目的:探究醒胰汤保留灌肠辅助治疗对急性重症胰腺炎(Acute severe pancreatitis,ASP)患者高迁移率族蛋B1(HMGB1)、白细胞介素-6(IL-6)、前列腺素E2水平及肠黏膜屏障功能的影响。方法:144例2021年3月~2023年3月我院收治ASP患者,采用随机...目的:探究醒胰汤保留灌肠辅助治疗对急性重症胰腺炎(Acute severe pancreatitis,ASP)患者高迁移率族蛋B1(HMGB1)、白细胞介素-6(IL-6)、前列腺素E2水平及肠黏膜屏障功能的影响。方法:144例2021年3月~2023年3月我院收治ASP患者,采用随机数字表法将其分为对照组、观察组,各72例。对照组予以常规干预及生长抑素持续2~3d的慢速静脉冲击注射治疗,观察组在对照组基础上予以醒胰汤保留灌肠治疗,两组均连续治疗1周。观察两组治疗期间的胃肠功能恢复时间、住院时间,治疗前、治疗1周后的肠黏膜屏障功能指标、血清细胞因子水平及治疗期间不良反应发生情况。结果:治疗1周后,观察组肠鸣音、排便恢复时间,发热、腹痛、腹胀缓解时间及住院时间均短于对照组(P<0.05)。治疗1周后,两组血清二胺氧化酶(DAO)、D-乳酸(D-Lactate)、血清内露素(PE)、HMGB1、IL-6、PGE2水平均较治疗前下降,且观察组低于对照组(P<0.05)。治疗期间,观察组不良反应发生率为19.44%,与对照组(18.06%)比较无统计学差异(P>0.05)。结论:醒胰汤保留灌肠辅助治疗可有效降低ASP患者血清HMGB1、IL-6、PGE2水平,控制机体炎症应激反应,改善胃肠道功能、肠黏膜屏障功能,且能缩短住院时间,效果显著,安全性良好,值得推广。展开更多
The double perovskite oxides Sr2Mg1-xF exMoO6-δ were investigated as catalysts for the methane oxidation.The structural properties of catalysts were characterized in detail by X-ray diffraction,X-ray photoelectron sp...The double perovskite oxides Sr2Mg1-xF exMoO6-δ were investigated as catalysts for the methane oxidation.The structural properties of catalysts were characterized in detail by X-ray diffraction,X-ray photoelectron spectroscopy and X-ray absorption spectroscopy.The catalytic property was strongly influenced by the Fe substitution.The relation between catalytic performance and the degree of Fe substitution was examined with regard to the structure and surface characteristics of the mixed oxides.The Fe-containing catalysts exhibited higher activity attributable to the possible（Fe2＋,Mo6＋） and （Fe3＋,Mo5＋）valency pairs,and the highest activity was observed for Sr2Mg0.2Fe0.8MoO6-δ.The enhancement of the catalytic activity may be correlated with the Fe-relating surface lattice oxygen species and was discussed in view of the presence of oxygen vacancies.展开更多
文摘目的:探究醒胰汤保留灌肠辅助治疗对急性重症胰腺炎(Acute severe pancreatitis,ASP)患者高迁移率族蛋B1(HMGB1)、白细胞介素-6(IL-6)、前列腺素E2水平及肠黏膜屏障功能的影响。方法:144例2021年3月~2023年3月我院收治ASP患者,采用随机数字表法将其分为对照组、观察组,各72例。对照组予以常规干预及生长抑素持续2~3d的慢速静脉冲击注射治疗,观察组在对照组基础上予以醒胰汤保留灌肠治疗,两组均连续治疗1周。观察两组治疗期间的胃肠功能恢复时间、住院时间,治疗前、治疗1周后的肠黏膜屏障功能指标、血清细胞因子水平及治疗期间不良反应发生情况。结果:治疗1周后,观察组肠鸣音、排便恢复时间,发热、腹痛、腹胀缓解时间及住院时间均短于对照组(P<0.05)。治疗1周后,两组血清二胺氧化酶(DAO)、D-乳酸(D-Lactate)、血清内露素(PE)、HMGB1、IL-6、PGE2水平均较治疗前下降,且观察组低于对照组(P<0.05)。治疗期间,观察组不良反应发生率为19.44%,与对照组(18.06%)比较无统计学差异(P>0.05)。结论:醒胰汤保留灌肠辅助治疗可有效降低ASP患者血清HMGB1、IL-6、PGE2水平,控制机体炎症应激反应,改善胃肠道功能、肠黏膜屏障功能,且能缩短住院时间,效果显著,安全性良好,值得推广。
基金the financial supports from the National Natural Science Foundation of China(No.20703042)National Basic Research Program of China(No.2010CB923300)+1 种基金USTC-NSRL Association Funding(No.KY2060030009)the Fundamental Research Funds for the Central Universities
文摘The double perovskite oxides Sr2Mg1-xF exMoO6-δ were investigated as catalysts for the methane oxidation.The structural properties of catalysts were characterized in detail by X-ray diffraction,X-ray photoelectron spectroscopy and X-ray absorption spectroscopy.The catalytic property was strongly influenced by the Fe substitution.The relation between catalytic performance and the degree of Fe substitution was examined with regard to the structure and surface characteristics of the mixed oxides.The Fe-containing catalysts exhibited higher activity attributable to the possible（Fe2＋,Mo6＋） and （Fe3＋,Mo5＋）valency pairs,and the highest activity was observed for Sr2Mg0.2Fe0.8MoO6-δ.The enhancement of the catalytic activity may be correlated with the Fe-relating surface lattice oxygen species and was discussed in view of the presence of oxygen vacancies.
