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基于MSC的电力营销业务系统研运一体化研究
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作者 张文 张波 +5 位作者 刘辉舟 万泉 陈雁 陈伟 欧阳红 赵永红 《电力信息与通信技术》 2024年第5期25-30,共6页
当前电力营销业务已由单一的供电服务逐渐转变为碳交易、客户侧储能、多能供应、能效服务、分布式电源等综合能源服务,及时响应用户需求变得尤为重要。针对传统建设模式中存在的跨环节协作壁垒、业务需求响应不及时等问题,文章借鉴中台... 当前电力营销业务已由单一的供电服务逐渐转变为碳交易、客户侧储能、多能供应、能效服务、分布式电源等综合能源服务,及时响应用户需求变得尤为重要。针对传统建设模式中存在的跨环节协作壁垒、业务需求响应不及时等问题,文章借鉴中台架构设计理念,首先提出一种公共共享服务研运一体化支撑平台(middle-platform service components,MSC),利用模型编排、服务编排、流程编排、界面编排进行微服务灵活实现及扩展;然后,结合架构资产统一管理以及MSC四编排引擎,基于多租户技术进行电力营销业务系统研运一体化建设;最后,通过在客户侧工单中心建设中的应用,证明该模式可为电力营销业务系统建设提供有效支撑。 展开更多
关键词 电力营销 中台 msc 研运一体化
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基于MSC.Fatigue的链条疲劳寿命分析与优化 被引量:1
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作者 付振明 李存志 +1 位作者 谢爱军 王桂斌 《机械工程师》 2023年第2期132-135,共4页
针对链条疲劳寿命可靠性设计求解复杂、试验周期长、试验成本高等问题,在ABAQUS有限元分析的基础上,提出了一种基于MSC.Fatigue的链条疲劳寿命分析方法,能够快速确定链条的最小疲劳寿命及其分布,找出链条设计薄弱环节。同时提出了一种... 针对链条疲劳寿命可靠性设计求解复杂、试验周期长、试验成本高等问题,在ABAQUS有限元分析的基础上,提出了一种基于MSC.Fatigue的链条疲劳寿命分析方法,能够快速确定链条的最小疲劳寿命及其分布,找出链条设计薄弱环节。同时提出了一种优化设计方案,并且对优化方案分别进行了MSC.Fatigue疲劳寿命分析和疲劳试验验证。疲劳寿命结果不仅满足了疲劳设计要求,而且更进一步验证了仿真分析与实际试验验证结果的一致性和有效性,为后续链系统的可靠性设计提供了依据。 展开更多
关键词 链条 有限元 疲劳寿命 msc.fatigue
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Impact of comorbid subthreshold depressive symptoms on cancerrelated fatigue and complications in adults with leukemia 被引量:1
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作者 Yue-Xian Liu Juan Wang 《World Journal of Psychiatry》 SCIE 2024年第7期1009-1016,共8页
BACKGROUND Patients not only experience symptoms caused by cancer but also suffer from the accompanying psychological pain.Therefore,these patients do not have high quality of life.According to the World Health Organi... BACKGROUND Patients not only experience symptoms caused by cancer but also suffer from the accompanying psychological pain.Therefore,these patients do not have high quality of life.According to the World Health Organization,the incidence of leukemia in China in 2020 was 5.1/100000,the mortality rate was 3.3/100000,and the prevalence rate was 16.7/100000.Therefore,it is important to examine the influence of comorbid subthreshold depressive symptoms on leukemia patients.AIM To determine the impact of comorbid subthreshold depressive symptoms on cancer-related fatigue and complications in leukemia patients,thereby providing a basis for early diagnosis and treatment in clinical practice.METHODS A questionnaire survey was conducted among leukemia patients admitted to a tertiary hospital in Xi'an,Shaanxi Province,China,from August 2022 to December 2023.Patients with a score>16 on the Chinese Classification of Mental Disorders(CCMD-3)and a Hamilton Depression Rating Scale score of 8-17 were classified as the subthreshold depressive group(n=95),while 100 leukemia patients admitted during the same period were classified as the control group.Data were collected using Epidata 3.1 software,and comparisons were made between the two groups regarding general clinical data,the Piper Fatigue Scale(PFS),the Pittsburgh Sleep Quality Index(PSQI),the Numeric Rating Scale for pain assessment,laboratory indicators,and the occurrence of complications.RESULTS In this survey,120 leukemia patients with depression were preliminarily screened,95 patients with subthreshold depression were ultimately selected as the subthreshold depression group,and 100 leukemia patients admitted during the same period were enrolled as the normal group.Comparison of basic clinical data between the two groups revealed no significant differences in age,sex,body mass index,cognitive function,or comorbidity with other chronic diseases.However,there were statistically significant differences in the use of radiotherapy and regular exercise between the two groups(P<0.05).Comparisons of scales and laboratory indicators revealed no significant differences in albumin or PSQI scores between the two groups,but there were statistically significant differences in pain scores,PSQI scores,PFS scores,hemoglobin levels,and C-reactive protein levels(P<0.05).Spearman’s correlation analysis indicated that cancer-related fatigue was correlated with age,hemoglobin levels,C-reactive protein levels,pain,and regular exercise among leukemia patients with subthreshold depression.Multivariate regression analysis revealed that advanced age,combined radiotherapy,pain,and low hemoglobin levels were risk factors for cancer-related fatigue in leukemia patients with comorbid subthreshold depression,while regular exercise was a protective factor against cancer-related fatigue.Follow-up comparisons revealed a significantly lower overall incidence of complications in the control group(4%)than in the depressive group(24.21%;P<0.001).CONCLUSION Leukemia patients with comorbid subthreshold depressive symptoms experience more severe cancer-related fatigue and a higher incidence of complications.These findings may be related to advanced age,combined radiotherapy,pain,and low hemoglobin levels,while regular exercise may effectively alleviate symptoms. 展开更多
