Background Vasoactive drugs are often necessary for reversing hypotension in patients with severe infection. The standard for evaluating effects of vasoactive drugs should not only be based on the increase of arterial...Background Vasoactive drugs are often necessary for reversing hypotension in patients with severe infection. The standard for evaluating effects of vasoactive drugs should not only be based on the increase of arterial blood pressure, but also on the blood flow perfusion of internal organs. The effects of dopamine and metaraminol on the renal function of the patients with septic shock were investigated retrospectively in this study. Methods Ninety-eight patients with septic shock were divided into three groups according to the highest infusing rate of metaraminol, with the lightest infusing rate of （0.1-0.5, 0.6-1.0, 〉1.0） pg · kg^-1 · min^-1 in group A, B and C respectively. Urine output, mean arterial blood pressure （MAP）, heart rate （HR）, urine output, blood urea nitrogen （BUN）, creatinine （CRE）, urine albumin （U-ALB）, urine β2-microglubulin （Uβ2-MG） and Apache Ⅲ scores were recorded. Results Before antishock therapy, hypotension, tachycardia and oliguria occurred to all the 98 patients with septic shock and CRE, BUN, U-ALB, Uβ2-MG and Apache Ⅲ scoring were abnormal in most cases. With the antishock therapy, MAP, HR, urine output, BUN and CRE in all patients returned gradually to normal （P〈0.05 or 〈0.01 compared to those before antishock therapy）. U-ALB, Uβ2-MG output and Apache Ⅲ scoring also reverted but remained abnormal （P〈0.01 compared to those before antishock therapy）. No statistically significant differences in the changes of these indices with the time existed among the three groups （P〉0.05）.Conclusion Dopamine and metaraminol when applied to the patients with septic shock could effectively maintain the circulatory stability and promote restoration of renal function.展开更多
目的:探究间羟胺联合腰硬联合麻醉对剖宫产产妇的影响。方法:选取2021年1月—2022年10月泉州市第一医院收治的100例待剖宫产产妇。根据随机数表法将其分为腰硬联合麻醉组和联合治疗组,各50例。腰硬联合麻醉组给予腰硬联合麻醉,联合治疗...目的:探究间羟胺联合腰硬联合麻醉对剖宫产产妇的影响。方法:选取2021年1月—2022年10月泉州市第一医院收治的100例待剖宫产产妇。根据随机数表法将其分为腰硬联合麻醉组和联合治疗组,各50例。腰硬联合麻醉组给予腰硬联合麻醉,联合治疗组给予间羟胺联合腰硬联合麻醉。比较两组麻醉前、术后收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、心输出量(CO)、心率(HR)、心脏指数(CI),手术指标,新生儿缺氧情况及不良反应。结果:术后,两组DBP、SBP、MAP下降,但联合治疗组DBP、SBP、MAP均高于腰硬联合麻醉组,差异有统计学意义(P<0.05)。术后,两组HR、CO、CI均降低,但联合治疗组HR、CO、CI均高于腰硬联合麻醉组,差异有统计学意义(P<0.05)。两组手术时间、术中失血量、术中液体输注量比较,差异无统计学意义(P>0.05)。两组新生儿1 min和5 min Apgar评分比较,差异无统计学意义(P>0.05)。联合治疗组不良反应发生率低于腰硬联合麻醉组,差异有统计学意义(P<0.05)。结论:间羟胺联合腰硬联合麻醉对剖宫产产妇进行干预,能较好地维护产妇血压、心率水平,调节产妇血流动力学,对新生儿Apgar评分有较小的影响,效果显著。展开更多
文摘Background Vasoactive drugs are often necessary for reversing hypotension in patients with severe infection. The standard for evaluating effects of vasoactive drugs should not only be based on the increase of arterial blood pressure, but also on the blood flow perfusion of internal organs. The effects of dopamine and metaraminol on the renal function of the patients with septic shock were investigated retrospectively in this study. Methods Ninety-eight patients with septic shock were divided into three groups according to the highest infusing rate of metaraminol, with the lightest infusing rate of （0.1-0.5, 0.6-1.0, 〉1.0） pg · kg^-1 · min^-1 in group A, B and C respectively. Urine output, mean arterial blood pressure （MAP）, heart rate （HR）, urine output, blood urea nitrogen （BUN）, creatinine （CRE）, urine albumin （U-ALB）, urine β2-microglubulin （Uβ2-MG） and Apache Ⅲ scores were recorded. Results Before antishock therapy, hypotension, tachycardia and oliguria occurred to all the 98 patients with septic shock and CRE, BUN, U-ALB, Uβ2-MG and Apache Ⅲ scoring were abnormal in most cases. With the antishock therapy, MAP, HR, urine output, BUN and CRE in all patients returned gradually to normal （P〈0.05 or 〈0.01 compared to those before antishock therapy）. U-ALB, Uβ2-MG output and Apache Ⅲ scoring also reverted but remained abnormal （P〈0.01 compared to those before antishock therapy）. No statistically significant differences in the changes of these indices with the time existed among the three groups （P〉0.05）.Conclusion Dopamine and metaraminol when applied to the patients with septic shock could effectively maintain the circulatory stability and promote restoration of renal function.
文摘目的:探究间羟胺联合腰硬联合麻醉对剖宫产产妇的影响。方法:选取2021年1月—2022年10月泉州市第一医院收治的100例待剖宫产产妇。根据随机数表法将其分为腰硬联合麻醉组和联合治疗组,各50例。腰硬联合麻醉组给予腰硬联合麻醉,联合治疗组给予间羟胺联合腰硬联合麻醉。比较两组麻醉前、术后收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、心输出量(CO)、心率(HR)、心脏指数(CI),手术指标,新生儿缺氧情况及不良反应。结果:术后,两组DBP、SBP、MAP下降,但联合治疗组DBP、SBP、MAP均高于腰硬联合麻醉组,差异有统计学意义(P<0.05)。术后,两组HR、CO、CI均降低,但联合治疗组HR、CO、CI均高于腰硬联合麻醉组,差异有统计学意义(P<0.05)。两组手术时间、术中失血量、术中液体输注量比较,差异无统计学意义(P>0.05)。两组新生儿1 min和5 min Apgar评分比较,差异无统计学意义(P>0.05)。联合治疗组不良反应发生率低于腰硬联合麻醉组,差异有统计学意义(P<0.05)。结论:间羟胺联合腰硬联合麻醉对剖宫产产妇进行干预,能较好地维护产妇血压、心率水平,调节产妇血流动力学,对新生儿Apgar评分有较小的影响,效果显著。
