Effects of Zhenren Yangzang Decoction Combined with Modified Shenling Baizhu Powder on Immune Function and Intestinal Microecology of Diarrhea Patients with Deficiency and Cold Syndrome

OBJECTIVE: To observe the effects of Zhenren Yangzang Decoction combined with modified Shenling Baizhu Powder on the immune function and intestinal microecology of diarrhea patients with deficiency and cold syndrome. METHODS: A total of 60 diarrhea patients with deficiency and cold syndrome were randomly divided into observation group and control group, with 30 cases in each group. The control group was treated with conventional western medicine. The observation group was given the treatment of Zhenren Yangzang Decoction combined with modified Shenling Baizhu Powder on the basis of the same treatment for 4 weeks. The clinical symptoms, fecal flora and immunoglobulin content of the 2 groups were observed and the clinical efficacy was evaluated. RESULTS: After treatment, the symptoms scores of fecal diarrhea, aversion to cold, cold limbs, loss of appetite, cold and painful waist and knee, abdominal fullness, abdominal distension and abdominal pain, and intestinal bacilli contents were significantly decreased(P < 0.05). The contents of lactobacillus, bifidus bacilli, IgG, IgM and IgA were significantly increased(P < 0.05), and the improvement of the above indexes in the observation group was significantly better than that in the control group(P < 0.05). The total effective rate after treatment in the observation group was 93.3%, which was significantly higher than 73.3% of the control group(P < 0.05). CONCLUSION: The treatment of diarrhea patients with deficiency and cold syndrome with Zhenren Yangzang Decoction and modified Shenling Baizhu Powder can effectively improve the intestinal micro-ecological environment, improve the immune function of patients and promote the rapid recovery of patients.

Preventive and therapeutic effect of long snake moxibustion on psoriasis with yang deficiency and external cold syndrome based on the theory of "treatment of winter disease in summer"

Psoriasis is a chronic inflammatory skin disease with multiple layers of silvery white scales on the surface of erythema papule as the main clinical characteristics,of which yang-deficiency external cold psoriasis is refractory,recurrent and severe in winter and mild in summer,which has a great impact on patients'physical and mental health and quality of life.Traditional Chinese medicine has unique insights in the treatment of psoriasis,both curative effect and safety,have obvious advantages.Based on the concept of"winter disease and summer treatment",long-snake moxibustion gives full play to its functions of warming the kidney,invigorating the marrow,warming the meridians,activating blood circulation and removing blood stasis,so as to restore the deficiency of Yang in patients with psoriasis with external cold syndrome,enhance disease resistance,and prevent psoriasis recurrence or aggravation in winter.Therefore,based on the theory of"winter disease and summer treatment",this paper preliminarily discusses the mechanism of long-snake moxibustion in the prevention and treatment of psoriasis with external cold syndrome of Yang deficiency,and provides new ideas and directions for the prevention and treatment of psoriasis with traditional Chinese medicine.

黄芪建中汤合暖胃汤治疗患儿脾胃虚寒型急性肠胃炎

目的观察黄芪建中汤合暖胃汤治疗脾胃虚寒型急性肠胃炎患儿的疗效。方法选取2021年2月-2023年5月医院收治的74例脾胃虚寒型急性肠胃炎患儿,以随机数字表法分为研究组与对照组,各37例。2组均接受对症治疗,对照组在此基础上采用奥美拉唑肠溶胶囊治疗,研究组在对照组的基础上接受黄芪建中汤合暖胃汤治疗。2组均治疗14 d。对比2组中医证候评分、病症恢复时间、临床疗效、炎症反应、胃肠激素及不良反应。结果治疗后,2组主症评分、次症评分、总评分明显降低(P<0.05),且研究组降低更为明显(P<0.05)。研究组发热、腹痛、呕吐、腹泻等病症恢复时间短于对照组(P<0.05)。研究组总有效率高于对照组(P<0.05)。治疗后,2组白细胞介素-17(IL-17)、基质金属蛋白酶-3(MMP-3)、中性粒细胞与淋巴细胞比值(NLR)水平明显降低(P<0.05),且研究组降低更为明显(P<0.05)。治疗后,2组胃泌素(GSA)水平明显降低(P<0.05),且研究组降低更为明显(P<0.05)。治疗后,2组胃动力素(MTL)水平明显升高(P<0.05),且研究组升高更为明显(P<0.05)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论黄芪建中汤合暖胃汤治疗脾胃虚寒型急性肠胃炎患儿疗效确切,可改善患儿临床症状与胃肠功能,促进患儿康复,减轻炎症反应,且安全可靠。