关键词 Subthreshold depression LEUKEMIA Cancer-related fatigue COMPLICATIONS Minor depression
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BM-MSCs延缓CD8^(+)初始T细胞衰老
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作者 高竞溪 赵晓妍 +3 位作者 朱星雨 孙昭 韩钦 赵春华 《基础医学与临床》 CAS 2024年第5期683-689,共7页
目的验证骨髓间充质干细胞(BM-MSCs)缓解免疫衰老的作用,探究其衰老改善的主要免疫细胞群体。方法分离获得小鼠脾淋巴细胞,刺激增殖7d构建复制性衰老细胞模型。利用流式细胞测量术检测年轻对照组、复制性衰老对照组和BM-MSCs共培养组T... 目的验证骨髓间充质干细胞(BM-MSCs)缓解免疫衰老的作用,探究其衰老改善的主要免疫细胞群体。方法分离获得小鼠脾淋巴细胞,刺激增殖7d构建复制性衰老细胞模型。利用流式细胞测量术检测年轻对照组、复制性衰老对照组和BM-MSCs共培养组T细胞亚群衰老标志物p16ink4a(p16)和p21cip1(p21)的表达水平。结果T淋巴细胞复制性衰老模型中观察到持续增殖后CD8^(+)T细胞较CD4^(+)T细胞衰老显著,在CD8^(+)T细胞的初始细胞、效应细胞亚群中,效应细胞衰老最显著;BM-MSCs共培养对衰老的效应细胞没有明显影响,主要通过延缓初始T细胞的衰老,达到缓解CD8^(+)T细胞衰老的作用(P<0.01,P<0.001)。结论与BM-MSCs共培养可以缓解T细胞的复制性衰老表型,对CD8^(+)T细胞的抗衰作用更显著,主要通过抑制初始T细胞的衰老实现。 展开更多
关键词 骨髓间充质干细胞(BM-mscs) T细胞衰老 延缓衰老
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Frequency Domain Fatigue Evaluation on SCR Girth-Weld Based on Structural Stress 被引量:1
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作者 ZHANG Long ZHAO Tian-feng 《China Ocean Engineering》 SCIE EI CSCD 2024年第2期255-270,共16页
The Steel Catenary Riser(SCR)is a vital component for transporting oil and gas from the seabed to the floating platform.The harsh environmental conditions and complex platform motion make the SCR’s girth-weld prone t... The Steel Catenary Riser(SCR)is a vital component for transporting oil and gas from the seabed to the floating platform.The harsh environmental conditions and complex platform motion make the SCR’s girth-weld prone to fatigue failure.The structural stress fatigue theory and Master S-N curve method provide accurate predictions for the fatigue damage on the welded joints,which demonstrate significant potential and compatibility in multi-axial and random fatigue evaluation.Here,we propose a new frequency fatigue model subjected to welded joints of SCR under multiaxial stress,which fully integrates the mesh-insensitive structural stress and frequency domain random process and transforms the conventional welding fatigue technique of SCR into a spectrum analysis technique utilizing structural stress.Besides,a full-scale FE model of SCR with welds is established to obtain the modal structural stress of the girth weld and the frequency response function(FRF)of modal coordinate,and a biaxial fatigue evaluation about the girth weld of the SCR can be achieved by taking the effects of multi-load correlation and pipe-soil interaction into account.The research results indicate that the frequency-domain fatigue results are aligned with the time-domain results,meeting the fatigue evaluation requirements of the SCR. 展开更多
关键词 SCR girth weld random vibration self(cross)power spectrum structural stress method biaxial fatigue damage
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骨免疫学视角下绝经后骨质疏松症防治新靶点:MΦ-BMSCs串扰
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作者 李琰 刘宁 +4 位作者 齐保玉 王旭 孙传睿 章轶立 魏戌 《中国骨质疏松杂志》 CAS CSCD 北大核心 2024年第5期732-738,共7页
绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)是以骨量下降、骨结构破坏、易发生骨折为特征的代谢性骨病。PMOP已严重威胁女性健康,制约社会经济发展。近年来雌激素缺乏引起PMOP相关机制研究取得进展,但仍未得到充分阐明。骨免... 绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)是以骨量下降、骨结构破坏、易发生骨折为特征的代谢性骨病。PMOP已严重威胁女性健康,制约社会经济发展。近年来雌激素缺乏引起PMOP相关机制研究取得进展,但仍未得到充分阐明。骨免疫学研究显示PMOP病理过程伴随着慢性炎症和免疫系统的参与。巨噬细胞(macrophage,MΦ)是重要的免疫细胞,被报道在骨稳态和再生中发挥作用。巨噬细胞的耗竭能加重OVX小鼠的骨丢失,减少骨髓间充质干细胞(bone mesenchymal stem cells,BMSCs)数量,降低BMSCs成骨分化能力。巨噬细胞的缺失对骨形成的影响似乎超过了其对破骨细胞活性的影响,MΦ与BMSCs之间的串扰可能在这一环节发挥着重要作用。本文基于骨免疫学理论对MΦ-BMSCs串扰和PMOP的相关性进行综述,旨在为PMOP的防治研究提供新思路。 展开更多
关键词 绝经后骨质疏松症 骨免疫学 巨噬细胞 间质干细胞 串扰
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基于MSC.Marc的机械扩径有限元分析
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作者 陈旭坤 黄晓华 《机械设计与制造工程》 2024年第8期30-34,共5页
