This paper is an introduction to mesh based generated reluctance network modeling using triangular elements.Many contributions on mesh based generated reluctance networks using rectangular shaped elements have been pu...This paper is an introduction to mesh based generated reluctance network modeling using triangular elements.Many contributions on mesh based generated reluctance networks using rectangular shaped elements have been published,but very few on those generated from a mesh using triangular elements.The use of triangular elements is aimed at extending the application of the approach to any shape of modeled devices.Basic concepts of the approach are presented in the case of electromagnetic devices.The procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB environment are also included.展开更多
This paper is an introduction to mesh based generated reluctance network modeling.An overview of scientific works which led to the development of this approach is first presented.Basic concepts of the approach are the...This paper is an introduction to mesh based generated reluctance network modeling.An overview of scientific works which led to the development of this approach is first presented.Basic concepts of the approach are then presented in the case of electromagnetic devices.A step-by-step procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB and Scilab environments are also included.展开更多
The modelling of the distribution transformer winding is the starting point and serves as important basis for the transformer characteristics analysis and the lightning pulse response prediction.A distributed paramete...The modelling of the distribution transformer winding is the starting point and serves as important basis for the transformer characteristics analysis and the lightning pulse response prediction.A distributed parameters model can depict the winding characteristics accurately,but it requires complex calculations.Lumped parameter model requires less calculations,but its applicable frequency range is not wide.This paper studies the amplitude-frequency characteristics of the lightning wave,compares the transformer modelling methods and finally proposes a modified lumped parameter model,based on the above comparison.The proposed model minimizes the errors provoked by the lumped parameter approximation,and the hyperbolic functions of the distributed parameter model.By this modification it becomes possible to accurately describe the winding characteristics and rapidly obtain the node voltage response.The proposed model can provide theoretical and experimental support to lightning protection of the distribution transformer.展开更多
Since air leakage is inevitable when earmuffs are worn improperly or together with safety glasses in factory or military,it is required to be considered to accurately predict earmuff attenuation.Besides unwanted air l...Since air leakage is inevitable when earmuffs are worn improperly or together with safety glasses in factory or military,it is required to be considered to accurately predict earmuff attenuation.Besides unwanted air leakage,under controlled air leakage is introduced to earmuff to achieve adjustable attenuations in different signal-to-noise ratios(SNRs)and balance between attenuation and speech intelligibility.This work is to develop an improved lumped parameter model(LPM)to predict earmuff attenuation with consideration of air leakage.Air leakage paths are introduced into conventional LPM without air leakage,and air leakage path impedance is analytically described by Maa’s microperforated tube impedance.Earmuff passive attenuation behavior can be analytically described and analyzed with the improved LPM.Finally,the validity of improved LPM is verified experimentally.The results indicate that the improved LPM can predict earmuff attenuation with air leakage,and air leakage deteriorates earmuff attenuation and turns resonance frequency higher.展开更多
Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the val...Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the valves time periods was well developed. With this model,the mass flow rate and dynamic pressure characteristics of constant volumes controlled by high-speed pneumatic PWM on /off valves was well described. A variable flow rate coefficient model was proposed to substitute for the constant one used in most of the prior works to investigate PWM on /off valves' dynamical pressure response, and a formula for disclosing the inherent relationship among the PWM command signal,static mass flow rate,and sonic conductance of the valve was newly derived.Finally,an extensive set of analytical experimental comparisons were implemented to verify the validity of the proposed mathematica model. With the proposed model, PWM on /off valves' characteristics,such as mass flow rate,step pressure response of the valve control system,mean pressure and ripple amplitude,not only in the linear range,but also in the nonlinear range can be wel predicted; Good agreement between measured and calculated results was obtained,which proved that the model is helpful for designing a control strategy in a closed loop control system.展开更多
Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the c...Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the coupled system,together with in vivo observations,shows that:(i)an inflow resistance that matches the characteristic impedance of the terminal arteries is required to avoid non-physiological wave reflections;(ii)periodic mean pressures and flow distributions in large arteries depend on arterial and peripheral resistances,but not on the compliances and inertias of the system,which only affect instantaneous pressure and flow waveforms;(iii)peripheral inertias have a minor effect on pulse waveforms under normal conditions;and(iv)the time constant of the diastolic pressure decay is the same in any 1-D model artery,if viscous dissipation can be neglected in these arteries,and it depends on all the peripheral compliances and resistances of the system.Following this analysis,we propose an algorithm to accurately estimate peripheral resistances and compliances from in vivo data.This algorithm is verified against numerical data simulated using a 1-D model network of the 55 largest human arteries,in which the parameters of the peripheral windkessel outflow models are known a priori.Pressure and flow waveforms in the aorta and the first generation of bifurcations are reproduced with relative root-mean-square errors smaller than 3%.展开更多
This paper mainly deals with the reservoir on the heat and mass transfer and mass and energy balance in a geothermal field.On the basis of briefing the general characteristics of the reservoir and the supposition of t...This paper mainly deals with the reservoir on the heat and mass transfer and mass and energy balance in a geothermal field.On the basis of briefing the general characteristics of the reservoir and the supposition of the reservoir modeling,the paper emphasizes the mathematical descriptions of hydra thermal transportation and convection by two methods according to the different models,such as lumped parameter model and distributed parameter model.It is effective to use these models in simulating the heterogeneous,and anisotropical fracture reservoir for the designed lifetime of 15 years.展开更多
The distinguishing feature of a vertical ball screw feed system without counterweight is that the spindle system weight directly acts on the kinematic joints.Research into the dynamic characteristics under acceleratio...The distinguishing feature of a vertical ball screw feed system without counterweight is that the spindle system weight directly acts on the kinematic joints.Research into the dynamic characteristics under acceleration and deceleration is an important step in improving the structural performance of vertical milling machines.The magnitude and direction of the inertial force change significantly when the spindle system accelerates and decelerates.Therefore,the kinematic joint contact stiffness changes under the action of the inertial force and the spindle system weight.Thus,the system transmission stiffness also varies and affects the dynamics.In this study,a variable-coefficient lumped parameter dynamic model that considers the changes in the spindle system weight and the magnitude and direction of the inertial force is established for a ball screw feed system without counterweight.In addition,a calculation method for the system stiffness is provided.Experiments on a vertical ball screw feed system under acceleration and deceleration with different accelerations are also performed to verify the proposed dynamic model.Finally,the influence of the spindle system position,the rated dynamic load of the screw-nut joint,and the screw tension force on the natural frequency of the vertical ball screw feed system under acceleration and deceleration are studied.The results show that the vertical ball screw feed system has obviously different variable dynamics under acceleration and deceleration.The influence of the rated dynamic load and the spindle system position on the natural frequency under acceleration and deceleration is much greater than that of the screw tension force.展开更多
To investigate the dynamic characteristics and damping theory of the passive hydraulic engine mount (PHEM), numerical prediction is performed through lumped parameter model. System parameters, including volume compl...To investigate the dynamic characteristics and damping theory of the passive hydraulic engine mount (PHEM), numerical prediction is performed through lumped parameter model. System parameters, including volume compliance of the decoupler chamber, effective piston area, fluid inertia and resistance of inertia track and direct-decoupler, are identified by means of experiments and finite element method (FEM). Dynamic behaviors are tested with elastomer test system for purpose of validating PHEM. With incorporation of inertia track and direct-decoupler, PHEM behaves effective and efficient vibration isolation in range of both low and high frequencies. The comparison of the numerical results with the experimental observations shows that the present PHEM achieves fairly good performance for the engine vibration isolation.展开更多
This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tum...This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tumor were developed to simulate time courses of average drug concentration (Ct) of tumor interstitium in two types of dosing regiments (i.e., single-shot and triple-shot ones). The two regiments were performed via antitumor drug, hydroxycamptothecin (HCPT), on rats, to measure the drug concentration in the tumor. The simulations of the drug concentration in the tumor of the two dosing regiments were conducted and compared with the experimental data on rats. The coefficients in the models were investigated. It is concluded that the triple-shot method is more effective than that of single-shot injection. The present lumped-parameter model is quantitatively competent for drug delivery in solid tumor.展开更多
