The expression and clinical significance of relevant cytokines in otitis media (OM) are discussed, and the alterations to the pathological state of the otitis media mucosa are further understood through the study of c...The expression and clinical significance of relevant cytokines in otitis media (OM) are discussed, and the alterations to the pathological state of the otitis media mucosa are further understood through the study of cytokine transduction pathways. More and more studies have shown that relevant cell proliferation and inflammation progression pathways play a role in the development of otitis media, such as the Jun amino-terminal protein kinase (JNK) mitogen-activated protein kinase (MAPK) signaling pathway, the NF-κB signaling pathway, and the PI3K/AKT/PTEN pathway, which are involved in the proliferation of the middle ear mucosa during otitis media, which affects the mucosal cilia, motor function, Eustachian tube function, and the mucosal ciliary function. These studies provide new ideas for the treatment of otitis media and further explore the feasibility of immunotherapy in the future treatment of otitis media. In this paper, we present a review of the latest research progress on the expression of various cytokines in otitis media.展开更多
In Iran, the implementation of public transport and non-motorized transport infrastructure warrants the need to allocate adequate funding from the state and city hall. In this regard, in city hall development plans (t...In Iran, the implementation of public transport and non-motorized transport infrastructure warrants the need to allocate adequate funding from the state and city hall. In this regard, in city hall development plans (the format approved by the Ministry of Interior), urban transportation plan has been one of the ten chapters. The purpose of this paper is to survey the content and documents related to the allocation of funds to the traffic sector in the former development program of Kerman city hall and by the way, assess the role of human-oriented transportation among the plans and programs of Kerman city hall. Therefore, the amount of funds allocated to the transport sector in Kerman city hall development plans and programs has been investigated for a period of six years (2009-2014). Comparative analysis method is used for surveying the position and the importance of sustainable transport among planners and urban management. Kerman is the historical city and the most important city in the South East of Iran. Due to uncontrolled population growth in recent decades, a large number of cars added to its pathways, so it is required to have a plan of sustainable transportation programs to be evaluated traffic. Results of the analysis indicate that the budget allocated to the development of the vehicle-oriented transportation is much more than human-oriented transportation and in fact, human-oriented systems of transport such as walking and cycling are considered less than the others. Also in the old fabric of Kerman city that has formed on the basis of the human-oriented transportation, the lowest level of funding is intended to regulate transportation. With this description, it is clear that achieving sustainable development and human-oriented in urban transport sector, it fundamentally needs paradigm shift in urban transport development and revision in the attitudes of managers and planners, and in the meantime it is necessary to correct the programming cycle of urban development along with review of the allocating funds mechanism and to define projects in various sectors. Urban and transport planners can conduct municipalities projects with costing not too much and hereto provide non-motorized styles in the field of urban transport networks. If only allocated apart of the overall funding for roads, highways and city streets to the development of public transport and non-motorized transportation options, the impact would be very high.展开更多
Recently, there has been an increased interest in the use of social media data as important traffic information sources.In this paper, we review social media based transportation research with social network analysis ...Recently, there has been an increased interest in the use of social media data as important traffic information sources.In this paper, we review social media based transportation research with social network analysis methods. We summarize main research topics in this field, and report collaboration patterns at levels of researchers, institutions, and countries, respectively.Finally, some future research directions are identified.展开更多
The hydrodynamic dispersion is an important factor influencing the reactive solute transport in the porous media, and many previous studies assumed that it linearly varied with the average velocity of the groundwater ...The hydrodynamic dispersion is an important factor influencing the reactive solute transport in the porous media, and many previous studies assumed that it linearly varied with the average velocity of the groundwater flow. Actually, such linear relationship has been challenged by more and more experimental observations, even in homogeneous media. In this study, we aim to investigate the relationship between hydrodynamics dispersion and the flow velocity in different types of porous media through a laboratory-controlled experiment. The results indicate that (1) the dispersion coefficient should not be a linear function of the flow velocity when the relationship between the flow velocity and the hydraulic gradient can be described by Darcy's law satisfactorily;(2) Power function works well in describing the dispersion coefficient changing with the flow velocity for different types of porous media, and the power value is between 1.0-2.0 for different particle sizes.展开更多
Quasi-two-dimensional(quasi-2D)perovskites with high stability usually suffers from poor device efficiency.Chemical tuning of the spacer cations has been an effective strategy to achieve efficient and stable quasi-2D ...Quasi-two-dimensional(quasi-2D)perovskites with high stability usually suffers from poor device efficiency.Chemical tuning of the spacer cations has been an effective strategy to achieve efficient and stable quasi-2D perovskite solar cells.Here,we demonstrate that 3-halogon-substituted benzylammonium iodide(3X-BAI,X=F,Cl,Br,I)can significantly affect the orientation of low-dimensional perovskites and charge transport from perovskite to hole extraction layer,as well as device performance.With 3Br-BAI,we achieve the highest device efficiency of 13.21%for quasi-2D perovskites with a nominal n=3 average composition.Our work provides a facile approach to regulate vertical crystal orientation and charge transport via tuning the molecular structure of organic spacer toward high performance quasi-2D perovskite solar cells.展开更多
