目的通过证据图描述和总结白介素-6(IL-6)/白介素-6受体(IL-6R)与多种健康结局孟德尔随机化研究中的证据,明确其分布,以期为该领域研究提供参考。方法系统检索PubMed、EMBASE、Web of Science、Scopus、中国知识基础设施工程、中国生物...目的通过证据图描述和总结白介素-6(IL-6)/白介素-6受体(IL-6R)与多种健康结局孟德尔随机化研究中的证据,明确其分布,以期为该领域研究提供参考。方法系统检索PubMed、EMBASE、Web of Science、Scopus、中国知识基础设施工程、中国生物医学文献服务系统、万方数据库、维普数据库中IL-6/IL-6R与多种疾病的孟德尔随机化研究,采用图表结合形式综合分析和展示纳入研究的基本信息、研究方法和研究结局。结果最终纳入38篇孟德尔随机化研究,2020年以后相关研究数增加趋势明显,纳入研究探讨IL-6、IL-6R、sIL-6R、gp130、IL-6RA 5种不同的表型和65种不同疾病间的因果关系。其中,遗传预测的IL-6水平与终末期肾病、精神分裂症、冠状动脉疾病和心房颤动存在因果关系,IL-6R与黑色素瘤、髓系白血病、膀胱癌、喉癌、眼癌和胆囊癌的发生率存在因果关系,sIL-6R水平与肺动脉高压、哮喘、抑郁、多发性硬化症、腹主动脉瘤等疾病患病率存在因果关系。结论孟德尔随机化研究提供了关于IL-6/IL-6R在多种健康结局中的因果作用的重要证据,涵盖精神心理、炎症、癌症和心血管疾病等,反映了IL-6/IL-6R在多种疾病中的广泛影响和IL-6领域研究的重要性。展开更多
Whitebacked planthopper (WBPH,Sogatella furcifera Horvath) is one ofthe most destructive insects for rice.The utilization of WBPH resistancegenes is always an efficient solution tothis problem. Besides five WBPHresist...Whitebacked planthopper (WBPH,Sogatella furcifera Horvath) is one ofthe most destructive insects for rice.The utilization of WBPH resistancegenes is always an efficient solution tothis problem. Besides five WBPHresistance genes registered, Wbph1,Wbph 2 , Wbph 3 , wbph 4 , andWbphS, classical segregation analysis展开更多
The existence of Smale horseshoes for a certain discretized perturbed nonlinear Schroedinger （NLS） equations was established by using n-dimensional versions of the Conley-Moser conditions. As a result, the discretiz...The existence of Smale horseshoes for a certain discretized perturbed nonlinear Schroedinger （NLS） equations was established by using n-dimensional versions of the Conley-Moser conditions. As a result, the discretized perturbed NLS system is shown to possess an invadant set A on which the dynamics is topologically conjugate to a shift on four symbols.展开更多
We present a fractional-order three-dimensional chaotic system, which can generate four-wing chaotic attractor. Dy- namics of the fractional-order system is investigated by numerical simulations. To rigorously verify ...We present a fractional-order three-dimensional chaotic system, which can generate four-wing chaotic attractor. Dy- namics of the fractional-order system is investigated by numerical simulations. To rigorously verify the chaos properties of this system, the existence of horseshoe in the four-wing attractor is presented. Firstly, a Poincar6 section is selected properly, and a first-return Poincar6 map is established. Then, a one-dimensional tensile horseshoe is discovered, which verifies the chaos existence of the system in mathematical view. Finally, the fractional-order chaotic attractor is imple- mented physically with a field-programmable gate array （FPGA） chip, which is useful in further engineering applications of information encryption and secure communications.展开更多
A typical airfoil section system with freeplay is investigated in the paper. The classic quasi-steady flow model is applied to calculate the aerodynamics, and a piecewise-stiffness model is adopted to characterize the...A typical airfoil section system with freeplay is investigated in the paper. The classic quasi-steady flow model is applied to calculate the aerodynamics, and a piecewise-stiffness model is adopted to characterize the non- linearity of the airfoil section＇s freeplay. There are two crit- ical speeds in the system, i.e., a lower critical speed, above which the system might generate limit cycle oscillation, and an upper critical one, above which the system will flutter. Then a Poincar6 map is constructed for the limit cycle os- cillations by using piecewise-linear solutions with and with- out contact in the system. Through analysis of the Poincar6 map, a series of equations which can determine the frequen- cies of period-1 limit cycle oscillations at any flight veloc- ity are derived. Finally, these analytic results are compared to the results of numerical simulations, and a good agree- ment is found. The effects of freeplay value and contact stiffness ratio on the limit cycle oscillation are also analyzed through numerical simulations of the original system. More- over, there exist multi-periods limit cycle oscillations and even complicated ＂chaotic＂ oscillations may occur, which are usually found in smooth nonlinear dynamic systems.展开更多
To fine map the previously detected quantitative trait loci （QTLs） affecting milk production traits on bovine chromosome 6 （BTA6）, 15 microsatellite markers situated within an interval of 14.3 cM spanning from BMS...To fine map the previously detected quantitative trait loci （QTLs） affecting milk production traits on bovine chromosome 6 （BTA6）, 15 microsatellite markers situated within an interval of 14.3 cM spanning from BMS690 to BM4528 were selected and 918 daughters of 8 sires were genotyped. Two mapping approaches, haplotype sharing based LD mapping and single marker regression mapping, were used to analyze the data. Both approaches revealed a quantitative trait locus （QTL） with significant effects on milk yield, fat yield and protein yield located in the segment flanked by markers BMS483 and MNB209, which spans a genetic distance of 0.6 cM and a physical distance of 1.5 Mb. In addition, the single marker regression mapping also revealed a QTL affecting fat percentage and protein percentage at marker DIK2291. Our fine mapping work will facilitate the cloning of candidate genes underlying the QTLs for milk production traits.展开更多
