The basic core traditional C hinese medicine for the prevention and treatment of COVID-19 and its active mechanisms

Background:COVID-19 has had a dramatic impact on human health,economies,societies,and livelihoods around the world.Traditional Chinese medicine(TCM)formulae have played an important role in the prevention and treatment of COVID-19.WHO evaluated the role of TCM in treating of COVID-19 and encouraged other countries to promote the use of TCM formulae.However,the key is to find the basic core traditional Chinese medicine(BC-TCM)among those formulae.Methods:For the first time,we mined the data of TCM formulae in CNIPA and analyzed herb characteristics and association rules.We then determined the BC-TCM and screened main compounds and therapeutic targets.Finally,the potential molecular mechanisms were explored by using enrichment analyses and molecular docking.Results:This study screened 123 patented TCM formulae,including 312 herbs.According to frequency statistics and association rules,nine herbs(Gan Cao,Jin Yinhua,Guang Huoxiang,Fu Ling,Huang Qi,Jie Geng,Lian Qiao,Cang Zhu,Ku Xingren)were selected as the BC-TCM.The BC-TCM involved 166 main compounds and 48 therapeutic targets.The active compounds Hederagenin,Spinasterol,Beta-sitosterol,and Liquiritin had high binding activity to the COVID-19 targets 3CL,ACE2,and core targets RELA,HSP90AA1,STAT3,MAPK3,and TP53 according to molecular docking results.Interestingly,Hederagenin might be a potential compound for the prevention and treatment of COVID-19.Conclusion:Our research predicted and confirmed the preventive therapeutic effect of BC-TCM on COVID-19.This has the potential to broaden the scope of TCM,guide people in using clinical formulae,and provide valuable insights for future TCM discovery research.

Clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema

To evaluate the clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema.Methods:One hundred and twenty patients with chronic eczema were randomly divided into an experimental group(60 cases)and a control group(60 cases).The experimental group was treated with skin acupuncture combined with external washing therapy,and the control group was treated with externally applied mometasone furoate cream.The patients’symptoms and total severity were scored and analyzed before and after the 4-week treatment.The symptoms scored included:erythema,papule/hard swelling,epidermal exfoliation,mossy lesion,exudation/scab,and pruritus.Clinical efficacy and adverse reactions were compared before and after the 4-week treatment.Results:Scores for the different kinds of skin derogation,pruritus symptoms,the eczema area,and severity index(EASI)were all reduced after the treatments.Pruritus symptoms and EASI scores in the experimental group were lower than those of the control group(P<0.05).The total effective rate in the experimental group was 81.03%,which was much higher than the 61.11%in the control group(Z=-2.391,P=0.017).Conclusion:The clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema was better than that of mometasone furoate cream.

Medicinal Characteristics of Jing Medicine

In the long process of living, working and fighting against diseases, the Jing people have formed a medical system with their own characteristics, which has made great contributions to the hygiene and health of the ethnic group and is still playing an important role today. As an indispensable part of Chinese traditional medicine system, Jingzu medicine has its own unique advantages and characteristics, which need to be further explored and sorted out. In this paper, the characteristics and advantages of Peking medicine were summarized from the characteristics of medicine use.

Effects of Medicated Bamboo Cupping Therapy of Zhuang Nationality Medicine on Long-term Efficacy and Quality of Life in the Treatment of Functional Dyspepsia with Stagnation of Liver Qi and Spleen Deficiency Syndrome

Objective:To investigate the effect of medicated bamboo cupping therapy of Zhuang nationality medicine on long-term efficacy and quality of life in the treatment of functional dyspepsia with stagnation of liver Qi and spleen deficiency syndrome,and to provide a new,effective and easy to promote treatment method for functional dyspepsia.Methods:A total of 150 cases of functional dyspepsia treated in our hospital from March 2014 to October 2015 were selected as research subjects,and they were divided into the treatment group(medicated bamboo cupping therapy),the control A group(Omeprazole Enteric-coated Tablets+Domperidone Tablets)and the control B group(acupuncture),50 cases in each group.The clinical efficacy,the gastric electrical index,the recurrence rate and the quality of life were observed and compared.Results:The total effective rate in the treatment group was higher than that in the control A group and the control B group(P<0.05).Compared with before treatment,the main frequency and electrical amplitude in each group was significantly improved,and the rhythm disorder coefficient was significantly reduced(P<0.05).After treatment,compared with the control A group and the control B group,the difference of rhythm disturbance coefficient in the treatment group was statistically significant(P<0.05).The recurrence rate in the treatment group was lower than that in the control A group and the control B group at 1 month,3 months and 6 months after drug discontinuance,with no significant difference(P>0.05).Compared with before treatment,scores of each physiological function after treatment had no significant change(P>0.05),and the scores of physiological function,body pain,general health,vitality,social function,emotional function and mental health were significantly improved(P<0.05).The comparison of scores in each group had no significant difference(P>0.05).Conclusion:The medicated bamboo cupping therapy of Zhuang nationality medicine on functional dyspepsia with stagnation of liver Qi and spleen deficiency syndrome can significantly improve clinical efficiency,and reduce the coefficient of rhythm.The long-term recurrence rate is low,and the quality of life is significantly improved.It is a convenient and effective treatment,which is worthy of promotion.

