To analyze the age of menarche of Chinese reproductive women and some related factors. Material & Methods The data used in this paper was collected through 'National Demography and Reproductive Health Survey...To analyze the age of menarche of Chinese reproductive women and some related factors. Material & Methods The data used in this paper was collected through 'National Demography and Reproductive Health Survey' of China in 1997. Results The menarche age declined successively and dramatically, from 16.45 years of the women born in 1947～1949 to 13.86 of those born in 1980～1982, decreasing by 0.65 years per decade. Conclusions The results revealed that some factors such as residence, year of birth, nationality, education level and living region had effects on the menarche age.展开更多
Lean body mass （LBM） and age at menarche （AAM） are two important complex traits for human health. The aim of this study was to identify pleiotropic genes for both traits using a powerful bivariate genome-wide asso...Lean body mass （LBM） and age at menarche （AAM） are two important complex traits for human health. The aim of this study was to identify pleiotropic genes for both traits using a powerful bivariate genome-wide association study （GWAS）. Two stud- ies, a discovery study and a replication study, were performed. In the discovery study, 909622 single nucleotide polymor- phisms （SNPs） were genotyped in 801 unrelated female Han Chinese subjects using the Affymetrix human genome-wide SNP array 6.0 platform. Then, a bivariate GWAS was performed to identify the SNPs that may be important for LBM and AAM. In the replication study, significant findings from the discovery study were validated in 1692 unrelated Caucasian female subjects One SNP rs3027009 that was bivafiately associated with left arm lean mass and AAM in the discovery samples （P=7.26x10-6） and in the replication samples （P=0.005） was identified. The SNP is located at the upstream of DARC （Duffy antigen receptor for chemokines） gene, suggesting that DARC may play an important role in regulating the metabolisms of both LBM and AAM.展开更多
文摘To analyze the age of menarche of Chinese reproductive women and some related factors. Material & Methods The data used in this paper was collected through 'National Demography and Reproductive Health Survey' of China in 1997. Results The menarche age declined successively and dramatically, from 16.45 years of the women born in 1947～1949 to 13.86 of those born in 1980～1982, decreasing by 0.65 years per decade. Conclusions The results revealed that some factors such as residence, year of birth, nationality, education level and living region had effects on the menarche age.
基金supported by the Shanghai Leading Academic Discipline Project(Grant No.S30501)a start-up fund from the Shanghai University of Science and Technology,China+1 种基金supported by grants from National Institutes of Health(Grant Nos.P50AR055081, R01AG026564,R01AR050496,RC2DE020756,R01AR057049,and R03TW008221)supported by the National Natural Science Foundation of China(Grant No.31100902)
文摘Lean body mass （LBM） and age at menarche （AAM） are two important complex traits for human health. The aim of this study was to identify pleiotropic genes for both traits using a powerful bivariate genome-wide association study （GWAS）. Two stud- ies, a discovery study and a replication study, were performed. In the discovery study, 909622 single nucleotide polymor- phisms （SNPs） were genotyped in 801 unrelated female Han Chinese subjects using the Affymetrix human genome-wide SNP array 6.0 platform. Then, a bivariate GWAS was performed to identify the SNPs that may be important for LBM and AAM. In the replication study, significant findings from the discovery study were validated in 1692 unrelated Caucasian female subjects One SNP rs3027009 that was bivafiately associated with left arm lean mass and AAM in the discovery samples （P=7.26x10-6） and in the replication samples （P=0.005） was identified. The SNP is located at the upstream of DARC （Duffy antigen receptor for chemokines） gene, suggesting that DARC may play an important role in regulating the metabolisms of both LBM and AAM.
