With over 10 million points of genetic variation from person to person, every individual’s genome is unique and provides a highly reliable form of identification. This is because the genetic code is specific to each ...With over 10 million points of genetic variation from person to person, every individual’s genome is unique and provides a highly reliable form of identification. This is because the genetic code is specific to each individual and does not change over time. Genetic information has been used to identify individuals in a variety of contexts, such as criminal investigations, paternity tests, and medical research. In this study, each individual’s genetic makeup has been formatted to create a secure, unique code that incorporates various elements, such as species, gender, and the genetic identification code itself. The combinations of markers required for this code have been derived from common single nucleotide polymorphisms (SNPs), points of variation found in the human genome. The final output is in the form of a 24 numerical code with each number having three possible combinations. The custom code can then be utilized to create various modes of identification on the decentralized blockchain network as well as personalized services and products that offer users a novel way to uniquely identify themselves in ways that were not possible before.展开更多
In the seismic safety evaluation (SSE) for key projects, the probability-consistent spectrum (PCS), usually obtained from probabilistic seismic hazard analysis (PSHA), is not consistent with the design response spectr...In the seismic safety evaluation (SSE) for key projects, the probability-consistent spectrum (PCS), usually obtained from probabilistic seismic hazard analysis (PSHA), is not consistent with the design response spectrum given by Code for Seismic Design of Buildings (GB50011-2001). Sometimes, there may be a remarkable difference be-tween them. If the PCS is lower than the corresponding code design response spectrum (CDS), the seismic fortifi-cation criterion for the key projects would be lower than that for the general industry and civil buildings. In the paper, the relation between PCS and CDS is discussed by using the ideal simple potential seismic source. The re-sults show that in the most areas influenced mainly by the potential sources of the epicentral earthquakes and the regional earthquakes, PCS is generally lower than CDS in the long periods. We point out that the long-period re-sponse spectra of the code should be further studied and combined with the probability method of seismic zoning as much as possible. Because of the uncertainties in SSE, it should be prudent to use the long-period response spectra given by SSE for key projects when they are lower than CDS.展开更多
In Systems Biology, system identification, which infers regulatory network in genetic system and metabolic pathways using experimentally observed time-course data, is one of the hottest issues. The efficient numerical...In Systems Biology, system identification, which infers regulatory network in genetic system and metabolic pathways using experimentally observed time-course data, is one of the hottest issues. The efficient numerical optimization algorithm to estimate more than 100 real-coded parameters should be developed for this purpose. New real-coded genetic algorithm (RCGA), the combination of AREX (adaptive real-coded ensemble crossover) with JGG (just generation gap), have applied to the inference of genetic interactions involving more than 100 parameters related to the interactions with using experimentally observed time-course data. Compared with conventional RCGA, the combination of UNDX (unimodal normal distribution crossover) with MGG (minimal generation gap), new algorithm has shown the superiority with improving early convergence in the first stage of search and suppressing evolutionary stagnation in the last stage of search.展开更多
Nature has developed codon as a tool to manipulate a two-electron spin symmetry (short-living electrons, forming a radical pair, arise from the Mg-bound nucleosidetriphosphate cleavage at the triplet/singlet (T/S) cro...Nature has developed codon as a tool to manipulate a two-electron spin symmetry (short-living electrons, forming a radical pair, arise from the Mg-bound nucleosidetriphosphate cleavage at the triplet/singlet (T/S) crossing), which permits or forbids further nucleotide synthesis (DNA/RNA) and the synthesis of proteins. The thesis is confirmed by conducting DFT:B3LYP (6-311G** basis set) computations (T/S potential energy surfaces) with the model system composed of the template (C-G-C-G-A nucleotide sequence) and the growing chain (G-C-G nucleotide sequence, DNA or RNA). The origin of codon is in hyperfine interaction between a single electron, transferred onto the template, and three 31P nuclei built into the phosphorus fragments of nucleotides. The nuclei, together with the polynucleotide structure, form a spiral twist that is homeomorphic to a triangle patch on the Poincare sphere. Each triangle has unique angle values depending on the nucleotide nature and their position in the codon. The patch tracing produces the Berry phase changing the electron spin orientation from “up” to “down”. The Berry phase accumulation proceeds around the (T/S) conical intersections (CIs). The CIs are a result of complementary recognition between nucleotide bases at distances exceeding the commonly accepted Watson-Crick pairing by 0.17 A. Upon changing spin symmetry, the DNA or RNA chain is allowed to elongate by attaching a newly coming nucleotide. Without complementary recognition between the bases, the chain stops its elongation. The Berry phase accumulation along the patch tracing explains the effect of Crick’s wobbling when the second nucleotide plays a primary role in recognition. The data is directly linked to creation of a quantum computing device.展开更多
