The purpose of this study was to determine the relationship between insulin resistance, obesity and serum prostate-specific antigen （PSA） levels in healthy men with serum PSA level below 4 ng mL-1. The men included ...The purpose of this study was to determine the relationship between insulin resistance, obesity and serum prostate-specific antigen （PSA） levels in healthy men with serum PSA level below 4 ng mL-1. The men included in the study cohort were 11 827 healthy male employees of the Korea Hydro and Nuclear Power Co., LTD who had undergone medical checkups including fasting glucose, fasting insulin and serum PSA between January 2003 and December 2008. Insulin resistance was calculated by homeostasis model assessment （HOMA [fasting glucose × fasting insulin]/22.5） and quantitative insulin sensitivity check index （QUICK/; 1/[log （fasting insulin） ＋ log （fasting glucose）]）. Age-adjusted body mass index （BMI） was significantly increased according to increasing quartile of insulin resistance as determined by HOMA and QUICKI, respectively, in analysis of variance （ANOVA） test and Duncan＇s multiple comparison test （P 〈 0.001）, but age-adjusted serum PSA concentration was significantly decreased according to increasing quartile of insulin resistance as determined by HOMA and QUICK/（P 〈 0.001）. Age, BMI, insulin resistance by HOMA or QUICK/were significantly independent variables to serum PSA level in a multivariate linear regression analysis （P 〈 0.001）. Insulin resistance was a significant independent variable to serum PSA level along with BMI. Insulin resistance and BMI were negatively correlated with serum PSA level in healthy men. Insulin resistance was positively correlated with BMI.展开更多
Prostate cancer(PCa)is the most common noncutaneous malignancy and second leading cause of cancerspecific mortality for men in the United States.There is a wide spectrum of aggressiveness ranging from biologically sig...Prostate cancer(PCa)is the most common noncutaneous malignancy and second leading cause of cancerspecific mortality for men in the United States.There is a wide spectrum of aggressiveness ranging from biologically significant to indolent disease,which has led to an interest in the identification of risk factors for its development and progression.Emerging evidence has suggested an association between metabolic syndrome(MetS)and PCa.MetS represents a cluster of metabolic derangements that confer an increased risk of cardiovascular disease and type 2 diabetes mellitus.Its individual components include obesity,dyslipidemias,high blood pressure,and high fasting glucose levels.Met S has become pervasive and is currently associated with a high socioeconomic cost in both industrialized and developing countries throughout the world.The relationship between MetS and PCa is complex and yet to be fully defined.A better understanding of this relationship will facilitate the development of novel therapeutic targets for the prevention of PCa and improvement of outcomes among diagnosed men in the future.In this review,we evaluate the current evidence on the role of MetS in the development and progression of PCa.We also discuss the clinical implications on the manage-ment of PCa and consider the future direction of this subject.展开更多
目的探讨不同年龄段代谢综合征相关因素对前列腺特异性抗原(PSA)的影响。方法收集2011年1月至2022年5月于太原市人民医院体检科就诊的6006例男性的临床资料,排除并发症和资料不完整者,根据年龄分为<40岁1819例、40~59岁2781例、60~79...目的探讨不同年龄段代谢综合征相关因素对前列腺特异性抗原(PSA)的影响。方法收集2011年1月至2022年5月于太原市人民医院体检科就诊的6006例男性的临床资料,排除并发症和资料不完整者,根据年龄分为<40岁1819例、40~59岁2781例、60~79岁1162例、≥80岁244例。比较各组有无代谢综合征、有无体质指数≥25 kg/m^(2)(超重)、有无空腹血糖≥6.1 mmol/L(高血糖)、有无收缩压/舒张压≥140/90 mm Hg(高血压)、有无甘油三酯≥1.7 mmol/L及(或)高密度脂蛋白<0.9 mmol/L(血脂紊乱)的PSA值,行Mann-Whitney U检验,并对60~79岁组采用多因素Logistic回归法分析代谢综合征相关因素对PSA≥4 ng/ml的影响。结果各年龄段合并代谢综合征者并不影响PSA值。40~59岁组,血脂紊乱者较正常者PSA值降低(0.78ng/ml vs 0.84 ng/ml);60~79岁组,超重者PSA值降低(1.05 ng/ml vs 1.23 ng/ml),高血压者PSA值升高(1.26 ng/ml vs 1.03 ng/ml),血脂紊乱者PSA值降低(0.98 ng/ml vs 1.24 ng/ml);≥80岁组,高血糖者PSA值降低(1.38 ng/ml vs 1.78 ng/ml),且差异均有统计学意义(P<0.05)。高血压是60~79岁者PSA≥4 ng/ml的独立危险因素(OR=2.290)。结论不同年龄段PSA筛查时,需注意超重、血脂紊乱、高血糖、高血压对PSA值的影响,可适当放宽PSA复查指征,减少因PSA水平波动而遗漏临床对前列腺癌的诊断。对于60~79岁男性,合并高血压者可能需要优先筛查PSA。展开更多
