The bi rare earth complexes EuTb( m MBA) 6(phen) 2·2H 2O, TbY( m MBA) 6(phen) 2·2H 2O were synthesized by the reaction of RECl 3 with m methylbenzoic acid and 1,10 phenanthroline in eth...The bi rare earth complexes EuTb( m MBA) 6(phen) 2·2H 2O, TbY( m MBA) 6(phen) 2·2H 2O were synthesized by the reaction of RECl 3 with m methylbenzoic acid and 1,10 phenanthroline in ethanol solution, where m MBA=m methylbenzoate and phen=1,10 phenanthroline. The luminescence properties of the title complexes were studied in comparison with the corresponding complexes Eu 2( m MBA) 6(phen) 2·2H 2O and Tb 2( m MBA) 6(phen) 2·2H 2O respectively. The results indicate that the emission intensity from europium ion can be greatly enhanced by the terbium ion, while the emission from terbium ion was strongly quenched by europium ion in EuTb( m MBA) 6(phen) 2·2H 2O; the emission intensity from terbium ion can be greatly enhanced by yttrium ion in TbY( m MBA) 6(phen) 2·2H 2O. The mechanism about the results was discussed.展开更多
Recent studies have revealed that bile acids(BAs)are not only facilitators of dietary lipid absorption but also important signaling molecules exerting multiple physiological functions.Some major signaling pathways inv...Recent studies have revealed that bile acids(BAs)are not only facilitators of dietary lipid absorption but also important signaling molecules exerting multiple physiological functions.Some major signaling pathways involving the nuclear BAs receptor farnesoid X receptor and the G protein-coupled BAs receptor TGR5/M-BAR have been identified to be the targets of BAs.BAs regulate their own homeostasis via signaling pathways.BAs also affect diverse metabolic pathways including glucose metabolism,lipid metabolism and energy expenditure.This paper suggests the mechanism of controlling metabolism via BA signaling and demonstrates that BA signaling is an attractive therapeutic target of the metabolic syndrome.展开更多
[Objectives]This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase( AR). [Methods]The isolated salvianolic acid M and rosmarinic acid wer...[Objectives]This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase( AR). [Methods]The isolated salvianolic acid M and rosmarinic acid were prepared into different concentrations of solutions for in vitro enzyme kinetics experiments. [Results]Salvianolic acid M and rosmarinic acid had the strongest inhibition effects at the concentration of 1 g/L. [Conclusions]Salvianolic acid M and rosmarinic acid have inhibition effects on human aldose reductase. The IC50 of salvianolic acid M is 0. 79 μg/mL,and that of rosmarinic acid is 1. 13 μg/mL.展开更多
Reactions of Cd（OAC）2·2H2O with m-thioacetatebenzoic acid（H2L） and 1,10-phenanthroline（phen） give rise to a metal-organic framework,[CdL（phen）]n（1）.X-ray single-crystal diffraction reveals that 1 crysta...Reactions of Cd（OAC）2·2H2O with m-thioacetatebenzoic acid（H2L） and 1,10-phenanthroline（phen） give rise to a metal-organic framework,[CdL（phen）]n（1）.X-ray single-crystal diffraction reveals that 1 crystallizes in the monoclinic system,space group C2/c,with a= 25.7099（5）,b=10.3872（2）,c=19.1820（4）,β=131.114（1）°,V=3859.4（1）3,Mr=502.80,Z= 8,F（000）=2000,μ=1.271 mm-1,Dc=1.731 g·cm-3,the final R=0.0226 and wR=0.0559 for 3817 observed reflections（Ⅰ〉 2σ（Ⅰ））.1 displays a 1D double-strand chain structure with crab-like dinuclear subunits,and extends into a 3D network by π-π interactions and C-H···O hydrogen bonds.Photoluminescence studies reveal that it displays intense structure-related fluorescent emission bands（λex=342 nm） at 370.5 and 389 nm in the solid state at room temperature.展开更多
The aim of the present work was to develop radiolabelling fatty acids based on 99Tcm carbonyl chemistry for heart imaging. Undecanoic acids functionalised with iminodiacetatic acid and cysteine were radiolabelled with...The aim of the present work was to develop radiolabelling fatty acids based on 99Tcm carbonyl chemistry for heart imaging. Undecanoic acids functionalised with iminodiacetatic acid and cysteine were radiolabelled with [99Tcm (CO)3(H2O)3]+ intermediates, and their radiolabelling conditions were carefully studied. Biodistribution of 99Tcm (CO)3-CYST FAC11 and 99Tcm (CO)3-IDA FAC11 were observed in normal mice. The results showed that two 99Tcm-labelled compounds had similar profile in terms of high initial radioactivity uptake and rapid washout of radio- tracers in the heart. 99Tcm (CO)3-IDA FAC11 was mainly excreted via hepatobiliary system in contrast to 99Tcm (CO)3-CYST FAC11, which was excreted from urinary system. It may be in part attributed to the more lipophilicity of 99Tcm (CO)3-IDA FAC11 than 99Tcm (CO)3-CYST FAC11.展开更多
