Population stratification is a problem in genetic association studies because it is likely to highlight loci that underlie the population structure rather than disease-related loci. At present, principal component ana...Population stratification is a problem in genetic association studies because it is likely to highlight loci that underlie the population structure rather than disease-related loci. At present, principal component analysis （PCA） has been proven to be an effective way to correct for population stratification. However, the conventional PCA algorithm is time-consuming when dealing with large datasets. We developed a Graphic processing unit （GPU）-based PCA software named SHEsisPCA （http：//analysis.bio-x.cn/SHEsisMain.htm） that is highly parallel with a highest speedup greater than 100 compared with its CPU version. A cluster algorithm based on X-means was also implemented as a way to detect population subgroups and to obtain matched cases and controls in order to reduce the genomic inflation and increase the power. A study of both simulated and real datasets showed that SHEsisPCA ran at an extremely high speed while the accuracy was hardly reduced. Therefore, SHEsisPCA can help correct for population stratification much more efficiently than the conventional CPU-based algorithms.展开更多
基金supported by the National Key Basic Research Program of China (973 Program) (No. 2015CB559100)the National High Technology Research and Development Program of China (863 Program) (Nos. 2012AA02A515 and2012AA021802)+2 种基金the Natural Science Foundation of China (Nos. 31325014, 81130022, 81272302 and 81421061)the National Program for Support of Top-Notch Young Professionals, the Program of Shanghai Subject Chief Scientist (No. 15XD1502200)"Shu Guang" project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation (No. 12SG17)
文摘Population stratification is a problem in genetic association studies because it is likely to highlight loci that underlie the population structure rather than disease-related loci. At present, principal component analysis （PCA） has been proven to be an effective way to correct for population stratification. However, the conventional PCA algorithm is time-consuming when dealing with large datasets. We developed a Graphic processing unit （GPU）-based PCA software named SHEsisPCA （http：//analysis.bio-x.cn/SHEsisMain.htm） that is highly parallel with a highest speedup greater than 100 compared with its CPU version. A cluster algorithm based on X-means was also implemented as a way to detect population subgroups and to obtain matched cases and controls in order to reduce the genomic inflation and increase the power. A study of both simulated and real datasets showed that SHEsisPCA ran at an extremely high speed while the accuracy was hardly reduced. Therefore, SHEsisPCA can help correct for population stratification much more efficiently than the conventional CPU-based algorithms.