基于MSC.Marc有限元分析软件对管件管端在机械扩径过程中的弹塑性变形进行研究。将管件机械扩径过程分为整圆、扩径变形和卸载3个阶段,管件在机械扩径变形过程中横截面的变形受多个工艺参数的影响,通过改变扩径模具半径和扩径模具边缘... 基于MSC.Marc有限元分析软件对管件管端在机械扩径过程中的弹塑性变形进行研究。将管件机械扩径过程分为整圆、扩径变形和卸载3个阶段,管件在机械扩径变形过程中横截面的变形受多个工艺参数的影响,通过改变扩径模具半径和扩径模具边缘角半径进行了多组数据的模拟仿真。由模拟结果可知,管件与扩径模具边缘接触位置应力、应变最大,且呈现向两边扩散的趋势。通过对管件机械扩径的模拟,得到了最佳的扩径模具半径以及扩径模具边缘角半径,为实际加工提供了理论参考。 展开更多
关键词 有限元分析 msc.Marc 机械扩径
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基于MSC.Patran的变速箱输出轴有限元分析
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作者 刘帅 《柴油机设计与制造》 2024年第3期1-6,共6页
随着汽车行业的发展,对汽车变速箱的性能与质量要求越来越高。传统的试验方法仅能提供有限的数据,不能全面反映汽车变速箱的性能与疲劳寿命。因此,有限元分析作为一种有效的模拟分析方法,受到了越来越多的关注和重视。基于MSC.Patran软... 随着汽车行业的发展,对汽车变速箱的性能与质量要求越来越高。传统的试验方法仅能提供有限的数据,不能全面反映汽车变速箱的性能与疲劳寿命。因此,有限元分析作为一种有效的模拟分析方法,受到了越来越多的关注和重视。基于MSC.Patran软件对汽车变速箱输出轴进行有限元分析,通过建立变速箱输出轴的有限元模型,探讨疲劳设计思路,预测变速箱在工作过程中的应力分布和疲劳寿命,提出提高疲劳强度的措施,以期为汽车变速箱的设计和制造提供参考。 展开更多
关键词 汽车变速箱 变速箱输出轴 有限元分析 msc.Patran软件 疲劳寿命
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A comparative study of the anti-fatigue activity of extracts from different parts of Cistanche tubulosa(Schenk)Wight Author links open overlay panel
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作者 Jianteng Dong Junjun Li +7 位作者 Yizhou Liu Lingwen Cui Xiangning Liu Gang Wang Qixin Wang David N.Criddle Pengfei Tu Chun Li 《Journal of Traditional Chinese Medical Sciences》 CAS 2024年第2期222-231,共10页
Objective To evaluate the anti-fatigue effects of different extracts from Cistanche tubulosa(Schenk)Wight(C.tubulosa,Rou Cong Rong),focusing on central and exercise-induced fatigue in mice.This study investigated the ... Objective To evaluate the anti-fatigue effects of different extracts from Cistanche tubulosa(Schenk)Wight(C.tubulosa,Rou Cong Rong),focusing on central and exercise-induced fatigue in mice.This study investigated the pharmacological effects of the total oligosaccharides,polysaccharides,and phenylethanoid glycosides(CPhGs)extracted from C.tubulosa.Methods Models of sleep deprivation and forced swimming fatigue were established to simulate central and exercise-induced fatigue.The mice were treated with different extracts of C.tubulosa,and their effects were assessed using behavioral tests to measure exercise capacity,learning,and memory function.Biochemical analyses were performed to evaluate the changes in serum and brain neurotransmitter levels,liver and muscle glycogen storage,and various fatigue-related biomarkers.Results This study found that treatment with C.tubulosa extract improved exercise capacity,learning,and memory in mice.Total oligosaccharides from C.tubulosa enhanced adrenocorticotropic hormone,cholinesterase,and thyroid-stimulating hormone levels,reduced cortisol levels in central fatigue models,and ameliorated biochemical markers of exercise-induced fatigue,including lowering lactic acid,blood urea nitrogen,and malondialdehyde levels.Among the tested extracts,the total oligosaccharides showed the most comprehensive anti-fatigue effects.Conclusion The anti-fatigue effects of C.tubulosa,particularly those of its total oligosaccharides,are pronounced in both central and exercise-induced fatigue.These effects are mediated by the regulation of neurotransmitter levels,enhancement of glycogen storage,and improvement of antioxidant enzyme activity,suggesting potential therapeutic benefits in fatigue-related conditions. 展开更多
关键词 Cistanche tubulosa ANTI-fatigue Central fatigue Exercise fatigue OLIGOSACCHARIDES
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Cryopreserved Fibroblast and Mesenchymal Stem Cells (MSCs) Being Alternative Mitochondrial Donors for Mitochondrial Organelle Transplantation (MOT)
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作者 Xianpeng Jiang Brent Segal +1 位作者 Mark S. Kindy Catherine C. Baucom 《Journal of Biomaterials and Nanobiotechnology》 2024年第4期65-77,共13页
Mitochondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, traumatic brain and spinal cord injuries, cerebral ... Mitochondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, traumatic brain and spinal cord injuries, cerebral stroke, and neurodegenerative diseases. The earlier MOT results in better efficacy in animal models of urgent diseases such as ischemic stroke, and traumatic brain and spinal cord injuries. There is no long-term method to preserve mitochondria. Routine MOT procedure from cell growth to mitochondrial injection often takes serval weeks and is not satisfactory for urgent use cases. Hypothesis: Cryopreserved cells might be mitochondrial donors for MOT. Methods: We isolated mitochondria from cryopreserved human fibroblasts and mesenchymal stem