The effect of a pure α-adrenergic agent, methoxamine on ventricularfibrillation (VF) amplitude and the relation between hemodynamic parameters andsurvival in a rodent cardiopulmonary resuscitation (CPR) model were st...The effect of a pure α-adrenergic agent, methoxamine on ventricularfibrillation (VF) amplitude and the relation between hemodynamic parameters andsurvival in a rodent cardiopulmonary resuscitation (CPR) model were studied.Our results suggested that: 1) VF amplitude decreased during untreated VF, butit increased during pericardial chest compression ; 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP)but not VF amplitude, and the survival also increased due to elevation of CPP;and 3) all surviving animals with successful defibrillhtion had a higher VF ampli-tude.展开更多
Objective: To study the effect of methoxamine hydrochloride on the cardiac work, myocardial damage and oxidative stress in elderly patients during general anesthesia induction. Methods:Elderly patients who received no...Objective: To study the effect of methoxamine hydrochloride on the cardiac work, myocardial damage and oxidative stress in elderly patients during general anesthesia induction. Methods:Elderly patients who received non-cardiac surgery under general anesthesia in Xianshuigu Hospital between April 2014 and December 2016 were selected and randomly divided into two groups, observation group received methoxamine hydrochloride combined with routine anesthesia, and control group received routine anesthesia. After the completion of anesthesia induction and operation, the cardiac work indexes, myocardial damage indexes, oxidative stress indexes and immune response indexes of the two groups were measured. Results: SVI and LVSW levels as well as serum NE, E, Cor, Ins and C-P contents of observation group after completion of anesthesia induction and operation were significantly lower than those of control group, serum CK-MB, cTnI, cTnT and Caspase-3 contents were not significantly different from those of control group, and peripheral blood CD3+CD4+, CD3+CD8+, CD1α+, CD80+ and CD86+ expression intensity were significantly higher than those of control group. Conclusion: Methoxamine hydrochloride for general anesthesia induction of elderly patients can reduce the cardiac work and inhibit the oxidative stress response.展开更多
Sulfobutylether－β－cyclodextrin（SBE－β－CD）was used as a chiral selector tor separatingten chlral drugs with resolution 1．2 by capillary zone electrophoresls（CZE）， The backgroundelectrolylc solution compris...Sulfobutylether－β－cyclodextrin（SBE－β－CD）was used as a chiral selector tor separatingten chlral drugs with resolution 1．2 by capillary zone electrophoresls（CZE）， The backgroundelectrolylc solution comprised of 120 mmol／L Britton－Robinson buffer（BRB） containing1 ～10mmol／L SBE－β－CD with the pH value adjusted from 5．0－6．8． Five of the drugs were better resolvedthan those previously reported with neutral CDs．展开更多
β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L ...β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L 0-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s). Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared. Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.展开更多
The purpose of this study was to investigate the effect of nonadrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO2(ETCO2)during CPR in a rodent model. Our results suggested that: 1) coronary perf...The purpose of this study was to investigate the effect of nonadrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO2(ETCO2)during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasopresin (AVP) and angiotension- Ⅱ(ANG- Ⅱ), but not by endothelin-1 (ET-1): 2) ETCO2 prior to defibrillation was decreased significantly by a pure a1 adrenergic agents,methoxamine and were increased significantly by non-adrenergic agents, ANG-Ⅱ and ET-1 during rodent CPR;3) a significant positive correlation between ETCO2 and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-Ⅱ have similar effect on resuscitability during rodent CPR.展开更多
文摘The effect of a pure α-adrenergic agent, methoxamine on ventricularfibrillation (VF) amplitude and the relation between hemodynamic parameters andsurvival in a rodent cardiopulmonary resuscitation (CPR) model were studied.Our results suggested that: 1) VF amplitude decreased during untreated VF, butit increased during pericardial chest compression ; 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP)but not VF amplitude, and the survival also increased due to elevation of CPP;and 3) all surviving animals with successful defibrillhtion had a higher VF ampli-tude.
文摘Objective: To study the effect of methoxamine hydrochloride on the cardiac work, myocardial damage and oxidative stress in elderly patients during general anesthesia induction. Methods:Elderly patients who received non-cardiac surgery under general anesthesia in Xianshuigu Hospital between April 2014 and December 2016 were selected and randomly divided into two groups, observation group received methoxamine hydrochloride combined with routine anesthesia, and control group received routine anesthesia. After the completion of anesthesia induction and operation, the cardiac work indexes, myocardial damage indexes, oxidative stress indexes and immune response indexes of the two groups were measured. Results: SVI and LVSW levels as well as serum NE, E, Cor, Ins and C-P contents of observation group after completion of anesthesia induction and operation were significantly lower than those of control group, serum CK-MB, cTnI, cTnT and Caspase-3 contents were not significantly different from those of control group, and peripheral blood CD3+CD4+, CD3+CD8+, CD1α+, CD80+ and CD86+ expression intensity were significantly higher than those of control group. Conclusion: Methoxamine hydrochloride for general anesthesia induction of elderly patients can reduce the cardiac work and inhibit the oxidative stress response.
文摘Sulfobutylether－β－cyclodextrin（SBE－β－CD）was used as a chiral selector tor separatingten chlral drugs with resolution 1．2 by capillary zone electrophoresls（CZE）， The backgroundelectrolylc solution comprised of 120 mmol／L Britton－Robinson buffer（BRB） containing1 ～10mmol／L SBE－β－CD with the pH value adjusted from 5．0－6．8． Five of the drugs were better resolvedthan those previously reported with neutral CDs．
文摘β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE). A solution comprising of 120 mmol/L Britton Robinson buffer (BRB) containing 10 mmol/L 0-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s). Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared. Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.
文摘The purpose of this study was to investigate the effect of nonadrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO2(ETCO2)during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasopresin (AVP) and angiotension- Ⅱ(ANG- Ⅱ), but not by endothelin-1 (ET-1): 2) ETCO2 prior to defibrillation was decreased significantly by a pure a1 adrenergic agents,methoxamine and were increased significantly by non-adrenergic agents, ANG-Ⅱ and ET-1 during rodent CPR;3) a significant positive correlation between ETCO2 and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-Ⅱ have similar effect on resuscitability during rodent CPR.
