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Use of low-frequency signals to improve imaging quality under high-velocity basalt 被引量:1
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作者 She Deping Guan Luping +1 位作者 Xu Ying Li Pei 《Applied Geophysics》 SCIE CSCD 2006年第2期112-119,共8页
Wave equation wave field numerical modeling technology is applied to the observation that deep layer imaging is difficult below a screening layer of high-velocity basalt. Three simple high-velocity basalt models are d... Wave equation wave field numerical modeling technology is applied to the observation that deep layer imaging is difficult below a screening layer of high-velocity basalt. Three simple high-velocity basalt models are designed on the basis of basalt formation characteristics. The analysis of deep-layer reflection seismic signal energy shows that lowfrequency seismic signals are capable of both penetrating the thin high-velocity basalt layer and reducing the diffraction noise caused by the rough surfaces. The simulation experiment of a complete 2D basalt model confirms that the low-frequency signals can be used to boost the quality of deep-layer imaging under the high-velocity basalt layer and achieve good results in low-pass filter processing of actual data. 展开更多
关键词 high-velocity screening layer BASALT low-frequency penetrating force and numerical modeling
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Efficiently identifying coalbed methane enrichment areas by detecting and locating low-frequency signals in the coal mine
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作者 Siyu Miao Guanwen Cheng +4 位作者 Haijiang Zhang Yuqi Huang Ning Gu Huasheng Zha Ji Gao 《Geohazard Mechanics》 2023年第1期86-93,共8页
Low-frequency signals have been widely found in the conventional oil/gas field and volcanic region as well as during hydraulic fracturing of unconventional oil/gas reservoirs.Their generation mechanism has been ascrib... Low-frequency signals have been widely found in the conventional oil/gas field and volcanic region as well as during hydraulic fracturing of unconventional oil/gas reservoirs.Their generation mechanism has been ascribed to the flow of gas/fluid in the fractures,which can induce the Krauklis wave around fractures and can further excite low-frequency seismic body wave signals at diffraction points.Thus,it is theoretically feasible to determine the gas/fluid enrichment areas and migration pathways by locating the low-frequency signals.Here we have utilized a surface dense seismic array deployed above the Sijiazhuang coal mine in Shanxi province to detect and locate such low-frequency signals that are dominant in the frequency range of 1.5–4.0 Hz.Waveform migrationbased location method is employed to locate these signals that have low signal to noise ratios.We further compare the distribution of low-frequency signals and coalbed methane concentrations that are estimated based on ambient noise tomography result with the same seismic array.The spatial consistency between low-frequency signals and coalbed methane enrichment areas suggests that detecting and locating low-frequency signals with a surface seismic array is an efficient way to identify gas enrichment areas and potential gas migration pathways. 展开更多
关键词 Coalbed methane Enrichment areas Efficiently detecting low-frequency signals Coal mine
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Enhancing Low-Frequency Microwave Absorption Through Structural Polarization Modulation of MXenes 被引量:2
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作者 Bo Shan Yang Wang +1 位作者 Xinyi Ji Yi Huang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第10期435-452,共18页
Two-dimensional carbon-based materials have shown promising electromagnetic wave absorption capabilities in mid-and high-frequency ranges,but face challenges in low-frequency absorption due to limited control over pol... Two-dimensional carbon-based materials have shown promising electromagnetic wave absorption capabilities in mid-and high-frequency ranges,but face challenges in low-frequency absorption due to limited control over polarization response mecha-nisms and ambiguous resonance behavior.In this study,we pro-pose a novel approach to enhance absorption efficiency in aligned three-dimensional(3D)MXene/CNF(cellulose nanofibers)cavities by modifying polarization properties and manipulating resonance response in the 3D MXene architecture.This controlled polarization mechanism results in a significant shift of the main absorption region from the X-band to the S-band,leading to a remarkable reflection loss value of-47.9 dB in the low-frequency range.Furthermore,our findings revealed the importance of the oriented electromagnetic coupling in influencing electromagnetic response and microwave absorption properties.The present study inspired us to develop a generic strategy for low-frequency tuned absorption in the absence of magnetic element participation,while orientation-induced polarization and the derived magnetic resonance coupling are the key controlling factors of the method. 展开更多
