Objective:The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer(NSCLC) and the impact on V20 and radiation pneumonitis(RP).Methods:Patients ...Objective:The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer(NSCLC) and the impact on V20 and radiation pneumonitis(RP).Methods:Patients who were pathologically or cytologically diagnosed of stage IIIA and IIIB NSCLC were treated with three-dimensional conformal radiation therapy(4000 cGy).Forty patients got at least 25% tumor reduction were randomly divided into two groups:group A of regular shrink field radiotherapy(20 cases) and group B of CT/CT image fused shrink field radiotherapy(20 cases).Dosage reached 6600 cGy.Clinical data,V20 and RP were observed within 3 months after radiotherapy.Statistical analysis was conducted for the NSCLC patients.Results:22.5%(9/40) patients got RP during follow-up.Group A accounted for 6 cases(30%),and group B had 3 cases(15%).There was no marked difference between the two groups(P = 0.256),univariate analysis revealed that the IV20 of A and B groups,and IV20 and CV20 of all patients were statistically related to the incidence of RP(P < 0.05).With Wilcoxon method assay,the ipsilateral lung V20 and contralateral lung V20 had statistical significance between the two groups(P < 0.05).Conclusion:The CT/CT image infusion treatment planning could increase the radical dosage with better tumor control probability but won't increase adverse reaction.展开更多
Owing to the remarkable advantages in mechanical behavior,cast steel nodes have been widely used in static structures.Nowadays,cast steel nodes also gain increasing popularity due to the superior fatigue performance i...Owing to the remarkable advantages in mechanical behavior,cast steel nodes have been widely used in static structures.Nowadays,cast steel nodes also gain increasing popularity due to the superior fatigue performance in dynamic structures,but they are not yet widely used because the fatigue properties of cast steel are not well understood.In this paper,the fatigue test of cast steel GS20Mn5V commonly used in steel castings is carried out.The strength of medium and low cycle fatigue and the fatigue limit are obtained.The feasibility of the estimated S-N(fatigue stress versus life)curve is tested.The double logarithmic linear model(DLLM)and the reversed generalized Pareto model(RGPM)are used to fit the experimental data,and the comparison is made.The P-S-N(the relationship between fatigue stress and life at different survival rates)curve obtained by the RGPM is proposed.The results show that the estimated S-N curve is not suitable for low cycle fatigue life,fitting the experimental data with the RGPM is the best,and obtaining the P-S-N curve from the RGPM is feasible.展开更多
文摘Objective:The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer(NSCLC) and the impact on V20 and radiation pneumonitis(RP).Methods:Patients who were pathologically or cytologically diagnosed of stage IIIA and IIIB NSCLC were treated with three-dimensional conformal radiation therapy(4000 cGy).Forty patients got at least 25% tumor reduction were randomly divided into two groups:group A of regular shrink field radiotherapy(20 cases) and group B of CT/CT image fused shrink field radiotherapy(20 cases).Dosage reached 6600 cGy.Clinical data,V20 and RP were observed within 3 months after radiotherapy.Statistical analysis was conducted for the NSCLC patients.Results:22.5%(9/40) patients got RP during follow-up.Group A accounted for 6 cases(30%),and group B had 3 cases(15%).There was no marked difference between the two groups(P = 0.256),univariate analysis revealed that the IV20 of A and B groups,and IV20 and CV20 of all patients were statistically related to the incidence of RP(P < 0.05).With Wilcoxon method assay,the ipsilateral lung V20 and contralateral lung V20 had statistical significance between the two groups(P < 0.05).Conclusion:The CT/CT image infusion treatment planning could increase the radical dosage with better tumor control probability but won't increase adverse reaction.
基金the National Key Research and Development Program of China(No.2017YFC0805100)the National Natural Science Foundation of China(No.51578137)+1 种基金the Priority Academic Program Development of the Jiangsu Higher Education Institutionsthe Open Research Fund Program of Jiangsu Key Laboratory of Engineering Mechanics。
文摘Owing to the remarkable advantages in mechanical behavior,cast steel nodes have been widely used in static structures.Nowadays,cast steel nodes also gain increasing popularity due to the superior fatigue performance in dynamic structures,but they are not yet widely used because the fatigue properties of cast steel are not well understood.In this paper,the fatigue test of cast steel GS20Mn5V commonly used in steel castings is carried out.The strength of medium and low cycle fatigue and the fatigue limit are obtained.The feasibility of the estimated S-N(fatigue stress versus life)curve is tested.The double logarithmic linear model(DLLM)and the reversed generalized Pareto model(RGPM)are used to fit the experimental data,and the comparison is made.The P-S-N(the relationship between fatigue stress and life at different survival rates)curve obtained by the RGPM is proposed.The results show that the estimated S-N curve is not suitable for low cycle fatigue life,fitting the experimental data with the RGPM is the best,and obtaining the P-S-N curve from the RGPM is feasible.