The most important method of understanding liquefaction-induced engineering failures comes from the investigation and analysis of earthquake damage.In May 2021,the Maduo M_(s)7.4 earthquake occurred on the Tibetan Pla...The most important method of understanding liquefaction-induced engineering failures comes from the investigation and analysis of earthquake damage.In May 2021,the Maduo M_(s)7.4 earthquake occurred on the Tibetan Plateau of China.The most representative engineering disaster caused by this earthquake was bridge damage on liquefied sites.In this study,the mutual relationships between the anti-liquefaction pre-design situation,the ground motion intensity,the site liquefaction severity,and the bridge damage state for this earthquake were systematically analyzed for typical bridge damage on the liquefied sites.Using field survey data and the current Chinese industry code,simulations of the liquefaction scenarios at typical bridge sites were performed for the pre-design seismic ground motion before the earthquake and the seismic ground motion during the earthquake.By combining these results with post-earthquake investigation results,the reason for the serious bridge damage resulting from this earthquake is revealed,and the necessary conditions for avoiding serious seismic damage to bridges built in liquefiable sites is presented.展开更多
Putting the people first in human rights protection is the most distinctive feature of the outlook on human rights in contemporary China. The codification of the Civil Code of the People’s Republic of China reflects ...Putting the people first in human rights protection is the most distinctive feature of the outlook on human rights in contemporary China. The codification of the Civil Code of the People’s Republic of China reflects the people’s legislation for themselves, which is guided by the principle of putting the people first in its external system and internal values. Functionally, the Civil Code of the People’s Republic of China reflects the obligation of the country to protect human rights, constructs the framework relationship between the country and individual people, and perfects the mechanism for human rights protection. The continuous expansion of the types, contents, and functions of civil rights in the Civil Code of the People’s Republic of China is required by the broad scope of human rights, with an aim to realize a happy life for the people, the most important human rights, and protect people’s personal rights, property rights, and right to dignity through specific rules. The universal sharing of human rights requires the universality of the subjects of civil rights. The equal sharing of human rights requires the equality of forms of civil rights protection. Meanwhile, it further requires the substantive equality of civil rights protection. Attention is paid to protecting the rights and interests of specific groups in external and embedded ways.展开更多
文摘With over 10 million points of genetic variation from person to person, every individual’s genome is unique and provides a highly reliable form of identification. This is because the genetic code is specific to each individual and does not change over time. Genetic information has been used to identify individuals in a variety of contexts, such as criminal investigations, paternity tests, and medical research. In this study, each individual’s genetic makeup has been formatted to create a secure, unique code that incorporates various elements, such as species, gender, and the genetic identification code itself. The combinations of markers required for this code have been derived from common single nucleotide polymorphisms (SNPs), points of variation found in the human genome. The final output is in the form of a 24 numerical code with each number having three possible combinations. The custom code can then be utilized to create various modes of identification on the decentralized blockchain network as well as personalized services and products that offer users a novel way to uniquely identify themselves in ways that were not possible before.
基金Shanghai Science & Technology Development Foundation (022512065) and Shanghai Construction Technology Development Foundation (A0206101).
文摘In the seismic safety evaluation (SSE) for key projects, the probability-consistent spectrum (PCS), usually obtained from probabilistic seismic hazard analysis (PSHA), is not consistent with the design response spectrum given by Code for Seismic Design of Buildings (GB50011-2001). Sometimes, there may be a remarkable difference be-tween them. If the PCS is lower than the corresponding code design response spectrum (CDS), the seismic fortifi-cation criterion for the key projects would be lower than that for the general industry and civil buildings. In the paper, the relation between PCS and CDS is discussed by using the ideal simple potential seismic source. The re-sults show that in the most areas influenced mainly by the potential sources of the epicentral earthquakes and the regional earthquakes, PCS is generally lower than CDS in the long periods. We point out that the long-period re-sponse spectra of the code should be further studied and combined with the probability method of seismic zoning as much as possible. Because of the uncertainties in SSE, it should be prudent to use the long-period response spectra given by SSE for key projects when they are lower than CDS.
