The Quality of Life of Chinese Middle-Aged Male Patients with Gastric Carcinoma After Total Gastrectomy and Nursing Intervention

OBJECTIVE The purpose of this study was to evaluate the quality of life （QOL） in Chinese middle-aged male patients with gastric carcinoma after total gastrectomy, to investigate the factors affecting their QOL, and to Study the effectiveness of nursing intervention.METHODS Structured questionnaire （EORTC QLQ-C30） was used among 162 middle-aged male patients after total gastrectomy （the patients finished the whole process of chemotherapy, and returned home, and society） for data collection and reevaluate the patients＇ aualitv of life with 2 months nursing intervention.RESULTS The patient＇s quality of life was related to their education level, economic condition, family support, and pathological staging. This study showed that patients got higher scores in Functional scales （except for CF）, and lower scores in Symptom scales and single items （except for FI） after receiving intervention than before it was received before.CONCLUSION The study revealed that the QOL in middleaged male patients after total gastrectomy was worse when there was inadequate attention. After implementing pertinent nursing intervention implementing, patients＇ mental attitude and negative behavior were improved, and their QOL was enhanced after returning home and into society.

Correlation of three grades with carotid atherosclerotic plaque by the ultrasound in middle-aged patients with hypertension

Objective:To explore the correlation of different hypertension grades with carotid atherosclerotic plaque in middle-aged patients with hypertension.Methods:A total of 300 patients with primary hypertension who were admitted in the Cardiology Department and Neurology Department of our hospital from January, 2015 to September, 2016 were included in the study and divided into 3 groups with 100 cases in each group according to the hypertension grade criteria. Moreover, 100 normal individuals who came for physical examinations were served as the control group. TCD was used to detect MCA, ACA, PCA, VA1, and BA. CDFI was used to detect CCA, ICA, ECA, and VA2. EDV, PSV, PI, and RI were detected, respectively. The nitrate reductase colorimetric method was used to detect NO, MDA, and SOD.Results:PSV and EDV in the internal carotid artery system in patients with hypertension were significantly reduced (P<0.05), while PI and RI were significantly increased (P<0.05);moreover, with the increasing of hypertension grading, PSV and EDV were gradually reduced, while PI and RI were increased. PSV and EDV in the vertebral artery system in patients with hypertension were significantly reduced (P<0.05), while PI and RI were significantly increased (P<0.05);moreover, with the increasing of hypertension grading, PSV and EDV were gradually reduced, while PI and RI were increased. SOD and NO in patients with hypertension were significantly lower than those in the control group (P<0.05), while MDA was significantly higher than that in the control group (P<0.05);moreover, with the increasing of hypertension grading, SOD and NO were gradually reduced, while MDA was gradually increased.Conclusions: TCD in combined with CDFI can make a comprehensive evaluation of hemodynamic indicators of intracranial and extracranial vessels in patients with hypertension, and is of great significance in the early detection of intracranial and extracranial arteriosclerosis.

Palliative chemotherapy for gastroesophageal cancer in old and very old patients: A retrospective cohort study at the National Center for Tumor Diseases, Heidelberg

