWDHURY MICHAEL E. SOULSBY AND JAMES N. PASLEY (Department of Physiology and Biophysics, University of Arkansas for Medical Scienses, Little Rock, Arkansas 72205, USA) 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1999年第2期103-109,共7页
Rat tail suspension offers a useful model to reproduce physiologic responses to weightlessness.The present study was conducted in the head-down-tilt(HDT) rat model to assess changes in metabolism of body tissues emp... Rat tail suspension offers a useful model to reproduce physiologic responses to weightlessness.The present study was conducted in the head-down-tilt(HDT) rat model to assess changes in metabolism of body tissues employing 3H-nicotine. Twelve male rats were used in the study. Half of the rats were tail suspended at 30°for two weeks on a 12/12 light/dark cycle. During this period,body weight, food and fluid intakes were measured. At term, animals were anesthetized and injected IV withe a solution contaming 4 microuries of micotine. After 90 min the animals were sacrificed, exsanguinated and tissues (brain,blood,trachea,salivary gland,lung,heart,esophagus,spleen, kidneys and testes) were harvested. The distribution of 3H-nicotine per gram of each tissue was determinded and ealeulated as percent of total injected radioactivity. Final body weights of suspended ammals were significantly (P < 0.0 5) lower than those of eontrols(309±21 vs 350±11g). 3HNicotine waw retained in greatest amounts by the kindneys, followed inorder by salivary glands, spleen, and gastrointestinal tissues. compared to non-suspended control, the tissue retention of nicotine in suspended animals was decreased in the following tissues:esphyagus (25 %), aorta (25%). fundus (25%), trachea (22%), adrenals (18%), spleen (17 %), and pancreas (12 %). The decreased retention of mcotine in tissues from suspended animals may be indicative of the fluid shifts and changes in blood flow to those tissue beds. The lack of differnces in nicotine retention in liver and kidney between control and suspended groups may implicate a normal metabolic function of these organs even under simulated weightlessness. 展开更多
关键词 GRAVITATION Animals Male NICOTINE RATs Rats sprague-Dawley Research support Non-U.s. Gov't Tissue distribution Tritium Weightlessness simulation
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Modeling and forecasting exchange rate volatility in Bangladesh using GARCH models:a comparison based on normal and Student's t-error distribution 被引量:2
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作者 S.M.Abdullah Salina Siddiqua +1 位作者 Muhammad Shahadat Hossain Siddiquee Nazmul Hossain 《Financial Innovation》 2017年第1期238-256,共19页
Background:Modeling exchange rate volatility has remained crucially important because of its diverse implications.This study aimed to address the issue of error distribution assumption in modeling and forecasting exch... Background:Modeling exchange rate volatility has remained crucially important because of its diverse implications.This study aimed to address the issue of error distribution assumption in modeling and forecasting exchange rate volatility between the Bangladeshi taka(BDT)and the US dollar($).Methods:Using daily exchange rates for 7 years(January 1,2008,to April 30,2015),this study attempted to model dynamics following generalized autoregressive conditional heteroscedastic(GARCH),asymmetric power ARCH(APARCH),exponential generalized autoregressive conditional heteroscedstic(EGARCH),threshold generalized autoregressive conditional heteroscedstic(TGARCH),and integrated generalized autoregressive conditional heteroscedstic(IGARCH)processes under both normal and Student’s t-distribution assumptions for errors.Results and Conclusions:It was found that,in contrast with the normal distribution,the application of Student’s t-distribution for errors helped the models satisfy the diagnostic tests and show improved forecasting accuracy.With such error distribution for out-of-sample volatility forecasting,AR(2)–GARCH(1,1)is considered the best. 展开更多