The Next Era:Flourish of National Health Care & Medicine with the World Leading Artificial Intelligence

MODERN medical diagnosis and practice heavily rely on biological data and information from patients’ body.The progress of biomedical sensor,material and mathematical technology provided ever-increasing methods to gather data.While providing more choices and more comprehensive picture of patients’ conditions to doctors and practitioners,these progresses also require more labor efforts to read,analyze,and make decisions based on those data.It is very difficult for the medical human resources to grow at a speed that matches such need for diagnosis-related expert knowledge.The shortage of expertise has caused long waiting time for check report and fatal misjudged diagnosis in public health system,and it will compromise our ability to move towards a more precise,more personalized and more efficient future of medicine.

Effects of China's National Essential Medicines Policy on the Use of Injection in Primary Health Facilities

The overuse of injection exists more than 20 years since economic reform in China.It is a persistent problem and seems becoming a new challenge in the new health reform period.This study was designed to assess the effect of national essential medicines policy(NEMP) on injection use at primary health facilities in China by investigating their prescription information.Questionnaires were designed and disseminated to collect empirical data on injection use at 120 primary health facilities in 6 provinces from January to September in 2010 and 2011.The injection use was measured as the indicator as the percentage of prescriptions with one or more injections.The results showed that the percentage of prescriptions with one or more injections was decreased from 38.91% to 36.82%(2 =11.158,P=0.001) in the all survey areas during the NEMP reform.The difference in level of the injection use in 2011 was significant among the eastern,central and western regions(2 =223.584,P=0.000);level of the injection use in western region was the lowest(27.73%),while that in the central region was the highest(43.10%).The level of the injection use in 2011 among different provinces was also of great difference(26.00%-58.25%,range:32.25%).The level of the injection use in 2011 was still much higher than the standard suggested by WHO for developing countries(13.4%-24.1%).It was concluded that NEMP has improved injection use in China,but the injection abuse situation remains serious,indicating that one of the priorities to the next stage of NEMP is to promote the rational use of drugs,especially the injection use.

运动是良医(Exercise is Medicine):运动促进健康的新理念——王正珍教授学术访谈录

面对科技进步、社会发展带来的生活方式转型与体力活动不足的现实困境,王正珍教授从医体结合有利于促进全民健身的视角入手,畅谈了体力活动与健康的关联、静坐少动与慢性疾病的关系、运动是良医(Exercise is Medicine)的理念、以及流行病学对体育科研的方法学启示等方面的内容,其相关论点对今后运动人体学科发展及体力活动与健康促进领域研究具有指导价值。

Problems faced by evidence-based medicine in evaluating lymphadenectomy for gastric cancer

Gastric cancer surgical management differs between Eastern Asia and Western countries. Extended lymphadenectomy (D2) is the standard of care in Japan and South Korea since decades, while the majority of United States patients receive at most a limited lymphadenectomy (D1). United States and Northern Europe are considered the scientific leaders in medicine and evidence-based procedures are the cornerstone of their clinical practice. However, surgeons in Eastern Asia are more experienced, as there are more new cases of gastric cancer in Japan (107898 in 2012) than in the entire European Union (81592), or in South Korea (31269) than in the entire United States (21155). For quite a long time evidence-based medicine (EBM) did not solve the question whether D2 improves long-term prognosis with respect to D1. Indeed, eastern surgeons were reluctant to perform D1 even in the frame of a clinical trial, as their patients had a very good prognosis after D2. Evidence-based surgical indications provided by Western trials were questioned, as surgical procedures could not be properly standardized. In the present study we analyzed indications about the optimal extension of lymphadenectomy in gastric cancer according to current scientific literature (2008-2012) and surgical guidelines. We searched PubMed for papers using the key words “lymphadenectomy or D1 or D2” AND “gastric cancer” from 2008 to 2012. Moreover, we reviewed national guidelines for gastric cancer management. The support to D2 lymphadenectomy increased progressively from 2008 to 2012: since 2010 papers supporting D2 have achieved a higher overall impact factor than the other papers. Till 2011, D2 was the procedure of choice according to experts’ opinion, while three meta-analyses found no survival advantage after D2 with respect to D1. In 2012-2013, however, two meta-analyses reported that D2 improves prognosis with respect to D1. D2 lymphadenectomy was proposed as the standard of care for advanced gastric cancer by Japanese National Guidelines since 1981 and was adopted as the standard procedure by the Italian Research Group for Gastric Cancer since the Nineties. D2 is now indicated as the standard of surgical treatment with curative intent by the German, British and ESMO-ESSO-ESTRO guidelines. At variance American NCCN guidelines recommend a D1+ or a modified D2 lymph node dissection. In conclusion, D2 lymphadenectomy, originally developed by Eastern surgeons, is now becoming the procedure of choice also in the West. In gastric cancer surgery EBM is lagging behind national guidelines, rather than preceding and orienting them. To eliminate this lag, EBM should value to a larger extent Eastern Asian literature and should evaluate not only the quality of the study design but also the quality of surgical procedures.

