经过四个半月的翻新工作,汉堡FürKunst und Gewerbe博物馆(MK&G)全新的接待大厅终于落成。该接待厅由本土工作室Besau Marguerre设计完成,为游客打造清晰的寻路系统与快速的空间定位是设计理念中的核心,而全新的配色方案与改...经过四个半月的翻新工作,汉堡FürKunst und Gewerbe博物馆(MK&G)全新的接待大厅终于落成。该接待厅由本土工作室Besau Marguerre设计完成,为游客打造清晰的寻路系统与快速的空间定位是设计理念中的核心,而全新的配色方案与改善后的音响效果,更为空间创造了宜人的氛围。项目的落成为提升博物馆的游客体验和安全做出了巨大的贡献,同时也使博物馆的服务达到了一个新的水平。展开更多
大坝的位移趋势对其安全运行十分重要,而在非常规条件下快速得到大坝的预测模型的研究则相对较少。为使管理人员可以高效地掌握大坝位移的变化性态,基于多核支持向量机(Multiple-kernels support vector machine,MK-SVM)算法构建了一种...大坝的位移趋势对其安全运行十分重要,而在非常规条件下快速得到大坝的预测模型的研究则相对较少。为使管理人员可以高效地掌握大坝位移的变化性态,基于多核支持向量机(Multiple-kernels support vector machine,MK-SVM)算法构建了一种快速实现大坝位移预测的模型,并讨论该模型参数的范围,利用相关评价指标计算度量模型的精度。由工程案例可知,该模型预测大坝变形的变化趋势与实测变形基本一致,模型预测精度可以满足工程运行需要。结论可为大坝管理人员提供有益借鉴。展开更多
Objective Schizophrenia(SZ)is associated with cognitive impairment,and it is known that the activity of cAMP response element binding protein(CREB)decreases in the brain of SZ patients.The previous study conducted by ...Objective Schizophrenia(SZ)is associated with cognitive impairment,and it is known that the activity of cAMP response element binding protein(CREB)decreases in the brain of SZ patients.The previous study conducted by the investigators revealed that the upregulation of CREB improves the MK801-related SZ cognitive deficit.The present study further investigates the mechanism on how CREB deficiency is associated with SZ-related cognitive impairment.Methods MK-801 was used to induce SZ in rats.Western blotting and immunofluorescence were performed to investigate CREB and the CREB-related pathway implicated in MK801 rats.The long-term potentiation and behavioral tests were performed to assess the synaptic plasticity and cognitive impairment,respectively.Results The phosphorylation of CREB at Ser133 decreased in the hippocampus of SZ rats.Interestingly,among the upstream kinases of CREB,merely ERK1/2 was downregulated,while CaMKII and PKA remained unchanged in the brain of MK801-related SZ rats.The inhibition of ERK1/2 by PD98059 reduced the phosphorylation of CREB-Ser133,and induced synaptic dysfunction in primary hippocampal neurons.Conversely,the activation of CREB attenuated the ERK1/2 inhibitor-induced synaptic and cognitive impairment.Conclusion These present findings partially suggest that the deficiency of the ERK1/2-CREB pathway is involved in MK801-related SZ cognitive impairment.The activation of the ERK1/2-CREB pathway may be therapeutically useful for treating SZ cognitive deficits.展开更多
文摘经过四个半月的翻新工作,汉堡FürKunst und Gewerbe博物馆(MK&G)全新的接待大厅终于落成。该接待厅由本土工作室Besau Marguerre设计完成,为游客打造清晰的寻路系统与快速的空间定位是设计理念中的核心,而全新的配色方案与改善后的音响效果,更为空间创造了宜人的氛围。项目的落成为提升博物馆的游客体验和安全做出了巨大的贡献,同时也使博物馆的服务达到了一个新的水平。
文摘大坝的位移趋势对其安全运行十分重要,而在非常规条件下快速得到大坝的预测模型的研究则相对较少。为使管理人员可以高效地掌握大坝位移的变化性态,基于多核支持向量机(Multiple-kernels support vector machine,MK-SVM)算法构建了一种快速实现大坝位移预测的模型,并讨论该模型参数的范围,利用相关评价指标计算度量模型的精度。由工程案例可知,该模型预测大坝变形的变化趋势与实测变形基本一致,模型预测精度可以满足工程运行需要。结论可为大坝管理人员提供有益借鉴。
基金supported in part by grants from National Natural Science Foundation of China(No.31929002,No.82201326 No.82071440 and No.92049107)Science,Technology and Innovation Commission of Shenzhen Municipality(No.JCYJ20210324141405014)+1 种基金Guangdong Basic and Applied Basic Research Foundation(No.2020B1515120017)the Academic Frontier Youth Team Project to Xiao-chuan WANG from Huazhong University of Science and Technology.
文摘Objective Schizophrenia(SZ)is associated with cognitive impairment,and it is known that the activity of cAMP response element binding protein(CREB)decreases in the brain of SZ patients.The previous study conducted by the investigators revealed that the upregulation of CREB improves the MK801-related SZ cognitive deficit.The present study further investigates the mechanism on how CREB deficiency is associated with SZ-related cognitive impairment.Methods MK-801 was used to induce SZ in rats.Western blotting and immunofluorescence were performed to investigate CREB and the CREB-related pathway implicated in MK801 rats.The long-term potentiation and behavioral tests were performed to assess the synaptic plasticity and cognitive impairment,respectively.Results The phosphorylation of CREB at Ser133 decreased in the hippocampus of SZ rats.Interestingly,among the upstream kinases of CREB,merely ERK1/2 was downregulated,while CaMKII and PKA remained unchanged in the brain of MK801-related SZ rats.The inhibition of ERK1/2 by PD98059 reduced the phosphorylation of CREB-Ser133,and induced synaptic dysfunction in primary hippocampal neurons.Conversely,the activation of CREB attenuated the ERK1/2 inhibitor-induced synaptic and cognitive impairment.Conclusion These present findings partially suggest that the deficiency of the ERK1/2-CREB pathway is involved in MK801-related SZ cognitive impairment.The activation of the ERK1/2-CREB pathway may be therapeutically useful for treating SZ cognitive deficits.
基金supported by the National Natural Science Foundation of China (30700260)National Key Technolo-gies R&D Program in the 10th 5-year-plan of China (2004BA720A22)
