Anti-IgE Induced 5-Hydroxy Tryptamine Release from Rat Peritoneal Mast Cells

Immediatehypersensitivityisrelatedwithcroslinkingofcel-boundIgEonthesurfaceofmastcelsandbasophils.Ratswereimmunizedwithovalbuminandtheperitonealmastcelswerecolectedfromimmunizedratsandchalengedwithrabitanti-ratIgEseruminvitro.The[3H]5-hydroxytryptaminereleaserateswereasayed.Theresultsshowedthekineticsandconcentration-responsecharacteristicsofserotoninreleasefromratmastcels.

ARIA指南2010版对抗组胺药物评价和使用建议

变应性鼻炎（AR）是耳鼻咽喉科临床常见的疾病,以清涕、喷嚏、鼻痒及鼻塞等作为主要症状,患病率可高达10%～20%。AR几乎均存在于各年龄阶段人群[1],患者深受疾病困扰,承担一定的生活、工作、经济及家庭等生理心理压力,并且有发展成为哮喘的风险。