益元宣肺汤对25例新冠肺炎CT值的影响

目的分析深圳地区2022年新型冠状病毒肺炎患者的舌象、症状及用药史,多辨为三焦壅滞、肺脾肾虚,拟益元宣肺汤,观察其对CT值恢复的临床疗效。方法选取25例符合益元宣肺汤证型者进行治疗观察,选同期对照组25例,观察益元宣肺汤对CT值的影响。结果治疗前对照组的N基因(31.99±1.16)、O基因(33.49±1.94)与治疗组的N基因(31.45±2.85)、O基因(33.40±3.96)比较,差异无统计学意义(P>0.05);对照组治疗到CT值符合出院标准所需时间为(4.28±1.88)d,治疗组为(2.80±1.26)d,差异有统计学意义(P<0.05)。结论治疗组通过服用益元宣肺汤,CT值恢复明显比对照组快,表明以调动肺脾肾之气、疏通三焦气机为主的益元宣肺汤效果明显。扶正补肺脾肾、通宣三焦的治疗方法,在促进病情好转,加快人体清除病毒的速度方面作用明显,利于新型冠状病毒肺炎患者康复。

Regulatory effects of Poria on substance and energy metabolism in cold-deficiency syndrome compared with heat-deficiency syndrome in rats

Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling(FL) in traditional Chinese medicine(TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi(FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu(ZM) in TCM, with cold property, as reference drugs, respectively. The appearance score, toe and rectal temperatures of the animals treated were assessed at different time points. Several indices in vivo correlated with substance and energy metabolism(glucokinas, phosphoglycerate kinase, cytochrome c reductase, cytochrome c oxydase, and Na^+-K^+-ATPase), endocrine system(triiodothyronine, thyroxine, and 17-hydroxycorticosteroid), nervous system(acetylcholin esterase), and cyclic nucleotide system were determined. The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models. FZ reversed the decreased levels of indices(substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model, and ZM showed obviously therapeutic effect on heat-deficiency syndrome(appearance score, substance and energy metabolism, and endocrine system). FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas, phosphoglycerate kinase, cytochrome c reductase and triiodothyronine in cold-deficiency model, but had no significant effect on heat-deficiency syndrome. Drug property of FL was inferred as trending to "flat and warm", which still need further study. It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with "flat" property.

Efficacy of Gastrosis No.1 Compound on Functional Dyspepsia of Spleen and Stomach Deficiency-Cold Syndrome:A Multi-Center,Double-Blind,Placebo-Controlled Clinical Trial

To assess the efficacy and safety of Gastrosis No.1 compound in the treatment of functional dyspepsia with Spleen （Pi） and Stomach （Wei） deficiency-cold syndrome. Methods： A randomized, double-blind, placebo-controlled trial was performed in 5 centers. Patients with functional dyspepsia （FD） of Spleen-deficiency and qi-stagnation syndrome （162 cases） were randomly assigned to groups given Chinese herbal medicine （CHM） Gastrosis No.1 compound or placebo in a 2：1 ratio. This trial included a 4-week treatment period and a 4-week follow-up period. The outcomes were the dyspepsia symptom scores （measured by total dyspepsia symptom scale and single dyspepsia symptom scale） and syndromes of traditional Chinese medicine score （measured by traditional Chinese medicine syndrome scale）. The outcomes were noted at weeks 0, 4 and 8. Results： Compared with patients in the placebo group, patients in the CHM group showed significant improvement in the dyspepsia symptom scores as rated by patients and investigators （P〈0.01）, and also showed improvement in syndromes of traditional Chinese medicine score （P〈0.01）. No serious adverse event was reported. Safety tests obtained after 4 weeks of treatment showed no abnormal values. Conclusion： CHM Gastrosis No.1 compound was effective and safe in the treatment of functional dyspepsia with Spleen and Stomach deficiency-cold syndrome.