The current 3D CABG model is time consuming,a lumped parameter CABG model may solve this problem.A coronary lumped parameter model without stenosis and graft was constructed.The stenosis resistance was calculated and ...The current 3D CABG model is time consuming,a lumped parameter CABG model may solve this problem.A coronary lumped parameter model without stenosis and graft was constructed.The stenosis resistance was calculated and graft model was constructed.After calculation,the graft flow results of CABG lumped parameter model fit well with 3D CABG model results.展开更多
The basic theme of this work is to identify the optimal measurement locations for pres- sure and flow in the systemic circulation to detect aortic stenoses and aneurysms in early stages of a disease. For this purpose,...The basic theme of this work is to identify the optimal measurement locations for pres- sure and flow in the systemic circulation to detect aortic stenoses and aneurysms in early stages of a disease. For this purpose, a linear elastic lumped parameter model of the fluid dynamical simulator, major arterial cardiovascular simulator (MACSim), is considered and global sensitivity analysis is applied to identify the better measurement locations for pressure and flow in the systemic circulation. The obtained results of sensitivity analysis provide insight that enable the experimentalists to optimize their experimental setups for detecting aortic stenoses and aneurysms using parameter estimation process. From the results, it is observed that the stenosis in the thoracic aorta can be identified from both pressure and flow at the location itself, nearby nodes, aorta ascendens, arcus aorta, arteria subclavia and arteria axillaris. On the other hand, the preferable measurement locations for abdominal aneurysms are locations themselves, nearby nodes and left/right leg of the body.展开更多
The paper deals with the simulation and the experimental verification of the hydraulic behavior of an electro-hydraulic load-sensing proportional control valve. An innovative CAE (computer aided engineering) methodo...The paper deals with the simulation and the experimental verification of the hydraulic behavior of an electro-hydraulic load-sensing proportional control valve. An innovative CAE (computer aided engineering) methodology, developed combining CFD (computational fluid dynamics) simulations with lumped and distributed numerical modeling, is firstly introduced and tailored by comparing the numerical results with measurements coming from an experimental campaign performed for a wide range of pressure loads and metered flow rates. Then, both the reliability and the limits of the numerical approach are highlighted through a detailed numerical vs. experimental comparison, involving the pressure of the main hydraulic lines, the flow rate through the first section and the local compensator displacement. Finally, the CAE methodology has been applied for assessing the internal ducts hydraulic permeability and the local compensator spring pre-load influence on the control valve metering curves. At the end of this analysis, an optimized design configuration, featuring a maximum controlled volumetric flow rate increased of more than 25%, has been proposed.展开更多
We extend the well-known concept and results for lumped parameters used in the spring-like models for linear materials to Hollomon’s power-law materials.We provide the generalized stiffness and effective mass coeffic...We extend the well-known concept and results for lumped parameters used in the spring-like models for linear materials to Hollomon’s power-law materials.We provide the generalized stiffness and effective mass coefficients for the power-law Euler-Bernoulli beams under standard geometric and load conditions.In particular,our mass-spring lumped parameter models reduce to the classical models when Hollomon’s law reduces to Hooke’s law.Since there are no known solutions to the dynamic power-law beam equations,solutions to our mass lumped models are compared to the low-order Galerkin approximations in the case of cantilever beams with circular and rectangular cross-sections.展开更多
Three degrees of freedom (3-DOF) Helmholtz resonator which consists of three cylindrical necks and cavities connected in series (neck-cavity-neck-cavity-neck-cavity) is suitable to reduce flow pulsation in hydraul...Three degrees of freedom (3-DOF) Helmholtz resonator which consists of three cylindrical necks and cavities connected in series (neck-cavity-neck-cavity-neck-cavity) is suitable to reduce flow pulsation in hydraulic system. A novel lumped parameter model (LPM) of 3-DOF Helmholtz resonator in hydraulic system is developed which considers the viscous friction loss of hy- draulic fluid in the necks. Applying the Newton's second law of motion to the equivalent mechanical model of the resonator, closed-form expression of transmission loss and resonance frequency is presented. Based on the LPM, an optimal design method which employs rotate vector optimization method (RVOM) is proposed. The purpose of the optimal design is to search the reso- nator's unknown parameters so that its resonance frequencies can coincide with the pump-induced flow pulsation harmonics respectively. The optimal design method is realized to design 3-DOF Helmholtz resonator for a certain type of aviation piston pump hydraulic system. The optimization result shows the feasibility of this method, and the simulation under optimum parame- ters reveals that the LPM can get the same precision as transfer matrix method (TMM).展开更多
