Temperature and salinity profile data, collected by southern elephant seals equipped with autonomous CTD-Satellite Relay Data Loggers(CTD-SRDLs) during the Antarctic wintertime in 2011 and 2012, were used to study the...Temperature and salinity profile data, collected by southern elephant seals equipped with autonomous CTD-Satellite Relay Data Loggers(CTD-SRDLs) during the Antarctic wintertime in 2011 and 2012, were used to study the evolution of water property and the resultant formation of the high density water in the Mackenzie Bay polynya(MBP) in front of the Amery Ice Shelf(AIS). In late March the upper 100–200 m layer is characterized by strong halocline and inversion thermocline. The mixed layer keeps deepening up to 250 m by mid-April with potential temperature remaining nearly the surface freezing point and sea surface salinity increasing from 34.00 to 34.21. From then on until mid-May, the whole water column stays isothermally at about^(-1).90℃while the surface salinity increases by a further 0.23. Hereafter the temperature increases while salinity decreases along with the increasing depth both by 0.1 order of magnitude vertically. The upper ocean heat content ranging from 120.5 to 2.9 MJ m^(-2), heat flux with the values of 9.8–287.0 W m^(-2) loss and the sea ice growth rates of 4.3–11.7 cm d^(-1) were estimated by using simple 1-D heat and salt budget methods. The MBP exists throughout the whole Antarctic winter(March to October) due to the air-sea-ice interaction, with an average size of about 5.0×10~3 km^2. It can be speculated that the decrease of the salinity of the upper ocean may occur after October each year. The recurring sea-ice production and the associated brine rejection process increase the salinity of the water column in the MBP progressively, resulting in, eventually, the formation of a large body of high density water.展开更多
在1842年的一篇医学文献中,首次提到声带反向运动疾病（paradoxic vocal fold movement discorder,PVFMD）,被描述为＂癔症性喉炎＂。1869年,由Mackenzie首次在喉镜下直接观察到声带的这种反常性运动,他认为声门关闭与患者的喘鸣直接相...在1842年的一篇医学文献中,首次提到声带反向运动疾病（paradoxic vocal fold movement discorder,PVFMD）,被描述为＂癔症性喉炎＂。1869年,由Mackenzie首次在喉镜下直接观察到声带的这种反常性运动,他认为声门关闭与患者的喘鸣直接相关。PVFMD患者平时的声带运动是正常的,表现为间歇性的声带收缩引起呼吸困难和喉部紧缩感。展开更多
Natural gas hydrate is widely distributed in continental slope sediments and permafrost,taken as a potential energy resource due to its gigantic amount.To develop the technologies for the industrial exploitation of na...Natural gas hydrate is widely distributed in continental slope sediments and permafrost,taken as a potential energy resource due to its gigantic amount.To develop the technologies for the industrial exploitation of natural gas hydrate,several production tests were carried out in permafrost and marine hydrate reservoirs,e.g.tests in permafrost hydrate reservoirs in Mackenzie Delta and Alaskan North Slope(Boswell et al.,2017)in the Antarctic,and those in marine hydrate reservoirs in Nankai Trough,offshore Japan(Yamamoto et al.,2014,2018),and South China Sea(SCS)(Li et al.,2018;Ye et al.,2020).As encouraged by the results obtained from the production tests,more tests are planned to develop technology for industrial exploitation of natural gas hydrate(Collett et al.,2022).Although production test can be conducted in permafrost hydrate reservoir for cost efficiency,generally it is thought industrial exploitation will be realized in marine hydrate reservoir because it is estimated with over 90%of hydrate resource.展开更多
The purpose of the study was to evaluate the effects of corticosteroids on histamine release and to compare their potency with the MacKenzie classification based on their vasoconstrictor effects. Thanks to ex Vivo cut...The purpose of the study was to evaluate the effects of corticosteroids on histamine release and to compare their potency with the MacKenzie classification based on their vasoconstrictor effects. Thanks to ex Vivo cutaneous microdialysis, we studied histamine-induced release over a period of time on excised abdominal skin from women. Eight corticosteroids were topically applied with occlusive dressing onto the skin, above probes, before anti-IgE injection. Histamine levels were assessed by an EIA method. In order to compare the different corticosteroids, AUC was calculated allowing an estimation of the amount of released histamine for 60 min of ex vivo cutaneous microdialysis. Diflucortolone 0.1% and micronized betamethasone dipropionate 0.05% are considered as corticosteroids with high potency in MacKenzie classification. Betamethasone dipropionate associated with propylene glycol 0.05%, belongs to a stronger class in Mackenzie classification. Our results showed that the decrease in histamine release was more important with difluocortolone than with both of these corticosteroids. Therefore there was no correlation between the vasoconstrictor potency of topical corticosteroids and their ability to inhibit histamine release.展开更多
Energy Daily,2017-03-03尽管资本投资达到历史最高纪录,但据英国石油和天然气活动调查发现,很少有项目按时交付运营和不超出预算的。英国石油和天然气局（OGA）发布了到2016年为止的石油和天然气活动的5年审查。审查发现,不到25%的石...Energy Daily,2017-03-03尽管资本投资达到历史最高纪录,但据英国石油和天然气活动调查发现,很少有项目按时交付运营和不超出预算的。英国石油和天然气局（OGA）发布了到2016年为止的石油和天然气活动的5年审查。审查发现,不到25%的石油和天然气项目按时交付,大部分比计划晚10个月运行。展开更多
