AIM To assess the relationship of brain-derived neurotrophic factor(BDNF) with cognitive impairment in patients with type 2 diabetes. METHODS The study included 40 patients with diabetes mellitus type 2(DM2), 37 patie...AIM To assess the relationship of brain-derived neurotrophic factor(BDNF) with cognitive impairment in patients with type 2 diabetes. METHODS The study included 40 patients with diabetes mellitus type 2(DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy(HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive impairment.RESULTS The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment. The levels of BDNF showed significant differences between patients with DM2(43.78 ± 9.05 vs 31.55 ± 10.24, P = 0.005). There were no differences between patients in HD(11.39 ± 8.87 vs 11.11 ± 10.64 P = 0.77); interestingly, ferritin levels were higher in patients with cognitive impairment(1564 ± 1335 vs 664 ± 484 P = 0.001). The comparison of BDNF values, using a Kruskal Wallis test, between patients with DM2, in HD and healthy controls showed statistical differences(P < 0.001).CONCLUSION Low levels of BDNF are associated with cognitive impairment in patients with DM2. The decrease of BDNF occurs early and progressively in patients in HD.展开更多
Objective: To evaluate the association between type 2 diabetes mellitus and the reduction of mandibular residual ridge in completely edentulous patients wearing complete dentures and to investigate the ef-fect of gend...Objective: To evaluate the association between type 2 diabetes mellitus and the reduction of mandibular residual ridge in completely edentulous patients wearing complete dentures and to investigate the ef-fect of gender, age and years of edentulousness / den-ture wearing on ridge resorption on both groups. Methods: Seventy-two (36 men and 36 women) with a mean age 63.5 years (range of 52 to 73 years) com-pletely edentulous denture-wearing patients were included in this study. Of these, there were 40 patients with type 2 diabetes mellitus and 32 control subjects participated in the study. Resorption in the mandibular residual ridges was assessed by using the mental foramen and the inferior border of the mandible, as they appear in panoramic radiographs, as reference points using Wical and Swoope Analysis method. Measurements were performed using “Dijite” Digital Caliper. The amount of mandibular ridge resorption was calculated and correlated with type 2 diabetes mellitus and the results were compared with control group. Differences in gender, age and years of edentulousness were investigated. Statistical analysis was performed using SPSS (V11.0). A 2-sample t-test was used to evaluate the differences in mean values of mandibular ridge resorption between diabetics and controls. Level of significance was set at 0.05. Results: The mean mandibular residual ridge resorption of all participants is 8.0 mm (26.9%), diabetic group significantly (P < 0.01) had two times more resorption compared with control group (35.8% versus 18.0%). Females recorded greater amount of resorption in diabetics 49.7% versus 21.8% (P < 0.001) and in controls 22.3% versus 13.7%, (P < 0.05) compared to males, respectively. There were no differences in both groups regarding the age of subjects and the length of time they have been edentulous and years of denture wearing. The amount of mandibular residual ridge resorption was directly related to the number of years of edentulousness. Conclusion: Completely edentulous, denture-wearing diabetics, women in particular, are at more risk to have ridge resorption than “nondiabetic” subjects. Reduced mandibular height is directly related to years of edentulousness and denture wear-ing with greater amount of resorption among diabet-ics.展开更多
Objectives To evaluate peripheral auditory dysfunction in senile dementia of Alzheimer’s disease (AD) and its relationship with cognitive dysfunction. Methods Pure tone thresholds,word recognition scores (WRS), acous...Objectives To evaluate peripheral auditory dysfunction in senile dementia of Alzheimer’s disease (AD) and its relationship with cognitive dysfunction. Methods Pure tone thresholds,word recognition scores (WRS), acoustic immittance and auditory brain-stem responses (ABR) were tested to evaluate the auditory function in 43 AD patients and 50 normal subjects. The test reliability in these subjects was examined before the test results were evaluated for their correlation with the Mini Mental State Examination(MMSE) score. Results There were no statistically significant differences in peripheral auditory functions between the two ears in the tested subjects or between the two groups when the auditometric results of the right ear were compared(P > 0.05). Also, there were no statistically significant differences between the two groups when audiometric test reliability, acoustic impedance and ABR results were compared(P > 0.05). Conclutions The pure tone audiometric threshold and WRS in AD patients are similar to those in comparable non-AD senile subjects. Peripheral auditory dysfunction is not related to cognitive dysfunction.展开更多
目的是揭示大学生心理类型的状况与特点。方法是以MBT(IMyers-Briggs Type Indicator)量表对我国346名大学生进行团体纸笔测验。结果:1)我国当代大学生最突出的、比例最高、人数最多的心理类型是ISTJ(内向感觉思维判断型,占15.6%),比例...目的是揭示大学生心理类型的状况与特点。方法是以MBT(IMyers-Briggs Type Indicator)量表对我国346名大学生进行团体纸笔测验。结果:1)我国当代大学生最突出的、比例最高、人数最多的心理类型是ISTJ(内向感觉思维判断型,占15.6%),比例最低、人数最少的心理类型为ISTP(内向感觉思维知觉型,占1.4%)。2)外向型(占56%)的大学生高于内向型(占44%)的大学生;感觉型(占27.7%)的大学生高于直觉型(21.9%)的大学生;思维型(占32.2%)的大学生要远多于情感型(占17.2%)的大学生;判断型大学生的比例(占49.4%)与知觉型的大学生的比例(50.6%)非常接近。3)影响心理类型的自变量的重要程度由强到弱分别依次是专业、民族、年级、生源,性别的影响程度很小,政治身份对心理类型产生负面影响。4)虽然专业、民族、年级、生源、性别、政治身份对心理类型的影响没有统计上的显著差异,但还是各具特点。结论:大学生心理类型最多的是ISTI、ESTJ,最少的是ISTP。展开更多
文摘AIM To assess the relationship of brain-derived neurotrophic factor(BDNF) with cognitive impairment in patients with type 2 diabetes. METHODS The study included 40 patients with diabetes mellitus type 2(DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy(HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive impairment.RESULTS The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment. The levels of BDNF showed significant differences between patients with DM2(43.78 ± 9.05 vs 31.55 ± 10.24, P = 0.005). There were no differences between patients in HD(11.39 ± 8.87 vs 11.11 ± 10.64 P = 0.77); interestingly, ferritin levels were higher in patients with cognitive impairment(1564 ± 1335 vs 664 ± 484 P = 0.001). The comparison of BDNF values, using a Kruskal Wallis test, between patients with DM2, in HD and healthy controls showed statistical differences(P < 0.001).CONCLUSION Low levels of BDNF are associated with cognitive impairment in patients with DM2. The decrease of BDNF occurs early and progressively in patients in HD.