AIM:To investigate the outcome of palliative chemotherapy in old patients with gastroesophageal cancer at the National Center for Tumor Diseases,Heidelberg.METHODS:Using a prospectively generated database,we retrospectively analyzed 55 patients≥70years under palliative chemotherapy for advanced gastroesophageal cancer at the outpatient clinic of the National Center for Tumor Diseases Heidelberg,Germany between January 2006 and December2013.Further requirements for inclusion were(1)histologically proven diagnosis of gastroesophageal cancer;(2)advanced(metastatic or inoperable)disease;and(3)no history of radiation or radiochemotherapy.The clinical information included Eastern Cooperative Oncology Group performance status(ECOG PS),presence and site of metastases at diagnosis,date of previous surgery and perioperative chemotherapy,start and stop date of first-line treatment,toxicities and consecutive dosage reductions of first-line treatment,response to first-line therapy,date of progression,usage of second-line therapies and date and cause of death.Survival times[progression-free survival(PFS),overall survival(OS)and residual survival(RS)]were calculated.Toxicity and safety were examined.Prognostic factors including ECOG PS,age and previousperioperative treatment were analyzed.RESULTS:Median age of our cohort was 76 years.86%of patients received a combination of two cytotoxic drugs.76 percent of patients had an oxaliplatin-based first-line therapy with the oxaliplatin and 5-fluorouracil regimen being the predominantely chosen regimen(69%).Drug modifications due to toxicity were necessary in 56%of patients,and 11%of patients stopped treatment due to toxicities.Survival times of our cohort are in good accordance with the major phaseⅢtrials that included mostly younger patients:PFS and OS were 5.8 and 9.5 mo,respectively.Survival differed significantly between patient groups with low(≤1)and high(≥2)ECOG PS(12.7 mo vs 3.8 mo,P<0.001).Very old patients(≥75 years)did not show a worse outcome in terms of survival.Patients receiving secondline treatment(51%)had a significantly longer RS than patients with best supportive care(6.8 vs 1.4 mo,P=0.001).Initial ECOG PS was a strong prognostic factor for PFS,OS and RS.CONCLUSION:Old patients with non-curable gastroesophageal cancer should be offered chemotherapy,and ECOG PS is a tool for balancing benefit and harm upfront.Second-line treatment is reasonable.

Survey for late-onset hypogonadism among old anti middle-aged males in Shanghai communities

This study sought to investigate late-onset hypogonadism （LOH） in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40-70 years were investigated. The aging male symptoms （AMS） scale and androgen deficiency in aging males （ADAM） questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors （total testosterone （TT）, free testosterone （fT）, sex hormone-binding globulin （SHBG） and bioavailability of testosterone （Bio-T））. There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results： TT was not related to aging （P〉O.05）; levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level.

Predictive clinical features of cardioembolic infarction in patients aged 85 years and older

Objective To assess predictive clinical factors of cardioembolic infarction in very old patients(85 years of age and older).Methods Prospective hospital-based stroke registry("The Sagrat Cor Hospital of Barcelona Stroke Registry")is an acute-care teaching hospital in Barcelona,Catalonia,Spain.From 956 first-ever cardioembolic stroke patients included in the stroke registry over a 24-year period,639 were younger than 85 years of age and 317 were 85 years or older(mean age:88.9 years).Demographics,clinical characteristics,risk factors and early outcome were compared.Predictors of cardioembolic infarction in the oldest age group were assessed by multivariate analyses.Results In a logistic regression model based on demographics,risk factors,clinical features and complications,female gender(odds ratio[OR]=1.74,95%confidence interval[CI]:1.27–2.39),heart failure(OR=2.27,95%CI:1.46–3.56),altered consciousness(OR=1.76,95%CI:1.28–2.42),and infectious complications(OR=2.01,95%CI:1.39–2.91)were predictors of cardioembolic stroke in the oldest age group.By contrast,heavy smoking,heart valve disease,hypertension,headache,early seizures,sensory deficit,and involvement of the posterior cerebral artery were independently associated with cardioembolic stroke in the younger group.Conclusions Identification of a differential clinical profile of cardioembolic stroke between patients aged 85 years or more and those younger than 85 years helps clinicians to the optimal management of ischemic infarction in the oldest segment of the population.

Treatment Outcomes in Head and Neck Cancer Patients 80 Years Old and over

Background: With the recent aging of society, the need for medical treatment of elderly patients with head and neck cancer seems to have been increasing. Method: The present study analyzed all 103 patients with head and neck cancer ≥80 years, and we compared results with those of the previous generation (Group P;range: 75 - 79 years) comprising 104 patients treated in the same period. Results: We provided treatment just as wanted and could not choose it often. The reasons were oncological factors such as unresectable tumor or distant metastasis, refusal of treatment, and physical factors such as poor PS or number of comorbidities. Conclusion: Treatment choices should be based on the wishes and motivations of the patient and the medical assessment of physical function. When a patient ≥80 years old is treated, the high incidence of complications and severity of the disease should be considered.