文摘目的通过证据图描述和总结白介素-6(IL-6)/白介素-6受体(IL-6R)与多种健康结局孟德尔随机化研究中的证据,明确其分布,以期为该领域研究提供参考。方法系统检索PubMed、EMBASE、Web of Science、Scopus、中国知识基础设施工程、中国生物医学文献服务系统、万方数据库、维普数据库中IL-6/IL-6R与多种疾病的孟德尔随机化研究,采用图表结合形式综合分析和展示纳入研究的基本信息、研究方法和研究结局。结果最终纳入38篇孟德尔随机化研究,2020年以后相关研究数增加趋势明显,纳入研究探讨IL-6、IL-6R、sIL-6R、gp130、IL-6RA 5种不同的表型和65种不同疾病间的因果关系。其中,遗传预测的IL-6水平与终末期肾病、精神分裂症、冠状动脉疾病和心房颤动存在因果关系,IL-6R与黑色素瘤、髓系白血病、膀胱癌、喉癌、眼癌和胆囊癌的发生率存在因果关系,sIL-6R水平与肺动脉高压、哮喘、抑郁、多发性硬化症、腹主动脉瘤等疾病患病率存在因果关系。结论孟德尔随机化研究提供了关于IL-6/IL-6R在多种健康结局中的因果作用的重要证据,涵盖精神心理、炎症、癌症和心血管疾病等,反映了IL-6/IL-6R在多种疾病中的广泛影响和IL-6领域研究的重要性。
文摘The existence of Smale horseshoes for a certain discretized perturbed nonlinear Schroedinger （NLS） equations was established by using n-dimensional versions of the Conley-Moser conditions. As a result, the discretized perturbed NLS system is shown to possess an invadant set A on which the dynamics is topologically conjugate to a shift on four symbols.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61502340 and 61374169)the Application Base and Frontier Technology Research Project of Tianjin,China(Grant No.15JCYBJC51800)the South African National Research Foundation Incentive Grants(Grant No.81705)
文摘We present a fractional-order three-dimensional chaotic system, which can generate four-wing chaotic attractor. Dy- namics of the fractional-order system is investigated by numerical simulations. To rigorously verify the chaos properties of this system, the existence of horseshoe in the four-wing attractor is presented. Firstly, a Poincar6 section is selected properly, and a first-return Poincar6 map is established. Then, a one-dimensional tensile horseshoe is discovered, which verifies the chaos existence of the system in mathematical view. Finally, the fractional-order chaotic attractor is imple- mented physically with a field-programmable gate array （FPGA） chip, which is useful in further engineering applications of information encryption and secure communications.
基金supported by the National Science Fund for Distinguished Young Scholars in China(11225212)the Young Teachers' Funds of Hunan Province,China
文摘A typical airfoil section system with freeplay is investigated in the paper. The classic quasi-steady flow model is applied to calculate the aerodynamics, and a piecewise-stiffness model is adopted to characterize the non- linearity of the airfoil section＇s freeplay. There are two crit- ical speeds in the system, i.e., a lower critical speed, above which the system might generate limit cycle oscillation, and an upper critical one, above which the system will flutter. Then a Poincar6 map is constructed for the limit cycle os- cillations by using piecewise-linear solutions with and with- out contact in the system. Through analysis of the Poincar6 map, a series of equations which can determine the frequen- cies of period-1 limit cycle oscillations at any flight veloc- ity are derived. Finally, these analytic results are compared to the results of numerical simulations, and a good agree- ment is found. The effects of freeplay value and contact stiffness ratio on the limit cycle oscillation are also analyzed through numerical simulations of the original system. More- over, there exist multi-periods limit cycle oscillations and even complicated ＂chaotic＂ oscillations may occur, which are usually found in smooth nonlinear dynamic systems.
基金supported by the National Key Basic Research Program of China (No. 2006CB102104)
文摘To fine map the previously detected quantitative trait loci （QTLs） affecting milk production traits on bovine chromosome 6 （BTA6）, 15 microsatellite markers situated within an interval of 14.3 cM spanning from BMS690 to BM4528 were selected and 918 daughters of 8 sires were genotyped. Two mapping approaches, haplotype sharing based LD mapping and single marker regression mapping, were used to analyze the data. Both approaches revealed a quantitative trait locus （QTL） with significant effects on milk yield, fat yield and protein yield located in the segment flanked by markers BMS483 and MNB209, which spans a genetic distance of 0.6 cM and a physical distance of 1.5 Mb. In addition, the single marker regression mapping also revealed a QTL affecting fat percentage and protein percentage at marker DIK2291. Our fine mapping work will facilitate the cloning of candidate genes underlying the QTLs for milk production traits.