目的探讨老年男性代谢综合征相关指标与血清前列腺特异性抗原(prostate-specific antigen,PSA)水平的关系。方法选择2005年4月至2009年1月在我科就诊的375例老年男性,测量身高、体质量,24小时动态血压监测,计算体质量指数(body mass ind...目的探讨老年男性代谢综合征相关指标与血清前列腺特异性抗原(prostate-specific antigen,PSA)水平的关系。方法选择2005年4月至2009年1月在我科就诊的375例老年男性,测量身高、体质量,24小时动态血压监测,计算体质量指数(body mass index,BMI),平均动脉压(mean arterial blood pressure,MAP),检测血PSA、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、C反应蛋白(CRP)、尿酸(UA),分析血PSA与代谢综合征各项指标的相关性。结果血PSA与BMI呈负相关(rs=-0.113,P<0.05),PSA与年龄(rs=0.109,P<0.05)、甘油三酯(rs=0.111,P<0.05)、空腹血糖(rs=0.166,P<0.01)、C反应蛋白(rs=0.115,P<0.05)呈正相关。结论老年男性血PSA水平与BMI、年龄、甘油三酯、空腹血糖、C反应蛋白存在相关性,代谢综合征的相关指标可影响血PSA水平,从而影响前列腺疾病的发生。展开更多
文摘The purpose of this study was to determine the relationship between insulin resistance, obesity and serum prostate-specific antigen （PSA） levels in healthy men with serum PSA level below 4 ng mL-1. The men included in the study cohort were 11 827 healthy male employees of the Korea Hydro and Nuclear Power Co., LTD who had undergone medical checkups including fasting glucose, fasting insulin and serum PSA between January 2003 and December 2008. Insulin resistance was calculated by homeostasis model assessment （HOMA [fasting glucose × fasting insulin]/22.5） and quantitative insulin sensitivity check index （QUICK/; 1/[log （fasting insulin） ＋ log （fasting glucose）]）. Age-adjusted body mass index （BMI） was significantly increased according to increasing quartile of insulin resistance as determined by HOMA and QUICKI, respectively, in analysis of variance （ANOVA） test and Duncan＇s multiple comparison test （P 〈 0.001）, but age-adjusted serum PSA concentration was significantly decreased according to increasing quartile of insulin resistance as determined by HOMA and QUICK/（P 〈 0.001）. Age, BMI, insulin resistance by HOMA or QUICK/were significantly independent variables to serum PSA level in a multivariate linear regression analysis （P 〈 0.001）. Insulin resistance was a significant independent variable to serum PSA level along with BMI. Insulin resistance and BMI were negatively correlated with serum PSA level in healthy men. Insulin resistance was positively correlated with BMI.
文摘Prostate cancer(PCa)is the most common noncutaneous malignancy and second leading cause of cancerspecific mortality for men in the United States.There is a wide spectrum of aggressiveness ranging from biologically significant to indolent disease,which has led to an interest in the identification of risk factors for its development and progression.Emerging evidence has suggested an association between metabolic syndrome(MetS)and PCa.MetS represents a cluster of metabolic derangements that confer an increased risk of cardiovascular disease and type 2 diabetes mellitus.Its individual components include obesity,dyslipidemias,high blood pressure,and high fasting glucose levels.Met S has become pervasive and is currently associated with a high socioeconomic cost in both industrialized and developing countries throughout the world.The relationship between MetS and PCa is complex and yet to be fully defined.A better understanding of this relationship will facilitate the development of novel therapeutic targets for the prevention of PCa and improvement of outcomes among diagnosed men in the future.In this review,we evaluate the current evidence on the role of MetS in the development and progression of PCa.We also discuss the clinical implications on the manage-ment of PCa and consider the future direction of this subject.
文摘目的探讨不同年龄段代谢综合征相关因素对前列腺特异性抗原(PSA)的影响。方法收集2011年1月至2022年5月于太原市人民医院体检科就诊的6006例男性的临床资料,排除并发症和资料不完整者,根据年龄分为<40岁1819例、40~59岁2781例、60~79岁1162例、≥80岁244例。比较各组有无代谢综合征、有无体质指数≥25 kg/m^(2)(超重)、有无空腹血糖≥6.1 mmol/L(高血糖)、有无收缩压/舒张压≥140/90 mm Hg(高血压)、有无甘油三酯≥1.7 mmol/L及(或)高密度脂蛋白<0.9 mmol/L(血脂紊乱)的PSA值,行Mann-Whitney U检验,并对60~79岁组采用多因素Logistic回归法分析代谢综合征相关因素对PSA≥4 ng/ml的影响。结果各年龄段合并代谢综合征者并不影响PSA值。40~59岁组,血脂紊乱者较正常者PSA值降低(0.78ng/ml vs 0.84 ng/ml);60~79岁组,超重者PSA值降低(1.05 ng/ml vs 1.23 ng/ml),高血压者PSA值升高(1.26 ng/ml vs 1.03 ng/ml),血脂紊乱者PSA值降低(0.98 ng/ml vs 1.24 ng/ml);≥80岁组,高血糖者PSA值降低(1.38 ng/ml vs 1.78 ng/ml),且差异均有统计学意义(P<0.05)。高血压是60~79岁者PSA≥4 ng/ml的独立危险因素(OR=2.290)。结论不同年龄段PSA筛查时,需注意超重、血脂紊乱、高血糖、高血压对PSA值的影响,可适当放宽PSA复查指征,减少因PSA水平波动而遗漏临床对前列腺癌的诊断。对于60~79岁男性,合并高血压者可能需要优先筛查PSA。
