Clinical efficacy,bone density,and follow-up in implant and orthodontic treatment for inclined adjacent teeth

BACKGROUND Tooth defects can cause elongation of occlusal teeth,leading to insufficient repair space.The combination of dental implant restoration and orthodontic treatment of oblique adjacent teeth has a significant therapeutic effect.AIM To explore clinical efficacy,bone density,and follow-up of implant and orthodontic treatment for patients with inclined adjacent teeth.METHODS In total,98 patients with oblique adjacent teeth were randomly assigned to implant restoration combined with orthodontic treatment(group A,n=49)or to receive implant restoration alone(group B,n=49).Changes in alveolar ridge bone density and apical bone density were observed before and after treatment in the two groups.Changes in chewing function and language function were compared between the two groups of patients.Follow-up lasted for 12 mo after repair to observe any adverse reactions in the oral cavity.RESULTS The clinical effective rates of group A and group B were 97.96%and 85.71%,respectively,with group A having a higher clinical effective rate than group B.After treatment,the bone density of the alveolar ridge and apical bone in both groups decreased compared to before treatment,while the chewing and language functions improved.The changes in various indicators in group A were more significant.After treatment,the satisfaction rate of group A(97.96%)was higher than that of group B(79.59%).The incidence of adverse reactions in group A(2.04%)was lower than that in group B(24.49%).CONCLUSION The amalgamation of implant restoration and orthodontic treatment for adjacent tilted teeth demonstrates notable clinical efficacy,diminishes alveolar bone resorption,and fosters patient functional rehabilitation while exhibiting negligible adverse reactions.

THE RELATIONSHIP BETWEEN THE CONCENTRATION OF METHIMAZOLE IN PLASMA AND INTRATHYROID AND ITS CURATIVE EFFECT

In order to investigate the relationship between concentration of methimazole(MMTand clinical curative efficacy,the concentration of MMI in Plasma and thyroid tissue was measuredin 26 patients with Graves' disease by HPLC,meanwhile their T-lymphocyte subsets,thyroid autoimmune antibodies and serum immunoglobulin were also measured.The results showed: ① The plasmaand intrathyroid concentrations of MMI of recovery group were much higher than those of unrecovery group(P<0.001).② The hardness of thyroid had a significant effect on the concentration ofMMI in thyroid.③Plasma concentration of MMI in the patients with no or 1￣2-degree enlargement of thyroid was much higher than that in the patients with 3-degree enlargement of thyroid(P<0.001). In addition, the plasma concentration of MMI in the subjects with soft thyroid was mudhigher than that in those with hard thyroid(P<0.001).Our study demonstrated that MMI playeda role in the immune supression of thyroid autoimmune antibodies and the immune regulation of Tand B-lymphocytes.Effective MMI concentration in the plasma and intrathyroid is the key of thesuccessful clinical treatment and correlates with the size and hardness of thyroid.

Clinical features and prognostic factors in 49 patients with follicular lymphoma at a single center:A retrospective analysis