文摘In Systems Biology, system identification, which infers regulatory network in genetic system and metabolic pathways using experimentally observed time-course data, is one of the hottest issues. The efficient numerical optimization algorithm to estimate more than 100 real-coded parameters should be developed for this purpose. New real-coded genetic algorithm (RCGA), the combination of AREX (adaptive real-coded ensemble crossover) with JGG (just generation gap), have applied to the inference of genetic interactions involving more than 100 parameters related to the interactions with using experimentally observed time-course data. Compared with conventional RCGA, the combination of UNDX (unimodal normal distribution crossover) with MGG (minimal generation gap), new algorithm has shown the superiority with improving early convergence in the first stage of search and suppressing evolutionary stagnation in the last stage of search.
文摘Nature has developed codon as a tool to manipulate a two-electron spin symmetry (short-living electrons, forming a radical pair, arise from the Mg-bound nucleosidetriphosphate cleavage at the triplet/singlet (T/S) crossing), which permits or forbids further nucleotide synthesis (DNA/RNA) and the synthesis of proteins. The thesis is confirmed by conducting DFT:B3LYP (6-311G** basis set) computations (T/S potential energy surfaces) with the model system composed of the template (C-G-C-G-A nucleotide sequence) and the growing chain (G-C-G nucleotide sequence, DNA or RNA). The origin of codon is in hyperfine interaction between a single electron, transferred onto the template, and three 31P nuclei built into the phosphorus fragments of nucleotides. The nuclei, together with the polynucleotide structure, form a spiral twist that is homeomorphic to a triangle patch on the Poincare sphere. Each triangle has unique angle values depending on the nucleotide nature and their position in the codon. The patch tracing produces the Berry phase changing the electron spin orientation from “up” to “down”. The Berry phase accumulation proceeds around the (T/S) conical intersections (CIs). The CIs are a result of complementary recognition between nucleotide bases at distances exceeding the commonly accepted Watson-Crick pairing by 0.17 A. Upon changing spin symmetry, the DNA or RNA chain is allowed to elongate by attaching a newly coming nucleotide. Without complementary recognition between the bases, the chain stops its elongation. The Berry phase accumulation along the patch tracing explains the effect of Crick’s wobbling when the second nucleotide plays a primary role in recognition. The data is directly linked to creation of a quantum computing device.
基金Natural Science Foundation of Heilongjiang Province under Grant No.ZD2019E009Key Project of National Natural Science Foundation of China under Grant No.U1939209。
文摘The most important method of understanding liquefaction-induced engineering failures comes from the investigation and analysis of earthquake damage.In May 2021,the Maduo M_(s)7.4 earthquake occurred on the Tibetan Plateau of China.The most representative engineering disaster caused by this earthquake was bridge damage on liquefied sites.In this study,the mutual relationships between the anti-liquefaction pre-design situation,the ground motion intensity,the site liquefaction severity,and the bridge damage state for this earthquake were systematically analyzed for typical bridge damage on the liquefied sites.Using field survey data and the current Chinese industry code,simulations of the liquefaction scenarios at typical bridge sites were performed for the pre-design seismic ground motion before the earthquake and the seismic ground motion during the earthquake.By combining these results with post-earthquake investigation results,the reason for the serious bridge damage resulting from this earthquake is revealed,and the necessary conditions for avoiding serious seismic damage to bridges built in liquefiable sites is presented.
基金accomplishment under the Scientific Research Fund Program of Renmin University of China (Project Approval No. 22XNQT12)。
文摘Putting the people first in human rights protection is the most distinctive feature of the outlook on human rights in contemporary China. The codification of the Civil Code of the People’s Republic of China reflects the people’s legislation for themselves, which is guided by the principle of putting the people first in its external system and internal values. Functionally, the Civil Code of the People’s Republic of China reflects the obligation of the country to protect human rights, constructs the framework relationship between the country and individual people, and perfects the mechanism for human rights protection. The continuous expansion of the types, contents, and functions of civil rights in the Civil Code of the People’s Republic of China is required by the broad scope of human rights, with an aim to realize a happy life for the people, the most important human rights, and protect people’s personal rights, property rights, and right to dignity through specific rules. The universal sharing of human rights requires the universality of the subjects of civil rights. The equal sharing of human rights requires the equality of forms of civil rights protection. Meanwhile, it further requires the substantive equality of civil rights protection. Attention is paid to protecting the rights and interests of specific groups in external and embedded ways.