CONTRAST ANALYSIS ON ECG,CT AND CLINICAL MANIFESTATION OF PATIENTS OVER SEVENTY YEARS OLD WITH STROKE

目的:探讨70岁以上老年人脑卒中患者的心电图、CT和临床表现的特点及其预防和治疗方法。方法:100例患者的心电图、CT和临床表现被分析了。结果:这些患者的心电图和CT改变以及临床表现是各不相同的。结论:70岁以上老年人的脑卒中患者是具有一定特点的。

Relationship between Waist Circumference, Waist-Height Ratio, Body Fat Percentage, Visceral Fat and Bone Mineral Density in Middle-Aged and Elderly Zhuang of China

Objective: To understand the correlation between different degrees of obesity and bone mineral density (BMD). Methods: 772 cases (300 men and 472 females) of Zhuang over 40 years old were randomly selected. The BMD and T score were calculated by measuring the right heel bone using a quantitative-ultrasound densitometer. Body composition index of body weight, waist circumference (WC), waist height ratio (WtHR), body fat percentage (BFP) and visceral fat (VF) were measured using a bioelectrical impedance method. Results: The BMI, WC, and WtHR of the male osteoporosis group were lower than those of the normal bone mass (NBM) group (P Conclusion: BMI is positively correlated with BMD in Zhuang. BFP has a greater correlation with female BMD, and a small reduction in BFP can result in a significant decrease in BMD. BMD of male was positively correlated with abdominal obesity indicators (WC, WtHR, VF). However, abdominal obesity has no obvious effect on the promotion of BMD in women, and increased WtHR can lead to a decrease in BMD. Zhuang can appropriately increase the amount of fat within the normal weight range. At the same time, reasonable exercise and balanced nutrition to avoid excessive obesity or low body weight can reduce the incidence of osteoporosis and osteoporosis fractures.

Effect of Atorvastatin on the levels of adiponectin and leptin and adiponectin-leptin ratio in the elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia

Objective To evaluate effects of Atorvastatin on the levels of adiponectin and leptin and adiponectin-leptin ratio in the elderly and middle-aged patients with type 2diabetes and combined hyperlipidemia.Methods Totally80 elderly and middle-aged patients with type 2 diabetes and combined hyperlipidemia were treated with Atorvastatin(10 mg/d)for 12 weeks.Fasting plasma levels

The study of the correlation between serum uric acid and insulin resistance in middle-aged and elderly hospitalized patients with type 2 diabetes

Objective To study the relationship between serum uric acid and insulin resistance in type 2 diabetic patients.Methods A total of 728 middle-aged and elderly type 2 diabetic patients were recruited and the anthropometric,clinical and biochemical parameters and