cells (MSCs) in cell banks and compared the mitochondrial viability and transplantation with the mitochondria from fresh cells. Key findings: We found that mitochondria from fresh and cryopreserved cells are comparable in mitochondrial viability and transplantation. We also obtained data showing that mitochondria of fibroblasts and MSCs had similar membrane potential and transfer ability, but MSC’s mitochondria had higher ATP content than fibroblast’s mitochondria. In addition, oxygen consumption rates (OCRs) were higher in MSC’s mitochondria compared to fibroblast’s mitochondria and did not change between fresh and frozen cells. Conclusion: Cryopreserved fibroblasts and MSCs are alternative mitochondrial donors for MOT to fresh cells. MSCs could provide higher ATP-produced mitochondria than fibroblasts. 展开更多
关键词 Mitochondria Mitochondrial Organelle Transplantation MOT CRYOPRESERVATION Fibroblasts mscS
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The Effect and Mechanism of Fructus lycii on Improvement of Exercise Fatigue Using a Network Pharmacological Approach with in vitro Experimental Verification
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作者 JI Xiao Ning LIU Zhao Ping +4 位作者 ZHANG Chao Zheng CHEN Min LIANG Jiang LU Jiang ZHANG Lei 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第1期42-53,共12页
Objective This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise fatigue.Methods A network pharmacological approach was used to explore potential mechanisms of actio... Objective This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise fatigue.Methods A network pharmacological approach was used to explore potential mechanisms of action of Fructus lycii.Skeletal muscle C2C12 cells and immunofluorescence were employed to verify the effect and mechanism of the representative components in Fructus lycii predicted by network pharmacological analysis.Results Six potential active components,namely quercetin,β-sitosterol,stigmasterol,7-Omethylluteolin-6-C-beta-glucoside_qt,atropine,and glycitein,were identified to have potency in improving exercise fatigue via multiple pathways,such as the PI3K-Akt,neuroactive ligand-receptor interaction,IL-17,TNF,and MAPK signaling pathways.The immunofluorescence results indicated that quercetin,a significant active component in Fructus lycii,increased the mean staining area of 2-NBDG,TMRM,and MitoTracker,and decreased the area of CellRox compared to the control.Furthermore,the protein expression levels of p-38 MAPK,p-MAPK,p-JNK,p-PI3K,and p-AKT markedly increased after quercetin treatment.Conclusion Fructus lycii might alleviate exercise fatigue through multiple components and pathways.Among these,quercetin appears to improve exercise fatigue by enhancing energy metabolism and reducing oxidative stress.The PI3K-AKT and MAPK signaling pathways also appear to play a role in this process. 展开更多
关键词 Fructus lycii Exercise fatigue Network pharmacology
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Effects of orientation on the fatigue crack growth behaviors of the ZK60 magnesium alloy in air and PBS
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作者 Jiaqi Hu Zheng Liu +1 位作者 Zuoliang Ning Hong Gao 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第1期281-294,共14页
Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tes... Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tests and(corrosion)fatigue crack growth tests were conducted.The rolled and transverse surfaces of the materials show distinct corrosion rate differences in the stable corrosion stage,but the truth is the opposite for the initial stage of corrosion.In air,specimen orientations have a significant influence on the plastic deformation mechanisms near the crack tip,which results in different fatigue fracture surfaces and cracking paths.Compared with R-T specimens,N-T specimens show a slower fatigue crack growth(FCG)rate in air,which can be attributed to crack closure effects and deformation twinning near the crack tip.The corrosion environment will not significantly change the main plastic deformation mechanisms for the same type of specimen.However,the FCG rate in phosphate buffer saline(PBS)is one order of magnitude higher than that in air,which is caused by the combined effects of hydrogen-induced cracking and anodic dissolution.Owing to the similar corrosion rates at crack tips,the specimens with different orientations display close FCG rates in PBS. 展开更多