AIM To study the peripheral mechanism of the inhibitory effect of intra third ventricular administration (icv) of histamine (HA) on gastric acid secretion in rats. METHODS Gastric acid was continuously washed wit...AIM To study the peripheral mechanism of the inhibitory effect of intra third ventricular administration (icv) of histamine (HA) on gastric acid secretion in rats. METHODS Gastric acid was continuously washed with 37℃ saline by a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenously (iv) by a syringe pump and their effect on pentagastrin induced (10μg·kg·h, iv) gastric acid secretion was observed. RESULTS The inhibitory effect of HA (1μg, icv) on gastric acid secretion was blocked by subdiaphragmatic vagotomy, and pretreatment with atropine (0 005mg·kg·h, iv). Pretreatment with somatostatin antagonist, cyclo [7 aminoheptanoyl Phe D Trp Lys Thr(Bzl)], ( 2μg - 4μg ·kg· 100min , iv) could also block the inhibitory effect of HA on gastric acid secretion in a dose dependent manner. CONCLUSION The inhibitory effect of centrally administrated HA on gastric acid secretion may be mediated by vagi, acetylcholine M receptor and somatostatin.展开更多
Calcium （Ca） plays an important role in the metabolism of higher plants. Recently, research on Ca^2＋ in plants has been focused especially at the cellular and molecular levels. Uptake, transport, and distribution a...Calcium （Ca） plays an important role in the metabolism of higher plants. Recently, research on Ca^2＋ in plants has been focused especially at the cellular and molecular levels. Uptake, transport, and distribution are also very important for Ca to accomplish its function at the whole-plant level. In this experiment, one-year-old apple seedlings （M. hupehensis Rehd.） were investigated to determine the distribution of stored Ca, the different forms of Ca, and Ca^2＋-ATPase activity after treatment with indole butyric acid （IBA）. The results showed that the total Ca measured in mature leaves and Ca^2＋- ATPase activity in tender leaves were higher compared with those in the control （CK）. Calcium nitrate and calcium chloride （ALe-Ca） and calcium phosphate and calcium carbonate （HAC-Ca） decreased in both mature leaves and shoots, whereas water-soluble calcium （H2O-Ca）, calcium pectate （NaCl-Ca）, and calcium oxalate （HCl-Ca） increased. The percentage of active calcium, calcium pectate, and water-soluble calcium increased, whereas the percentage of calcium phosphate and calcium carbonate decreased. When treated with IBA, calcium fractions and percentage of the different forms of Ca was enhanced in 40 part per million （ppm） IBA compared with 20 ppm IBA and water. The results indicated that IBA increased the percentage of both active calcium （NaCl-Ca and H2O-Ca） in tender shoots and boosted the transportation of stored Ca in plants. IBA promoted Ca^2＋-ATPase activity and Ca^2＋ uptake in tender shoots of M. hupehensis. It can improve the total Ca contents and the relative percentage of Ca.展开更多
The present paper covers an X-ray photoelectron spectroscopic (XPS) method proposed for identifying Bronsted and Lewis acidic sites in zeolites and estimating acidic strength of these sites. It was found that the adso...The present paper covers an X-ray photoelectron spectroscopic (XPS) method proposed for identifying Bronsted and Lewis acidic sites in zeolites and estimating acidic strength of these sites. It was found that the adsorption of pyridine on different acidic sites of H[M]-ZSM-5 zeolites exhibited three peaks: A (402.20-401.30 eV), B (400.95-400.40 eV) and C (399. 40-399. 10 eV). The peaks A and B are assigned to the N(?) level of pyridine adsorbed on Bronsted and Lewis acidic sites, and peak C is assigned to the N(?) level of pyridine adsorbed on a weak Lewis site and/or strongly physisorbed pyridine, respectively. The comparison of the ratio of the Bronsted and Lewis acidic sites determined from the relative intensities of the N(?), peaks with IR spectroscopic data shows that there is an inhomoge-neous distribution of Bronsted and Lewis acidic sites in H[M]-ZSM-5 zeolites. The N(?), binding energies of pyridine adsorbed on these zeolites directly reflect acidic strength, and these results are in good agreement with those observed in NH3-TPD experiments.展开更多