HDSMP结合CDSMP模式对老年高血压患者疾病应对和自我管理能力的影响

目的 探讨本土化的高血压、糖尿病自我管理教程(hypertension&diabetes self-management program, HDSMP)结合美国斯坦福大学首创的普适性慢性病自我管理项目(chronic disease self-management program, CDSMP)对老年高血压患者疾病应对和自我管理能力的影响。方法 选取2021年6-12月在郑州大学第一附属医院内科门诊就诊的符合纳入和排除标准的300例老年高血压患者作为研究对象,采用随机数字表法分为对照组150例和干预组150例。对照组患者接受以健康讲座和宣教手册为主的健康教育,干预组患者接受HDSMP结合CDSMP模式的慢性病自我管理,以自我管理小组的形式进行。两组患者的干预时间均为8周。评价并比较两组患者干预前后的疾病认知情况、生活质量、疾病应对能力、自我管理能力、血压控制效果。结果 干预组干预后对高血压知识(包括疾病诊断标准、高危因素、高血压危害、治疗方法)知晓率相比较干预前和对照组干预后均明显升高,差异有统计学意义(P<0.05)。干预组干预后健康调查简表(SF-36)各维度评分相比较干预前和对照组干预后均明显升高,差异有统计学意义(P<0.05)。干预组干预后医学应对方式问卷(medical coping modes questionnaire, MCMQ)中的面对得分相比较对照组干预后明显升高[(22.70±2.28)分vs.(20.95±2.62)分],屈服、回避得分相比较对照组干预后明显降低[(5.13±1.36)分vs.(5.96±1.65)分,(13.72±1.45)分vs.(15.10±1.49)分],差异有统计学意义(P<0.05)。干预组干预后自我管理各维度评分和总评分均显著高于对照组干预后(P<0.05)。两组患者干预后的舒张压和收缩压相比较干预前均显著降低,其中干预组相比较对照组降低更明显(P<0.05),干预后干预组的血压控制达标率相比较对照组明显升高(收缩压:88.67%vs. 76.00%,舒张压:93.33%vs. 78.67%,P<0.05)。结论 HDSMP结合CDSMP模式对提高和改善老年高血压患者的疾病应对能力、自我效能和自我管理能力的效果更佳,从而能进一步提高和改善患者的血压控制达标率及生活质量水平。

人文关怀在老年白内障患者术后护理中的应用效果分析

目的分析人文关怀理念应用于白内障手术老年患者术后护理中的效果。方法简单随机选取2021年6月—2022年6月六盘水市人民医院接受手术治疗的60例白内障老年患者为研究对象,根据“抛硬币”法(正面和反面)分为研究组(人文关怀护理)、对照组(常规护理),每组30例,对比两组患者的护理效果。结果护理后,研究组的生活质量评分高于对照组,差异有统计学意义(P<0.05);研究组的护理满意率高于对照组,差异有统计学意义(P<0.05);研究组的护理依从率为96.67%,高于对照组的76.67%,差异有统计学意义(χ^(2)=5.192,P<0.05);护理后,研究组的焦虑、抑郁评分低于对照组,差异有统计学意义(P均<0.05)。结论人文关怀应用于老年白内障患者术后护理中,可提高护理有效性,调节患者的负面情绪,让老年白内障患者生活质量提升,患者的护理满意度较高。

乌灵胶囊联合小剂量喹硫平用于失眠伴焦虑抑郁高龄老年患者的疗效分析

目的 探讨乌灵胶囊联合小剂量喹硫平治疗高龄老年失眠伴焦虑抑郁患者的疗效和安全性。方法 回顾性分析2020年6月-2022年12月在我院门诊就诊或住院治疗的96例失眠伴焦虑抑郁高龄老年(≥80岁)患者的临床资料。根据治疗方案的不同将患者分为乌灵胶囊组(0.99 g,每天3次,34例)、喹硫平组(25~50 mg,每晚1次,30例)和联合组(同时服用乌灵胶囊和喹硫平,用法用量同单药组,32例)。比较3组患者治疗前和治疗8周后的睡眠监测指标(总睡眠时间、睡眠效率、睡眠潜伏期、觉醒次数)、匹兹堡睡眠质量指数量表(PSQI)评分、14项汉密尔顿焦虑量表(HAMA-14)评分、17项汉密尔顿抑郁量表(HAMD-17)评分、简易智能精神状态量表(MMSE)评分、血清白细胞介素1β(IL-1β)和肿瘤坏死因子α(TNF-α)水平,以及疗效和不良反应发生情况。结果 与治疗前比较,3组患者治疗后的总睡眠时间、睡眠效率、MMSE评分均显著延长或升高(P<0.05),睡眠潜伏期、觉醒次数、PSQI评分、HAMA-14评分、HAMD-17评分、血清IL-1β和TNF-α水平均显著缩短或降低(P<0.05),喹硫平组患者的睡眠潜伏期、觉醒次数、HAMA-14评分、HAMD-17评分、血清TNF-α水平均明显短于或低于乌灵胶囊组,且联合组各定量指标均显著优于喹硫平组和乌灵胶囊组(P<0.05)。联合组患者的治疗总有效率显著高于喹硫平组和乌灵胶囊组(P<0.05),3组患者的总不良反应发生率比较差异无统计学意义(P>0.05)。结论 乌灵胶囊联合小剂量喹硫平用于高龄老年失眠伴焦虑抑郁患者的疗效优于各药单用,不良反应未见明显增加。