In this paper, we discuss the development of MPEG media transport （MMT）, which is a next-generation media transport standard effort by ISQ/MPEG. The architecture and functional areas of MMT are described. The functi...In this paper, we discuss the development of MPEG media transport （MMT）, which is a next-generation media transport standard effort by ISQ/MPEG. The architecture and functional areas of MMT are described. The functionality of existing media transport is analyzed to determine whether there is a need for this new media standard. From this analysis, potential areas for standardization in MMT have been identified.展开更多
Clay minerals can hinder the transport of various contaminants in soil and aquifer, but how clay minerals affect the transport of nanoparticles in aquifers has not been investigated in depth. In this paper, the transp...Clay minerals can hinder the transport of various contaminants in soil and aquifer, but how clay minerals affect the transport of nanoparticles in aquifers has not been investigated in depth. In this paper, the transport of surfactants dispersed multi-walled carbon nanotubes（MWCNTs） in welldefined quartz sand and mixtures of quartz sand and clay minerals（kaolinite and montmorillonite） with varying ionic strengths was studied. Sodium dodecyl benzenesulfonate（SDBS） and octyl-phenolethoxylate（TX100） MWCNT suspensions can migrate through quartz sand easily, but the presence of less than 2% w/w clay minerals in quartz sand can significantly hinder the transport of MWCNT suspensions, especially at high ion strength（0.6 m M CaCl2）. The inhibition mechanism of clay minerals for surfactant-dispersed MWCNTs in porous media is the interception of MWCNTs. Kaolinite has stronger inhibition effect for MWCNTs transport than montmorillonite because more kaolinite can be retained in the quartz sand. Adsorption of surfactants by clay minerals does not affect the transport of MWCNTs significantly. This finding is important for the environmental assessment of MWCNT transport risks in soils and aquifers.展开更多
The pressure evolution associated with the transient shock-induced infiltration of gas flow through granular media consisting of mobile particles is numerically investigated using a coupled Eulerian–Lagrangian approa...The pressure evolution associated with the transient shock-induced infiltration of gas flow through granular media consisting of mobile particles is numerically investigated using a coupled Eulerian–Lagrangian approach.The coupling between shock compaction and interstitial flow has been revealed.A distinctive two-stage diffusing pressure field with deflection occurring at the tail of the compaction front is found,with corresponding spikes in both gaseous velocity and temperature profiles emerging within the width of the compaction front.The compaction front,together with the deflection pressure,reaches a steady state during the later period.An analytical prediction of the steady deflection pressure that considers the contributions of porosity and the non-isothermal effect is proposed.The isothermal single-phase method we developed,combining the porosity jump condition across the compaction front,shows consistent pressure evolution with the non-isothermal CMP-PIC one under weak shock strength and low column permeability.Lastly,the microscale mechanism governing the formation of not only pressure deflection but also gaseous velocity and temperature spikes within the width of the compaction front has been described.These aforementioned evolutions of the flow field are shown to arise from the nozzling effects associated with the particle-scale variations in the volume fraction.展开更多
Gas flow in shales follows a number of physical mechanisms that include Knudsen diffusion,Darcy flow,and adsorption in the matrix and micro pores.The aim of the study is to resolve the interplay of gas transport in th...Gas flow in shales follows a number of physical mechanisms that include Knudsen diffusion,Darcy flow,and adsorption in the matrix and micro pores.The aim of the study is to resolve the interplay of gas transport in these media at increased effective stress as well as net pore pressure.In this research,we investigated the nature of gas transport in the matrix of shale by sending He,CH_(4)and CO_(2)gases through a transient upstream pressure pulse decay instrument.A series of experiments were conducted at constant pore pressures and a gradually increasing confining pressure.The same study was done in three different scenarios,injecting He,CO_(2)and CH_(4).At a constant pore pressure,gas permeability appears to decrease with an increasing confining pressure and effective stress.With increasing effective stress,the slip factor also decreases along with the permeability.The decrease in slip could be attributed to prestressing,that is likely to create new fractures.Among the three purged gases,permeability of shale to CH_(4)is the highest,and that to CO_(2)is the lowest owing to its high adsorption.Higher permeability of CH_(4)against He,could be attributed to the dual transport mechanism.展开更多
文摘The expression and clinical significance of relevant cytokines in otitis media (OM) are discussed, and the alterations to the pathological state of the otitis media mucosa are further understood through the study of cytokine transduction pathways. More and more studies have shown that relevant cell proliferation and inflammation progression pathways play a role in the development of otitis media, such as the Jun amino-terminal protein kinase (JNK) mitogen-activated protein kinase (MAPK) signaling pathway, the NF-κB signaling pathway, and the PI3K/AKT/PTEN pathway, which are involved in the proliferation of the middle ear mucosa during otitis media, which affects the mucosal cilia, motor function, Eustachian tube function, and the mucosal ciliary function. These studies provide new ideas for the treatment of otitis media and further explore the feasibility of immunotherapy in the future treatment of otitis media. In this paper, we present a review of the latest research progress on the expression of various cytokines in otitis media.
