Solid dispersion is an established concept for drug solubility and bioavailability enhancement but strongly dependent on the choice of an appropriate carrier and preparation technique[1,2].Ternary solid dispersion is ...Solid dispersion is an established concept for drug solubility and bioavailability enhancement but strongly dependent on the choice of an appropriate carrier and preparation technique[1,2].Ternary solid dispersion is one of the promising methods to increase the solubility of poorly-water soluble drug.The present work was conducted to increase the solubility of manidipine hydrochloride(MDP)using ternary solid dispersion prepared by melting and then solidifying at low temperature.The effect of cooling technique on the physicochemical properties of the developed system was investigated.展开更多
Blood pressure(BP)plays an important role in the development and progression of cardiovascular disease.Moreover,hypertensive patients often have additional cardiovascular risk factors.Despite the abundance of antihype...Blood pressure(BP)plays an important role in the development and progression of cardiovascular disease.Moreover,hypertensive patients often have additional cardiovascular risk factors.Despite the abundance of antihypertensive drug categories,satisfactory BP regulation is often difficult to achieve.A major cause of this difficulty to properly manage BP is the less than optimal adherence of subjects to treatment.This is often due to the various adverse effects of the antihypertensive drugs.Calcium channel blockers(CCB)have an established efficacy for reducing BP.However,their side effect of peripheral edema is often a cause for the discontinuation of treatment.Manidipine holds some unique properties differentiating it from the rest of the CCB class.It has a better safety profile with a lower incidence of peripheral edema.Moreover,there are indications that manidipine holds additional beneficial attributes,such as improvement of renal function and decrease of insulin resistance.展开更多
文摘Solid dispersion is an established concept for drug solubility and bioavailability enhancement but strongly dependent on the choice of an appropriate carrier and preparation technique[1,2].Ternary solid dispersion is one of the promising methods to increase the solubility of poorly-water soluble drug.The present work was conducted to increase the solubility of manidipine hydrochloride(MDP)using ternary solid dispersion prepared by melting and then solidifying at low temperature.The effect of cooling technique on the physicochemical properties of the developed system was investigated.
文摘Blood pressure(BP)plays an important role in the development and progression of cardiovascular disease.Moreover,hypertensive patients often have additional cardiovascular risk factors.Despite the abundance of antihypertensive drug categories,satisfactory BP regulation is often difficult to achieve.A major cause of this difficulty to properly manage BP is the less than optimal adherence of subjects to treatment.This is often due to the various adverse effects of the antihypertensive drugs.Calcium channel blockers(CCB)have an established efficacy for reducing BP.However,their side effect of peripheral edema is often a cause for the discontinuation of treatment.Manidipine holds some unique properties differentiating it from the rest of the CCB class.It has a better safety profile with a lower incidence of peripheral edema.Moreover,there are indications that manidipine holds additional beneficial attributes,such as improvement of renal function and decrease of insulin resistance.