Objective To investigate the change of serum and uric acid of ty pe 2diabetic patient s concomitant with stroke.Methods We selected 202patien ts randomly,and divided them into 3groups:diabetic concomitant with stroke ...Objective To investigate the change of serum and uric acid of ty pe 2diabetic patient s concomitant with stroke.Methods We selected 202patien ts randomly,and divided them into 3groups:diabetic concomitant with stroke gr oup,simp le stroke and simple diabetes group.We tested serum uric acid(UA)an d serum fat of all patients and anal ysis its relationship with type 2dia betes and stroke.Results There was apparent difference in serum UA a nd HDL level be tween type 2diabetic with stroke group and simple diabetic group.Conclusion De crease of HDL is one important risk factor fo r type 2diabetic patients concomi ta nt with stroke,and hypercuricemia i s another important risk factor for male type 2diabetic patients concom itant with stroke.展开更多
基金supported by Natural Science Foundation of Hebei Province(202140)
文摘The bi rare earth complexes EuTb( m MBA) 6(phen) 2·2H 2O, TbY( m MBA) 6(phen) 2·2H 2O were synthesized by the reaction of RECl 3 with m methylbenzoic acid and 1,10 phenanthroline in ethanol solution, where m MBA=m methylbenzoate and phen=1,10 phenanthroline. The luminescence properties of the title complexes were studied in comparison with the corresponding complexes Eu 2( m MBA) 6(phen) 2·2H 2O and Tb 2( m MBA) 6(phen) 2·2H 2O respectively. The results indicate that the emission intensity from europium ion can be greatly enhanced by the terbium ion, while the emission from terbium ion was strongly quenched by europium ion in EuTb( m MBA) 6(phen) 2·2H 2O; the emission intensity from terbium ion can be greatly enhanced by yttrium ion in TbY( m MBA) 6(phen) 2·2H 2O. The mechanism about the results was discussed.
文摘Recent studies have revealed that bile acids(BAs)are not only facilitators of dietary lipid absorption but also important signaling molecules exerting multiple physiological functions.Some major signaling pathways involving the nuclear BAs receptor farnesoid X receptor and the G protein-coupled BAs receptor TGR5/M-BAR have been identified to be the targets of BAs.BAs regulate their own homeostasis via signaling pathways.BAs also affect diverse metabolic pathways including glucose metabolism,lipid metabolism and energy expenditure.This paper suggests the mechanism of controlling metabolism via BA signaling and demonstrates that BA signaling is an attractive therapeutic target of the metabolic syndrome.
基金Supported by Scientific Research Plan for Colleges and Universities in Xinjiang Uygur Autonomous Region(XJEDU2018Y025)
文摘[Objectives]This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase( AR). [Methods]The isolated salvianolic acid M and rosmarinic acid were prepared into different concentrations of solutions for in vitro enzyme kinetics experiments. [Results]Salvianolic acid M and rosmarinic acid had the strongest inhibition effects at the concentration of 1 g/L. [Conclusions]Salvianolic acid M and rosmarinic acid have inhibition effects on human aldose reductase. The IC50 of salvianolic acid M is 0. 79 μg/mL,and that of rosmarinic acid is 1. 13 μg/mL.
文摘Reactions of Cd（OAC）2·2H2O with m-thioacetatebenzoic acid（H2L） and 1,10-phenanthroline（phen） give rise to a metal-organic framework,[CdL（phen）]n（1）.X-ray single-crystal diffraction reveals that 1 crystallizes in the monoclinic system,space group C2/c,with a= 25.7099（5）,b=10.3872（2）,c=19.1820（4）,β=131.114（1）°,V=3859.4（1）3,Mr=502.80,Z= 8,F（000）=2000,μ=1.271 mm-1,Dc=1.731 g·cm-3,the final R=0.0226 and wR=0.0559 for 3817 observed reflections（Ⅰ〉 2σ（Ⅰ））.1 displays a 1D double-strand chain structure with crab-like dinuclear subunits,and extends into a 3D network by π-π interactions and C-H···O hydrogen bonds.Photoluminescence studies reveal that it displays intense structure-related fluorescent emission bands（λex=342 nm） at 370.5 and 389 nm in the solid state at room temperature.
基金Supported by the Co-ordinated Research Programme of the International Atomic Energy Agency (Contract No: 12469/R0)
文摘The aim of the present work was to develop radiolabelling fatty acids based on 99Tcm carbonyl chemistry for heart imaging. Undecanoic acids functionalised with iminodiacetatic acid and cysteine were radiolabelled with [99Tcm (CO)3(H2O)3]+ intermediates, and their radiolabelling conditions were carefully studied. Biodistribution of 99Tcm (CO)3-CYST FAC11 and 99Tcm (CO)3-IDA FAC11 were observed in normal mice. The results showed that two 99Tcm-labelled compounds had similar profile in terms of high initial radioactivity uptake and rapid washout of radio- tracers in the heart. 99Tcm (CO)3-IDA FAC11 was mainly excreted via hepatobiliary system in contrast to 99Tcm (CO)3-CYST FAC11, which was excreted from urinary system. It may be in part attributed to the more lipophilicity of 99Tcm (CO)3-IDA FAC11 than 99Tcm (CO)3-CYST FAC11.