BACKGROUND Follicular lymphoma(FL)is a type of B-cell lymphoma that originates at the germinal center and has a low malignancy rate.FL has become the most common inert lymphoma in Europe and America but has a relatively low incidence in Asia.AIM To explore the clinical features,curative effects,and prognostic factors of FL.METHODS Completed medical records of 49 patients with FL who were admitted to the Ningbo First Hospital from June 2010 to June 2021 were examined.These patients were definitively diagnosed by pathological biopsy or immunohistochemical staining.The diagnostic criteria were based on the 2008 World Health Organization classification of lymphomas.Ann Arbor staging was performed according to the imaging and bone marrow examination results.Risk stratification of all patients was performed based on the International Prognostic Index(IPI),age-adjusted IPI,Follicular Lymphoma International Prognosis Index(FLIPI),and FLIPI2 to compare the efficacy of different treatment regimens and analyze the related prognostic factors.RESULTS The age of onset in patients ranged from 24 to 76 years,with a median age of 51 years.Most patients developed the disease at 40–59 years of age,and the male:female ratio was 1.6:1.No significant difference was noted in the curative effect between the non-chemotherapy,combined chemotherapy,and other chemotherapy regimens(P>0.05).Hemoglobin(Hb)level<120 g/L,Ki-67 value>50%,bone marrow involvement,and clinical stagesⅢ–IV were associated with a poor prognosis of FL(P<0.05).However,the influence of other indicators was not statistically significant.Risk grouping was performed using the FLIPI,and the results showed that 24.5%,40.8%,and 34.7%of patients were in the low-,moderate-,and high-risk groups,respectively.According to the survival analysis results,the survival rate of patients was lower in the high-risk group than in the other low-risk and moderate-risk groups(P<0.05).CONCLUSION FL mainly occurs in middle-aged and elderly men,primarily affecting lymph nodes and bone marrow.Hb level,Ki-67 value,bone marrow involvement,and clinical staging were used to evaluate prognosis.

Comparative study of the clinical efficacy of all-inside and traditional techniques in anterior cruciate ligament reconstruction

BACKGROUND Many studies have focused on the femoral tunnel technique and fixation method,but few studies have involved the tibial tunnel technique and fixation method.The all-inside technique is one of the new techniques that has been described in recent years.All-inside anterior cruciate ligament(ACL)reconstruction is based on a tibial socket instead of a full tunnel.This method has many potential advantages.AIM To compare clinical outcomes of knee ACL autograft reconstruction using allinside quadrupled semitendinosus(AIST)and traditional hamstring tendon(TBT)techniques.METHODS From January 2017 to October 2019,the clinical data of 80 patients with ACL reconstruction were retrospectively analyzed,including 67 males and 13 females.The patients had an average age of 24.3±3.1 years(age range:18-33 years).The AIST technique was used in 42 patients and the TBT technique was used in 38 patients.The time between operation and injury,operative duration,postoperative visual analogue scale(VAS)score and knee functional recovery were recorded and compared between the two groups.The International Knee Documentation Committee(IKDC)and Lysholm scoring system were used to comprehensively evaluate clinical efficacy.RESULTS Eighty patients were followed for 24-36 mo,with an average follow-up duration of 27.5±1.8 mo.There were no significant differences in the time between surgery and injury,operative duration,IKDC and Lysholm scores of the affected knee at the last follow-up evaluation between the two groups.There were significant differences in VAS scores 1 d,3 d,7 d,2 wk and 1 mo after surgery(P<0.05).There was no significant difference in VAS score at 3 mo,6 mo and 1 year after operation.CONCLUSION The efficacy of the AIST ACL reconstruction technique was comparable to the TBT technique,but the postoperative pain was less with the AIST technique.Thus,the AIST technique is an ideal treatment choice for ACL reconstruction.

Clinical symptoms of cervical and shoulder MTrPs combined with the "third stage" dialectical traction in the treatment of cervical radiculopathy and its effect on the serum inflammatory factors of patients

Objective:To observe the clinical efficacy of acupotomology in the treatment of cervical and shoulder myofascial pain trigger point for cervical radiculopathy,and to detect its effect on COX-2,PGE2,5-HT,TNF-α and other inflammatory factors.Methods:A total of 110 CSR patients were selected as the research objects and divided into observation group(Acupotomology to release the trigger points of myofascial pain in neck and shoulder combined with"three-stage"dialectical traction method)and control group(conventional acupuncture combined with"Stage 3"dialectical traction)with 55 cases.Before and after treatment,the two groups were compared by improving the efficacy of MacNab,simplifying the SCORE of Mc Gill Pain Scale,measuring cervical curvature and serum levels of inflammatory factors such as COX-2,PGE2,5-HT and TNF-α.Results:After two weeks of treatment,the total effective rate of the observation group was 96.36%,higher than that of the control group(83.63%),and the difference was statistically significant(P<0.05).After the treatment,PRI,VAS,PPI and other scores of the two groups were all lower than those before the treatment,with statistical significance(P<0.05).However,there was no statistically significant difference in PRI,VAS and PPI scores between the two groups after treatment(P>0.05).The serum inflammatory factors of coX-2,PGE2,5-HT and TNF-αin the two groups were significantly lower after treatment than before treatment(P<0.05).However,the comparison of cox-2,PGE2,5-ht and TNF-αbetween the two groups showed no statistical significance(P>0.05).The cervical curvature values measured after treatment were significantly increased compared with those before treatment,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the two groups(P>0.05).Conclusion:The combination of acumotomology and"three-stage"dialectical traction method can significantly improve the pain and discomfort of patients with cervical radiculopathy,significantly reduce the symptoms,restore the physiological curvature of cervical vertebra,and reduce the inflammatory factors in serum.