文摘In Iran, the implementation of public transport and non-motorized transport infrastructure warrants the need to allocate adequate funding from the state and city hall. In this regard, in city hall development plans (the format approved by the Ministry of Interior), urban transportation plan has been one of the ten chapters. The purpose of this paper is to survey the content and documents related to the allocation of funds to the traffic sector in the former development program of Kerman city hall and by the way, assess the role of human-oriented transportation among the plans and programs of Kerman city hall. Therefore, the amount of funds allocated to the transport sector in Kerman city hall development plans and programs has been investigated for a period of six years (2009-2014). Comparative analysis method is used for surveying the position and the importance of sustainable transport among planners and urban management. Kerman is the historical city and the most important city in the South East of Iran. Due to uncontrolled population growth in recent decades, a large number of cars added to its pathways, so it is required to have a plan of sustainable transportation programs to be evaluated traffic. Results of the analysis indicate that the budget allocated to the development of the vehicle-oriented transportation is much more than human-oriented transportation and in fact, human-oriented systems of transport such as walking and cycling are considered less than the others. Also in the old fabric of Kerman city that has formed on the basis of the human-oriented transportation, the lowest level of funding is intended to regulate transportation. With this description, it is clear that achieving sustainable development and human-oriented in urban transport sector, it fundamentally needs paradigm shift in urban transport development and revision in the attitudes of managers and planners, and in the meantime it is necessary to correct the programming cycle of urban development along with review of the allocating funds mechanism and to define projects in various sectors. Urban and transport planners can conduct municipalities projects with costing not too much and hereto provide non-motorized styles in the field of urban transport networks. If only allocated apart of the overall funding for roads, highways and city streets to the development of public transport and non-motorized transportation options, the impact would be very high.
基金partially supported by National Natural Science Foundation of China(61533019,71232006,61233001)the Early Career Development Award of SKLMCCS
文摘Recently, there has been an increased interest in the use of social media data as important traffic information sources.In this paper, we review social media based transportation research with social network analysis methods. We summarize main research topics in this field, and report collaboration patterns at levels of researchers, institutions, and countries, respectively.Finally, some future research directions are identified.
基金partially supported by the National Natural Science Foundation of China (Grant Nos. 41831289, 41877191, 41602256)
文摘The hydrodynamic dispersion is an important factor influencing the reactive solute transport in the porous media, and many previous studies assumed that it linearly varied with the average velocity of the groundwater flow. Actually, such linear relationship has been challenged by more and more experimental observations, even in homogeneous media. In this study, we aim to investigate the relationship between hydrodynamics dispersion and the flow velocity in different types of porous media through a laboratory-controlled experiment. The results indicate that (1) the dispersion coefficient should not be a linear function of the flow velocity when the relationship between the flow velocity and the hydraulic gradient can be described by Darcy's law satisfactorily;(2) Power function works well in describing the dispersion coefficient changing with the flow velocity for different types of porous media, and the power value is between 1.0-2.0 for different particle sizes.
基金supported financially by the National Natural Science Foundation of China(61974066,61961160733,62005223)the National Science Fund for Distinguished Young Scholars(61725502)+2 种基金the Major Program of Natural Science Research of Jiangsu Higher Education Institutions of China(18KJA510002)the Joint Research Funds of Department of Science&Technology of Shaanxi Province and Northwestern Polytechnical University(2020GXLH-Z-024)the Synergetic Innovation Center for Organic Electronics and Information Displays。
文摘Quasi-two-dimensional(quasi-2D)perovskites with high stability usually suffers from poor device efficiency.Chemical tuning of the spacer cations has been an effective strategy to achieve efficient and stable quasi-2D perovskite solar cells.Here,we demonstrate that 3-halogon-substituted benzylammonium iodide(3X-BAI,X=F,Cl,Br,I)can significantly affect the orientation of low-dimensional perovskites and charge transport from perovskite to hole extraction layer,as well as device performance.With 3Br-BAI,we achieve the highest device efficiency of 13.21%for quasi-2D perovskites with a nominal n=3 average composition.Our work provides a facile approach to regulate vertical crystal orientation and charge transport via tuning the molecular structure of organic spacer toward high performance quasi-2D perovskite solar cells.
