Considering the development of magnetic resonance imaging （MRI） under ultrahigh magnetic field （〉3 T）, the exploration of novel contrast agents （CAs） for ultrahigh field MRI is urgently needed. Herein, we repor...Considering the development of magnetic resonance imaging （MRI） under ultrahigh magnetic field （〉3 T）, the exploration of novel contrast agents （CAs） for ultrahigh field MRI is urgently needed. Herein, we report polyethyleneimine （PEI）-coated TbF3 nanoparticles （NPs）, which were synthesized by a facile solvothermal method, as potential dual-mode CAs for ultrahigh field MRI and X-ray computed tomography （CT）. Owing to their strong paramagnetism, the TbF3 NPs showed excellent transverse relaxivity （395.77 mM-l.s-1） and negligible longitudinal relaxivity under an ultrahigh magnetic field （7 T） with a great potential as a T2-weighted MRI contrast agent. Furthermore, by comparison with the clinically used CT CAs （iohexol）, the TbF3 NPs showed superior X-ray attenuation ability. The practical application for T2-weighted MRI and CT imaging was demonstrated with an animal model. Moreover, cell cytotoxicity and in vivo toxicity assessments implied the low toxicity of TbF3 NPs. In summary the above results indicate that TbF3 NPs are promising candidates for ultrahigh field MRI and CT dual-mode imaging.展开更多
We described a case of a 71-year-old woman with an epithelioid hemangioendothelioma (EHE) in her left axilla,a rare location which hasn’t been reported yet.The patient suffered from numbness,pain and decreased muscle...We described a case of a 71-year-old woman with an epithelioid hemangioendothelioma (EHE) in her left axilla,a rare location which hasn’t been reported yet.The patient suffered from numbness,pain and decreased muscle strength of her left upper extremity. Sonography revealed a hypoechoic mass surrounded the axillary artery and brachial artery. No obvious capsule was demonstrated.CT showed a soft-tissue mass with some calcifications and peripheral ring-like enhancement. The MRI indicated a mass with mainly intermediate signal intensity on T1-weighted imagine and intermediate signal intensity on T2-weighted imagine. The diagnosis was confirmed by histopathologic examination after surgery. There are some correlations of these imaging features with its histopathologic characters.展开更多
The development of multifunctional nanoparticles for diagnosis and therapy of cancer has been a focus of research in recent years. Owing to excellent properties of chemophotothermal therapy and tumor targeting accompa...The development of multifunctional nanoparticles for diagnosis and therapy of cancer has been a focus of research in recent years. Owing to excellent properties of chemophotothermal therapy and tumor targeting accompanied by magnetic resonance （MR） or computed tomography （CT） imaging, mesoporous silica has been widely applied to tumor diagnosing carriers. However, previous research focused more on chemotherapy combined with photothermal therapeutic strategies but ignored intuitive assessment of tumors. In this work, we report a novel nanoprobe consisKng of hyaluronic-acid-modified gold nanorods@mSiO2@Mn@DOX （GNR@MMH@DOX） nanoparticles, which realize multifunctional integration of therapeutics and imaging. Au nanorods （GNRs） were synthesized without a seed precursor by a water bath method, then sequentially modified with mesoporous silica, doped with Mn2＋, and loaded with doxorubicin in a solution. In vitro and in vivo assays verified their great biocompatibility, good stability, and attractive specificity of targeting to receptor CD44, which is overexpressed on cancer cells. In addition, GNR@MMH nanoparticles proved to be a more distinguishable CT/MR imaging contrast compared to commercial contrast agents. The article demonstrates promising composition for CT/MR imaging and photothermal therapy of tumors, giving new insights into the diagnosis and therapy of different kinds of malignant tumors.展开更多
基金This work was supported by the National Natural Science Foundation of China （No. 21425101, 21371011, and 21321001） and the National Basic Research Program of China （No. 2014CB643800）.
文摘Considering the development of magnetic resonance imaging （MRI） under ultrahigh magnetic field （〉3 T）, the exploration of novel contrast agents （CAs） for ultrahigh field MRI is urgently needed. Herein, we report polyethyleneimine （PEI）-coated TbF3 nanoparticles （NPs）, which were synthesized by a facile solvothermal method, as potential dual-mode CAs for ultrahigh field MRI and X-ray computed tomography （CT）. Owing to their strong paramagnetism, the TbF3 NPs showed excellent transverse relaxivity （395.77 mM-l.s-1） and negligible longitudinal relaxivity under an ultrahigh magnetic field （7 T） with a great potential as a T2-weighted MRI contrast agent. Furthermore, by comparison with the clinically used CT CAs （iohexol）, the TbF3 NPs showed superior X-ray attenuation ability. The practical application for T2-weighted MRI and CT imaging was demonstrated with an animal model. Moreover, cell cytotoxicity and in vivo toxicity assessments implied the low toxicity of TbF3 NPs. In summary the above results indicate that TbF3 NPs are promising candidates for ultrahigh field MRI and CT dual-mode imaging.
文摘We described a case of a 71-year-old woman with an epithelioid hemangioendothelioma (EHE) in her left axilla,a rare location which hasn’t been reported yet.The patient suffered from numbness,pain and decreased muscle strength of her left upper extremity. Sonography revealed a hypoechoic mass surrounded the axillary artery and brachial artery. No obvious capsule was demonstrated.CT showed a soft-tissue mass with some calcifications and peripheral ring-like enhancement. The MRI indicated a mass with mainly intermediate signal intensity on T1-weighted imagine and intermediate signal intensity on T2-weighted imagine. The diagnosis was confirmed by histopathologic examination after surgery. There are some correlations of these imaging features with its histopathologic characters.
文摘The development of multifunctional nanoparticles for diagnosis and therapy of cancer has been a focus of research in recent years. Owing to excellent properties of chemophotothermal therapy and tumor targeting accompanied by magnetic resonance （MR） or computed tomography （CT） imaging, mesoporous silica has been widely applied to tumor diagnosing carriers. However, previous research focused more on chemotherapy combined with photothermal therapeutic strategies but ignored intuitive assessment of tumors. In this work, we report a novel nanoprobe consisKng of hyaluronic-acid-modified gold nanorods@mSiO2@Mn@DOX （GNR@MMH@DOX） nanoparticles, which realize multifunctional integration of therapeutics and imaging. Au nanorods （GNRs） were synthesized without a seed precursor by a water bath method, then sequentially modified with mesoporous silica, doped with Mn2＋, and loaded with doxorubicin in a solution. In vitro and in vivo assays verified their great biocompatibility, good stability, and attractive specificity of targeting to receptor CD44, which is overexpressed on cancer cells. In addition, GNR@MMH nanoparticles proved to be a more distinguishable CT/MR imaging contrast compared to commercial contrast agents. The article demonstrates promising composition for CT/MR imaging and photothermal therapy of tumors, giving new insights into the diagnosis and therapy of different kinds of malignant tumors.