Clinical effects of acupoints moxibustion therapy on postsurgical gastroparesis syndrome after resection of esophageal cardia cancer

OBJECTIVE:To evaluate effects of acupoints moxibustion therapy on postsurgical gastroparesis syndrome(PGS) after resection of esophageal cardia cancer.METHODS:60 patients with PGS after resection of esophageal cardia cancer,admitted to the second affiliated hospital to Nanyang medical college from August 2012 to August 2015,were selected and studied randomly.They were divided into the treatment group and the control group by single blind controlled method,30 cases in each group.The gastric paralysis main symptom index(GCSI,by symptom ratings quantitative score table) score,drainage volume of gastric juice and value of motilin were recorded respectively at 1,7,14 and 21 days after treatment in two groups.Apart from conventional therapies,acupoints moxibustion was given on Shenque,Guanyuan,Qihai,Zhongwan acupoints,twice a day,30 minutes once,7 days as a course of treatment and for 3 courses in the treatment group.In the control group,the conventional therapies were given,7 days as a course of treatment and for 3 courses.RESULTS:The GCSI score,drainage volume of gastric juice,value of motilin in the treatment group were better than that of the control group at 7,14,21 days respectively,and there were significant differences between two groups(P<0.05).The treatment group had a more sigi curative effect than that in the control group at 7,14 days respectively(P<0.05),but there was no significant difference at 21 day between the two groups(x^2=5.68,P<0.13);nevertheless,there were more recovery cases in the treatment group than those in the control group at 21 day(x^2=4.59,P<0.032).The total effective rate was 100.00% in treatment group,and 83.00% in the control group(P<0.05).CONCLUSIONS:Acupoints moxibustion has the advantageof addressing both the symptoms and root causes of PGS after resection of esophageal cardia cancer.

Observation on Therapeutic Effects of Electroacupuncture on Polycystic Ovary Syndrome of Kidney Deficiency and Phlegm Dampness Type and Oxidative Stress Level

Objective:To observe the clinical effect of electroacupuncture on improving polycystic ovary syndrome(PCOS)of kidney deficiency and phlegm dampness type and serum oxidative stress level.Methods:There were 68 patients with polycystic ovary syndrome were randomly divided into observation group(34 cases)and the control group(34 cases),The observation group was treated by electroacupuncture,while the control group was treated by placebo electroacupuncture.Combined with the evaluation of menstrual cycle,menstrual color,quality,quantity and TCM symptom integral index,the difference of curative effect between the two groups was observed,and the levels of peripheral blood,sex hormones,insulin resistance and oxidative stress were detected before and after treatment for 3 months.Results:The total effective rate in the observation group was better than that in the control group(P<0.01);After intervention,serum LH,FSH,E_(2) and LH/FSH in the observation group were significantly different from those before intervention.The D values of serum LH,FSH,LH/FSH and E_(2) before and after intervention were significantly different between the two groups(P<0.01);Comparing the level of androgen,the serum A4 and T in the observation group were significantly different from those before intervention(P<0.01);After intervention,there was a significant difference in serum A4 and T between the two groups(P<0.01),and there was a significant difference in D value between the two groups before and after intervention;There was a difference in insulin resistance in the observation group before and after intervention(P<0.05),and there was a significant difference in D value between the two groups before and after intervention(P<0.01);After the intervention,the serum SOD,MDA,ROS in the observation group were significantly different from those before the intervention;After intervention,the results of serum SOD and ROS in the observation group were significantly different from those in the control group;There was no significant difference in serum MDA results.There were significant differences in SOD,MDA,ROS between the two groups before and after intervention.Conclusion:Electroacupuncture can improve oxidative stress injury,insulin resistance and hyperandrogenism in PCOS patients.