关键词 Hierarchical structure MXene Microwave absorption low-frequency
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Low-frequency bandgap and vibration suppression mechanism of a novel square hierarchical honeycomb metamaterial
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作者 Xingjian DONG Shuo WANG +5 位作者 Anshuai WANG Liang WANG Zhaozhan ZHANG Yuanhao TIE Qingyu LIN Yongtao SUN 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第10期1841-1856,共16页
The suppression of low-frequency vibration and noise has always been an important issue in a wide range of engineering applications.To address this concern,a novel square hierarchical honeycomb metamaterial capable of... The suppression of low-frequency vibration and noise has always been an important issue in a wide range of engineering applications.To address this concern,a novel square hierarchical honeycomb metamaterial capable of reducing low-frequency noise has been developed.By combining Bloch’s theorem with the finite element method,the band structure is calculated.Numerical results indicate that this metamaterial can produce multiple low-frequency bandgaps within 500 Hz,with a bandgap ratio exceeding 50%.The first bandgap spans from 169.57 Hz to 216.42 Hz.To reveal the formation mechanism of the bandgap,a vibrational mode analysis is performed.Numerical analysis demonstrates that the bandgap is attributed to the suppression of elastic wave propagation by the vibrations of the structure’s two protruding corners and overall expansion vibrations.Additionally,detailed parametric analyses are conducted to investigate the effect ofθ,i.e.,the angle between the protruding corner of the structure and the horizontal direction,on the band structures and the total effective bandgap width.It is found that reducingθis conducive to obtaining lower frequency bandgaps.The propagation characteristics of elastic waves in the structure are explored by the group velocity,phase velocity,and wave propagation direction.Finally,the transmission characteristics of a finite periodic structure are investigated experimentally.The results indicate significant acceleration amplitude attenuation within the bandgap range,confirming the structure’s excellent low-frequency vibration suppression capability. 展开更多
关键词 wave propagation vibration suppression METAMATERIAL low-frequency bandgap
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Dynamic characteristics of coal specimens with varying static preloading levels under low-frequency disturbance load
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作者 WEN Xiao-ze FENG Guo-rui +5 位作者 GUO Jun YU Lu-yang QIAN Rui-peng ZHANG Jie ZHANG Peng-fei FENG Wen-ming 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2644-2657,共14页
The mechanical properties of residual coal pillars under the influence of upward mining disturbances significantly affect the safety of residual mining activities on working faces.This study conducted low-frequency di... The mechanical properties of residual coal pillars under the influence of upward mining disturbances significantly affect the safety of residual mining activities on working faces.This study conducted low-frequency disturbance dynamic uniaxial compression tests on coal specimens using a self-developed dynamic-static load coupling electro-hydraulic servo system,and studied the strength evolutions,surface deformations,acoustic emission(AE)characteristic parameters,and the failure modes of coal specimens with different static preloading levels were studied.The disturbance damage is positively correlated with the coal specimen static preload level.Specifically,the cumulative AE count rates of the initial accelerated damage stage for the coal specimens with static preloading level of 60%and 70%of the uniaxial compressive strength(UCS)were 2.66 and 3.19 times that of the 50%UCS specimens,respectively.Macroscopically,this behaviour manifested as a decrease in the compressive strength,and the mean strengths of the disturbance-damaged coal specimens with 60%and 70%of UCS static preloading decreased by 8.53%and 9.32%,respectively,compared to those of the specimens under pure static loading.The crack sources,such as the primary fissures,strongly control the dynamic response of the coal specimen.The difference between the dynamic responses of the coal specimens and that of dense rocks is significant. 展开更多
关键词 low-frequency disturbance dynamic response coal specimens static preloading level
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A seismic elastic moduli module for the measurements of low-frequency wave dispersion and attenuation of fluid-saturated rocks under different pressures
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作者 Yan-Xiao He Shang-Xu Wang +9 位作者 Gen-Yang Tang Chao Sun Hong-Bing Li San-Yi Yuan Xian Wei Li-Deng Gan Xiao-Feng Dai Qiang Ge Peng-Peng Wei Hui-Qing Zhang 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期162-181,共20页
