大萼香茶菜乙素和己素的化学结构

从大萼香茶菜［Ｒａｂｄｏｓｉａ ｍ ａｃｒｏｃａｌｙｘ（Ｄｕｎｎ） Ｈａｒａ］叶的乙醇提取物中又分得两种二萜类成分，经ＩＲ、ＭＳ、１ Ｈ－１Ｈ ＣＯＳＹ、１３Ｃ－１ Ｈ ＣＯＳＹ 和ＮＯＥ等光谱分析及衍生物制备，确证其化学结构为新型二萜。

大萼香茶菜中的新二萜化合物

On the basis of the investigation on natural product antitumor agents,a new diterpenoid named macrocalyxin J was isolated from the leaves of Rabdosia macrocalyx（Dunn） Hara by silica gel column chromatography.Based on IR,MS,1H NMR,13C NMR and 2D NMR spectroscopies,the structure of macrocalyxin J was determined as（1α,6β,11β,14α）-1,7∶6,20-diepoxy-6,11-dihydroxy-6,7-seco-ent-kaur-16-ene-7,15-dione-14-acetate.The antitumor activity of the compound was assayed by MTT method.Macrocalyxin J was shown to have a potency in vitro against the cultures of Hela cells.

九华香茶菜二萜成分的研究

从九华香茶菜的干叶中得到6种成分。除β-谷甾醇和齐墩果酸外,四种为二萜类化合物,其中三种为已知二萜成分excisanin A、excisanin B和macrocalyxin A;另一种为新的二萜化合物,命名为九华香茶菜甲素。体外抗癌实验证明,九华香茶菜甲素对Hela细胞和肺癌细胞(A549)均有抑制作用。通过理化常数的测定、光谱分析和衍生物的制备,测定了其结构为（1）式。