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Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture 被引量:5
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作者 Dhavan Sharma Wenkai Jia +6 位作者 Fei Long Shweta Pati Qinghui Chen Yibing Qyang Bruce Lee Chang Kyong Choi Feng Zhao 《Bioactive Materials》 SCIE 2019年第1期142-150,共9页
Natural tissues contain highly organized cellular architecture.One of the major challenges in tissue engineering is to develop engineered tissue constructs that promote cellular growth in physiological directionality.... Natural tissues contain highly organized cellular architecture.One of the major challenges in tissue engineering is to develop engineered tissue constructs that promote cellular growth in physiological directionality.To address this issue,micro-patterned polydimethylsiloxane(PDMS)substrates have been widely used in cell sheet engineering due to their low microfabrication cost,higher stability,excellent biocompatibility,and most importantly,ability to guide cellular growth and patterning.However,the current methods for PDMS surface modification either require a complicated procedure or generate a non-uniform surface coating,leading to the production of poor-quality cell layers.A simple and efficient surface coating method is critically needed to improve the uniformity and quality of the generated cell layers.Herein,a fast,simple and inexpensive surface coating method was analyzed for its ability to uniformly coat polydopamine(PD)with or without collagen on micro-grated PDMS substrates without altering essential surface topographical features.Topographical feature,stiffness and cytotoxicity of these PD and/or collagen based surface coatings were further analyzed.Results showed that the PD-based coating method facilitated aligned and uniform cell growth,therefore holds great promise for cell sheet engineering as well as completely biological tissue biomanufacturing. 展开更多
关键词 POLYDIMETHYLSILOXANE POLYDOPAMINE COLLAGEN micro-grating Human mesenchymal stem cell
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Fabrication of micrometre-sized periodic gratings in free-standing metallic foils for laser-plasma experiments
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作者 C.C.Gheorghiu M.Cerchez +6 位作者 E.Aktan R.Prasad F.Yilmaz N.Yilmaz D.Popa O.Willi V.Leca 《High Power Laser Science and Engineering》 SCIE CAS CSCD 2022年第1期17-31,共15页
Engineered targets are expected to play a key role in future high-power laser experiments calling for joined, extensive knowledge in materials properties, engineering techniques and plasma physics. In this work, we pr... Engineered targets are expected to play a key role in future high-power laser experiments calling for joined, extensive knowledge in materials properties, engineering techniques and plasma physics. In this work, we propose a novel patterning procedure of self-supported 10 μm thick Au and Cu foils for obtaining micrometre-sized periodic gratings as targets for high-power laser applications. Accessible techniques were considered, by using cold rolling, electronbeam lithography and the Ar-ion milling process. The developed patterning procedure allows efficient control of the grating and foil surface on large area. Targets consisting of patterned regions of 450 μm × 450 μm, with 2 μm periodic gratings, were prepared on 25 mm × 25 mm Au and Cu free-standing foils, and preliminary investigations of the microtargets interacting with an ultrashort, relativistic laser pulse were performed. These test experiments demonstrated that,in certain conditions, the micro-gratings show enhanced laser energy absorption and higher efficiency in accelerating charge particle beams compared with planar thin foils of similar thickness. 展开更多
关键词 laser driven plasmas on structured targets metallic foils micro-grating patterned targets
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