关键词 Magnesium alloy ORIENTATION CORROSION fatigue crack growth
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Research on Driver’s Fatigue Detection Based on Information Fusion
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作者 Meiyan Zhang Boqi Zhao +4 位作者 Jipu Li Qisong Wang Dan Liu Jinwei Sun Jingxiao Liao 《Computers, Materials & Continua》 SCIE EI 2024年第4期1039-1061,共23页
Driving fatigue is a physiological phenomenon that often occurs during driving.After the driver enters a fatigued state,the attentionis lax,the response is slow,and the ability todeal with emergencies is significantly... Driving fatigue is a physiological phenomenon that often occurs during driving.After the driver enters a fatigued state,the attentionis lax,the response is slow,and the ability todeal with emergencies is significantly reduced,which can easily cause traffic accidents.Therefore,studying driver fatigue detectionmethods is significant in ensuring safe driving.However,the fatigue state of actual drivers is easily interfered with by the external environment(glasses and light),which leads to many problems,such as weak reliability of fatigue driving detection.Moreover,fatigue is a slow process,first manifested in physiological signals and then reflected in human face images.To improve the accuracy and stability of fatigue detection,this paper proposed a driver fatigue detection method based on image information and physiological information,designed a fatigue driving detection device,built a simulation driving experiment platform,and collected facial as well as physiological information of drivers during driving.Finally,the effectiveness of the fatigue detection method was evaluated.Eye movement feature parameters and physiological signal features of drivers’fatigue levels were extracted.The driver fatigue detection model was trained to classify fatigue and non-fatigue states based on the extracted features.Accuracy rates of the image,electroencephalogram(EEG),and blood oxygen signals were 86%,82%,and 71%,separately.Information fusion theory was presented to facilitate the fatigue detection effect;the fatigue features were fused using multiple kernel learning and typical correlation analysis methods to increase the detection accuracy to 94%.It can be seen that the fatigue driving detectionmethod based onmulti-source feature fusion effectively detected driver fatigue state,and the accuracy rate was higher than that of a single information source.In summary,fatigue drivingmonitoring has broad development prospects and can be used in traffic accident prevention and wearable driver fatigue recognition. 展开更多
关键词 Driving fatigue information fusion EEG blood oxygen
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基于MSC.MARC软件的泵室结构分析
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作者 仲召伟 张丽娟 +1 位作者 胡林生 胡红胜 《治淮》 2024年第4期18-20,共3页
以泰兴马甸抽水站工程为例,采用MSC.MARC软件求解该泵站在上下游水位变化工况下的整体空间位移和主应力分布情况,对泵室结构进行空间有限元分析。研究表明,三维有限元分析可以较为全面、直观地反映结构的整体位移和应力情况,方便对其进... 以泰兴马甸抽水站工程为例,采用MSC.MARC软件求解该泵站在上下游水位变化工况下的整体空间位移和主应力分布情况,对泵室结构进行空间有限元分析。研究表明,三维有限元分析可以较为全面、直观地反映结构的整体位移和应力情况,方便对其进行安全评价,是解决实际工程中空间结构应力应变问题的一种有效方法。 展开更多
关键词 泵室结构 有限元 msc.MARC软件 位移 应力
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A critical review of wheel/rail high frequency vibration-induced vibration fatigue of railway bogie in China
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作者 Xingwen Wu Zhenxian Zhang +7 位作者 Wubin Cai Ningrui Yang Xuesong Jin Ping Wang Zefeng Wen Maoru Chi Shuling Liang Yunhua Huang 《Railway Sciences》 2024年第2期177-215,共39页
Purpose–This review aims to give a critical view of the wheel/rail high frequency vibration-induced vibration fatigue in railway bogie.Design/methodology/approach–Vibration fatigue of railway bogie arising from the ... Purpose–This review aims to give a critical view of the wheel/rail high frequency vibration-induced vibration fatigue in railway bogie.Design/methodology/approach–Vibration fatigue of railway bogie arising from the wheel/rail high frequency vibration has become the main concern of railway operators.Previous reviews usually focused on the formation mechanism of wheel/rail high frequency vibration.This paper thus gives a critical review of the vibration fatigue of railway bogie owing to the short-pitch irregularities-induced high frequency vibration,including a brief introduction of short-pitch irregularities,associated high frequency vibration in railway bogie,typical vibration fatigue failure cases of railway