Data mining analysis of Professor Liu Shangyi＇s prescription characteristics in clinical medicine for the treatment of cancer patients with stomachache

Objective： To analyze National Chinese Medicine Master Liu Shangyi’s prescription characteristics of clinical medicinefor the treatment of cancer patients with stomachache. Methods： Data on prescriptions for cancer patients withstomachache between January 2014 and July 2016 were collected. The composing principles were analyzed byunsupervised data mining methods including Apriori algorithm in association rules and complex system entropy cluster.Results： Based on the analysis of 120 prescriptions, the frequency of each herb and association rules among the herbswere computed. Four core combinations and two new prescriptions were mined from the database. Compared to thebefore treatment, the clinical symptomatic grading of stomachache after treatment was lower （P 〈 0.001）. Conclusion：Professor Liu has been successful in the treatment of cancer patients with stomachache by prescribing medication thataids in activating blood circulation, removing dampness, and alleviating pain.

Teaching Reform and Practice of Traditional Chinese Medicine Course Based on National Standard and Ideological and Political Theories Teaching in All Courses

Under the new situation,how to integrate the ideological and political theories teaching in all courses for Chinese medicine major and meet the requirements of national standards for teaching quality,improve the training quality of Chinese medicine talents and strengthen the connotative development of Chinese medicine higher education are urgent issues to be solved in Chinese medicine colleges.This paper introduces the practical experience of teaching reform of traditional Chinese medicine courses based on national standards of teaching quality and ideological and political theories teaching in all courses from the aspects of curriculum setting,teaching content,teaching methods and teaching practice,which can provide reference for teaching reform of other professional courses based on national standards of teaching quality and ideological and political theories teaching in all courses.

Prevention of violence risk and interventions of Chinese and western medicine nursing on emotion

Accumulation of bad emotion with patients and their relations added violence risk.Workplace violence of nursing is an acute injury to nurse,and long-term threats and challenges to their physical and mental health and professional values. It also has an potential problem on parties negotiate the settlement of medical disputes,as well as boosting reform of national health system.Identifying and managing patients' emotion has positive impact on doubts and resentments elimination,anger escalation avoidance,violence prevention. This study proposed emotional intervention program in terms of traditional Chinese medicine and modern nursing care,which based on introducing the research status on nursing workplace violence. The purpose is to culture the ability of patients' self-identification and emotions regulation,take effective protective measure. The research provides the reference on perfecting the medical security system and related policy research.

Discussion on Ideological and Political Theories Teaching in Traditional Chinese Medicine Courses Based on National Standard for Teaching Quality

This paper analyzes the necessity and existing problems of ideological and political theories teaching in traditional Chinese medicine courses,and puts forward some suggestions,such as improving the ideological and political ability of professional teachers,perfecting the evaluation mechanism,and exploring ideological and political elements based on the characteristics of courses,so as to provide the basis for ideological and political theories teaching in traditional Chinese medicine courses under the National Standard for Teaching Quality.

Study on the development of Yunnan national medicine nursing based on the development model of cultural ecosphere

National medicine nursing is a valuable resource of health industry in Yunnan Province,which provides important support for the strategy strengthening the province with traditional Chinese medicine.The development of National medicine nursing is influenced by multiple factors.Based on the development model of cultural ecosphere,this paper analysed its development trend and put forward some suggestions for promoting its development.

The embryonic period of ethnic medicine in Xinjiang

The industrious and brave Uyghurs have lived in the western regions for generations,creating and developing western region medicine while developing production.The original medical treatment originated from the self-protection of primitive humans.Early interactions with nature led to a spontaneous search for medicines and techniques and the realization that some plants could cure diseases,such as massage,pinching,kneading,rubbing,bone setting,and simple surgery.During this period,superstition and sorcery were also accompanied in the process of curing diseases.This is also the medical activity of the farming and nomadic peoples in Central Asia’s hinterland before the opening of the silk road.