Knowledge about the seismic elastic modulus dispersion,and associated attenuation,in fluid-saturated rocks is essential for better interpretation of seismic observations taken as part of hydrocarbon identification and... Knowledge about the seismic elastic modulus dispersion,and associated attenuation,in fluid-saturated rocks is essential for better interpretation of seismic observations taken as part of hydrocarbon identification and time-lapse seismic surveillance of both conventional and unconventional reservoir and overburden performances.A Seismic Elastic Moduli Module has been developed,based on the forced-oscillations method,to experimentally investigate the frequency dependence of Young's modulus and Poisson's ratio,as well as the inferred attenuation,of cylindrical samples under different confining pressure conditions.Calibration with three standard samples showed that the measured elastic moduli were consistent with the published data,indicating that the new apparatus can operate reliably over a wide frequency range of f∈[1-2000,10^(6)]Hz.The Young's modulus and Poisson's ratio of the shale and the tight sandstone samples were measured under axial stress oscillations to assess the frequency-and pressure-dependent effects.Under dry condition,both samples appear to be nearly frequency independent,with weak pressure dependence for the shale and significant pressure dependence for the sandstone.In particular,it was found that the tight sandstone with complex pore microstructure exhibited apparent dispersion and attenuation under brine or glycerin saturation conditions,the levels of which were strongly influenced by the increased effective pressure.In addition,the measured Young's moduli results were compared with the theoretical predictions from a scaled poroelastic model with a reasonably good agreement,revealing that the combined fluid flow mechanisms at both mesoscopic and microscopic scales possibly responsible for the measured dispersion. 展开更多
关键词 low-frequency measurements Dispersion and attenuation Rock physics Fluid flow
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Low-frequency oscillation of train-network system considering traction power supply mode
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作者 Yuchen Liu Xiaoqin Lyu +1 位作者 Mingyuan Chang Qiqi Yang 《Railway Engineering Science》 EI 2024年第2期244-256,共13页
The low-frequency oscillation(LFO)has occurred in the train-network system due to the introduction of the power electronics of the trains.The modeling and analyzing method in current researches based on electrified ra... The low-frequency oscillation(LFO)has occurred in the train-network system due to the introduction of the power electronics of the trains.The modeling and analyzing method in current researches based on electrified railway unilateral power supply system are not suitable for the LFO analysis in a bilateral power supply system,where the trains are supplied by two traction substations.In this work,based on the single-input and single-output impedance model of China CRH5 trains,the node admittance matrices of the train-network system both in unilateral and bilateral power supply modes are established,including three-phase power grid,traction transformers and traction network.Then the modal analysis is used to study the oscillation modes and propagation characteristics of the unilateral and bilateral power supply systems.Moreover,the influence of the equivalent inductance of the power grid,the length of the transmission line,and the length of the traction network are analyzed on the critical oscillation mode of the bilateral power supply system.Finally,the theoretical analysis results are verified by the time-domain simulation model in MATLAB/Simulink. 展开更多
关键词 low-frequency oscillation Train-network system Modal analysis Bilateral power supply Participation factor
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Suppression of low-frequency ultrasound broadband vibration using star-shaped single-phase metamaterials
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作者 Rui Zhao Jian Zheng +4 位作者 Jin Guo Yunbo Shi Hengzhen Feng Jun Tang Jun Liu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第4期217-224,共8页
In order to suppress the low-frequency ultrasound vibration in the broadband range of 20 k Hz—100 k Hz,this paper proposes and discusses an acoustic metamaterial with low-frequency ultrasound vibration attenuation pr... In order to suppress the low-frequency ultrasound vibration in the broadband range of 20 k Hz—100 k Hz,this paper proposes and discusses an acoustic metamaterial with low-frequency ultrasound vibration attenuation properties,which is configured by hybrid arc and sharp-angle convergent star-shaped lattices.The effect of the dispersion relation and the bandgap characteristic for the scatterers in star-shaped are simulated and analyzed.The target bandgap width is extended by optimizing the geometry parameters of arc and sharp-angle convergent lattices.The proposed metamaterial configured by optimized hybrid lattices exhibits remarkable broad bandgap characteristics by bandgap complementarity,and the simulation results verify a 99%vibration attenuation amplitude can be obtained in the frequency of20 k Hz—100 k Hz.After the fabrication of the proposed hybrid configurational star-shaped metamaterial by 3D printing technique,the transmission loss experiments are performed,and the experimental results indicate that the fabricated metamaterial has the characteristics of broadband vibration attenuation and an amplitude greater than 85%attenuation for the target frequency.These results demonstrate that the hybrid configurational star-shaped metamaterials can effectively widen the bandgap and realize high efficiency attenuation,which has capability for the vibration attenuation in the application of highprecise equipment. 展开更多