bogie and methodologies used for the assessment of vibration fatigue and research gaps.Findings–The results showed that the resulting excitation frequencies of short-pitch irregularity vary substantially due to different track types and formation mechanisms.The axle box-mounted components are much more vulnerable to vibration fatigue compared with other components.The wheel polygonal wear and rail corrugation-induced high frequency vibration is the main driving force of fatigue failure,and the fatigue crack usually initiates from the defect of the weld seam.Vibration spectrum for attachments of railway bogie defined in the standard underestimates the vibration level arising from the short-pitch irregularities.The current investigations on vibration fatigue mainly focus on the methods to improve the accuracy of fatigue damage assessment,and a systematical design method for vibration fatigue remains a huge gap to improve the survival probability when the rail vehicle is subjected to vibration fatigue.Originality/value–The research can facilitate the development of a new methodology to improve the fatigue life of railway vehicles when subjected to wheel/rail high frequency vibration. 展开更多
关键词 Wheel/rail high frequency vibration Vibration fatigue Railway bogie fatigue damage assessment
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Efficacy of ginseng-based Renshenguben oral solution for cancer-related fatigue among patients with advanced-stage hepatocellular carcinoma:A prospective multicenter cohort study
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作者 Ming-Da Wang Chen Yuan +5 位作者 Ke-Chun Wang Nan-Ya Wang Ying-Jian Liang Hong Zhu Xiang-Min Tong Tian Yang 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第3期249-256,共8页
Background:Cancer-related fatigue(CRF)is a common and debilitating symptom experienced by patients with advanced-stage cancer,especially those undergoing antitumor therapy.This study aimed to evaluate the efficacy and... Background:Cancer-related fatigue(CRF)is a common and debilitating symptom experienced by patients with advanced-stage cancer,especially those undergoing antitumor therapy.This study aimed to evaluate the efficacy and safety of Renshenguben(RSGB)oral solution,a ginseng-based traditional Chinese medicine,in alleviating CRF in patients with advanced hepatocellular carcinoma(HCC)receiving antitumor treatment.Methods:In this prospective,open-label,controlled,multicenter study,patients with advanced HCC at BCLC stage C and a brief fatigue inventory(BFI)score of≥4 were enrolled.Participants were assigned to the RSGB group(RSGB,10 mL twice daily)or the control group(with supportive care).Primary and secondary endpoints were the change in multidimensional fatigue inventory(MFI)score,and BFI and functional assessment of cancer therapy-hepatobiliary(FACT-Hep)scores at weeks 4 and 8 after enrollment.Adverse events(AEs)and toxicities were assessed.Results:A total of 409 participants were enrolled,with 206 assigned to the RSGB group.At week 4,there was a trend towards improvement,but the differences were not statistically significant.At week 8,the RSGB group exhibited a significantly lower MFI score(P<0.05)compared to the control group,indicating improved fatigue levels.Additionally,the RSGB group showed significantly greater decrease in BFI and FACT-Hep scores at week 8(P<0.05).Subgroup analyses among patients receiving various antitumor treatments showed similar results.Multivariate linear regression analyses revealed that the RSGB group experienced a significantly substantial decrease in MFI,BFI,and FACT-Hep scores at week 8.No serious drug-related AEs or toxicities were observed.Conclusions:RSGB oral solution effectively reduced CRF in patients with advanced HCC undergoing antitumor therapy over an eight-week period,with no discernible toxicities.These findings support the potential of RSGB oral solution as an adjunctive treatment for managing CRF in this patient population. 展开更多
关键词 Cancer-related fatigue Hepatocellular carcinoma Renshenguben oral solution EFFICACY Safety GINSENG
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Thermal fatigue and wear of compacted graphite iron brake discs with various thermomechanical properties
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作者 Gui-quan Wang Zhuo Xu +2 位作者 Zhong-li Liu Xiang Chen Yan-xiang Li 《China Foundry》 SCIE EI CAS CSCD 2024年第3期248-256,共9页