Randomized Controlled Trial on Treatment of Bronchial Asthma of Qi-deficiency Cold Syndrome Type by Pingchuan Yiqi Granule (平喘益气颗粒)

Objective： To evaluate the effect and safety of Pingchuan Yiqi Granule （平喘益气颗粒, PYG） in treating bronchial asthma of qi-deficiency cold syndrome type （BS-QDC）. Methods： With the randomized, positive agent parallel controlled design adopted, the 80 subjects enrolled were assigned in the ratio of 3：1 to two groups, the 60 patients in the trial group were treated with PYG and the 20 in the control group treated with Ruyi Dingchuan Pill （如意定喘丸,RDP）, with the therapeutic course consisting of 7 days for both groups. The clinical effects, effects on TCM syndrome and the changes of lung function after treatment were observed. Results： The effect of the treatment on asthma in the trial group： clinically controlled rate was 6.67%, markedly effective rate 51.67%, improved rate 33.33% and ineffective rate 8.33%; and the corresponding rates in the control group were 5.00%, 50.00%, 30.00%, and 15.00% respectively. Comparison between the two groups showed insignificant difference （P〉0.05）. The effect on TCM syndrome in the treated group： clinically controlled rate was 11.67%, markedly effective rate 58.33%, effective rate 21.67% and ineffective rate 8.33%; and those in the control group were 10.00%, 50.00%, 30.00% and 10.00% respectively, also showing insignificant difference between the two groups （P〉0.05）. Lung function test showed that the change on forced expiratory volume in 1 second （FEV1） after treatment in the trial group was of statistical significance （P〈0.05）, but no significant difference was shown in the change of peak expiratory flow （PEE P〉0.05）; while the changes in the control group were just the opposite, showing insignificance in FEV1 （P〉0.05） but significance in PEF （P〈0.05）. Comparison of the therapeutic effect on lung function between the two groups showed no significant difference （P〉0.05）. No adverse reaction was found in either group in the course of treatment. Conclusion： PYG used to treat BS-QDC is effective and safe, it＇s effect is similar to that of RDP.

新外来中药紫锥菊对虚热证虚寒证小鼠甲状腺激素和物质能量代谢的影响

目的:考察紫锥菊水提物对虚寒、虚热证小鼠内分泌激素、物质能量代谢水平的影响,探讨紫锥菊水提物的药性。方法:将KM雄性小鼠随机分为空白组、虚热模型组、虚热西洋参组、虚热紫锥菊水提物低剂量组、虚热紫锥菊水提物高剂量组、虚寒模型组、虚寒人参组、虚寒紫锥菊水提物低剂量组、虚寒紫锥菊水提物高剂量组;虚热模型组小鼠每天灌胃甲状腺片水溶液(160 mg/kg),虚寒模型组小鼠灌胃氢化可的松溶液(25 mg/kg),1次/d,连续14 d制备虚热、虚寒模型,各给药组灌胃相应药物。检测各组小鼠血清三碘甲状腺原氨酸(T_(3))、甲状腺素(T_(4))、总胆固醇(TC)、三酰甘油(TG)、总蛋白(TP)、白蛋白(ALB)以及血糖(GLU)等指标变化,比色法检测小鼠肝脏乳酸脱氢酶(LDH)、琥珀酸脱氢酶(SDH)、Na^(+)-K^(+)-ATP酶活力,采用实时聚合酶链反应法检测小鼠肝组织细胞色素c氧化酶7A2(COX7A2)、琥珀酸脱氢酶复合体D亚基(SDHD)mRNA表达情况。结果:与虚热模型组比较,紫锥菊水提物对虚热小鼠整体状态有一定程度改善,体质量和脾脏指数有所改善(P<0.05),T_(3)、T_(4)水平显著降低(P<0.05,P<0.01),TP、ALB、GLU、LDH的水平显著升高(P<0.01),SDH、Na^(+)-K^(+)-ATP酶、COX7A2、SDHD mRNA的表达水平显著降低(P<0.05,P<0.01),紫锥菊水提物与寒凉性质的西洋参表现出相似的作用;与虚寒模型组比较,紫锥菊水提物对虚寒小鼠整体状态、胸腺指数以及脾脏指数无明显改善,紫锥菊水提物高剂量显著升高SDH、Na^(+)-K^(+)-ATP酶水平(P<0.01),而紫锥菊水提物对虚寒小鼠T_(3)、T_(4)、TP、ALB、TC、TG、GLU、COX7A2 mRNA、SDHD mRNA表达水平的调节不明显,差异无统计学意义(P>0.05),紫锥菊水提物与温热性质的人参作用趋于相反。结论:紫锥菊水提物性凉,可能是紫锥菊寒凉药性的物质基础。