关键词 Star-shaped metamaterials BROADBAND Vibration attenuation low-frequency ultrasound vibration Transmission loss
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Current optimization-based control of dual three-phase PMSM for low-frequency temperature swing reduction
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作者 Linlin Lu Xueqing Wang +3 位作者 Luhan Jin Qiong Liu Yun Zhang Yao Mao 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第4期238-246,共9页
In this paper,a control scheme based on current optimization is proposed for dual three-phase permanent-magnet synchronous motor(DTP-PMSM)drive to reduce the low-frequency temperature swing.The reduction of temperatur... In this paper,a control scheme based on current optimization is proposed for dual three-phase permanent-magnet synchronous motor(DTP-PMSM)drive to reduce the low-frequency temperature swing.The reduction of temperature swing can be equivalent to reducing maximum instantaneous phase copper loss in this paper.First,a two-level optimization aiming at minimizing maximum instantaneous phase copper loss at each electrical angle is proposed.Then,the optimization is transformed to a singlelevel optimization by introducing the auxiliary variable for easy solving.Considering that singleobjective optimization trades a great total copper loss for a small reduction of maximum phase copper loss,the optimization considering both instantaneous total copper loss and maximum phase copper loss is proposed,which has the same performance of temperature swing reduction but with lower total loss.In this way,the proposed control scheme can reduce maximum junction temperature by 11%.Both simulation and experimental results are presented to prove the effectiveness and superiority of the proposed control scheme for low-frequency temperature swing reduction. 展开更多
关键词 Dual three-phase PMSM low-frequency temperature swing Copper loss Current optimization Connected neutral points
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High-order Bragg forward scattering and frequency shift of low-frequency underwater acoustic field by moving rough sea surface
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作者 莫亚枭 张朝金 +2 位作者 鹿力成 孙启航 马力 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期459-470,共12页
Acoustic scattering modulation caused by an undulating sea surface on the space-time dimension seriously affects underwater detection and target recognition.Herein,underwater acoustic scattering modulation from a movi... Acoustic scattering modulation caused by an undulating sea surface on the space-time dimension seriously affects underwater detection and target recognition.Herein,underwater acoustic scattering modulation from a moving rough sea surface is studied based on integral equation and parabolic equation.And with the principles of grating and constructive interference,the mechanism of this acoustic scattering modulation is explained.The periodicity of the interference of moving rough sea surface will lead to the interference of the scattering field at a series of discrete angles,which will form comb-like and frequency-shift characteristics on the intensity and the frequency spectrum of the acoustic scattering field,respectively,which is a high-order Bragg scattering phenomenon.Unlike the conventional Doppler effect,the frequency shifts of the Bragg scattering phenomenon are multiples of the undulating sea surface frequency and are independent of the incident sound wave frequency.Therefore,even if a low-frequency underwater acoustic field is incident,it will produce obvious frequency shifts.Moreover,under the action of ideal sinusoidal waves,swells,fully grown wind waves,unsteady wind waves,or mixed waves,different moving rough sea surfaces create different acoustic scattering processes and possess different frequency shift characteristics.For the swell wave,which tends to be a single harmonic wave,the moving rough sea surface produces more obvious high-order scattering and frequency shifts.The same phenomena are observed on the sea surface under fully grown wind waves,however,the frequency shift slightly offsets the multiple peak frequencies of the wind wave spectrum.Comparing with the swell and fully-grown wind waves,the acoustic scattering and frequency shift are not obvious for the sea surface under unsteady wind waves. 展开更多
关键词 high-order Bragg scattering frequency shift low-frequency acoustic field moving rough sea surface