Accurate on-board occupant injury risk prediction of motor vehicle crashes(MVCs)can decrease fatality rates by providing critical information timely and improving injury severity triage rates.The present implemented p...Accurate on-board occupant injury risk prediction of motor vehicle crashes(MVCs)can decrease fatality rates by providing critical information timely and improving injury severity triage rates.The present implemented prediction algorithms in vehicle safety systems are probabilistic and rely on multi-variate logistic regression of real-world vehicle collision databases.As a result,they do not utilize important vehicle and occupant features and tend to overgeneralize the solution space.This study presents a framework to address these problems with deterministic and computationally efficient lumped parameter model simulations driven by a database of vehicle crash tests.A 648-case mixed database was generated with finite element and multi-body models and validated under the principal directions of impact with experimental results for a single vehicle body type.Using the finite element database,we developed lumped parameter models for four principal modes of impact(i.e.,frontal,rear,near side and far side)with parameters identified via genetic algorithm optimization.To obtain confidence bounds for the injury risk prediction,the parameter uncertainty and model adequacy were evaluated with arbitrary and bootstrapped polynomial chaos expansion.The developed algorithm was able to achieve over triage rates of 17.1%±8.5%,whilst keeping the under triage rates below 8%on a finite element-multi body model database of a single vehicle body type.This study demonstrated the feasibility and importance of using low-complexity deterministic models with uncertainty quantification in enhanced occupant injury risk prediction.Further research is required to evaluate the effectiveness of this framework under a wide range of vehicle types.With the flexibility of parameter adjustment and high computational efficiency,the present framework is generic in nature so as to maximize future applicability in improved on-board triage decision making in active safety systems.展开更多
This paper reports the experimental and theoretical study of the surge occurred in prototyping an ultra micro centrifugal compressor. As the first step, the 10 times size model of an ultra micro centrifugal compressor...This paper reports the experimental and theoretical study of the surge occurred in prototyping an ultra micro centrifugal compressor. As the first step, the 10 times size model of an ultra micro centrifugal compressor having the 40 mm outer diameter was designed and manufactured. The detailed experimental investigations for the transient behavior of surge with several different values of B parameter were carded out. The experimental results during the surge were compared with those obtained by the non-linear lumped parameter theory in order to validate the effectiveness of the theoretical surge model for the micro centrifugal compressor. As a result, the quite different behavior of the surge appeared for the different values of B both in the experiment and in the analysis.展开更多
The interaction between an elastic structure and electrodynamic shakers commonly exists in Ground Flutter Simulation Tests(GFST)with multi-point excitations,causing a considerable discrepancy between the practical exc...The interaction between an elastic structure and electrodynamic shakers commonly exists in Ground Flutter Simulation Tests(GFST)with multi-point excitations,causing a considerable discrepancy between the practical excitation forces and desired ones.To investigate the excitation force characteristics on a cantilever beam excited by a voltage-sourced electrodynamic shaker,the coupled shaker-beam system is modeled to derive the excitation force formula using Hamilton’s principle and Galerkin’s approach.Simulation results using the multi-mode beam model coupled with the shaker model are in good agreement with experimental results,verifying that the proposed multi-mode method can accurately predict the excitation force.Furthermore,parametric studies show that the influence of system parameters on the excitation force is related to the shaker’s operating mode.Unlike in current mode of shaker,when the beam resonant frequency approaches the suspension frequency of shaker armature,the variation of excitation force amplitude in voltage mode is no longer minimal.Meanwhile,if the exciting point in the GFST is located far away from the modal node,it is essential to compensate the force because the accuracy of tests can be reduced dramatically.The coupled shaker-beam model proposed in this paper can provide the basis for compensation measures.展开更多
文摘This paper is an introduction to mesh based generated reluctance network modeling using triangular elements.Many contributions on mesh based generated reluctance networks using rectangular shaped elements have been published,but very few on those generated from a mesh using triangular elements.The use of triangular elements is aimed at extending the application of the approach to any shape of modeled devices.Basic concepts of the approach are presented in the case of electromagnetic devices.The procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB environment are also included.
