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A Meta-analysis Reveals Prognostic Role of Programmed Death Ligand-1 in Asian Patients with Non-small Cell Lung Cancer 被引量:1
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作者 胡晓燕 张炜 +4 位作者 胡悦 张用 龚瑞 梁金燕 刘莉 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2016年第3期313-320,共8页
Accumulating studies explored the clinicopathologic and prognostic value of programmed death ligand-1(PD-L1) in non-small cell lung cancer(NSCLC), but the results were controversial. We therefore conducted a meta-... Accumulating studies explored the clinicopathologic and prognostic value of programmed death ligand-1(PD-L1) in non-small cell lung cancer(NSCLC), but the results were controversial. We therefore conducted a meta-analysis to evaluate the predictive role of PD-L1 in NSCLC patients. We systematically collected relevant studies from Pub Med, Embase, Web of Science and China National Knowledge Infrastructure. The pooled hazard ratios(HRs) with 95% confidence intervals(CIs) for overall survival(OS), and odd ratios(ORs) with 95% CIs for clinicopathologic factors were calculated. A total of 15 studies involving 3605 patients were included in this meta-analysis. The results showed no prognostic role of PD-L1 in the whole patients(HR=1.60, 95% CI: 0.88–2.89, P=0.123). Subgroup analysis showed that PD-L1 was associated with decreased OS in Asian patients(HR=2.00, 95% CI: 1.55–2.57, P〈0.001). Among all the clinicopathologic factors, PD-L1 overexpression was significantly in relevance with poor tumor cell differentiation(HR=1.84, 95% CI: 1.49–2.28, P〈0.001), late stage(HR=1.21, 95% CI: 1.02–1.43, P=0.026) and anaplastic lymphoma kinase(ALK) translocation(HR=2.63, 95% CI: 1.08–6.40, P=0.034), but not with other factors. In conclusion, our meta-analysis demonstrated that PD-L1 has a prognostic role in Asian patients with NSCLC. 展开更多
关键词 meta-analysis overall survival clinicopathologic factors non-small cell lung cancer
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An Elderly Patient with Advanced Lung Cancer Achieved Long-Term Survival Using Chinese Medicine:An Alternative Treatment Strategy for Cancer Patients Aged 80 or Older without A Tissue Confirmed Diagnosis 被引量:1
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作者 刘瑞 何姝霖 +2 位作者 Yoshiro Hirasak 郑红刚 花宝金 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2016年第7期545-548,共4页
Lung cancer is the leading cause of cancerrelated mortality in China.(1'2) Meanwhile, the average life expectancy in the aging population has increased from 46 years in 1950 to 75 years in 2010.
关键词 lung An Elderly Patient with Advanced lung cancer Achieved Long-Term survival Using Chinese Medicine Long
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Longer Overall Survival in A Patient with Advanced Non-small Cell Lung Cancer Treated with Chinese Medicine and Chemotherapy 被引量:3
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作者 陈衍智 李占东 +2 位作者 周宁 孙红 李萍萍 《Chinese Journal of Integrative Medicine》 SCIE CAS 2012年第8期626-628,共3页
Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the industrialized world. Despite significant progress in early stage of the disease, the overall survival rates for advanced disease remain... Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the industrialized world. Despite significant progress in early stage of the disease, the overall survival rates for advanced disease remain low. Herein we present a case of NSCLC who was treated with Chinese medicine and chemotherapy with a longer overall survival. 展开更多
关键词 NSCLC lung Longer Overall survival in A Patient with Advanced Non-small Cell lung cancer Treated with Chinese Medicine and Chemotherapy
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