Study of hypoechoic nodule diagnosis of BPH in outer gland of the prostate by TRUS and autopsy

To investigate the possibility of benign prostatic hyperplasia (BPH) in prostatic outer gland by transrectal ultrasound (TRUS) and autopsy examination.Methods Fifty-nine patients were biopsied by TRUS guided in sagittal and longitudinal sections,respectively,because hypoechoic nodules were found in the outer glands of the prostates.The specimens were stained by HE methods.The whole prostate specimens obtained from 16 men at autopsy were studied.Sonogram of the specimens was investigated by putting them in water.Them the specimens were sliced down perpendicularly to the urethra,histologically processed and stained by HE methods.Results Pathologically,22 of the 59 specimens were of benign prostate hyperplasia (BPH),29 of prostate cancer (PCa),1 of prostatic intraepithelial neoplasia (PIN) and 7 of tuberculosis (TB).A clear-cut interface between inner gland and outer gland,and multiple calculi and cysts were found on sonogram.Pathological diagnosis of BPH of the outer glands was made in all HE-stained autopsied specimens with varying degrees of hyperplasia of the glands,small muscles and stroma.Conclusion It is suggested that hypoechoic nodules in outer gland of the prostate by TRUS on sonogram may be benign hyperplastic nodules besides PCa,PIN,and TB.10 refs,5 figs.

经直肠超声造影对前列腺癌的定量诊断价值

目的探讨经直肠前列腺超声造影(contrast-enhanced transrectal ultrasonography,CETRUS)对前列腺增生(hyper-plasia of prostate,BPH)背景下的前列腺外腺癌结节(nodule of carcinoma of prostat)的定量诊断价值。方法回顾性地分析经细针穿刺有病理证实的21例(21个病灶)前列腺外腺癌结节,经超声造影后应用Qontraxt软件生成时间-强度曲线(time-intensitycurve,TIC),获得Qontraxt软件中的各项参数:峰值强度(peak enhancement,PK)、达峰时间(time to peak,TP)、斜率(sharpness)、曲线下面积(area under the enhancement curve,AUC),比较外腺癌结节、周边外腺组织及内腺增生组织各组间的差异。结果前列腺外腺癌结节组的Sharpness、AUC(分别为0.177430±0.046191和4.700±1.998)明显大于其周边外腺组织组(分别为0.12557±0.028999和2.671±1.083)(P均<0.05);前列腺外腺癌结节组与前列腺内腺增生组织组组间各参数差异均无统计学意义(P均>0.05);前列腺内腺增生组织组的PK、AUC(分别为33.433±9.195和5.257±1.597)明显大于前列腺外腺癌结节周边外腺组织组(分别为21.857±9.756和2.671±1.083)(P均<0.05)。结论 CETRUS对前列腺外腺癌结节有定量诊断价值,为前列腺癌的定性诊断提供更多可靠信息。

前列腺外腺增生性低回声结节的组织形态学定量研究

目的:探讨前列腺外腺增生性低回声结节的组织形态学特点。 方法:应用苏木精 伊红染色和免疫组化染 色结合计算机辅助图像分析方法,对22例病理证实为良性前列腺增生的外腺低回声结节穿刺标本进行组织成分定 量分析。 结果:前列腺外腺增生性低回声结节中间质、上皮、腺腔和间质中平滑肌成分所占整个前列腺组织的面 积百分比分别为(72.52±13.14)%、(20.57±9.01)%、(6.85±4.51)%和(24.14±6.31)%。 结论:与前列腺内 腺一样,前列腺外腺也可出现增生性低回声结节,但两者的成分构成百分比有所不同。

超声结合尸检对前列腺外腺良性增生性低回声结节的研究

目的 应用经直肠超声(TRUS)结合尸检探讨前列腺外腺是否存在良性增生性结节的可能性。 方法 59例TRUS显示的前列腺外腺低回声结节行定点穿刺活检,HE染色;选取前列腺尸检标本16例,行水槽实验和HE染色。 结果 59例前列腺外腺低回声结节穿刺标本病理诊断为良性前列腺增生(BPH)22例,前列腺癌(PCa)29例,前列腺上皮内瘤变(PIN)1例,前列腺结核(TB)7例。水槽实验提示尸检标本声像图内外腺分界清楚,实质内见多发强回声钙化灶及多发囊肿; 16例前列腺尸检标本HE染色外腺均可见腺体、平滑肌和纤维结缔组织不同程度的增生,病理证实为BPH。 结论 TRUS显示的前列腺外腺低回声结节除了PCa、PIN、TB等疾病之外,还存在良性增生性结节。