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A low-frequency pure metal metamaterial absorber with continuously tunable stiffness
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作者 Xingzhong WANG Shiteng RUI +2 位作者 Shaokun YANG Weiquan ZHANG Fuyin MA 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第7期1209-1224,共16页
To address the incompatibility between high environmental adaptability and deep subwavelength characteristics in conventional local resonance metamaterials,and overcome the deficiencies in the stability of existing ac... To address the incompatibility between high environmental adaptability and deep subwavelength characteristics in conventional local resonance metamaterials,and overcome the deficiencies in the stability of existing active control techniques for band gaps,this paper proposes a design method of pure metal vibration damping metamaterial with continuously tunable stiffness for wideband elastic wave absorption.We design a dual-helix narrow-slit pure metal metamaterial unit,which possesses the triple advantage of high spatial compactness,low stiffness characteristics,and high structural stability,enabling the opening of elastic flexural band gaps in the low-frequency range.Similar to the principle of a sliding rheostat,the introduction of continuously sliding plug-ins into the helical slits enables the continuous variation of the stiffness of the metamaterial unit,achieving a continuously tunable band gap effect.This successfully extends the effective band gap by more than ten times.The experimental results indicate that this metamaterial unit can be used as an additional vibration absorber to absorb the low-frequency vibration energy effectively.Furthermore,it advances the metamaterial absorbers from a purely passive narrowband design to a wideband tunable one.The pure metal double-helix metamaterials retain the subwavelength properties of metamaterials and are suitable for deployment in harsh environments.Simultaneously,by adjusting its stiffness,it substantially broadens the effective band gap range,presenting promising potential applications in various mechanical equipment operating under adverse conditions. 展开更多
关键词 elastic metamaterial absorber continuously tunable stiffness low-frequency vibration damping variable stiffness design pure metal structure
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Altered spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitude of low-frequency fluctuations:a functional magnetic resonance imaging study
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作者 Xue-Lin Wang Xu-Jun Zheng +8 位作者 Li-Juan Zhang Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Xu Chen Yi Shao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第9期1665-1674,共10页
AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)method.METHO... AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)method.METHODS:Twenty HR patients and 20 healthy controls(HCs)were respectively recruited.The age,gender,and educational background characteristics of the two groups were similar.After functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the fALFF method.Receiver operating characteristic(ROC)curve analysis was used to classify the data.Further,we used Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with HR.RESULTS:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus(RO-MFG)and right lingual gyrus.In contrast,the values of fALFFs in the left middle temporal gyrus(MTG),left superior temporal pole(STP),left middle frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and right supplementary motor area(SMA)were higher in the HR group.The results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group(P<0.001).The fALFF values of the left middle frontal gyrus in HR patients were positively correlated with anxiety scores(r=0.9232;P<0.0001)and depression scores(r=0.9682;P<0.0001).CONCLUSION:fALFF values in multiple brain regions of HR patients are abnormal,suggesting that these brain regions in HR patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of HR. 展开更多
关键词 hypertensive retinopathy fractional amplitude of low-frequency fluctuation brain region magnetic resonance imaging
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Diagnosing ratio of electron density to collision frequency of plasma surrounding scaled model in a shock tube using low-frequency alternating magnetic field phase shift
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作者 吴明兴 谢楷 +3 位作者 刘艳 徐晗 张宝 田得阳 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期519-530,共12页