Herbal Medicine Belongs to Not Only the Nationality, But Also the World

On the view point of herb research in the world traditional medicines, Digeda is used to vary the plants originated from different species and families, such as India Digeda （Hurghada） is Swertie chirayita （Buch. -Ham.）, Nepal Digeda （Hurghada） is Swertia cliete. Tibetan Digeda （Geda） are Saxifrage umbellulate Hook. f. ＆Thoms. and 5axifraga umbelluleta Hook. f. ＆Thoms. var. pectinata （C. Marq. ＆ Airy-Shaw） J. T. Pan. Alatan Digeda （Hurghada） is Saxifrage unguiculata Engl. Menken Digeda （Hurghada） now differs greatly. In Mongolia, Mongolian doctors use Parnassia palustris as the Digeda; Gisborne to Hurghada （Sandinista） are Swertia erythrosticta and Gentiana Ioureirii. Temuco uses Swertia pseudochineis as Digeda （Baghdad）. In Inner Mongolia Autonomous Region of China, Mongolian medicine Digeda is mainly originated from the three kinds of medicinal plants in Gentianaceae, Swertie pseudochinensis Hara, Gentianopsis barbata Froel Ma, and Lomatogonium rotetwn （L.） Friesex Nym. Additionally, in Inner Mongolia and Tibetan Autonomous Regions of China, the used Digeda is different from Inner Mongolia fork Medicine, Parnassia palustris and P. orepohila, Tibetan fork medicine is different from G. gilvostriata Flat Lei, G. barbara and G. paludosa. Halenia sibirica is recorded in Inner Mongolian Medicine 5tanderds. Therefore, herbal medicine Digede belongs to not only the nationality, but also the world.

Correlation between haplotype of apolipoprotein B gene and natural longevity persons in Uygur Nationality

CAMS&PUMC, Beijing 100005, China; 3 Medical Genetic Laboratory, Institute of Basic Medical Science, CAMS&PUMC, Kunming 650118, ChinaThis paper investigated the correlation between polymorphisms and haplotypes in the apolipoprotein B (apoB) gene (SP-I/D, XbaI-RFLP, VNTR) and natural longevity persons among the Uygur people in Xin-jiang. For this purpose, 191 healthy Uygur individuals aged above 90 from Hetian area of Xinjiang were recruited, and another 53 persons aged 65—70 from the same nationality, the same region and with the same gender ratio, served as the control group. Genotyping was performed by PCR-SSP, PCR-RFLP and PCR-sequencing methods. Logistic regression analyses revealed that the frequencies of X+X+ genotype, M and L alleles and the genetypes composed of M and L were significantly higher in the longevity group than in the control group. In haplotype analyses, we found that, in the long-lived people, the frequency of haplotypes composed of the X+ and M alleles was significantly higher whereas the frequency of haplotypes composed of the X- and S alleles was significantly lower (both P<0.05) I than those of their controls. These results indicated that the S allele, SS genotype and X+-S, D-S, D-X+-S haplotypes were the possible adverse factors, whereas the M, L alleles, X+X+, MM, ML, LL genotypes and I-X+-M, X+-M haplotypes were the possibe protective factors for the naturally long-lived Uygur people in China.

国医大师熊继柏治疗失眠的方药规律分析

目的对国医大师熊继柏教授治疗失眠的病案进行数据挖掘,分析熊继柏教授诊治失眠的用方、用药经验。方法基于中医传承辅助平台软件(V3.5),归纳和分析熊继柏教授在湖南中医药大学第一附属医院治疗失眠患者的门诊病历数据,利用该平台软件的关联规则、复杂系统熵聚类等统计方法进行数据挖掘和分析,总结药物的性味、归经、应用频次、药对组合及合方,对“证-症-方”“证-症-药”“证-方-药”进行关联,结合熊继柏教授对失眠病因病机、治则治法的认识,明确核心用药,探索其对失眠的诊治规律及遣方用药心得。结果通过总结分析,共纳入病历276份,处方中用药频次较多的有酸枣仁、龙齿、茯神、甘草,重在补虚安神;黄连、陈皮、竹茹、半夏、珍珠母、远志,重在清热化痰安神。用药性味偏甘、苦、辛,归经多为心、脾经。并归纳出虚证治疗常用合方为酸枣仁汤、枕中丹和甘麦大枣汤;因痰所致失眠治疗的主方为温胆汤及温胆汤类方(枣仁温胆汤、黄连温胆汤及十味温胆汤)。结论国医大师熊继柏治疗失眠以“补脾化痰清热,养血补肝宁心”为治疗原则,以温胆汤为基础进行加减化裁。