AIM To evaluate differences in capsule endoscopy(CE) performed in the setting of obscure gastrointestinal bleeding(OGIB) among premenopausal women(PMW) and menopausal women(MW).METHODS Retrospective, single-center stu...AIM To evaluate differences in capsule endoscopy(CE) performed in the setting of obscure gastrointestinal bleeding(OGIB) among premenopausal women(PMW) and menopausal women(MW).METHODS Retrospective, single-center study, including female patients submitted to CE in the setting of OGIB between May 2011 and December 2016. Patients were divided into 2 groups according to age, considering fertile age as ≤ 55 years and postmenopausal age as > 55 years. The diagnostic yield(DY), the rebleeding rate and the time to rebleed were evaluated and compared between groups. Rebleeding was defined as a drop of Hb > 2 g/dL or need for transfusional support or presence of melena/hematochezia.RESULTS A hundred and eighty three female patients underwent CE for OGIB, of whom 30.6%(n = 56) were PMW and 69.4%(n = 127) were MW. The DY was 30.4% in PMW and 63.8% in MW. The most common findings were angiodysplasias in both groups(PMW: 21.4%, MW: 44.9%)(P = 0.003). In PMW, only 1.8% required therapeutic endoscopy. In 17.3% of MW, CE findingsled to additional endoscopic treatment. Rebleeding at 1, 3 and 5 years in PMW was 3.6%, 10.2%, 10.2% and 22.0%, 32.3% and 34.2% in MW. Postmenopausal status was significantly associated with higher DY(P < 0.001), TY(P = 0.003), rebleeding(P = 0.031) and lower time to rebleed(P = 0.001).CONCLUSION PMW with suspected OGIB are less likely to have significant findings in CE. In MW DY, need for endoscopic treatment and rebleeding were significantly higher while time to rebleed was lower.展开更多
目的探讨血清补体C1q肿瘤坏死因子相关蛋白3（CTRP3）表达水平与绝经期前女性冠心病的关系。方法选择2014-10~2015-06拟诊冠心病住院的经冠脉造影术（CAG）证实的冠心病组50例女性患者,另外50例经CAG检查确认冠状动脉完全正常设为对照组...目的探讨血清补体C1q肿瘤坏死因子相关蛋白3（CTRP3）表达水平与绝经期前女性冠心病的关系。方法选择2014-10~2015-06拟诊冠心病住院的经冠脉造影术（CAG）证实的冠心病组50例女性患者,另外50例经CAG检查确认冠状动脉完全正常设为对照组,这两组患者按照是否绝经分别分为绝经前女性冠心病组（n=20）、绝经后女性冠心病对照组（n=30）、绝经前女性正常对照组（n=20）、绝经后女性正常对照组（n=30）。采用酶联免疫法（ELISA）检测血清中CTRP3、脂联素（APN）水平,同时检测血脂、同型半胱氨酸（Hcy）水平。结果 ①血清CTRP3水平（pg/ml）在绝经前女性冠心病组（26.45±24.32）高于绝经后女性冠心病对照组（7.05±5.61,P〈0.05）、绝经前女性正常对照组（6.92±4.37,P〈0.05）、绝经后女性正常对照组（8.09±6.85,P〈0.01）;②脂联素水平（μg/ml）在绝经前女性冠心病组高于绝经前女性正常对照组（518.21±402.91 vs 197.58±85.205,P〈0.05）;③同型半胱氨酸水平（mmol/L）在绝经前女性冠心病组高于绝经前女性正常对照组（12.61±2.86 vs 9.35±0.95,P〈0.01）;④CTRP3与脂联素呈正相关（r=0.731,P〈0.000 1）,CTRP3与其他心血管因素如总胆固醇、甘油三酯、低密度脂蛋白、空腹血糖、血尿酸、同型半胱氨酸无相关性。结论 CTRP3与绝经前女性冠心病有关联。展开更多