沙库巴曲缬沙坦联合芪苈强心胶囊治疗扩张型心肌病的效果

目的探讨沙库巴曲缬沙坦联合芪苈强心胶囊治疗扩张型心肌病(DCM)的效果及对心肌纤维化、心室重构(VR)的影响。方法选取2019年1月至2023年1月陕西中医药大学第二附属医院收治的62例DCM患者作为研究对象,采用随机数字表法将患者分为研究组和对照组各31例。对照组男20例,女11例;年龄(45.72±4.89)岁;美国纽约心脏病协会(NYHA)心功能分级:Ⅱ级15例,Ⅲ级16例。研究组男14例,女17例;年龄(46.91±5.36)岁;NYHA心功能分级:Ⅱ级12例,Ⅲ级19例。对照组给予强心、利尿、β受体阻滞剂、醛固酮抑制剂和沙库巴曲缬沙坦钠口服治疗;研究组在对照组基础上给予芪苈强心胶囊口服治疗;两组均持续治疗3个月。比较两组临床疗效,治疗前后左心室射血分数(LVEF)、左心室舒张末期容积(LVEDV)、左心室舒张末期内径(LVEDD)、血清N末端脑钠肽前体(NT-proBNP)、层粘蛋白(LN)、透明质酸(HA)、转化生长因子-β1(TGF-β1)、6 min步行距离(6MWD)、生活质量综合评定问卷(GQOLI-74)评分及治疗期间不良反应发生率。采用独立样本t检验、配对样本t检验和χ^(2)检验。结果研究组总有效率为93.55%(29/31),高于对照组的74.19%(23/31)(P<0.05);治疗后,研究组LVEF高于对照组[(47.11±5.68)%比(43.92±4.35)%],LVEDV、LVEDD均低于对照组[(145.38±16.37)ml比(163.09±20.42)ml、(45.90±4.26)mm比(49.21±5.12)mm](均P<0.05);治疗后,研究组LN、HA和TGF-β1均低于对照组[(153.82±11.24)μg/L比(186.31±14.73)μg/L、(165.48±16.75)μg/L比(197.06±19.62)μg/L、(36.91±3.77)μg/L比(40.52±2.63)μg/L](均P<0.05);治疗后,研究组血清NT-proBNP低于对照组[(827.95±76.13)ng/L比(932.74±59.25)ng/L],GQOLI-74评分高于对照组[(89.61±3.17)分比(81.83±4.92)分],6MWD长于对照组[(346.75±32.45)m比(308.26±29.71)m](均P<0.05);研究组治疗期间不良反应总发生率为19.35%(6/31),与对照组的12.90%(4/31)比较,差异无统计学意义(P>0.05)。结论沙库巴曲缬沙坦联合芪苈强心胶囊可增强DCM的临床疗效,有效抑制VR和心肌纤维化。

