In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups （mild, moderate, severe） according to minimum oxygen saturation, and 35 healthy subjects were examined as...In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups （mild, moderate, severe） according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation 〈 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation 〉 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montrea Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.展开更多
Rapid and accurate perception of threat information is a critical ability and a prerequisite to survive natural selection for humans.To investigate whether threatening stimuli,especially phylogenetic and ontogenetic t...Rapid and accurate perception of threat information is a critical ability and a prerequisite to survive natural selection for humans.To investigate whether threatening stimuli,especially phylogenetic and ontogenetic threats,are processed automatically,we analyzed the visual mismatch negativity(vMMN,an event-related potential component reflecting automatic processing)elicited by the threats with a cross-modal oddball paradigm,where participants were required to focus on the auditory stimuli and ignore the visual stimuli in each block.In this study,neutral(non-threatening)images served as standard stimuli(80%),and phylogenetic(10%)and ontogenetic(10%)threat stimuli served as deviant stimuli when testing a large sample(N=96)of healthy volunteers.Threat-related visual mismatch negativity(threat-vMMN)was obtained by subtracting the event-related potential(ERP)elicited by standard stimuli from that elicited by deviant stimuli.The results indicated that the vMMN can be elicited by threat information.More importantly,the phylogenetic threat information elicited larger threat-vMMN than ontogenetic threat information.These findings suggest that perception of threat information was automatic,providing an evidential basis for the attentional advantages of survival processing.That is,automatic perception of phylogenetic threats has a particular evolutionary origin.展开更多
We detected the event-related potential mismatch negativity （MMN） of 30 depression patients and compared to 30 age,gender,and education-matched healthy controls.Results showed that amplitudes of frequency and durati...We detected the event-related potential mismatch negativity （MMN） of 30 depression patients and compared to 30 age,gender,and education-matched healthy controls.Results showed that amplitudes of frequency and duration MMN were lower in depression patients compared with control patients,indicating abnormality in auditory processing （i.e.,cognitive impairment）.Following escitalopram treatment for 8 weeks,the amplitudes of frequency and duration MMN were significantly increased and Hamilton Rating Scale for Depression scores were significantly decreased in depression patients.These data suggest that escitalopram can improve cognitive function of patients with depression.Further,MMN may be a useful tool for evaluating cognitive function and treatment effects.展开更多
基金supported by the National Natural Science Foundation of China,No. 30973309
文摘In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups （mild, moderate, severe） according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation 〈 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation 〉 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montrea Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.
文摘Rapid and accurate perception of threat information is a critical ability and a prerequisite to survive natural selection for humans.To investigate whether threatening stimuli,especially phylogenetic and ontogenetic threats,are processed automatically,we analyzed the visual mismatch negativity(vMMN,an event-related potential component reflecting automatic processing)elicited by the threats with a cross-modal oddball paradigm,where participants were required to focus on the auditory stimuli and ignore the visual stimuli in each block.In this study,neutral(non-threatening)images served as standard stimuli(80%),and phylogenetic(10%)and ontogenetic(10%)threat stimuli served as deviant stimuli when testing a large sample(N=96)of healthy volunteers.Threat-related visual mismatch negativity(threat-vMMN)was obtained by subtracting the event-related potential(ERP)elicited by standard stimuli from that elicited by deviant stimuli.The results indicated that the vMMN can be elicited by threat information.More importantly,the phylogenetic threat information elicited larger threat-vMMN than ontogenetic threat information.These findings suggest that perception of threat information was automatic,providing an evidential basis for the attentional advantages of survival processing.That is,automatic perception of phylogenetic threats has a particular evolutionary origin.
基金the Medical Research Foundation of Jiangsu Provincial Department of Public Health,No.H201043
文摘We detected the event-related potential mismatch negativity （MMN） of 30 depression patients and compared to 30 age,gender,and education-matched healthy controls.Results showed that amplitudes of frequency and duration MMN were lower in depression patients compared with control patients,indicating abnormality in auditory processing （i.e.,cognitive impairment）.Following escitalopram treatment for 8 weeks,the amplitudes of frequency and duration MMN were significantly increased and Hamilton Rating Scale for Depression scores were significantly decreased in depression patients.These data suggest that escitalopram can improve cognitive function of patients with depression.Further,MMN may be a useful tool for evaluating cognitive function and treatment effects.