A non-contact low-frequency(LF)method of diagnosing the plasma surrounding a scaled model in a shock tube is proposed.This method utilizes the phase shift occurring after the transmission of an LF alternating magnetic... A non-contact low-frequency(LF)method of diagnosing the plasma surrounding a scaled model in a shock tube is proposed.This method utilizes the phase shift occurring after the transmission of an LF alternating magnetic field through the plasma to directly measure the ratio of the plasma loop average electron density to collision frequency.An equivalent circuit model is used to analyze the relationship of the phase shift of the magnetic field component of LF electromagnetic waves with the plasma electron density and collision frequency.The applicable range of the LF method on a given plasma scale is analyzed.The upper diagnostic limit for the ratio of the electron density(unit:m^(-3))to collision frequency(unit:Hz)exceeds 1×10^(11),enabling an electron density to exceed 1×10^(20)m^(-3)and a collision frequency to be less than 1 GHz.In this work,the feasibility of using the LF phase shift to implement the plasma diagnosis is also assessed.Diagnosis experiments on shock tube equipment are conducted by using both the electrostatic probe method and LF method.By comparing the diagnostic results of the two methods,the inversion results are relatively consistent with each other,thereby preliminarily verifying the feasibility of the LF method.The ratio of the electron density to the collision frequency has a relatively uniform distribution during the plasma stabilization.The LF diagnostic path is a loop around the model,which is suitable for diagnosing the plasma that surrounds the model.Finally,the causes of diagnostic discrepancy between the two methods are analyzed.The proposed method provides a new avenue for diagnosing high-density enveloping plasma. 展开更多
关键词 low-frequency alternating magnetic field phase shift shock-tube plasma diagnosis electron density collision frequency
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The dynamics of low-frequency signal acoustic intensity vector vortex structure in shallow sea
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作者 V.A.Shchurov 《Chinese Journal of Acoustics》 CSCD 2019年第2期113-131,共19页
Spatiotemporal vector and phase properties of interference field of low-frequency signalling tone between three local vortices in a real shallow sea wave-guide have been studied.It has been demonstrated that in the fi... Spatiotemporal vector and phase properties of interference field of low-frequency signalling tone between three local vortices in a real shallow sea wave-guide have been studied.It has been demonstrated that in the field of constructive interference,components of particle velocity field and acoustic pressure are coherent.As a consequence the transfer of signal energy alog the axis of a shallow sea wave-guide is accomplished with plane wave.Physical objects are detected in the field of destructive interference,which,according to known deterministic signs,can be defined as local vortices of the intensity vector.A large-scale vorticity with acoustic intensity vector curl,components different from zero originates in the vicinity of local vortices.Regular particle displacements of local vortices have been detected against combined receiving device phase centre along the axis of a wave-guide.It has been demonstrated that the structure of vortices depends on signal/noise ratio.Local vortices and vorticity form vortex structure of vector acoustic field.Signalling tone with frequency of 88 ± 1 Hz from near-surface moving sound source was taken into consideration.Introduced results of full-scale experiment expand our concepts of real fundamental properties of shallow sea acoustic field and are to be considered in theoretical models. 展开更多
关键词 Re The DYNAMICS of low-frequency signal acoustic intensity VECTOR VORTEX structure in SHALLOW SEA
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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function
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作者 Chonglin Su Taiqi Huang +3 位作者 Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen 《Neural Regeneration Research》 SCIE CAS 2025年第9期2520-2537,共18页
The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental challenges.In the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an impo... The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental challenges.In the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and neuroplasticity.The glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic mechanisms.Protein interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive functions.An appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive impairment.Patients with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor expression.This review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive activities.It emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive impairment.This provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders. 展开更多
关键词 brain-derived neurotrophic factor calcium signaling glucocorticoid receptor GLUCOCORTICOID glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders NEUROPLASTICITY stress
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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases
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作者 Fengcheng Deng Dan Yang +6 位作者 Lingxi Qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua Huang 《Neural Regeneration Research》 SCIE CAS 2025年第11期3095-3112,共18页
