The emergence of disseminated metastasis is the leading cause of mortality in patients with malignant tumor.The pre-metastatic microenvironment,including the primary tumor-derived components,pre-metastatic niche(PMN),...The emergence of disseminated metastasis is the leading cause of mortality in patients with malignant tumor.The pre-metastatic microenvironment,including the primary tumor-derived components,pre-metastatic niche(PMN),circulating tumor cells(CTCs),micro-metastases,and tumor immune microenvironment(TIM),are the crucial factors to initiate metastasis and form macro-metastases.It may be a more promising strategy for directly targeting pre-metastatic microenvironment-interrelated factors and cells before they have the chance to form secondary tumors to prevent metastasis.During recent years,a variety of nanosystems,with specific microstructures and functional properties,have been devised to selectively target pre-metastatic cells components and interrelated molecular,and exhibited strong potential on anti-metastatic therapy by absorbing and neutralizing primary tumor-derived components,preventing establishment of the PMN,eliminating the CTCs,eradicating the micro-metastases and modulating the TIM.In this review,we comprehensively review the emerging nanosystems based on the pre-metastatic microenvironments.Hopefully,this review can cast new lights for early preventing and attenuating metastatic progression.展开更多
基金supported by National Natural Science Foundation of China(Nos.92059110 and 81872808)Development Fund for Shanghai Talents(No.2020090)+2 种基金FDU 2025-Excellence Program Fund,National Key R&D Program of China(No.2017YFE0126900)Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01)ZJLab.
文摘The emergence of disseminated metastasis is the leading cause of mortality in patients with malignant tumor.The pre-metastatic microenvironment,including the primary tumor-derived components,pre-metastatic niche(PMN),circulating tumor cells(CTCs),micro-metastases,and tumor immune microenvironment(TIM),are the crucial factors to initiate metastasis and form macro-metastases.It may be a more promising strategy for directly targeting pre-metastatic microenvironment-interrelated factors and cells before they have the chance to form secondary tumors to prevent metastasis.During recent years,a variety of nanosystems,with specific microstructures and functional properties,have been devised to selectively target pre-metastatic cells components and interrelated molecular,and exhibited strong potential on anti-metastatic therapy by absorbing and neutralizing primary tumor-derived components,preventing establishment of the PMN,eliminating the CTCs,eradicating the micro-metastases and modulating the TIM.In this review,we comprehensively review the emerging nanosystems based on the pre-metastatic microenvironments.Hopefully,this review can cast new lights for early preventing and attenuating metastatic progression.