目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)合并超重及肥胖的绝经前女性患者腹部脂肪分布与胰岛素抵抗及骨矿物质密度的关系。方法选取2016年1月至2017年10月于北京积水潭医院住院的新发T2DM合并超重或肥胖的绝经前女性患者28...目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)合并超重及肥胖的绝经前女性患者腹部脂肪分布与胰岛素抵抗及骨矿物质密度的关系。方法选取2016年1月至2017年10月于北京积水潭医院住院的新发T2DM合并超重或肥胖的绝经前女性患者28例作为T2DM组,以同期住院的口服糖耐量试验正常的超重或肥胖绝经前女性30例作为对照组。对所有患者应用定量CT技术测量第2、3、4腰椎的平均骨矿物质密度,腹部总脂肪体积,皮下脂肪体积,内脏脂肪体积,同时测量患者腹围、体重指数、血尿酸、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、同型半胱氨酸、空腹血糖及空腹血胰岛素水平。比较两组间各参数的差别,并分析平均骨矿物质密度、稳态胰岛素抵抗指数(homeostasis model assessment for insulin resistance,HOMA-RI)及稳态胰岛β细胞功能指数(homeostasis model assessment forβcell,HOMA-β)的自然对数ln(HOMA-RI)及ln(HOMA-R)与腹部总脂肪体积、皮下脂肪体积、内脏脂肪体积的关系。结果T2DM组平均骨矿物质密度、皮下脂肪体积低于对照组,内脏脂肪体积、内脏脂肪体积/皮下脂肪体积比值高于对照组,差异有显著性(P<0.05);两组腹部总脂肪体积比较差异无显著性(P>0.05)。多重线性回归分析显示,年龄及内脏脂肪体积/皮下脂肪体积比值与平均骨矿物质密度呈负相关关系(P<0.05),内脏脂肪体积与ln(HOMA-RI)呈正相关关系(P<0.05)。结论2型糖尿病合并超重及肥胖的绝经前女性患者会出现骨矿物质密度下降,其平均骨矿物质密度与年龄、内脏脂肪体积/皮下脂肪体积比值呈负相关关系,内脏脂肪含量对胰岛素抵抗程度有较大影响,但胰岛素抵抗并不是造成该类骨矿物质密度下降的原因。展开更多
目的分析北京地区健康绝经期前女性不同年龄阶段血清I型原胶原氨基端肽(procollagen type 1 N-terminal propeptide,P1NP)和I型胶原羧基端肽交联(βcross-linked C-telopeptide of type 1 collagen,β-CTX)水平的分布趋势差异并初步建...目的分析北京地区健康绝经期前女性不同年龄阶段血清I型原胶原氨基端肽(procollagen type 1 N-terminal propeptide,P1NP)和I型胶原羧基端肽交联(βcross-linked C-telopeptide of type 1 collagen,β-CTX)水平的分布趋势差异并初步建立两者的参考区间。方法以北京地区健康绝经期前女性作为研究对象,应用罗氏电化学发光免疫分析技术,对符合入组标准的272名30~54岁女性血清P1NP和β-CTX水平进行检测。以5岁为一年龄段进行分组:30~34岁,35~39岁,40~44岁,45~49岁,50~54岁;运用局部加权回归散点平滑法和Kolmogorov-Smirnov Z检验比较不同年龄段两者的组间分布趋势差异,确定参考人群的特异年龄段,并应用非参数方法建立参考区间。结果 272名入组受试者的平均年龄为(39.51±5.85)岁,总体P1NP与β-CTX水平呈非正态分布。35~39岁与40~44岁的血清P1NP与β-CTX水平分布趋势比较差异无统计学意义(P>0.05);进一步将30~34岁及45~49岁水平分别与35~44岁水平的分布趋势比较,差异有统计学意义(P<0.05)。因此将35~44岁年龄段的健康绝经期前女性作为参考人群,由此所建立的血清P1NP参考区间为:17.95~65.60 ng/m L,血清β-CTX参考区间为0.10~0.49 ng/m L。结论北京地区35~44岁健康绝经期前女性血清骨转换标志物P1NP和β-CTX水平分布趋势相对平稳,受变异因素影响最小,两者在此年龄段人群的测定结果适宜作为建立参考区间的参考值。展开更多
文摘AIM To evaluate differences in capsule endoscopy(CE) performed in the setting of obscure gastrointestinal bleeding(OGIB) among premenopausal women(PMW) and menopausal women(MW).METHODS Retrospective, single-center study, including female patients submitted to CE in the setting of OGIB between May 2011 and December 2016. Patients were divided into 2 groups according to age, considering fertile age as ≤ 55 years and postmenopausal age as > 55 years. The diagnostic yield(DY), the rebleeding rate and the time to rebleed were evaluated and compared between groups. Rebleeding was defined as a drop of Hb > 2 g/dL or need for transfusional support or presence of melena/hematochezia.RESULTS A hundred and eighty three female patients underwent CE for OGIB, of whom 30.6%(n = 56) were PMW and 69.4%(n = 127) were MW. The DY was 30.4% in PMW and 63.8% in MW. The most common findings were angiodysplasias in both groups(PMW: 21.4%, MW: 44.9%)(P = 0.003). In PMW, only 1.8% required therapeutic endoscopy. In 17.3% of MW, CE findingsled to additional endoscopic treatment. Rebleeding at 1, 3 and 5 years in PMW was 3.6%, 10.2%, 10.2% and 22.0%, 32.3% and 34.2% in MW. Postmenopausal status was significantly associated with higher DY(P < 0.001), TY(P = 0.003), rebleeding(P = 0.031) and lower time to rebleed(P = 0.001).CONCLUSION PMW with suspected OGIB are less likely to have significant findings in CE. In MW DY, need for endoscopic treatment and rebleeding were significantly higher while time to rebleed was lower.