新外来中药辣木叶对虚热及虚寒证候模型生物学表达特征的影响

目的:研究辣木叶对虚热证、虚寒证小鼠生物学表达特征的影响。方法:昆明种雄性小鼠分为空白组、虚热模型组、虚热西洋参组、虚热辣木叶(高、中、低剂量)组、虚寒模型组、虚寒人参组、虚寒辣木叶(高、中、低剂量)组。分别采用灌胃甲状腺素片溶液、氢化可的松溶液制备虚热模型、虚寒模型。采用酶联免疫吸附试验(ELISA)检测各组小鼠血清中环腺苷酸(cAMP)、环鸟苷酸(cGMP)、cAMP/cGMP、3,5,3′-三碘甲腺原氨酸(T_(3))、甲状腺素(T_(4))、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)指标的含量。结果:与虚热模型组比较,虚热西洋参组cAMP、cAMP/cGMP、T_(3)、T_(4)含量显著降低,IL-6、IL-1β显著下降;虚热辣木叶组cAMP、cAMP/cGMP、T_(3)、T_(4)含量显著降低,IL-6、IL-1β显著下降。与虚寒模型组比较,虚寒人参组cAMP、cAMP/cGMP、T_(3)、T_(4)含量显著升高;IL-6、IL-1β显著下降;虚寒辣木叶组cAMP、cAMP/cGMP含量无明显变化,T_(3)、T_(4)含量显著降低,IL-6、IL-1β显著下降。结论:研究发现辣木叶与西洋参作用相似,药性寒凉;与人参作用相反。在免疫因子水平上,辣木叶具有双向调节作用,可能受物质基础中不同活性成分的影响,对虚寒、虚热小鼠模型都有免疫调节作用。但结合环核苷酸代谢水平、激素水平考虑,其具备“偏寒”或“凉”的药性,符合药性理论分析辣木叶寒凉药性的结论。

Effects of Plasma Cortisol and Its Receplor on Patients with Deficiency－Cold and Deficiency－Heat Syndromes

lasma cortisol levels and leukocyte glucocorticosteroid receptor (GCR) contents were assayed in 10 patients with Deficiency-Cold Syndrome, 10 patients with Deficiency-Heat Syndrome, and 10healthy subjects as normal control. The results showed practically normal plasma cortisol levels in the De-ticiency-Cold Group, but the leukocyte GCR contents were markedly lowered. In the Deficiency-Heatgroup, plasma cortisol levels were remarkably elevated and the leukocyte GCR contents also tended to behigher than normal. The quantity of plasma cortisol concentrations multiplied by leukocyte GCR contentscan be taken as a sensitive index for the differentiation of Cold and Heat natures in Deficiency Syndromes.