贝伐珠单抗联合奥希替尼治疗伴EGFRT790M突变的晚期NSCLC的疗效观察

目的探讨伴表皮生长因子受体-T790M(EGFRT790M)突变的晚期非小细胞肺癌(NSCLC)应用贝伐珠单抗联合奥希替尼治疗的临床疗效。方法选取接受治疗并经病理检查证实伴EGFRT790M突变的晚期NSCLC患者102例进行研究。应用随机数字表法将上述患者分为对照组(n=51)与观察组(n=51)。对照组患者给予奥希替尼治疗,观察组患者给予贝伐珠单抗联合奥希替尼治疗,两组患者均治疗3个月。比较两组患者的近期疗效、远期疗效、血清指标[糖类抗原125(CA125)、癌胚抗原(CEA)、血管内皮生长因子(VEGF)]以及治疗过程中的不良反应。结果观察组患者治疗有效率为56.86%,高于对照组患者的治疗有效率(35.29%)(P<0.05);观察组患者有效控制率为88.24%,与对照组患者的有效控制率(78.43%)比较无统计学差异(P>0.05);观察组患者进展率为23.53%,低于对照组患者的进展率(47.06%)(P<0.05);观察组患者无进展生存期长于对照组患者(P<0.05);观察组患者病死率为9.80%,低于对照组患者病死率(31.37%)(P<0.05);治疗3个月后,观察组患者CA125、CEA、VEGF水平均低于对照组患者(P<0.05);治疗过程中,观察组不良反应率与对照组比较无统计学意义(P>0.05)。结论贝伐珠单抗联合奥希替尼治疗伴EGFRT790M突变的晚期NSCLC患者的临床疗效良好,可提高患者无进展生存期、降低肿瘤标志物表达水平。

经皮激光椎间盘减压术联合熥敷颈腰痛砂治疗腰椎间盘突出症临床观察

目的观察PLDD联合熥敷颈腰痛砂治疗LDH的临床疗效。方法采用随机数字表法将68例患者分为治疗组(PLDD+熥敷颈腰痛砂)、对照组(单纯PLDD治疗)各34例。组内及组间比较两组受试者治疗前及治疗后1周、1个月、2个月、6个月后的视觉模拟疼痛评分(VAS)、日本骨科协会评估治疗分数(JOA)、Oswestry功能障碍指数(ODI)及改良MacNab疗效的优良率,并进行安全性评价。结果两组治疗前VAS、ODI、JOA比较,差异无统计学意义(P>0.05)。与本组治疗前比较,两组经治疗后VAS、ODI、JOA均明显改善(P<0.05);术后1周、术后1个月、术后2个月治疗组在疼痛缓解程度上优于对照组,差异有统计学意义(P<0.05);治疗组患者术后1周、术后1个月、术后2个月、术后6个月JOA疼痛评分、ODI评分均优于对照组,差异有统计学意义(P<0.05);两组患者术后2个月、术后6个月的有效率比较,差异无统计学意义(P>0.05);治疗组患者术后2个月、术后6个月优良率分别为94.1%、97.1%,优于对照组术后2个月、术后6个月的优良率,差异有统计学意义(P<0.05)。结论PLDD联合熥敷颈腰痛砂治疗LDH疗效显著,能有效缓解下腰痛、下肢放射痛症状,明显改善腰椎活动功能。

贝利尤单抗在治疗儿童狼疮性肾炎中的有效性及安全性分析

目的分析贝利尤单抗治疗儿童狼疮性肾炎(LN)的有效性和安全性。方法回顾性收集2021年7月1日至2024年7月31日在广西壮族自治区人民医院儿科接受贝利尤单抗治疗20周的12例LN患儿的临床资料。分析患儿治疗前后的临床表现、免疫和泌尿系统相关指标变化、疾病活动度变化、糖皮质激素减量情况以及药物不良反应情况。结果与贝利尤单抗治疗前相比,治疗后皮疹、发热、LN和血液系统损伤的患儿比例下降,糖皮质激素用量减少,CD19^(+)细胞计数降低,抗dsDNA抗体阳性率下降,24 h尿蛋白定量、尿红细胞计数、尿白细胞计数下降,差异有统计学意义(P<0.05)。贝利尤单抗治疗不同时间点(0、2、4、8、12、16、20周)的系统性红斑狼疮疾病活动指数-2000(SLEDAI-2000)评分差异有统计学意义(P<0.05),随治疗时间延长评分呈下降趋势。在12例LN患儿中,5例至观察终点(20周)达到狼疮低疾病活动状态(LLDAS),3例达到临床缓解。研究期间未发生严重感染事件,也未发现对贝利尤单抗过敏。结论贝利尤单抗有助于LN患儿SLEDAI-2000评分下降,减轻肾脏损伤,有助于达到LLDAS和临床缓解状态,且可以减少糖皮质激素使用剂量,从而减少不良反应。