The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enh... The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain axis.The gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine systems.Conversely,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host interactions.This reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological diseases.The coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological diseases.This study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological diseases.Recent pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional disorders.This can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage forms.These findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases. 展开更多
关键词 cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway STRATEGY THERAPIES
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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease
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作者 Mackenzie M.Spicer Jianqi Yang +5 位作者 Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher 《Neural Regeneration Research》 SCIE CAS 2025年第10期2969-2981,共13页
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rode... Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease. 展开更多
关键词 adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus EXERCISE learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)
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Netrin-1 signaling pathway mechanisms in neurodegenerative diseases
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作者 Kedong Zhu Hualong Wang +2 位作者 Keqiang Ye Guiqin Chen Zhaohui Zhang 《Neural Regeneration Research》 SCIE CAS 2025年第4期960-972,共13页
Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal sur... Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders. 展开更多
关键词 Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways NETRIN-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C
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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease
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作者 Milica Zeljkovic Jovanovic Jelena Stanojevic +4 位作者 Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic 《Neural Regeneration Research》 SCIE CAS 2025年第7期2053-2067,共15页
An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease prog... An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in PD.Repetitive transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's disease.However,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain unknown.The purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated signaling.Animals with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod test.Immunoblot,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate putamen.Prolonged intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate putamen.Treatment with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor symptoms.After treatment with prolonged intermittent theta burst stimulation,complete motor recovery was observed.This improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst stimulation.Our results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)R.Intermittent theta burst stimulation reversed these effects by restoring the abundances of A_(1)R and A_(2A)R to control levels.The shift in ARs expression likely restored the balance between dopamine-adenosine signaling,ultimately leading to the recovery of motor control. 展开更多
关键词 A_(1)R A_(2A)R adenosine receptors ADENOSINE ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling
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Low-frequency data analysis and expansion 被引量:9
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作者 张军华 张彬彬 +2 位作者 张在金 梁鸿贤 葛大明 《Applied Geophysics》 SCIE CSCD 2015年第2期212-220,275,共10页
The use of low-frequency seismic data improves the seismic resolution, and the imaging and inversion quality. Furthermore, low-frequency data are applied in hydrocarbon exploration; thus, we need to better use low-fre... The use of low-frequency seismic data improves the seismic resolution, and the imaging and inversion quality. Furthermore, low-frequency data are applied in hydrocarbon exploration; thus, we need to better use low-frequency data. In seismic wavelets, the loss of low-frequency data decreases the main lobe amplitude and increases the first side lobe amplitude and results in the periodic shocking attenuation of the secondary side lobe. The loss of low frequencies likely produces pseudo-events and the false appearance of higher resolution. We use models to examine the removal of low-frequency data in seismic data processing. The results suggest that the removal of low frequencies create distortions, especially for steep structures and thin layers. We also perform low-frequency expansion using compressed sensing and sparse constraints and develop the corresponding module. Finally, we apply the proposed method to real common image point gathers with good results. 展开更多
关键词 seismic wavelet forward modeling low-frequency expansion compressed sensing sparse constraint
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