住院老年共病患者肌少症现况、影响因素及对策

目的 调查住院老年共病患者肌少症现况,并分析其影响因素,为住院老年共病患者肌少症防治提供参考依据。方法 采用便利抽样法,选择2020年1月—2023年3月本院385例住院老年共病患者作为研究对象。采用一般资料调查表和电子病历系统收集患者相关资料,根据住院老年共病患者是否肌少症将其分为肌少症组和非肌少症组,并采用二元Logistic回归分析其肌少症的影响因素。结果 住院老年共病患者肌少症占比34.81%(134/385),其中男性肌少症占比53.73%(72/134),女性46.27%(62/134)。Logistic回归分析结果显示,高龄(OR=1.106)、高衰弱评分(OR=2.827)、高Charlson共病指数(Charlson Comorbidity Index,CCI)(OR=1.507)是住院老年共病患者肌少症的危险因素(均P<0.05),高ADL评分(OR=0.961)、高体质量指数(body mass index,BMI)(OR=0.314)是其保护因素(均P<0.05)。结论 住院老年共病患者肌少症占比较高,医护人员应关注高龄、低BMI、低ADL评分、高衰弱评分、高CCI评分患者,并采取相应防治措施,以延缓住院老年共病患者肌少症的发生或发展。

基于决策树的老年肿瘤患者经外周静脉置入中心静脉导管相关深静脉血栓形成预测模型

目的建立老年肿瘤患者经外周静脉置入中心静脉导管(PICC)相关深静脉血栓形成的决策树模型。方法选取2017年3月至2021年5月某医院行PICC的400例老年肿瘤患者作为模型组,2021年6月至2023年2月该医院行PICC的120例老年肿瘤患者作为验证组。采用logistic回归方法筛选老年肿瘤患者PICC相关深静脉血栓形成的危险因素,采用SPSS Modeler软件构建老年肿瘤患者PICC相关深静脉血栓形成的决策树模型,并分析该模型的预测效能。结果400例老年肿瘤患者中有74例发生PICC相关深静脉血栓,深静脉血栓的发生率为18.50%。logistic回归分析结果显示,体质量指数、穿刺次数、导管留置时间、糖尿病及慢性肾功能不全是老年肿瘤患者PICC相关深静脉血栓形成的危险因素(P<0.05)。老年肿瘤患者PICC相关深静脉血栓形成决策树模型的分类节点为糖尿病、导管留置时间、慢性肾功能不全、穿刺次数及体质量指数5个临床特征,其中糖尿病是最重要的预测因子。决策树模型的AUC(AUC=0.749,95%CI:0.688~0.811)高于logistic回归模型(AUC=0.701,95%CI:0.633~0.770)(P<0.05),验证组的AUC为0.812(95%CI:0.783~0.841)。结论体质量指数、穿刺次数、导管留置时间、糖尿病及慢性肾功能不全是老年肿瘤患者PICC相关深静脉血栓形成的危险因素,本研究构建的老年肿瘤患者PICC相关深静脉血栓形成决策树模型具有较高的准确性。