文摘Objective: To evaluate the association between type 2 diabetes mellitus and the reduction of mandibular residual ridge in completely edentulous patients wearing complete dentures and to investigate the ef-fect of gender, age and years of edentulousness / den-ture wearing on ridge resorption on both groups. Methods: Seventy-two (36 men and 36 women) with a mean age 63.5 years (range of 52 to 73 years) com-pletely edentulous denture-wearing patients were included in this study. Of these, there were 40 patients with type 2 diabetes mellitus and 32 control subjects participated in the study. Resorption in the mandibular residual ridges was assessed by using the mental foramen and the inferior border of the mandible, as they appear in panoramic radiographs, as reference points using Wical and Swoope Analysis method. Measurements were performed using “Dijite” Digital Caliper. The amount of mandibular ridge resorption was calculated and correlated with type 2 diabetes mellitus and the results were compared with control group. Differences in gender, age and years of edentulousness were investigated. Statistical analysis was performed using SPSS (V11.0). A 2-sample t-test was used to evaluate the differences in mean values of mandibular ridge resorption between diabetics and controls. Level of significance was set at 0.05. Results: The mean mandibular residual ridge resorption of all participants is 8.0 mm (26.9%), diabetic group significantly (P < 0.01) had two times more resorption compared with control group (35.8% versus 18.0%). Females recorded greater amount of resorption in diabetics 49.7% versus 21.8% (P < 0.001) and in controls 22.3% versus 13.7%, (P < 0.05) compared to males, respectively. There were no differences in both groups regarding the age of subjects and the length of time they have been edentulous and years of denture wearing. The amount of mandibular residual ridge resorption was directly related to the number of years of edentulousness. Conclusion: Completely edentulous, denture-wearing diabetics, women in particular, are at more risk to have ridge resorption than “nondiabetic” subjects. Reduced mandibular height is directly related to years of edentulousness and denture wear-ing with greater amount of resorption among diabet-ics.
基金Beijing Brain Aging Key Laboratory Foundation (951890600)
文摘Objectives To evaluate peripheral auditory dysfunction in senile dementia of Alzheimer’s disease (AD) and its relationship with cognitive dysfunction. Methods Pure tone thresholds,word recognition scores (WRS), acoustic immittance and auditory brain-stem responses (ABR) were tested to evaluate the auditory function in 43 AD patients and 50 normal subjects. The test reliability in these subjects was examined before the test results were evaluated for their correlation with the Mini Mental State Examination(MMSE) score. Results There were no statistically significant differences in peripheral auditory functions between the two ears in the tested subjects or between the two groups when the auditometric results of the right ear were compared(P > 0.05). Also, there were no statistically significant differences between the two groups when audiometric test reliability, acoustic impedance and ABR results were compared(P > 0.05). Conclutions The pure tone audiometric threshold and WRS in AD patients are similar to those in comparable non-AD senile subjects. Peripheral auditory dysfunction is not related to cognitive dysfunction.
文摘目的是揭示大学生心理类型的状况与特点。方法是以MBT(IMyers-Briggs Type Indicator)量表对我国346名大学生进行团体纸笔测验。结果:1)我国当代大学生最突出的、比例最高、人数最多的心理类型是ISTJ(内向感觉思维判断型,占15.6%),比例最低、人数最少的心理类型为ISTP(内向感觉思维知觉型,占1.4%)。2)外向型(占56%)的大学生高于内向型(占44%)的大学生;感觉型(占27.7%)的大学生高于直觉型(21.9%)的大学生;思维型(占32.2%)的大学生要远多于情感型(占17.2%)的大学生;判断型大学生的比例(占49.4%)与知觉型的大学生的比例(50.6%)非常接近。3)影响心理类型的自变量的重要程度由强到弱分别依次是专业、民族、年级、生源,性别的影响程度很小,政治身份对心理类型产生负面影响。4)虽然专业、民族、年级、生源、性别、政治身份对心理类型的影响没有统计上的显著差异,但还是各具特点。结论:大学生心理类型最多的是ISTI、ESTJ,最少的是ISTP。