当归四逆汤加减治疗糖尿病足患者的疗效及对其血液流变学的影响

目的 观察当归四逆汤加减治疗糖尿病足(Diabeticfoot,DF)的疗效及对患者血液流变学的改善作用。方法 选取2021年3月—2023年3月期间在黑龙江中医药大学附属第一医院确诊并接受非手术治疗的DF患者82例,按随机数字表法分为对照组和观察组,每组各41例。对照组予以常规治疗,观察组给予常规治疗联合当归四逆汤加减方剂治疗。治疗8周后评价两组患者临床综合疗效,评价中医证候评分、创面局部症状评分,检测糖代谢相关指标[空腹血糖(Fasting postprandial blood glucose,FPG)、餐后2 h血糖(2-hour postprandial blood glucose,2 h PG)、糖化血红蛋白(Glycosylated hemoglobin A1c,HbA1c)],监测足远端动脉血流速度及踝肱指数(Ankle brachial index,ABI),检测血液流变学指标[全血黏度、血浆黏度(Plasma viscosity,PV)],检测血清炎症因子[白介素-1β(Interleukin-1β,IL-1β)、白介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)]、血管内皮生长因子(Vascular endothelial growth factor,VEGF)和低氧诱导因子-1(Hypoxia inducible factor-1α,HIF-1α)。结果 治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且观察组中医证候积分明显低于对照组,观察组降分幅度优于对照组,差异有统计学意义(P<0.05)。治疗后两组患者创面面积、肉芽形态、渗出、疼痛评分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组创面面积、肉芽形态、渗出、疼痛评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者FPG、2 h PG、HbA1c指标均较治疗前降低,差异有统计学意义(P<0.05);但两组间比较,差异无统计学意义(P>0.05)。治疗后两组患者胫后动脉、足背动脉的平均血流速度及ABI均较治疗前升高,差异有统计学意义(P<0.05);且观察组胫后动脉、足背动脉的平均血流速度及ABI均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者全血低切和高切黏度、PV指标均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组全血低切和高切黏度、PV指标均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清IL-1β、IL-6和TNF-α水平均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组血清IL-1β、IL-6和TNF-α水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清VEGF水平较治疗前升高,HIF-1α水平较治疗前降低,差异有统计学意义(P<0.05);且观察组VEGF水平明显高于对照组,HIF-1α水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组总有效率92.86%(39/42)明显高于对照组的76.19%(32/42),差异有统计学意义(P<0.05)。治疗期间,两组间不良反应发生率比较,差异无统计学意义(P>0.05)。结论 当归四逆汤加减方剂对DF具有一定的治疗作用,可能通过调节血液流变学,改善血液循环状态、抑制炎症反应、调节HIF-1α和VEGF表达等促进病情缓解。

基于“建中”理论探讨肿瘤营养不良病机及治法

肿瘤营养不良是恶性肿瘤最常见的并发症之一,以食欲减退、消化道营养影响症状、体重减轻为主要临床表现。中医认为其属虚劳类病。追其源头,多因肿瘤瘀毒结聚、抗肿瘤治疗损伤导致中焦虚寒、肠失传化,引起五脏精气不足,渐至于机体气血阴阳虚衰。从“建中”理论出发可以认为该病的基本病机为中焦虚寒、肠失传化。在治疗上,应以温补中焦助运化为主要治法,方剂用大建中汤与参苓白术散温胃散寒、益气健脾。又因肿瘤患者病情复杂,往往还存在痰湿困脾、瘀血阻滞,所以还需开胃醒脾增摄入、化瘀散寒强功效,强调芳香化湿药物与活血化瘀药物的使用,从而达到改善患者胃肠蠕动排空功能与调整肠道紊乱菌群的目的。临床应注重胃肠道消化功能的提高,增加营养物质摄入、消化及吸收,最终实现改善患者营养状态、降低营养风险的目的。

