The characteristics of body build of middle - and old -aged women and its rule of variations as well as the basic sizes of various parts are discussed. All these are based on the body measurements of this age group, a...The characteristics of body build of middle - and old -aged women and its rule of variations as well as the basic sizes of various parts are discussed. All these are based on the body measurements of this age group, and also on the statistical studies of the measurement data. By setting the regression equation, the calculating formulae of various control parts are obtained, thus establishing the prototype of this age group for women.展开更多
Inhibition of Notch1 signaling has been shown to promote astrocyte-derived neurogenesis after stroke.To investigate the regulatory role of Notch1 signaling in this process,in this study,we used a rat model of stroke b...Inhibition of Notch1 signaling has been shown to promote astrocyte-derived neurogenesis after stroke.To investigate the regulatory role of Notch1 signaling in this process,in this study,we used a rat model of stroke based on middle cerebral artery occlusion and assessed the behavior of reactive astrocytes post-stroke.We used theγ-secretase inhibitor N-[N-(3,5-diuorophenacetyl)-1-alanyl]-S-phenylglycine t-butylester(DAPT)to block Notch1 signaling at 1,4,and 7 days after injury.Our results showed that only administration of DAPT at 4 days after stroke promoted astrocyte-derived neurogenesis,as manifested by recovery of white matter fiber bundle integrity on magnetic resonance imaging,which is consistent with recovery of neurologic function.These findings suggest that inhibition of Notch1 signaling at the subacute stage post-stroke mediates neural repair by promoting astrocyte-derived neurogenesis.展开更多
Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia,but the mechanism underlying this relationship is unclea r.In this study,we found that miR-324-3p expression was d...Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia,but the mechanism underlying this relationship is unclea r.In this study,we found that miR-324-3p expression was decreased in patients with acute ischemic stroke and in in vitro and in vivo models of ischemic stro ke.miR-324-3p agomir potentiated ischemic brain damage in rats subjected to middle cerebral artery occlusion,as indicated by increased infarct volumes and cell apoptosis rates and greater neurological deficits.In a PC12 cell oxygen-glucose deprivation/reoxygenation model,a miR-324-3 p mimic decreased cell viability and expression of the anti-apoptotic protein BCL2 and increased expression of the pro-apoptotic protein BAX and rates of cell apoptosis,whereas treatment with a miR-324-3p inhibitor had the opposite effects.Silencing miR-324-3p increased adenosine A1 receptor(A1R)expression thro ugh regulation of GATA binding protein 2(GATA2).These findings suggest that silencing miR-324-3p reduces ischemic brain damage via the GATA2/A1R axis.展开更多
To investigate the multi-scale features in two persistent heavy rainfall （PHR） events in the middle and lower reaches of the Yangtze River （MLRYR） in June of 1982 and 1998, this study examines the impact of multi-...To investigate the multi-scale features in two persistent heavy rainfall （PHR） events in the middle and lower reaches of the Yangtze River （MLRYR） in June of 1982 and 1998, this study examines the impact of multi-scale oscillations in the north and south of 30°N on the PHR events by performing sensitivity experiments with the Weather Research and Forecast （WRF） model. It is found that the 60-day low- pass perturbation made a trivial contribution to the MLRYR precipitation during the PHR event in 1982. This PHR event resulted mainly from the combined effects of 30-60-day oscillation at low latitudes and 10-30-day oscillation at both high and low latitudes. The southwesterly anomalies associated with the 30- 60-day anticyclonic anomaly over the northwestern Pacific facilitated moisture transport from the ocean to the MLRYR and enhanced the low-level convergence and ascending motion in the MLRYR. This similarly occurred in the 10-30-day oscillation as well. Moreover, the 10 30-day anomalies at high latitudes played a role in strengthening the large-scale low-level convergence over the MLRYR. The PHR event in 1998 was mainly related to the 60-day oscillation at both high and low latitudes and 30-60-day oscillation at low latitudes. The 60-day low-pass filtered anomalous cyclone at high latitudes in the north of 30°N contributed to the development of low-level convergence and ascending motion in northern MLRYR while the anomalous anticyclone at low latitudes in the south of 30°N not only increased the moisture in the MLRYR but also preconditioned the dynamical factors favorable for PHR over the whole area. The 30-60-day perturbations located north and south of 30°N worked together producing positive moisture anomaly in the MLRYR. In addition, the anomalous circulation in the south of 30°N tended to favor the development of ascending motion and low-level convergence in the MLRYR.展开更多
基金This work was supported by Chins Textile University and the corporation foundation
文摘The characteristics of body build of middle - and old -aged women and its rule of variations as well as the basic sizes of various parts are discussed. All these are based on the body measurements of this age group, and also on the statistical studies of the measurement data. By setting the regression equation, the calculating formulae of various control parts are obtained, thus establishing the prototype of this age group for women.