文摘This paper is an introduction to mesh based generated reluctance network modeling.An overview of scientific works which led to the development of this approach is first presented.Basic concepts of the approach are then presented in the case of electromagnetic devices.A step-by-step procedure for coding the approach in the case of a flat linear permanent magnet machine is presented.Codes developed under MATLAB and Scilab environments are also included.
基金supported by the National Key Research and Development Plan of China under Grant(2016YFB0900600XXX)
文摘The modelling of the distribution transformer winding is the starting point and serves as important basis for the transformer characteristics analysis and the lightning pulse response prediction.A distributed parameters model can depict the winding characteristics accurately,but it requires complex calculations.Lumped parameter model requires less calculations,but its applicable frequency range is not wide.This paper studies the amplitude-frequency characteristics of the lightning wave,compares the transformer modelling methods and finally proposes a modified lumped parameter model,based on the above comparison.The proposed model minimizes the errors provoked by the lumped parameter approximation,and the hyperbolic functions of the distributed parameter model.By this modification it becomes possible to accurately describe the winding characteristics and rapidly obtain the node voltage response.The proposed model can provide theoretical and experimental support to lightning protection of the distribution transformer.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11934009 and 11874216)。
文摘Since air leakage is inevitable when earmuffs are worn improperly or together with safety glasses in factory or military,it is required to be considered to accurately predict earmuff attenuation.Besides unwanted air leakage,under controlled air leakage is introduced to earmuff to achieve adjustable attenuations in different signal-to-noise ratios(SNRs)and balance between attenuation and speech intelligibility.This work is to develop an improved lumped parameter model(LPM)to predict earmuff attenuation with consideration of air leakage.Air leakage paths are introduced into conventional LPM without air leakage,and air leakage path impedance is analytically described by Maa’s microperforated tube impedance.Earmuff passive attenuation behavior can be analytically described and analyzed with the improved LPM.Finally,the validity of improved LPM is verified experimentally.The results indicate that the improved LPM can predict earmuff attenuation with air leakage,and air leakage deteriorates earmuff attenuation and turns resonance frequency higher.
基金National Natural Science Foundation of China(No.51205362)Zhejiang Provincial National Science Foundation of China(No.LQ12E05017)
文摘Aiming at solving the problem of strong coupling characteristic of the key parameters of high-speed pneumatic pulse width modulation( PWM) on / off valve, a general lumped parameter mathematical model based on the valves time periods was well developed. With this model,the mass flow rate and dynamic pressure characteristics of constant volumes controlled by high-speed pneumatic PWM on /off valves was well described. A variable flow rate coefficient model was proposed to substitute for the constant one used in most of the prior works to investigate PWM on /off valves' dynamical pressure response, and a formula for disclosing the inherent relationship among the PWM command signal,static mass flow rate,and sonic conductance of the valve was newly derived.Finally,an extensive set of analytical experimental comparisons were implemented to verify the validity of the proposed mathematica model. With the proposed model, PWM on /off valves' characteristics,such as mass flow rate,step pressure response of the valve control system,mean pressure and ripple amplitude,not only in the linear range,but also in the nonlinear range can be wel predicted; Good agreement between measured and calculated results was obtained,which proved that the model is helpful for designing a control strategy in a closed loop control system.
