Long-term follow-up of antithrombotic management patterns in patients with acute coronary syndrome in China

Objective To describe the long-term antithrombotic management patterns(AMPs)and clinical outcomes of Chinese patients with acute coronary syndrome(ACS).Methods This was an observational,multicenter,longitudinal cohort extension study of Chinese patients who had completed the EPICOR Asia 2-year follow-up study post-hospitalization for an ACS event.Changes in AMP and clinical outcomes for up to 5 years post-ACS event were evaluated.Results Overall,2334 patients with ACS were enrolled at 49 sites.The mean age was 61.6 years and 76.3%were men.By study end,2093 patients completed the 3-year follow-up.At baseline(2 years post-ACS event),72.4%of patents received one antiplatelet(AP)medication,with aspirin being the preferred one.A small proportion of patients(21.5%)was treated with two or more APs(2+AP),and even fewer patients(6.1%)did not receive any AP medication at baseline.Upon study completion,the proportion of patients without AP therapy increased to 13.6%,while the percentage of patients on one AP and 2+AP decreased to 69.3%and 17.1%,respectively.Numerically,a higher incidence of clinical events(composite of all-cause mortality,myocardial infarction,stroke)was observed for the 2+AP(13.2%)subgroup than for the no AP(10.5%)and one AP(8.6%)subgroups.Furthermore,the 2+AP subgroup exhibited the greatest number of bleeding events,outpatient visits,and hospitalization rates.Unlike myocardial infarction or stroke,bleeding events prompted an adjustment in AMP.Conclusion Most patients in China received at least one AP medication up to 5 years after an ACS event.

Contemporary Patterns of Management of Tetralogy of Fallot:Data from a Single Center in China

Background:There is scarce research on large cohorts with tetralogy of Fallot(TOF)from China.The database in Fuwai Hospital was reviewed to ascertain current trends in the management of TOF and to determine the prevalence of various surgical techniques and the optimal early outcome.Methods:This cross-sectional study included 1861 patients who underwent surgery between 2012 and 2017 and were aged 0-18 years old with a primary diagnosis of TOF.A total of 1760 eligible patients were included in the analyses.Results:A total of 1683 patients underwent repair of TOF as a one-stage operation(primary repair).Sixty-one patients underwent repair of TOF after prior palliation.Of patients who underwent one-stage repair(n=1683):858 were 6 months to 1 year old,421 were 1 to 2 years old,251 were 2-18 years old,and 145 were 3 to 6 months old.Of patients who underwent repair following prior palliation(n=61),58(95.1%)were older than 1 year of age.Of 1744 complete repairs,986(56.0%)had annulus-sparing(AS)repair.Total in-hospital mortality was 15 of 1744(0.9%)for complete repair(including one-stage and staged repairs).The total incidence of the optimal early outcome was 78.2%in terms of a composite of the absence of death in the first year,significant right ventricular outflow tract obstruction,significant pulmonary valve insufficiency,or catheter or surgical reintervention.Conclusions:Surgical correction in patients with TOF can achieve an acceptable outcome in terms of death and reintervention.Primary repair at 6 months to 1 year of age is the most prevalent strategy in our centre.However,the relatively high incidence of early undesirable surgical adequacy of the pulmonary valve(PV)represents a wake-up call.

Cutting technic for Pinus elliottii plantation of the multi-benefit management pattern

The cutting technic for thePinus elliottii plantation of the multi-benefit management pattern in the hilly region of Jiangxi Province was studied by establishing the model of growth progress according to Richards function and simulating the tending cutting on computer by use of dynamic programming. The results showed that the best time for the initial thinning was at tree age of 8–10 and final cutting was at tree age of 25. The optimal thinning project was 3 times of thinning cutting including the first thinning, and the thinning time was at tree ages of 8, 12 and 16, respectively. Their thinning intensities were separately 950, 700 and 300 trunks per hectare, and the preserved density was 550 trunks per hectare until the final cutting Keywords Pinus elliottir - Multi-benefit management pattern - Richards function - Cutting technic - Dynamic programming CLC number S757.4 Document code A Foundation item: This study was supported by Natural Science Foundation of Jiangxi Province (A grant 0330023)Biography: WANG Qing-chun (1970-), male, Ph. Doctor, Senior Engineer in Academy of Forest Inventory & Planning, Jiangxi, Nanchang 330046, P.R. China.Responsible editor: Song Funan

Research on the Emergency Response Mechanism and the Applications on Coastal Communities Storm Disaster Management

In this paper, we conduct research on the emergency response mechanism and applications on the coastal communities storm disaster management. Investment of pre-disaster prevention and the post-disaster remedy is larger in emergency in the financial system that has been structural problems, although in a disaster and financial support is especially important after a disaster, but increase before preventive investment should be the focus of our general government. Before preventive emergency government investment is to prevent incident broke out and reduce the incident after the outbreak of the impact of the main means. Under these circumstances, we analyze the coastal communities storm disaster management mode with the integration of the enhanced emergency response mechanism that will be meaningful for promoting the management efficiency and effectiveness.

Application Strategy of Dynamic Management Mode in Municipal Road Survey and Design Management

With the continuous improvement of urbanization level,the construction of municipal roads has received more attention.The rational application of dynamic management mode to the survey and design management of municipal roads is conducive to improve the survey and design management level of municipal roads and further realizing the optimization of the construction effect of municipal roads.In this paper,the various factors which are affecting the management of municipal road survey and design as well the principles of municipal road design were discussed.Further,the recommendation of the application strategy of dynamic management mode in municipal road survey and design management was proposed in this paper.

Reasonable management of perennial planting grassland contributes to positive succession of soil microbial community in Sanjiangyuan of Qinghai-Tibetan Plateau,China

Grassland reconstruction is a major approach to alleviate the‘black beach’in Sanjiangyuan of the Qinghai-Tibetan Plateau.It is vital to understand how to manage the planting grassland after reconstruction.And which artificial grassland management pattern is more likely to restore the degraded grassland of‘black beach?’To provide the scientific basis for the restoration of‘black beach’,we investigated the changes in vegetation characteristics,soil physicochemical properties and soil microbial community structure of planting grassland under different management patterns,and explored the effect of the management patterns on community succession of planting grassland.In this study,vegetation characteristics and soil physicochemical properties were measured by field investigation and laboratory analyses,respectively.Soil microbial community composition was determined by high-throughput sequencing techniques.The results showed that there were significant differences in vegetation characteristics,soil physicochemical properties and soil microbial community structure of the planting grassland under different management patterns.Actinobacteria and Basidiomycota were mainly controlled by vegetation plant species diversity,aboveground biomass(AGB)and soil organic carbon(SOC).Shannon-Wiener index,AGB and SOC peaked and the relative abundance of amplicon sequence variants annotated by Actinobacteria and Basidiomycota were significantly enriched under the management pattern of the planting once treatment.Additionally,the soil had the highest bacterial diversity and the lowest fungal diversity under the planting once treatment,becoming a‘bacterial’soil.These vegetation characteristics and soil environment were more conducive to overall positive community succession,indicating that the planting once treatment is the most reasonable management pattern for restoring the‘black beach’.