Henry Mackenzie＇ s The Man of Feeling （1771 ）, widely read m its time, has been generally regarded as an exemplar of sentimental fiction. As a typical man of the world, Mackenzie made arduous efforts to distance hi...Henry Mackenzie＇ s The Man of Feeling （1771 ）, widely read m its time, has been generally regarded as an exemplar of sentimental fiction. As a typical man of the world, Mackenzie made arduous efforts to distance himself from Harley, the simple and naive sentimental hero he created in his novel. The novel described how the innocence and tenderness of Harley were thwarted by the evil world and how Harley responded with sighs and tears. The same response was asked of the reader. Hence, readings of sentimental novels became tear-demanding exhibitions of pathos, while the unkindness and perverseness of the world were minimized and even concealed.展开更多
基金the Science and Technology Basic Work of the Ministry of Science and Technology of China (No. 2012FY112300)
文摘Temperature and salinity profile data, collected by southern elephant seals equipped with autonomous CTD-Satellite Relay Data Loggers(CTD-SRDLs) during the Antarctic wintertime in 2011 and 2012, were used to study the evolution of water property and the resultant formation of the high density water in the Mackenzie Bay polynya(MBP) in front of the Amery Ice Shelf(AIS). In late March the upper 100–200 m layer is characterized by strong halocline and inversion thermocline. The mixed layer keeps deepening up to 250 m by mid-April with potential temperature remaining nearly the surface freezing point and sea surface salinity increasing from 34.00 to 34.21. From then on until mid-May, the whole water column stays isothermally at about^(-1).90℃while the surface salinity increases by a further 0.23. Hereafter the temperature increases while salinity decreases along with the increasing depth both by 0.1 order of magnitude vertically. The upper ocean heat content ranging from 120.5 to 2.9 MJ m^(-2), heat flux with the values of 9.8–287.0 W m^(-2) loss and the sea ice growth rates of 4.3–11.7 cm d^(-1) were estimated by using simple 1-D heat and salt budget methods. The MBP exists throughout the whole Antarctic winter(March to October) due to the air-sea-ice interaction, with an average size of about 5.0×10~3 km^2. It can be speculated that the decrease of the salinity of the upper ocean may occur after October each year. The recurring sea-ice production and the associated brine rejection process increase the salinity of the water column in the MBP progressively, resulting in, eventually, the formation of a large body of high density water.
文摘在1842年的一篇医学文献中,首次提到声带反向运动疾病（paradoxic vocal fold movement discorder,PVFMD）,被描述为＂癔症性喉炎＂。1869年,由Mackenzie首次在喉镜下直接观察到声带的这种反常性运动,他认为声门关闭与患者的喘鸣直接相关。PVFMD患者平时的声带运动是正常的,表现为间歇性的声带收缩引起呼吸困难和喉部紧缩感。
文摘Natural gas hydrate is widely distributed in continental slope sediments and permafrost,taken as a potential energy resource due to its gigantic amount.To develop the technologies for the industrial exploitation of natural gas hydrate,several production tests were carried out in permafrost and marine hydrate reservoirs,e.g.tests in permafrost hydrate reservoirs in Mackenzie Delta and Alaskan North Slope(Boswell et al.,2017)in the Antarctic,and those in marine hydrate reservoirs in Nankai Trough,offshore Japan(Yamamoto et al.,2014,2018),and South China Sea(SCS)(Li et al.,2018;Ye et al.,2020).As encouraged by the results obtained from the production tests,more tests are planned to develop technology for industrial exploitation of natural gas hydrate(Collett et al.,2022).Although production test can be conducted in permafrost hydrate reservoir for cost efficiency,generally it is thought industrial exploitation will be realized in marine hydrate reservoir because it is estimated with over 90%of hydrate resource.
文摘The purpose of the study was to evaluate the effects of corticosteroids on histamine release and to compare their potency with the MacKenzie classification based on their vasoconstrictor effects. Thanks to ex Vivo cutaneous microdialysis, we studied histamine-induced release over a period of time on excised abdominal skin from women. Eight corticosteroids were topically applied with occlusive dressing onto the skin, above probes, before anti-IgE injection. Histamine levels were assessed by an EIA method. In order to compare the different corticosteroids, AUC was calculated allowing an estimation of the amount of released histamine for 60 min of ex vivo cutaneous microdialysis. Diflucortolone 0.1% and micronized betamethasone dipropionate 0.05% are considered as corticosteroids with high potency in MacKenzie classification. Betamethasone dipropionate associated with propylene glycol 0.05%, belongs to a stronger class in Mackenzie classification. Our results showed that the decrease in histamine release was more important with difluocortolone than with both of these corticosteroids. Therefore there was no correlation between the vasoconstrictor potency of topical corticosteroids and their ability to inhibit histamine release.
基金This paper is supported by Science Foundation of BLCU （supported by ＂the Fundamental Research Funds for the Central Universities＂） （No. 12YBG022）.
文摘Henry Mackenzie＇ s The Man of Feeling （1771 ）, widely read m its time, has been generally regarded as an exemplar of sentimental fiction. As a typical man of the world, Mackenzie made arduous efforts to distance himself from Harley, the simple and naive sentimental hero he created in his novel. The novel described how the innocence and tenderness of Harley were thwarted by the evil world and how Harley responded with sighs and tears. The same response was asked of the reader. Hence, readings of sentimental novels became tear-demanding exhibitions of pathos, while the unkindness and perverseness of the world were minimized and even concealed.