基金the EU RTN Haemodel Project(contract number HPRN-CT-2002-00270)and by an EPSRC Advanced Research Fellowship.
文摘Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the coupled system,together with in vivo observations,shows that:(i)an inflow resistance that matches the characteristic impedance of the terminal arteries is required to avoid non-physiological wave reflections;(ii)periodic mean pressures and flow distributions in large arteries depend on arterial and peripheral resistances,but not on the compliances and inertias of the system,which only affect instantaneous pressure and flow waveforms;(iii)peripheral inertias have a minor effect on pulse waveforms under normal conditions;and(iv)the time constant of the diastolic pressure decay is the same in any 1-D model artery,if viscous dissipation can be neglected in these arteries,and it depends on all the peripheral compliances and resistances of the system.Following this analysis,we propose an algorithm to accurately estimate peripheral resistances and compliances from in vivo data.This algorithm is verified against numerical data simulated using a 1-D model network of the 55 largest human arteries,in which the parameters of the peripheral windkessel outflow models are known a priori.Pressure and flow waveforms in the aorta and the first generation of bifurcations are reproduced with relative root-mean-square errors smaller than 3%.
文摘This paper mainly deals with the reservoir on the heat and mass transfer and mass and energy balance in a geothermal field.On the basis of briefing the general characteristics of the reservoir and the supposition of the reservoir modeling,the paper emphasizes the mathematical descriptions of hydra thermal transportation and convection by two methods according to the different models,such as lumped parameter model and distributed parameter model.It is effective to use these models in simulating the heterogeneous,and anisotropical fracture reservoir for the designed lifetime of 15 years.
基金Supported by Key Program of National Natural Science Foundation of China(Grant No.51235009)National Natural Science Foundation of China(Grant No.51605374).
文摘The distinguishing feature of a vertical ball screw feed system without counterweight is that the spindle system weight directly acts on the kinematic joints.Research into the dynamic characteristics under acceleration and deceleration is an important step in improving the structural performance of vertical milling machines.The magnitude and direction of the inertial force change significantly when the spindle system accelerates and decelerates.Therefore,the kinematic joint contact stiffness changes under the action of the inertial force and the spindle system weight.Thus,the system transmission stiffness also varies and affects the dynamics.In this study,a variable-coefficient lumped parameter dynamic model that considers the changes in the spindle system weight and the magnitude and direction of the inertial force is established for a ball screw feed system without counterweight.In addition,a calculation method for the system stiffness is provided.Experiments on a vertical ball screw feed system under acceleration and deceleration with different accelerations are also performed to verify the proposed dynamic model.Finally,the influence of the spindle system position,the rated dynamic load of the screw-nut joint,and the screw tension force on the natural frequency of the vertical ball screw feed system under acceleration and deceleration are studied.The results show that the vertical ball screw feed system has obviously different variable dynamics under acceleration and deceleration.The influence of the rated dynamic load and the spindle system position on the natural frequency under acceleration and deceleration is much greater than that of the screw tension force.
基金National Hi-tech Research Development Program of China(863 Program,No.2001AA505000-11)
文摘To investigate the dynamic characteristics and damping theory of the passive hydraulic engine mount (PHEM), numerical prediction is performed through lumped parameter model. System parameters, including volume compliance of the decoupler chamber, effective piston area, fluid inertia and resistance of inertia track and direct-decoupler, are identified by means of experiments and finite element method (FEM). Dynamic behaviors are tested with elastomer test system for purpose of validating PHEM. With incorporation of inertia track and direct-decoupler, PHEM behaves effective and efficient vibration isolation in range of both low and high frequencies. The comparison of the numerical results with the experimental observations shows that the present PHEM achieves fairly good performance for the engine vibration isolation.
