AIM To evaluate the long-term effectiveness and late toxicities of paclitaxel(PTX) plus cisplatin(DDP) with concurrent radiotherapy for locally advanced esophageal squamous cancer.METHODS Between 2008 and 2011, 76 pat...AIM To evaluate the long-term effectiveness and late toxicities of paclitaxel(PTX) plus cisplatin(DDP) with concurrent radiotherapy for locally advanced esophageal squamous cancer.METHODS Between 2008 and 2011, 76 patients were enrolled in a phase Ⅱ study on the treatment of loco-regionally advanced esophageal cancer with radiotherapy(68.4 Gy/44 fractions or 61.2 Gy/34 fractions) combined with 4-cycle chemotherapy consisting of DDP(25 mg/m^2 per day for 3 d) and PTX(175 mg/m^2 for 3 h). The primary endpoints were overall survival and progression-free survival, and the secondary endpoints were toxicity and the treatment failure pattern.RESULTS A total of 76 patients were enrolled in this study, of whom 63.2% finished the whole regimen. The 5-year survival rates for the per-protocol population and intent-to-treat population were 25.4% and 26.4%, respectively, and the median survival rates were 23.7 mo and 28.5 mo, respectively. Grade 3 or 4 late toxicity was observed in only one patient(heart failure). In log-rank analysis, the pretreatment stage(stage Ⅱ + Ⅲ: 36.1 mo vs stage Ⅳ: 14.9 mo) and the completed cycle(1-3 cycles: 16.1 mo vs 4 cycles: 35.5 mo) were significant prognostic factors(P = 0.037 < 0.05 and P = 0.013 < 0.05).CONCLUSION Radiotherapy combined with chemotherapy consisting of PTX and DDP is a safe and effective definitive treatment for loco-regionally advanced esophageal squamous cancer.展开更多
BACKGROUND: The feasibility and immediate outcome of laparoscopic fenestration for patients with congenital liver cysts have been generally recognized. The aim of the present study was to assess the long-term results ...BACKGROUND: The feasibility and immediate outcome of laparoscopic fenestration for patients with congenital liver cysts have been generally recognized. The aim of the present study was to assess the long-term results after laparoscopic fenestration. METHODS: A retrospective study was performed on 44 patients with congenital liver cysts who had undergone laparoscopic fenestration between June 1998 and December 2004. Among them, 30 were women and 14 men, aged 57 years on average (range 18-76 years). While 14 patients had solitary cysts, 20 had multiple cysts, and 10 had polycystic liver disease. The results of laparoscopic fenestration, including mortality, morbidity, mean postoperative hospital stay, and recurrences of cysts were evaluated. RESULTS: There was no perioperative death and the morbidity rate was 11% (5/44). All complications were treated conservatively. The mean postoperative hospital stay was 4 days. A mean follow-up of 57 months showed that the rates of cyst recurrence and symptom recurrence were 9% and 4.5%, respectively. CONCLUSION: Laparoscopic fenestration as a feasible and safe treatment procedure for patients with congenital liver cysts can yield very good long-term results.展开更多
This paper summarized the long-term follow-up results and our clinical treatment experience of 426 patients with carcinoma of salivary gland, who had undergone surgical treatment in our department from 1957 to 1976 su...This paper summarized the long-term follow-up results and our clinical treatment experience of 426 patients with carcinoma of salivary gland, who had undergone surgical treatment in our department from 1957 to 1976 successively. Our study showed that the 10-year and 15-year survival rates were 63.3% and 59.1% respectively, much higher than the results presented by other researchers. The following four points were concluded: 1. The long-term treatment result of salivary gland carcinoma is determined not only on mode of treatment and clinical stage, but more on its pathologic type. For high malignant salivary carcinoma, comprehensive multidiscipline treatments should be adopted. 2. Management of primary focus." The different operative principle and mode shouht be worked out in advance according to pathologic type and primary site of tumors. 3. Management of lymphonode: For cases with undifferentiated carcinoma, low-differentiated mucoepiderrnoid carcinoma, squamous cell carcinoma, adenocarcinoma and papillary cystadenocarcinoma, elective neck dissection should be performed. 4. Prevention of distant metastasis: Preoperative biopsy should be avoided. Frozen-section should be made during the operation and, diagnosis and treatment be accomplished in the meantime.展开更多
A new common phrase scoring method is proposed according to term frequency-inverse document frequency （TFIDF） and independence of the phrase. Combining the two properties can help identify more reasonable common phr...A new common phrase scoring method is proposed according to term frequency-inverse document frequency （TFIDF） and independence of the phrase. Combining the two properties can help identify more reasonable common phrases, which improve the accuracy of clustering. Also, the equation to measure the in-dependence of a phrase is proposed in this paper. The new algorithm which improves suffix tree clustering algorithm （STC） is named as improved suffix tree clustering （ISTC）. To validate the proposed algorithm, a prototype system is implemented and used to cluster several groups of web search results obtained from Google search engine. Experimental results show that the improved algorithm offers higher accuracy than traditional suffix tree clustering.展开更多
Generally speaking,confluence property is not preserved when Term Rewriting Systems(TRSs) are combined,even if they are canonical.In this paper we give some sufficient conditions for ensuring the confluence property o...Generally speaking,confluence property is not preserved when Term Rewriting Systems(TRSs) are combined,even if they are canonical.In this paper we give some sufficient conditions for ensuring the confluence property of combined left-linear,overlapping TRSs.展开更多