压贴三棱镜联合手术矫正共同性内斜视疗效观察

目的:探讨压贴三棱镜联合手术治疗共同性内斜视矫正的效果。方法:回顾性分析笔者医院2018年5月-2020年6月60例共同性内斜视患儿临床资料,将给予压贴三棱镜并接受斜视矫正手术治疗的患儿纳入A组,将采用单纯手术治疗的患儿29例纳入B组,比较两组矫正效果、双眼视功能以及眼球屈光度。结果:A组术后3个月正位率93.55%高于B组68.97%(P<0.05);两组治疗后同时视功能比较,差异无统计学意义(P>0.05);A组术后1个月、术后3个月有融合功能比例分别为64.52%、74.19%高于B组37.93%、48.28%(P<0.05);A组术后7 d、术后1个月、术后3个月平均融合范围大于B组(P<0.05);A组术后1个月、术后3个月近立体视功能优于B组(P<0.05);两组治疗后柱镜屈光度、球镜屈光度、散光值、散光轴位比较,差异无统计学意义(P>0.05)。结论:共同性内斜视矫正术前联合使用压贴三棱镜提高了术后正位率,增强了术后融合功能和立体视功能恢复效果,不影响眼球屈光度。

外周血PD-1、CTLA-4、T-reg、pDC与鼻咽癌患者临床特征及疗效的相关性

目的:探讨初治鼻咽癌患者治疗前外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC与患者临床特征及即刻疗效的关系,以及以上指标在鼻咽癌患者及健康人群中的表达差异。方法:收集112例初治鼻咽癌患者治疗前临床资料及淋巴细胞亚群和树突细胞亚群数据,进行外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC与鼻咽癌患者临床特征及即刻疗效的相关性分析,从112例鼻咽癌患者中随机选取30例患者作为病例组,年龄、性别匹配的30例同期体检健康者作为对照组,分析两组外周血PD-1/CTL(%)、CTLA-4/CTL(%)、T-reg(%)、pDC表达差异。结果:112例初治鼻咽癌患者中,年龄≥50岁组与年龄<50岁组相比,外周血PD-1/CTL(%)更高。CTLA-4/CTL(%)与T分期、N分期、TNM分期呈负相关,CTLA-4/CT(%)越高,疗效越好。T-reg(%)与N分期呈正相关,T-reg(%)与M分期存在“S”型曲线关系。pDC与N分期、TNM分期呈负相关。病例组与对照组外周血PD-1/CTL(%)、T-reg(%)差异存在统计学意义,病例组与对照组外周血CTLA-4/CTL(%)差异不存在统计学意义。结论:外周血CTLA-4/CT(%)越高,鼻咽癌T分期、N分期、TNM分期越早,外周血CTLA-4/CT(%)越高,疗效越好。外周血T-reg(%)越高,N分期越晚。当外周血T-reg(%)<20%时,鼻咽癌可能未发生远处转移,当外周血T-reg(%)为20%~50%时,外周血T-reg(%)表达越高,发生远处转移的可能越大,当外周血T-reg(%)>50%时,鼻咽癌已经远处转移的可能性大。外周血pDC越高,N分期、TNM分期越早。外周血以上指标可动态观察,有望成为预测鼻咽癌患者疗效及预后的生物标志物。