基金Project suppoted by the National Natural Science Foundation of China (Grant No10372026)the Shanghai Leading Academic Discipline Project (Grant NoB112)
文摘This work aims to investigate the effects of dosing regiments on drug delivery in solid tumors and to validate them with experiments on rats. The lumped parameter models of pharmacokinetics and of drug delivery in tumor were developed to simulate time courses of average drug concentration (Ct) of tumor interstitium in two types of dosing regiments (i.e., single-shot and triple-shot ones). The two regiments were performed via antitumor drug, hydroxycamptothecin (HCPT), on rats, to measure the drug concentration in the tumor. The simulations of the drug concentration in the tumor of the two dosing regiments were conducted and compared with the experimental data on rats. The coefficients in the models were investigated. It is concluded that the triple-shot method is more effective than that of single-shot injection. The present lumped-parameter model is quantitatively competent for drug delivery in solid tumor.
基金supported by National Natural Science Foundation of China(11832003,11772016,11472022).
文摘The current 3D CABG model is time consuming,a lumped parameter CABG model may solve this problem.A coronary lumped parameter model without stenosis and graft was constructed.The stenosis resistance was calculated and graft model was constructed.After calculation,the graft flow results of CABG lumped parameter model fit well with 3D CABG model results.
文摘The basic theme of this work is to identify the optimal measurement locations for pres- sure and flow in the systemic circulation to detect aortic stenoses and aneurysms in early stages of a disease. For this purpose, a linear elastic lumped parameter model of the fluid dynamical simulator, major arterial cardiovascular simulator (MACSim), is considered and global sensitivity analysis is applied to identify the better measurement locations for pressure and flow in the systemic circulation. The obtained results of sensitivity analysis provide insight that enable the experimentalists to optimize their experimental setups for detecting aortic stenoses and aneurysms using parameter estimation process. From the results, it is observed that the stenosis in the thoracic aorta can be identified from both pressure and flow at the location itself, nearby nodes, aorta ascendens, arcus aorta, arteria subclavia and arteria axillaris. On the other hand, the preferable measurement locations for abdominal aneurysms are locations themselves, nearby nodes and left/right leg of the body.
文摘The paper deals with the simulation and the experimental verification of the hydraulic behavior of an electro-hydraulic load-sensing proportional control valve. An innovative CAE (computer aided engineering) methodology, developed combining CFD (computational fluid dynamics) simulations with lumped and distributed numerical modeling, is firstly introduced and tailored by comparing the numerical results with measurements coming from an experimental campaign performed for a wide range of pressure loads and metered flow rates. Then, both the reliability and the limits of the numerical approach are highlighted through a detailed numerical vs. experimental comparison, involving the pressure of the main hydraulic lines, the flow rate through the first section and the local compensator displacement. Finally, the CAE methodology has been applied for assessing the internal ducts hydraulic permeability and the local compensator spring pre-load influence on the control valve metering curves. At the end of this analysis, an optimized design configuration, featuring a maximum controlled volumetric flow rate increased of more than 25%, has been proposed.
文摘We extend the well-known concept and results for lumped parameters used in the spring-like models for linear materials to Hollomon’s power-law materials.We provide the generalized stiffness and effective mass coefficients for the power-law Euler-Bernoulli beams under standard geometric and load conditions.In particular,our mass-spring lumped parameter models reduce to the classical models when Hollomon’s law reduces to Hooke’s law.Since there are no known solutions to the dynamic power-law beam equations,solutions to our mass lumped models are compared to the low-order Galerkin approximations in the case of cantilever beams with circular and rectangular cross-sections.
基金National Science Fund for Distinguished Young Scholars (50825502)
文摘Three degrees of freedom (3-DOF) Helmholtz resonator which consists of three cylindrical necks and cavities connected in series (neck-cavity-neck-cavity-neck-cavity) is suitable to reduce flow pulsation in hydraulic system. A novel lumped parameter model (LPM) of 3-DOF Helmholtz resonator in hydraulic system is developed which considers the viscous friction loss of hy- draulic fluid in the necks. Applying the Newton's second law of motion to the equivalent mechanical model of the resonator, closed-form expression of transmission loss and resonance frequency is presented. Based on the LPM, an optimal design method which employs rotate vector optimization method (RVOM) is proposed. The purpose of the optimal design is to search the reso- nator's unknown parameters so that its resonance frequencies can coincide with the pump-induced flow pulsation harmonics respectively. The optimal design method is realized to design 3-DOF Helmholtz resonator for a certain type of aviation piston pump hydraulic system. The optimization result shows the feasibility of this method, and the simulation under optimum parame- ters reveals that the LPM can get the same precision as transfer matrix method (TMM).