理中汤加味治疗小儿抗生素相关腹泻脾胃虚寒证的临床效果

目的探讨理中汤加味治疗小儿抗生素相关腹泻脾胃虚寒证的临床效果。方法选取2023年1—6月南通市中医院收治的50例小儿抗生素相关腹泻脾胃虚寒证患儿作为研究对象,根据随机数表法分为两组,每组25例,对照组予以双歧杆菌三联活菌散口服治疗,观察组在对照组基础之上另予以理中汤加味治疗。比较两组临床疗效、中医证候积分、日均腹泻次数及腹泻持续时间。结果治疗1周,观察组临床总有效率为100.00%,高于对照组的76.00%,差异有统计学意义(χ^(2)=4.735,P<0.05);观察组各项中医证候积分均低于对照组,差异有统计学意义(P均<0.05)。治疗后72 h,观察组日均腹泻次数少于对照组,腹泻持续时间较对照组短,差异有统计学意义(P均<0.05)。结论理中汤加味治疗小儿抗生素相关腹泻脾胃虚寒证临床疗效显著,促进症状改善,缩短腹泻时间。

黄芪建中汤加味对脾胃虚寒型胃溃疡的影响

目的:探讨黄芪建中汤加味对脾胃虚寒型胃溃疡的影响。方法:选取2022年6月—2023年8月淄博市中医医院收治的76例脾胃虚寒型胃溃疡患者。随机将其分为对照组和观察组,各38例。对照组给予常规治疗,观察组在对照组基础上给予黄芪建中汤加味治疗。比较两组治疗前后炎症因子、中医症候积分、氧化应激指标及临床疗效。结果:治疗后,两组白细胞介素-10(IL-10)、白细胞介素-6(IL-6)与肿瘤坏死因子-α(TNF-α)水平低于治疗前,观察组IL-6、IL-10、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组丙二醛(MDA)低于治疗前,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)高于治疗前,观察组MDA低于对照组,SOD及GSH-Px均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组胃脘疼痛、胸胁满闷、食欲不振、嗳气吞酸及倦怠乏力评分均低于治疗前,观察组胃脘疼痛、胸胁满闷、食欲不振、嗳气吞酸及倦怠乏力评分均低于对照组,差异有统计学意义(P<0.05)。观察组总有效率为94.74%,高于对照组的76.32%,差异有统计学意义(P<0.05)。结论:在西药治疗基础上联合黄芪建中汤加味可有效减轻脾胃虚寒型胃溃疡患者的炎症反应,改善其氧化应激反应,改善其病情,提高治疗效果。

温中健脾养胃汤治疗老年脾胃虚寒型慢性浅表性胃炎临床观察

目的 探究自拟温中健脾养胃汤治疗老年脾胃虚寒型慢性浅表性胃炎(CSG)的效果。方法 选取2018年3月—2021年3月蕲春县人民医院收治的脾胃虚寒型CSG患者100例,随机分为观察组(50例)、对照组(50例);对照组接受常规疗法,观察组在此基础上联合自拟温中健脾养胃汤。比较两组疗效,临床症状中医证候积分、幽门螺杆菌(Hp)转阴时间、胃黏膜病理学评分、白细胞计数(WBC)、白细胞介素-6(IL-6)以及肿瘤坏死因子-α(TNF-α)水平。结果 观察组治疗总有效率92.00%(46/50)显著高于对照组的74.00%(37/50)(P<0.05);观察组Hp转阴时间低于对照组(P<0.05),且中医证候积分、胃黏膜病理学评分、WBC计数、IL-6以及TNF-α水平亦低于对照组(P<0.05),差异有统计学意义。结论 温中健脾养胃汤辅助能提高CSG治疗总有效率、同时能缓解胃黏膜病理学和炎性反应。