基金supported by the National Natural Science Foundation of China,Nos.81801660(to XZH)and 81771788(to YMY)。
文摘Inhibition of Notch1 signaling has been shown to promote astrocyte-derived neurogenesis after stroke.To investigate the regulatory role of Notch1 signaling in this process,in this study,we used a rat model of stroke based on middle cerebral artery occlusion and assessed the behavior of reactive astrocytes post-stroke.We used theγ-secretase inhibitor N-[N-(3,5-diuorophenacetyl)-1-alanyl]-S-phenylglycine t-butylester(DAPT)to block Notch1 signaling at 1,4,and 7 days after injury.Our results showed that only administration of DAPT at 4 days after stroke promoted astrocyte-derived neurogenesis,as manifested by recovery of white matter fiber bundle integrity on magnetic resonance imaging,which is consistent with recovery of neurologic function.These findings suggest that inhibition of Notch1 signaling at the subacute stage post-stroke mediates neural repair by promoting astrocyte-derived neurogenesis.
基金funded by the National Natural Science Foundation of China,No.81803937(to YCM and QXD)Science and Technology Innovation Activity Plan for College Students of Zhejiang Province(Xinmiao Talent Plan),No.2020R413079(to AQZ)Wenzhou Science and Technology Plan Project,No.Y20210122(to QXD)。
文摘Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia,but the mechanism underlying this relationship is unclea r.In this study,we found that miR-324-3p expression was decreased in patients with acute ischemic stroke and in in vitro and in vivo models of ischemic stro ke.miR-324-3p agomir potentiated ischemic brain damage in rats subjected to middle cerebral artery occlusion,as indicated by increased infarct volumes and cell apoptosis rates and greater neurological deficits.In a PC12 cell oxygen-glucose deprivation/reoxygenation model,a miR-324-3 p mimic decreased cell viability and expression of the anti-apoptotic protein BCL2 and increased expression of the pro-apoptotic protein BAX and rates of cell apoptosis,whereas treatment with a miR-324-3p inhibitor had the opposite effects.Silencing miR-324-3p increased adenosine A1 receptor(A1R)expression thro ugh regulation of GATA binding protein 2(GATA2).These findings suggest that silencing miR-324-3p reduces ischemic brain damage via the GATA2/A1R axis.
基金Supported by the National Key Basic Research and Development(973)Program of China(2012CB417201)
文摘To investigate the multi-scale features in two persistent heavy rainfall （PHR） events in the middle and lower reaches of the Yangtze River （MLRYR） in June of 1982 and 1998, this study examines the impact of multi-scale oscillations in the north and south of 30°N on the PHR events by performing sensitivity experiments with the Weather Research and Forecast （WRF） model. It is found that the 60-day low- pass perturbation made a trivial contribution to the MLRYR precipitation during the PHR event in 1982. This PHR event resulted mainly from the combined effects of 30-60-day oscillation at low latitudes and 10-30-day oscillation at both high and low latitudes. The southwesterly anomalies associated with the 30- 60-day anticyclonic anomaly over the northwestern Pacific facilitated moisture transport from the ocean to the MLRYR and enhanced the low-level convergence and ascending motion in the MLRYR. This similarly occurred in the 10-30-day oscillation as well. Moreover, the 10 30-day anomalies at high latitudes played a role in strengthening the large-scale low-level convergence over the MLRYR. The PHR event in 1998 was mainly related to the 60-day oscillation at both high and low latitudes and 30-60-day oscillation at low latitudes. The 60-day low-pass filtered anomalous cyclone at high latitudes in the north of 30°N contributed to the development of low-level convergence and ascending motion in northern MLRYR while the anomalous anticyclone at low latitudes in the south of 30°N not only increased the moisture in the MLRYR but also preconditioned the dynamical factors favorable for PHR over the whole area. The 30-60-day perturbations located north and south of 30°N worked together producing positive moisture anomaly in the MLRYR. In addition, the anomalous circulation in the south of 30°N tended to favor the development of ascending motion and low-level convergence in the MLRYR.