关键词 Exchange rate VOLATILITY ARCH GARCH student’s t Error distribution
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Distribution of constitutive nitric oxide synthase in the jejunum of adult rat 被引量:6
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作者 ChenYM QianZM 《World Journal of Gastroenterology》 SCIE CAS CSCD 2002年第3期537-539,共3页
AIM: To study the distribution of the constitutive nitric oxide synthase (NOS) in the jejunum of adult rat. METHODS: The distribution of endothelial NOS (eNOS) was detected by immunohistochemistry. Immunofluorescence ... AIM: To study the distribution of the constitutive nitric oxide synthase (NOS) in the jejunum of adult rat. METHODS: The distribution of endothelial NOS (eNOS) was detected by immunohistochemistry. Immunofluorescence histochemical dual staining technique were used for studying the distribution of neuronal NOS (nNOS) and eNOS. The dual stained slides were observed under a confocal laser scanning microscope. RESULTS: Positive neuronal NOS (nNOS) and endothelial NOS (eNOS) cells were found to be distributed in lamina propria of villi, and the epithelial cell was not stained. eNOS was mainly located in submucosal vascular endothelia, while nNOS was mainly situated in myenteric plexus. Some cells in the villi had both nNOS and eNOS. More than 80% of the cells were positive for both nNOS and eNOS, the rest cells were positive either for nNOS or for eNOS. CONCLUSION: The two constitutive nitric oxide synthases are distributed differently in the jejunum of rat. nNOS distributed in myenteric plexus is a neurotransmitter in the non-adrenergic non-cholinergic (NANC) inhibitory nerves. eNOS distributed in endothelial and smooth muscle cells of blood vessels plays vasodilator role. eNOS and nNOS are coexpressed in some cells of lamina propria of villi. NO generated by those NOS is very important in the physiological and pathological process of small intestine. 展开更多
关键词 Animals Immunohistochemistry JEJUNUM Male Nitric Oxide synthase Nitric Oxide synthase Type I Nitric Oxide synthase Type III RATs Rats sprague-Dawley Research support Non-U.s. Gov't Tissue distribution
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基于T-S模糊逻辑的混合储能孤岛直流微电网功率分配控制
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作者 张伟杰 顾吉鹏 +3 位作者 张有兵 杨晓东 娄伟 汪斌杰 《电力自动化设备》 EI CSCD 北大核心 2024年第6期135-144,共10页
在含混合储能的直流微电网中,传统阻容下垂控制无法解决由线路电阻和负荷功率波动导致的系统功率分配失衡问题。为此,提出一种基于Takagi-Sugeno(T-S)模糊逻辑的自适应阻容下垂控制方法以实现混合储能的分频分配。根据蓄电池和超级电容... 在含混合储能的直流微电网中,传统阻容下垂控制无法解决由线路电阻和负荷功率波动导致的系统功率分配失衡问题。为此,提出一种基于Takagi-Sugeno(T-S)模糊逻辑的自适应阻容下垂控制方法以实现混合储能的分频分配。根据蓄电池和超级电容的物理特性,建立单个蓄电池支路输出电压、蓄电池组间输出功率差额和阻性下垂系数之间的T-S模糊逻辑关系,以及单个超级电容支路输出功率及其变化率、超级电容组间功率差额和容性下垂系数之间的T-S模糊逻辑关系,并由此构建基于T-S模糊逻辑的阻容下垂控制器。推导含混合储能的直流微电网中各部分的平均阻抗模型,并采用阻抗比分析法对微电网的小信号稳定性进行研究。MATLAB/Simulink仿真结果表明,基于T-S模糊逻辑的阻容下垂控制可保证在线路电阻和负荷功率波动情况下系统功率的合理分配。 展开更多
关键词 直流微电网 混合储能 T-s模糊逻辑 功率分配 稳定性分析
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国内S Zorb装置运行情况分析
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作者 韩乔昆 艾中秋 王卿 《石油炼制与化工》 CAS CSCD 北大核心 2024年第10期73-78,共6页
介绍了国内S Zorb装置的分布情况以及其中28套工业装置在2023年的运行情况,通过对比不同S Zorb装置的2023年运行数据发现,不同S Zorb装置原料硫含量和烯烃含量、主要操作参数、辛烷值损失、吸附剂活性虽然存在较大的差别,但所有装置均... 介绍了国内S Zorb装置的分布情况以及其中28套工业装置在2023年的运行情况,通过对比不同S Zorb装置的2023年运行数据发现,不同S Zorb装置原料硫含量和烯烃含量、主要操作参数、辛烷值损失、吸附剂活性虽然存在较大的差别,但所有装置均可稳定生产满足国Ⅵ标准的汽油,说明S Zorb装置具有较好的适应性。汇总了2011年以来中国石化S Zorb装置的运行数据,结果发现,中国石化S Zorb装置的原料硫含量波动较大,烯烃含量呈逐年下降趋势,而装置脱硫率基本不变,烯烃饱和反应及辛烷值损失变化较大。 展开更多
关键词 s Zorb 装置分布 运行参数 烯烃
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