文摘In this paper, we discuss the development of MPEG media transport （MMT）, which is a next-generation media transport standard effort by ISQ/MPEG. The architecture and functional areas of MMT are described. The functionality of existing media transport is analyzed to determine whether there is a need for this new media standard. From this analysis, potential areas for standardization in MMT have been identified.
基金supported by National Natural Science Foundation of China (41002088)Fundamental Research Project (SK201002,SK201502) of the Institute of Hydrogeology and Environmental Geology,Chinese Academy of Geological Sciences
文摘Clay minerals can hinder the transport of various contaminants in soil and aquifer, but how clay minerals affect the transport of nanoparticles in aquifers has not been investigated in depth. In this paper, the transport of surfactants dispersed multi-walled carbon nanotubes（MWCNTs） in welldefined quartz sand and mixtures of quartz sand and clay minerals（kaolinite and montmorillonite） with varying ionic strengths was studied. Sodium dodecyl benzenesulfonate（SDBS） and octyl-phenolethoxylate（TX100） MWCNT suspensions can migrate through quartz sand easily, but the presence of less than 2% w/w clay minerals in quartz sand can significantly hinder the transport of MWCNT suspensions, especially at high ion strength（0.6 m M CaCl2）. The inhibition mechanism of clay minerals for surfactant-dispersed MWCNTs in porous media is the interception of MWCNTs. Kaolinite has stronger inhibition effect for MWCNTs transport than montmorillonite because more kaolinite can be retained in the quartz sand. Adsorption of surfactants by clay minerals does not affect the transport of MWCNTs significantly. This finding is important for the environmental assessment of MWCNT transport risks in soils and aquifers.
基金Supported by ihe Major State Basic Research Development Program of China （973 Program） （2010CB428801, 2010CB428804） the National Science Foundation of China （40972166）+1 种基金 the Major Science and Technology Program for Water Pollution Control and Treatment （2009ZX07212-003） the Technology Development and Applications for Ecology System Reconstruction and Restoration of Yongding River （D08040903700000）
基金supported by National Natural Science Foundation of China(Grants No.11972088,No.12122203).
文摘The pressure evolution associated with the transient shock-induced infiltration of gas flow through granular media consisting of mobile particles is numerically investigated using a coupled Eulerian–Lagrangian approach.The coupling between shock compaction and interstitial flow has been revealed.A distinctive two-stage diffusing pressure field with deflection occurring at the tail of the compaction front is found,with corresponding spikes in both gaseous velocity and temperature profiles emerging within the width of the compaction front.The compaction front,together with the deflection pressure,reaches a steady state during the later period.An analytical prediction of the steady deflection pressure that considers the contributions of porosity and the non-isothermal effect is proposed.The isothermal single-phase method we developed,combining the porosity jump condition across the compaction front,shows consistent pressure evolution with the non-isothermal CMP-PIC one under weak shock strength and low column permeability.Lastly,the microscale mechanism governing the formation of not only pressure deflection but also gaseous velocity and temperature spikes within the width of the compaction front has been described.These aforementioned evolutions of the flow field are shown to arise from the nozzling effects associated with the particle-scale variations in the volume fraction.
文摘Gas flow in shales follows a number of physical mechanisms that include Knudsen diffusion,Darcy flow,and adsorption in the matrix and micro pores.The aim of the study is to resolve the interplay of gas transport in these media at increased effective stress as well as net pore pressure.In this research,we investigated the nature of gas transport in the matrix of shale by sending He,CH_(4)and CO_(2)gases through a transient upstream pressure pulse decay instrument.A series of experiments were conducted at constant pore pressures and a gradually increasing confining pressure.The same study was done in three different scenarios,injecting He,CO_(2)and CH_(4).At a constant pore pressure,gas permeability appears to decrease with an increasing confining pressure and effective stress.With increasing effective stress,the slip factor also decreases along with the permeability.The decrease in slip could be attributed to prestressing,that is likely to create new fractures.Among the three purged gases,permeability of shale to CH_(4)is the highest,and that to CO_(2)is the lowest owing to its high adsorption.Higher permeability of CH_(4)against He,could be attributed to the dual transport mechanism.