脾胃虚寒型胃脘痛患者腹部穴位按摩及隔姜灸护理临床观察

目的观察脾胃虚寒型胃脘痛患者应用腹部穴位按摩及隔姜灸护理的效果。方法选入2021年1月—2022年1月上海市嘉定区中医医院治疗脾胃虚寒型胃脘痛患者58例,将使用腹部穴位按摩及隔姜灸护理的29例患者作为结合组,将使用腹部穴位按摩护理治疗的29例作为单一组,对比2组临床疗效、中医证候积分、生活质量量表(SF-36)评分、视觉模拟量表(VAS)评分、护理满意度。结果结合组总有效率为93.10%(27/29),高于单一组的68.97%(20/29)(P<0.05)。护理后,结合组的胃脘或脘腹胀满、胃脘疼痛、嗳气反酸的中医证候积分低于单一组;生理职能、社会功能、心理健康得分高于单一组;VAS评分低于单一组,差异均有统计学意义(P<0.05)。结合组护理满意度为96.55%(28/29),高于单一组的72.41%(21/29)(P<0.05)。结论脾胃虚寒型胃脘痛患者应用腹部穴位按摩及隔姜灸护理,较仅使用腹部穴位按摩护理的临床效果好,能够改善患者临床症状、减轻疼痛,提高护理满意度及生活质量。

温针灸联合小建中汤加减治疗在脾胃虚寒型消化性溃疡中的临床效果观察

目的 研究温针灸联合小建中汤加减治疗在脾胃虚寒型消化性溃疡中的临床效果。方法 80例脾胃虚寒型消化性溃疡患者,按照住院号录入系统后,采取住院号尾数奇偶性分为对照组(奇数)与观察组(偶数),每组40例。对照组服用小建中汤加减治疗,观察组服用小建中汤加减治疗的同时采取温针灸治疗。比较两组临床疗效、临床改善情况、中医证候积分、临床相关指标[血清表皮生长因子(EGF)、胃液EGF、胃黏膜表皮生长因子受体(EGFR)(积分光密度、面积百分比)、血清一氧化氮(NO)、白细胞介素-10(IL-10)]。结果 观察组的总有效率95.00%高于对照组的77.50%(P<0.05)。治疗后,两组胃痛、胃胀、乏力、纳差积分均较治疗前减少,且观察组胃痛、胃胀、乏力、纳差积分分别为(1.23±0.30)、(1.11±0.23)、(1.01±0.12)、(0.87±0.16)分,低于对照组的(3.97±0.46)、(2.55±0.34)、(1.58±0.21)、(1.58±0.27)分(P<0.05)。观察组溃疡面积(2.31±0.78)cm^(2)小于对照组的(4.81±1.89)cm^(2),溃疡复发率5.00%低于对照组的20.00%,幽门螺杆菌(Hp)清除率92.50%高于对照组的75.00%(P<0.05)。治疗后,两组血清EGF、胃液EGF、积分光密度、面积百分比水平均较治疗前增高,且观察组血清EGF(0.59±0.11)ng/ml、胃液EGF(0.83±0.16)ng/ml、积分光密度(1.78±0.23)D、面积百分比(28.72±4.12)%高于对照组的(0.43±0.10)ng/ml、(0.47±0.20)ng/ml、(1.34±0.24)D、(21.52±3.87)%(P<0.05)。治疗后,两组NO、IL-10水平均较治疗前增高,且观察组NO(74.80±9.75)μmol/L、IL-10(123.25±5.11)ng/L高于对照组的(62.14±10.25)μmol/L、(110.57±5.44)ng/L(P<0.05)。结论 脾胃虚寒型消化性溃疡通过采取温针灸联合小建中汤加减治疗后临床效果提高,可有效改善患者的临床症状及相关临床指标,减轻患者的痛苦,促进患者尽快恢复,具有较高的临床应用价值。

雾化治疗联合苍耳子散、温肺止流丹治疗变应性鼻炎患儿的效果

目的探讨雾化治疗联合苍耳子散、温肺止流丹治疗肺气虚寒证的变应性鼻炎患儿的效果。方法选取2022年3月—2023年6月福建省建瓯市立医院的80例变应性鼻炎患儿。按随机数字表法将其分为观察组和对照组,每组40例。对照组患儿采用常规雾化治疗,观察组患儿采用雾化治疗联合苍耳子散、温肺止流丹治疗。对2组变应性鼻炎患儿治疗前后鼻塞、喷嚏、鼻痒、流涕等鼻部症状改善情况、治疗总有效率及治疗期间不良反应发生情况进行对比分析。结果2组变应性鼻炎患儿治疗前鼻塞、喷嚏、鼻痒、流涕等鼻部症状评分比较,差异无统计学意义(P>0.05);治疗后,观察组变应性鼻炎患儿鼻塞、喷嚏、鼻痒、流涕等鼻部症状评分低于对照组(P<0.05);观察组鼻炎患儿治疗总有效率为97.50%,高于对照组的82.50%(P<0.05);2组鼻炎患儿治疗期间未出现明显不良反应,差异无统计学意义(P>0.05)。结论雾化治疗联合苍耳子散、温肺止流丹治疗肺气虚寒证变应性鼻炎患儿具有良好的效果,能有效促进患儿鼻塞、喷嚏、鼻痒、流涕等鼻部症状改善,且不会引起明显不良反应,安全性较高。

