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Future of the current anticoronaviral agents: A viewpoint on thevalidation for the next COVIDs and pandemics
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作者 AMGAD M.RABIE 《BIOCELL》 SCIE 2023年第10期2133-2139,共7页
Despite the global decline in the severity of the coronavirus disease 2019 (COVID-19) cases, the disease stillrepresents a major concern to the relevant scientific and medical communities. The primary concern of drug ... Despite the global decline in the severity of the coronavirus disease 2019 (COVID-19) cases, the disease stillrepresents a major concern to the relevant scientific and medical communities. The primary concern of drug scientists,virologists, and other concerned specialists in this respect is to find ready-to-use suitable and potent anticoronaviraltherapies that are broadly effective against the different species/strains of the coronaviruses in general, not only againstthe current and previous coronaviruses (e.g., the recently-appeared severe acute respiratory syndrome coronavirus 2“SARS-CoV-2”), i.e., effective antiviral agents for treatment and/or prophylaxis of any coronaviral infections, includingthose of the coming ones from the next species and strains (if any). As an expert in this field, I tried, in this up-to-dateperspective “viewpoint” article, to evaluate the suitability and applicability of using the currently-availableanticoronaviral agents for the next coronavirus diseases (COVIDs) and coronaviral pandemics, highlighting the mostimportant general guidelines that should be considered in the next pandemics from the therapeutic points of view. 展开更多
关键词 SARS-CoV-2/COVID-19 Spike(S)protein/Main protease(Mpro)/RNA-dependent RNA polymerase(RdRp) General anticoronaviral drug Specific anti-COVID-19 medication Molnupiravir/Nirmatrelvir/Riboprine/Ensitrelvir Drug design and development
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