二乌止痛散外敷治疗急性踝关节扭伤的疗效观察

目的观察二乌止痛散外敷治疗急性踝关节扭伤的疗效。方法选取2021年1月至2022年9月台州市黄岩区中医院骨伤科收治的急性踝关节扭伤患者60例,采用随机数字表法分为对照组与观察组,每组各30例,对照组在POLICE治疗原则上予以扶他林外用处理,观察组在POLICE治疗原则上予以二乌止痛散外敷于患处,比较两组患者治疗前后1周和2周时的VAS疼痛评分及AOFAS踝关节功能评分。结果两组患者在治疗期间均未发生不良反应。组内治疗前后VAS疼痛评分及AOFAS踝关节功能评分比较,差异有统计学意义(P<0.05)。两组治疗后VAS评分及AOFAS评分比较,差异有统计学意义(P<0.05)。结论二乌止痛散外敷治疗急性踝关节扭伤疗效显著,可明显缓解患者踝关节疼痛,提高踝关节功能,加速踝关节康复,值得临床推广。

泻火解毒法治疗原矛头蝮蛇咬伤的临床观察

目的观察泻火解毒法治疗原矛头蝮蛇咬伤的临床疗效。方法选择2022年7月1日至2023年8月1日在我院治疗的原矛头蝮蛇咬伤患者108例,按随机数字表法分为治疗组和对照组各54例。对照组给予常规治疗,治疗组在对照组的基础上给予口服蛇伤胶囊(泻火解毒法治疗毒蛇咬伤代表方)治疗,观察两组患者治疗后第1、3、5、7天时的患肢周径差、肿胀消退时间、治疗疗程及患肢疼痛评分。结果两组患者治疗后第1、3天时的患肢周径差比较,差异均无统计学意义(均P>0.05);治疗后第5、7天时,治疗组的患肢周径差明显低于对照组,差异均有统计学意义(均P<0.05)。治疗组的患肢肿胀消退时间、治疗疗程均短于对照组,差异有统计学意义(均P<0.05)。治疗第3、5、7天时,治疗组的患肢疼痛评分均明显低于对照组,差异均有统计学意义(均P<0.05)。结论泻火解毒法治疗原矛头蝮蛇咬伤的临床疗效好,值得推广应用。

超声引导下注射治疗脑卒中后肩痛综合征的临床应用

目的 评估超声引导下注射治疗脑卒中后肩痛综合征(SHS)的临床效果。方法 选取我院就诊的100例脑卒中后SHS患者,采用计算机随机分为观察组(超声引导下注射)与对照组(借助体表标志注射),每组患者50例。对比两组治疗前后的肩关节功能、生活质量及不良反应发生情况。结果 重复测量方差分析结果显示,mRs评分与肩关节功能评分的组间、时间及交互效应差异有统计学意义(P<0.01);组内比较,治疗前后不同时间的mRs评分与肩关节功能评分存在差异,随着治疗时间的延长mRs评分下降,肩关节功能评分升高,差异有统计学意义(P<0.01);组间比较,观察组治疗第1个星期、第1个月和第3个月的mRs评分低于对照组,肩关节功能评分均高于对照组,差异有统计学意义(P<0.01);交互效应:mRs评分与肩关节功能评分的组间效应与时间效应存在交互作用(P<0.01)。两组不良反应发生率差异无统计学意义(P>0.05)。结论 超声引导下注射治疗能够有效改善脑卒中后SHS患者的疼痛症状、上肢功能和生存质量,效果优于传统借助体表标志进行的注射治疗。

少腹逐瘀汤治疗子宫内膜异位症性不孕的研究进展

子宫内膜异位症(EMT)是近年来育龄期妇女高发疾病。其常表现为进行性加重的痛经、性交痛、月经紊乱、不孕症等。其中EMT女性患者中生育力下降,患者比例逐年升高。少腹逐瘀汤出自《医林改错》,其功效为散寒温经,活血化瘀,有调经种子第一方之称,可治疗瘀血阻滞,久不受孕。通过收集、分析和梳理了近年来少腹逐瘀汤治疗子宫内膜异位症性不孕的相关文献,总结了其可能的治疗机制及临床疗效,为少腹逐瘀汤治疗子宫内膜异位症性不孕提供有力依据。