文摘AIM To study the peripheral mechanism of the inhibitory effect of intra third ventricular administration (icv) of histamine (HA) on gastric acid secretion in rats. METHODS Gastric acid was continuously washed with 37℃ saline by a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenously (iv) by a syringe pump and their effect on pentagastrin induced (10μg·kg·h, iv) gastric acid secretion was observed. RESULTS The inhibitory effect of HA (1μg, icv) on gastric acid secretion was blocked by subdiaphragmatic vagotomy, and pretreatment with atropine (0 005mg·kg·h, iv). Pretreatment with somatostatin antagonist, cyclo [7 aminoheptanoyl Phe D Trp Lys Thr(Bzl)], ( 2μg - 4μg ·kg· 100min , iv) could also block the inhibitory effect of HA on gastric acid secretion in a dose dependent manner. CONCLUSION The inhibitory effect of centrally administrated HA on gastric acid secretion may be mediated by vagi, acetylcholine M receptor and somatostatin.
基金The study was supported financially by the National Natural Science Foundation of China(30170655&30270923).
文摘Calcium （Ca） plays an important role in the metabolism of higher plants. Recently, research on Ca^2＋ in plants has been focused especially at the cellular and molecular levels. Uptake, transport, and distribution are also very important for Ca to accomplish its function at the whole-plant level. In this experiment, one-year-old apple seedlings （M. hupehensis Rehd.） were investigated to determine the distribution of stored Ca, the different forms of Ca, and Ca^2＋-ATPase activity after treatment with indole butyric acid （IBA）. The results showed that the total Ca measured in mature leaves and Ca^2＋- ATPase activity in tender leaves were higher compared with those in the control （CK）. Calcium nitrate and calcium chloride （ALe-Ca） and calcium phosphate and calcium carbonate （HAC-Ca） decreased in both mature leaves and shoots, whereas water-soluble calcium （H2O-Ca）, calcium pectate （NaCl-Ca）, and calcium oxalate （HCl-Ca） increased. The percentage of active calcium, calcium pectate, and water-soluble calcium increased, whereas the percentage of calcium phosphate and calcium carbonate decreased. When treated with IBA, calcium fractions and percentage of the different forms of Ca was enhanced in 40 part per million （ppm） IBA compared with 20 ppm IBA and water. The results indicated that IBA increased the percentage of both active calcium （NaCl-Ca and H2O-Ca） in tender shoots and boosted the transportation of stored Ca in plants. IBA promoted Ca^2＋-ATPase activity and Ca^2＋ uptake in tender shoots of M. hupehensis. It can improve the total Ca contents and the relative percentage of Ca.
文摘The present paper covers an X-ray photoelectron spectroscopic (XPS) method proposed for identifying Bronsted and Lewis acidic sites in zeolites and estimating acidic strength of these sites. It was found that the adsorption of pyridine on different acidic sites of H[M]-ZSM-5 zeolites exhibited three peaks: A (402.20-401.30 eV), B (400.95-400.40 eV) and C (399. 40-399. 10 eV). The peaks A and B are assigned to the N(?) level of pyridine adsorbed on Bronsted and Lewis acidic sites, and peak C is assigned to the N(?) level of pyridine adsorbed on a weak Lewis site and/or strongly physisorbed pyridine, respectively. The comparison of the ratio of the Bronsted and Lewis acidic sites determined from the relative intensities of the N(?), peaks with IR spectroscopic data shows that there is an inhomoge-neous distribution of Bronsted and Lewis acidic sites in H[M]-ZSM-5 zeolites. The N(?), binding energies of pyridine adsorbed on these zeolites directly reflect acidic strength, and these results are in good agreement with those observed in NH3-TPD experiments.
文摘Objective To investigate the change of serum and uric acid of ty pe 2diabetic patient s concomitant with stroke.Methods We selected 202patien ts randomly,and divided them into 3groups:diabetic concomitant with stroke gr oup,simp le stroke and simple diabetes group.We tested serum uric acid(UA)an d serum fat of all patients and anal ysis its relationship with type 2dia betes and stroke.Results There was apparent difference in serum UA a nd HDL level be tween type 2diabetic with stroke group and simple diabetic group.Conclusion De crease of HDL is one important risk factor fo r type 2diabetic patients concomi ta nt with stroke,and hypercuricemia i s another important risk factor for male type 2diabetic patients concom itant with stroke.