文摘目的探讨血清补体C1q肿瘤坏死因子相关蛋白3（CTRP3）表达水平与绝经期前女性冠心病的关系。方法选择2014-10~2015-06拟诊冠心病住院的经冠脉造影术（CAG）证实的冠心病组50例女性患者,另外50例经CAG检查确认冠状动脉完全正常设为对照组,这两组患者按照是否绝经分别分为绝经前女性冠心病组（n=20）、绝经后女性冠心病对照组（n=30）、绝经前女性正常对照组（n=20）、绝经后女性正常对照组（n=30）。采用酶联免疫法（ELISA）检测血清中CTRP3、脂联素（APN）水平,同时检测血脂、同型半胱氨酸（Hcy）水平。结果 ①血清CTRP3水平（pg/ml）在绝经前女性冠心病组（26.45±24.32）高于绝经后女性冠心病对照组（7.05±5.61,P〈0.05）、绝经前女性正常对照组（6.92±4.37,P〈0.05）、绝经后女性正常对照组（8.09±6.85,P〈0.01）;②脂联素水平（μg/ml）在绝经前女性冠心病组高于绝经前女性正常对照组（518.21±402.91 vs 197.58±85.205,P〈0.05）;③同型半胱氨酸水平（mmol/L）在绝经前女性冠心病组高于绝经前女性正常对照组（12.61±2.86 vs 9.35±0.95,P〈0.01）;④CTRP3与脂联素呈正相关（r=0.731,P〈0.000 1）,CTRP3与其他心血管因素如总胆固醇、甘油三酯、低密度脂蛋白、空腹血糖、血尿酸、同型半胱氨酸无相关性。结论 CTRP3与绝经前女性冠心病有关联。
文摘目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)合并超重及肥胖的绝经前女性患者腹部脂肪分布与胰岛素抵抗及骨矿物质密度的关系。方法选取2016年1月至2017年10月于北京积水潭医院住院的新发T2DM合并超重或肥胖的绝经前女性患者28例作为T2DM组,以同期住院的口服糖耐量试验正常的超重或肥胖绝经前女性30例作为对照组。对所有患者应用定量CT技术测量第2、3、4腰椎的平均骨矿物质密度,腹部总脂肪体积,皮下脂肪体积,内脏脂肪体积,同时测量患者腹围、体重指数、血尿酸、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、同型半胱氨酸、空腹血糖及空腹血胰岛素水平。比较两组间各参数的差别,并分析平均骨矿物质密度、稳态胰岛素抵抗指数(homeostasis model assessment for insulin resistance,HOMA-RI)及稳态胰岛β细胞功能指数(homeostasis model assessment forβcell,HOMA-β)的自然对数ln(HOMA-RI)及ln(HOMA-R)与腹部总脂肪体积、皮下脂肪体积、内脏脂肪体积的关系。结果T2DM组平均骨矿物质密度、皮下脂肪体积低于对照组,内脏脂肪体积、内脏脂肪体积/皮下脂肪体积比值高于对照组,差异有显著性(P<0.05);两组腹部总脂肪体积比较差异无显著性(P>0.05)。多重线性回归分析显示,年龄及内脏脂肪体积/皮下脂肪体积比值与平均骨矿物质密度呈负相关关系(P<0.05),内脏脂肪体积与ln(HOMA-RI)呈正相关关系(P<0.05)。结论2型糖尿病合并超重及肥胖的绝经前女性患者会出现骨矿物质密度下降,其平均骨矿物质密度与年龄、内脏脂肪体积/皮下脂肪体积比值呈负相关关系,内脏脂肪含量对胰岛素抵抗程度有较大影响,但胰岛素抵抗并不是造成该类骨矿物质密度下降的原因。