电针结合直肠功能训练治疗卒中后便秘疗效观察

[目的]观察电针结合直肠功能训练治疗卒中后便秘(post-stroke constipation,PSC)的临床疗效。[方法]选择2021年12月至2023年3月苏北人民医院康复科收治的PSC患者60例,采用随机数字表法分为治疗组(29例,1例脱落)和对照组(29例,1例脱落)。对照组给予综合性、个体化的直肠功能训练,治疗组在对照组的基础上给予电针治疗,两组均治疗4周。观察两组治疗前后的便秘临床症状评分量表(Cleveland Clinic Score,CCS)评分、盆底表面肌电评估及疗效情况。[结果]两组患者治疗前比较差异无统计学意义(P>0.05)。治疗4周后,两组治疗后的CCS评分均显著降低(P<0.001),且治疗组CCS评分低于对照组(P<0.01)。两组治疗后快速收缩、紧张收缩、耐力收缩阶段肌电值均显著升高(P<0.001),且治疗组上述阶段的肌电值均高于对照组(P<0.05)。治疗组的总有效率(93.10%)高于对照组(72.41%),差异有统计学意义(P<0.05)。[结论]电针结合直肠功能训练治疗PSC,可改善患者排便频率及伴随症状,提高盆底快慢肌的肌力和慢肌的耐力,提升治疗效果。

探讨采用CRRT治疗MODS的临床使用价值

目的分析采用CRRT治疗MODS的临床效果。方法选取我院2010年1月—2016年10月收治的MODS患者46例为研究对象。采用随机数字表法,将其分为两组。给予对照组患者常规治疗;在对照组患者的治疗基础上,给予观察组患者CRRT治疗。对比两组患者的临床疗效。结果观察组病情好转患者数量多于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患者的UA、BUN、SCr水平均低于对照组,组间对比,差异具有统计学意义(P<0.05)。结论采用CRRT治疗MODS的临床效果显著,能够有效改善患者的病情。

麻防犀角地黄汤治疗寒包火型银屑病临床疗效观察

目的:探讨麻防犀角地黄汤治疗寒包火型银屑病(Ps)的临床疗效。方法:选取2021年1月~2022年7月桐城市中医医院收治的60例寒包火型Ps患者,采用随机数字表法分为观察组和对照组各30例。两组均外用卡泊三醇软膏,对照组口服阿维A胶囊,观察组服用麻防犀角地黄汤,疗程均为8周。比较两组疗效和治疗前后中医症候积分、面积与严重性指数(PASI)评分、皮肤病生活质量指数(DLQI)评分及白介素-23(IL-23)、白介素-17(IL-17)、CD4+辅助型T1细胞/T2细胞(Th1/Th2),比较两组不良反应发生率和随访6个月复发率。结果:观察组有效率为70.00%,与对照组的83.33%无显著差异(P<0.05);治疗后,观察组病程迁延、秋冬疕重、受寒疕重中医证候积分和PASI评分、DLQI评分分别为(3.60±0.75)分、(3.24±0.76)分、(3.29±0.22)分、(28.12±4.95)分和(11.52±1.82)分,低于对照组的(4.49±0.87)分、(4.01±0.78)分、(3.54±0.30)分、(33.25±5.09)分和(13.97±2.03)分(P<0.05);观察组IL-23、IL-17水平为(2.25±0.37)pg/mL和(7.13±1.19)pg/mL,低于对照组(3.43±0.51)pg/mL和(9.04±1.36)pg/mL,Th1/Th2为(4.91±0.79),高于对照组(3.52±0.58)(P<0.05);观察组复发率为16.67%,低于对照组的43.33%(P<0.05)。结论:麻防犀角地黄汤治疗寒包火型Ps疗效确切,可降低复发率。