The increase in payload capacity of trucks has heightened the demand for cost-effective yet high performance brake discs.In this work,the thermal fatigue and wear of compacted graphite iron brake discs were investigat... The increase in payload capacity of trucks has heightened the demand for cost-effective yet high performance brake discs.In this work,the thermal fatigue and wear of compacted graphite iron brake discs were investigated,aiming to provide an experimental foundation for achieving a balance between their thermal and mechanical properties.Compacted graphite iron brake discs with different tensile strengths,macrohardnesses,specific heat capacities and thermal diffusion coefficients were produced by changing the proportion and strength of ferrite.The peak temperature,pressure load and friction coefficient of compacted graphite iron brake discs were analyzed through inertia friction tests.The morphology of thermal cracks and 3D profiles of the worn surfaces were also discussed.It is found that the thermal fatigue of compacted graphite iron discs is determined by their thermal properties.A compacted graphite iron with the highest specific heat capacity and thermal diffusion coefficient exhibits optimal thermal fatigue resistance.Oxidization of the matrix at low temperatures significantly weakens the function of alloy strengthening in hindering the propagation of thermal cracks.Despite the reduced hardness,increasing the ferrite proportion can mitigate wear loss resulting from low disc temperatures and the absence of abrasive wear. 展开更多
关键词 compacted graphite iron brake disc thermomechanical properties thermal fatigue WEAR
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Improving fatigue properties of normal direction ultrasonic vibration assisted face grinding Inconel 718 by regulating machined surface integrity
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作者 Nianwei Xu Renke Kang +4 位作者 Bi Zhang Yuan Zhang Chenxu Wang Yan Bao Zhigang Dong 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第3期458-475,共18页
Fatigue properties are crucial for critical aero-engine components in extreme serviceenvironments,which are significantly affected by surface integrity(SI)indexes(especially surface topography,residual stressσ_(res),... Fatigue properties are crucial for critical aero-engine components in extreme serviceenvironments,which are significantly affected by surface integrity(SI)indexes(especially surface topography,residual stressσ_(res),and microhardness)after machining processes.Normal-direction ultrasonic vibration-assisted face grinding(ND-UVAFG)has advantages in improving the machinability of Inconel 718,but there is a competitive relationship between higher compressiveσ_(res)and higher surface roughness R_(a)in affecting fatigue strength.The lack of a quantitative relationship between multiple SI indexes and fatigue strength makes theindeterminacy of a regulatory strategy for improving fatigue properties.In this work,a model of fatigue strength(σ_f)_(sur)considering multiple SI indexes was developed.Then,high-cycle fatigue tests were carried out on Inconel 718 samples with different SI characteristics,and the influence of ND-UVAFG process parameters on SI was analyzed.Based on SI indexes data,the(σ_f)_(sur)distribution in the grinding surface layer for ND-UVAFG Inconel 718 samples was determined using the developed model,and then the fatigue crack initiation(FCI)sites were furtherpredicted.The predicted FCI sites corresponded well with the experimental results,therebyverifying this model.A strategy for improving the fatigue life was proposed in this work,which was to transfer the fatigue source from the machined surface to the bulk material by controlling the SI indexes.Finally,a critical condition of SI indexes that FCI sites appeared on the surface or in bulk material was given by fitting the predicted results.According to the critical condition,an SI field where FCI sites appeared in the bulk material could be obtained.In this field,thefatigue life of Inconel 718 samples could be improved by approximately 140%. 展开更多
关键词 surface integrity fatigue strength Inconel 718 ultrasonic assisted grinding
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Effects of Intermittent Hypoxia Exposure on Symptoms of Chronic Fatigue Syndrome in Repeated Restraint Stress and Forced Swimming Induced-Mouse Model
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作者 Paul Roger Mabounda Kounga Yajun Zhang +2 位作者 Hongxia Wang Ru Wang Peijie Chen 《Journal of Biosciences and Medicines》 2024年第10期304-315,共12页