基金Supported by National Natural Science Foundation of China,No.21172043 and No.21441010
文摘AIM To evaluate the long-term effectiveness and late toxicities of paclitaxel(PTX) plus cisplatin(DDP) with concurrent radiotherapy for locally advanced esophageal squamous cancer.METHODS Between 2008 and 2011, 76 patients were enrolled in a phase Ⅱ study on the treatment of loco-regionally advanced esophageal cancer with radiotherapy(68.4 Gy/44 fractions or 61.2 Gy/34 fractions) combined with 4-cycle chemotherapy consisting of DDP(25 mg/m^2 per day for 3 d) and PTX(175 mg/m^2 for 3 h). The primary endpoints were overall survival and progression-free survival, and the secondary endpoints were toxicity and the treatment failure pattern.RESULTS A total of 76 patients were enrolled in this study, of whom 63.2% finished the whole regimen. The 5-year survival rates for the per-protocol population and intent-to-treat population were 25.4% and 26.4%, respectively, and the median survival rates were 23.7 mo and 28.5 mo, respectively. Grade 3 or 4 late toxicity was observed in only one patient(heart failure). In log-rank analysis, the pretreatment stage(stage Ⅱ + Ⅲ: 36.1 mo vs stage Ⅳ: 14.9 mo) and the completed cycle(1-3 cycles: 16.1 mo vs 4 cycles: 35.5 mo) were significant prognostic factors(P = 0.037 < 0.05 and P = 0.013 < 0.05).CONCLUSION Radiotherapy combined with chemotherapy consisting of PTX and DDP is a safe and effective definitive treatment for loco-regionally advanced esophageal squamous cancer.
文摘BACKGROUND: The feasibility and immediate outcome of laparoscopic fenestration for patients with congenital liver cysts have been generally recognized. The aim of the present study was to assess the long-term results after laparoscopic fenestration. METHODS: A retrospective study was performed on 44 patients with congenital liver cysts who had undergone laparoscopic fenestration between June 1998 and December 2004. Among them, 30 were women and 14 men, aged 57 years on average (range 18-76 years). While 14 patients had solitary cysts, 20 had multiple cysts, and 10 had polycystic liver disease. The results of laparoscopic fenestration, including mortality, morbidity, mean postoperative hospital stay, and recurrences of cysts were evaluated. RESULTS: There was no perioperative death and the morbidity rate was 11% (5/44). All complications were treated conservatively. The mean postoperative hospital stay was 4 days. A mean follow-up of 57 months showed that the rates of cyst recurrence and symptom recurrence were 9% and 4.5%, respectively. CONCLUSION: Laparoscopic fenestration as a feasible and safe treatment procedure for patients with congenital liver cysts can yield very good long-term results.
文摘This paper summarized the long-term follow-up results and our clinical treatment experience of 426 patients with carcinoma of salivary gland, who had undergone surgical treatment in our department from 1957 to 1976 successively. Our study showed that the 10-year and 15-year survival rates were 63.3% and 59.1% respectively, much higher than the results presented by other researchers. The following four points were concluded: 1. The long-term treatment result of salivary gland carcinoma is determined not only on mode of treatment and clinical stage, but more on its pathologic type. For high malignant salivary carcinoma, comprehensive multidiscipline treatments should be adopted. 2. Management of primary focus." The different operative principle and mode shouht be worked out in advance according to pathologic type and primary site of tumors. 3. Management of lymphonode: For cases with undifferentiated carcinoma, low-differentiated mucoepiderrnoid carcinoma, squamous cell carcinoma, adenocarcinoma and papillary cystadenocarcinoma, elective neck dissection should be performed. 4. Prevention of distant metastasis: Preoperative biopsy should be avoided. Frozen-section should be made during the operation and, diagnosis and treatment be accomplished in the meantime.
基金Foundation item: Supported by the National Natural Science Foundation of China (60503020, 60503033, 60703086)Opening Foundation of Jiangsu Key Laboratory of Computer Information Processing Technology in Soochow Uni-versity (KJS0714)+1 种基金Research Foundation of Nanjing University of Posts and Telecommunications (NY207052, NY207082)National Natural Science Foundation of Jiangsu (BK2006094).
文摘A new common phrase scoring method is proposed according to term frequency-inverse document frequency （TFIDF） and independence of the phrase. Combining the two properties can help identify more reasonable common phrases, which improve the accuracy of clustering. Also, the equation to measure the in-dependence of a phrase is proposed in this paper. The new algorithm which improves suffix tree clustering algorithm （STC） is named as improved suffix tree clustering （ISTC）. To validate the proposed algorithm, a prototype system is implemented and used to cluster several groups of web search results obtained from Google search engine. Experimental results show that the improved algorithm offers higher accuracy than traditional suffix tree clustering.
基金This work was supported partly by The National Science FoundationThe Ministry of Electronic Industries and High Technology Program under The National Commission of Science & Technology.
文摘Generally speaking,confluence property is not preserved when Term Rewriting Systems(TRSs) are combined,even if they are canonical.In this paper we give some sufficient conditions for ensuring the confluence property of combined left-linear,overlapping TRSs.
