MXene,a family of two-dimensional(2D)transition metal carbides and nitrides have attracted extensive interests for many biochemical applications,including tumour elimination,biosensors,and magnetic resonance imaging(M...MXene,a family of two-dimensional(2D)transition metal carbides and nitrides have attracted extensive interests for many biochemical applications,including tumour elimination,biosensors,and magnetic resonance imaging(MRI).In this article,we firstly discovered that Ti3C2Tx MXene exhibited a highly efficient adsorption capability as hemoperfusion absorbent towards middle-molecular mass and protein bound uremic toxins in the end stage of renal disease(ESRD)treatment.Molecular scale investigations reveal that the high efficiency of MXene for the removal of uremic toxins could be attributed to synergistic effects of physical/chemical adsorption,electrostatic interaction surface of 2D MXene,and transformation of protein secondary structure.2D MXene materials could be used as a new hemoperfusion sorbent with ultrahigh efficiency for removing uremic toxins during the treatment of kidney disease.展开更多
基金support of National Natural Science Foundation of China(NO.22102141)H.Y.would like to acknowledge the financial support of the“Young scientists lifting project”of Jiangsu Province,China(TJ-2022-072).
文摘MXene,a family of two-dimensional(2D)transition metal carbides and nitrides have attracted extensive interests for many biochemical applications,including tumour elimination,biosensors,and magnetic resonance imaging(MRI).In this article,we firstly discovered that Ti3C2Tx MXene exhibited a highly efficient adsorption capability as hemoperfusion absorbent towards middle-molecular mass and protein bound uremic toxins in the end stage of renal disease(ESRD)treatment.Molecular scale investigations reveal that the high efficiency of MXene for the removal of uremic toxins could be attributed to synergistic effects of physical/chemical adsorption,electrostatic interaction surface of 2D MXene,and transformation of protein secondary structure.2D MXene materials could be used as a new hemoperfusion sorbent with ultrahigh efficiency for removing uremic toxins during the treatment of kidney disease.