Background: Chronic fatigue syndrome (CFS) shows as its main symptoms debilitating fatigue that is not relieved by physiological rest, depression, inflammation, learning disability and memory impairment. But, intermit... Background: Chronic fatigue syndrome (CFS) shows as its main symptoms debilitating fatigue that is not relieved by physiological rest, depression, inflammation, learning disability and memory impairment. But, intermittent hypoxia, consisting of alternating exposure to hypoxia and normoxia, plays a very important role in improving CFS. However, the essential components for improving learning and memory in CFS patients as well as their mechanism are largely unknown. Objectives: This study aims to analyze the effects of 12% and 15% hypoxia on the expression of alpha tumor necrosis factor (TNF-α) and nuclear factor kappa B (NF-κB) in CFS induced-mouse model for clarifying the effects on the learning and memory function. Methods: A total of 48 type IC mice were used. The CFS mouse model was established using restrained stress and repeated forced swimming. Treatment of CFS was done by exposing CFS mice to intermittent hypoxia at 12% and 15%. The effects of intermittent hypoxia on learning and memory as well as its mechanism of action on inflammation were tested respectively with the Morris test, the SDS page, the immunohistochemistry technique and the Nissl staining. Results: We found that 12% and 15% intermittent hypoxia exposure improved learning capacity and memory of CFS induced-mice. SDS page showed that CFS caused higher TNF-α expression. By exposing CFS mice to 12% and 15% intermittent hypoxia, TNF-α expression decreased significantly, with a much better effect at 15%. Both TNF-α and NF-κB increased in CFS state and decreased after treatment with intermittent hypoxia. Conclusion: Intermittent hypoxia improves learning capacity and memory. It acted by decreasing NF-κB come to down-regulating TNF-α and ameliorates learning capacity and memory impairment in CFS mice. 展开更多
关键词 Chronic fatigue Syndrome Intermittent Hypoxia STRESS Learning Capacity MEMORY
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Fatigue Resistance of RCA Modified Asphalt Based on Dielectric Properties
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作者 陆佳宝 王国忠 +1 位作者 HU Jiangsan LIU Zhongning 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第1期91-101,共11页
In order to study the anti-fatigue performance of RCA modified asphalt (RMA),the performance of RMA and 90#matrix asphalt with different modifier content were measured by asphalt penetration,ductility,softening point,... In order to study the anti-fatigue performance of RCA modified asphalt (RMA),the performance of RMA and 90#matrix asphalt with different modifier content were measured by asphalt penetration,ductility,softening point,Brookfield viscosity,rheological index,infrared spectrum and dielectric constant test.This paper discusses the changes of asphalt basic indexes,fatigue properties and asphalt components based on dielectric properties under different modifier contents,and analyzes the grey correlation degree between components and asphalt pavement performance indexes.The results show that the optimum content of RCA modifier is 16.7%of the asphalt quality according to the penetration,ductility,softening point,Brockfield viscosity,viscosity temperature curve and fatigue life.In the phase angle-strain curve,there is disorder in the latter part of the curve.According to the strain (ε_(d)) corresponding to the disorder point,a new fatigue failure criterion is proposed and proved.Based on the new asphalt fatigue failure criterion,the fatigue prediction model of asphalt mixture is improved,and the fatigue life predicted by the improved fatigue model is compared with the fatigue life obtained by four-point bending fatigue test.The results show that the proposed new asphalt fatigue failure criterion is reasonable,and the fatigue life predicted by the improved asphalt mixture fatigue prediction model is accurate.The research method of classifying asphalt components based on dielectric properties is simple and effective,and the components have a high correlation with the road performance of base asphalt and modified asphalt. 展开更多
关键词 dielectric properties anti-fatigue performance fatigue failure criterion RCA modified asphalt
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