基金the National Natural Science Foundation of China(Grant Nos.51705276 and 51675295)Tsinghua University Initiative Scientific Research Program(Grant No.2019Z08QCX13)the National Key R&D Program of China(Grant Nos.2017YFE0118400 and2018YFE0192900)。
文摘Accurate on-board occupant injury risk prediction of motor vehicle crashes(MVCs)can decrease fatality rates by providing critical information timely and improving injury severity triage rates.The present implemented prediction algorithms in vehicle safety systems are probabilistic and rely on multi-variate logistic regression of real-world vehicle collision databases.As a result,they do not utilize important vehicle and occupant features and tend to overgeneralize the solution space.This study presents a framework to address these problems with deterministic and computationally efficient lumped parameter model simulations driven by a database of vehicle crash tests.A 648-case mixed database was generated with finite element and multi-body models and validated under the principal directions of impact with experimental results for a single vehicle body type.Using the finite element database,we developed lumped parameter models for four principal modes of impact(i.e.,frontal,rear,near side and far side)with parameters identified via genetic algorithm optimization.To obtain confidence bounds for the injury risk prediction,the parameter uncertainty and model adequacy were evaluated with arbitrary and bootstrapped polynomial chaos expansion.The developed algorithm was able to achieve over triage rates of 17.1%±8.5%,whilst keeping the under triage rates below 8%on a finite element-multi body model database of a single vehicle body type.This study demonstrated the feasibility and importance of using low-complexity deterministic models with uncertainty quantification in enhanced occupant injury risk prediction.Further research is required to evaluate the effectiveness of this framework under a wide range of vehicle types.With the flexibility of parameter adjustment and high computational efficiency,the present framework is generic in nature so as to maximize future applicability in improved on-board triage decision making in active safety systems.
文摘This paper reports the experimental and theoretical study of the surge occurred in prototyping an ultra micro centrifugal compressor. As the first step, the 10 times size model of an ultra micro centrifugal compressor having the 40 mm outer diameter was designed and manufactured. The detailed experimental investigations for the transient behavior of surge with several different values of B parameter were carded out. The experimental results during the surge were compared with those obtained by the non-linear lumped parameter theory in order to validate the effectiveness of the theoretical surge model for the micro centrifugal compressor. As a result, the quite different behavior of the surge appeared for the different values of B both in the experiment and in the analysis.
基金co-supported by the Overseas Expertise Introduction Project for Discipline In-novation(111 Project,BP0719007)the National Natural Science Foundation of China(No.12002280)。
文摘The interaction between an elastic structure and electrodynamic shakers commonly exists in Ground Flutter Simulation Tests(GFST)with multi-point excitations,causing a considerable discrepancy between the practical excitation forces and desired ones.To investigate the excitation force characteristics on a cantilever beam excited by a voltage-sourced electrodynamic shaker,the coupled shaker-beam system is modeled to derive the excitation force formula using Hamilton’s principle and Galerkin’s approach.Simulation results using the multi-mode beam model coupled with the shaker model are in good agreement with experimental results,verifying that the proposed multi-mode method can accurately predict the excitation force.Furthermore,parametric studies show that the influence of system parameters on the excitation force is related to the shaker’s operating mode.Unlike in current mode of shaker,when the beam resonant frequency approaches the suspension frequency of shaker armature,the variation of excitation force amplitude in voltage mode is no longer minimal.Meanwhile,if the exciting point in the GFST is located far away from the modal node,it is essential to compensate the force because the accuracy of tests can be reduced dramatically.The coupled shaker-beam model proposed in this paper can provide the basis for compensation measures.