妇科再造丸治疗虚寒性痛经的疗效观察

目的针对虚寒性痛经患者给予妇科再造丸治疗,对治疗效果及安全性予以观察。方法240例虚寒性痛经患者,按照1~240发放数字卡片,单号为观察组,双号为对照组,各120例,分别采取妇科再造丸联合去氧孕烯炔雌醇片(商品名:妈富隆)治疗与单一妈富隆治疗。比较两组疗效、不良反应发生情况及治疗前及治疗后中医证候积分、疼痛程度、血清学指标[前列腺素E_(2)(PGE_(2))、前列腺素F_(2a)(PGF_(2a))]。结果观察组总有效率96.67%高于对照组的81.67%,差异明显(P<0.05)。治疗后,两组小腹冷痛、肛门坠胀、肢体畏寒、腰骶酸痛积分均低于本组治疗前,且观察组小腹冷痛、肛门坠胀、肢体畏寒、腰骶酸痛积分分别为(0.53±0.13)、(0.64±0.13)、(0.53±0.14)、(0.63±0.21)分,低于对照组的(1.32±0.23)、(1.64±0.51)、(1.12±0.26)、(1.22±0.24)分,差异明显(P<0.05)。治疗后,两组视觉模拟评分法(VAS)评分、PGF_(2a)低于本组治疗前,PGE_(2)高于本组治疗前,且观察组VAS评分(1.12±0.52)分、PGF_(2a)(29.03±3.14)pg/ml低于对照组的(2.83±0.57)分、(34.20±3.57)pg/ml,PGE_(2)(28.57±3.85)pg/ml高于对照组的(25.24±3.64)pg/ml,差异明显(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论妇科再造丸应用于虚寒性痛经治疗中,能够促进患者中医证候及血清学指标改善,缓解疼痛,安全有效。

中医辨证施治治疗脾胃虚寒型慢性胃炎的临床效果分析

目的探讨中医辨证施治治疗脾胃虚寒型慢性胃炎的临床效果分析。方法64例脾胃虚寒型慢性胃炎患者,随机分为对照组和观察组,每组32例。对照组使用常规西医治疗,观察组在此基础上使用中医辨证施治。比较两组的临床疗效及治疗前后中医证候积分、血清炎性因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]。结果观察组治疗总有效率为93.75%,明显高于对照组的68.75%(P<0.05)。治疗后,观察组胃脘隐痛、喜温喜按、泛吐清水、便溏、神疲乏力积分分别为(0.90±0.18)、(0.87±0.16)、(0.92±0.19)、(0.86±0.17)、(0.93±0.20)分,均低于对照组的(1.47±0.23)、(1.44±0.22)、(1.50±0.24)、(1.46±0.23)、(1.51±0.24)分(P<0.05)。治疗后,观察组IL-1β、IL-6、TNF-α、CRP水平分别为(14.27±2.54)ng/L、(20.33±3.02)ng/L、(4.59±0.78)ng/L、(3.02±0.75)mg/L,低于对照组的(18.96±3.31)ng/L、(27.84±3.56)ng/L、(7.13±1.16)ng/L、(6.87±1.28)mg/L(P<0.05)。结论中医辨证施治治疗脾胃虚寒型慢性胃炎的临床效果显著,能有效缓解中医证候,减轻炎症反应,具有积极的临床意义。