分析创新扩散理论模式干预对中风后遗症老年患者的应用效果

目的:分析创新扩散理论模式干预对中风后遗症老年患者日常生活活动能力及睡眠质量的影响。方法:选取2022年5月至2023年5月厦门大学附属中山医院全能医学科收治的中风后遗症老年患者86例作为研究对象,按照随机数字表法分为观察组和对照组,每组43例。对照组给予常规护理干预,观察组给予创新扩散理论模式干预。采用美国国立卫生研究院卒中量表(NIHSS)比较2组患者干预前后神经功能缺损程度,评定2组中风后遗症老年患者护理前后睡眠质量的变化,从夜间总睡眠时间、睡眠潜伏期、睡眠效率进行判定;采用日常生活能力量表(ADL)比较2组患者的生命质量。结果:干预后,观察组NIHSS评分显著低于对照组,观察组ADL评分显著高于对照组,观察组总睡眠时间、睡眠效率显著高于对照组,睡眠潜伏期显著低于对照组,差异均有统计学意义(均P<0.05)。结论:创新扩散理论模式下的干预措施对中风后遗症老年患者日常生活活动能力及睡眠质量提升具有积极的影响,能有效提高患者的生命质量,值得临床推广应用。

左旋氨氯地平的时间药理学对纠正老年非杓型高血压的作用

目的按照时间治疗学的原则,探讨不同时间服用长效钙拮抗剂(CCB)左旋氨氯地平对老年非杓型高血压患者血压的影响。方法采用90217型无创动态血压监测仪,动态血压监测的方法筛选出54例入选前≥4周未使用二氢吡啶类CCB的老年非杓型高血压患者,随机分为左旋氨氯地平晨起服药组(n=28)和晚上服药组(n=26),2.5mg/d,共治疗48周。药物治疗前后分别进行诊室血压和动态血压监测的检查。结果1)不同时间服药组的诊室收缩压(SBP)在治疗后均明显降低(P<0.05),两组间的诊室SBP在治疗前后差异均无统计学意义(P>0.05)。2)动态血压结果显示,晨起服药及夜间服药均能降低夜间SBP(P<0.05,P<0.01),夜间服药更能有效地降低全天的SBP。3)晨起服药组的白天血压达标率(SBP<135mmHg)为39.3%,晚上服药组的白天血压达标率为30.8%,差异无统计学意义(P>0.05)。晨起服药组的夜间血压达标率(SBP<125mmHg)为28.6%,晚上服药组的夜间血压达标率为61.5%,差异有非常显著意义(P<0.01)。4)两组间纠正血压昼夜节律异常(由非杓型纠正为杓型)比例的差异有非常显著意义(晨起服药组17.9%比晚上服药组46.2%,P<0.01)。结论对于非杓型老年高血压患者,左旋氨氯地平在晚上服用时可以较好地纠正夜间的高负荷血压,提高夜间血压达标率。夜间及白天服用长效CCB均能有效地降低夜间血压。

80岁以上高龄患者腹腔镜胆囊切除术的临床分析

目的评价80岁以上高龄患者腹腔镜胆囊切除术的可行性和临床价值。方法回顾分析74例80岁以上高龄胆囊结石患者的临床资料。结果所有手术患者均痊愈出院,其中31例患者接受腹腔镜胆囊切除术,手术患者平均住院时间为11.3 d,术前准备时间平均为5.76 d。结论通过加强围术期处理,大多数高龄老年患者行腹腔镜胆囊切除手术是安全可靠的。

医学生与老年患者交流／沟通问题的调查分析

目的调查分析医学生与老年患者交流/沟通的现状,以提高医学生的医患沟通技能。方法对90名医学实习生进行问卷调查,数据录入和分析采用SPSS13.0软件。结果医学生对医患交流/沟通的重要性有一定认识,但在沟通的主动性上不够充分;对于医患沟通内容和背景知识的准备还远远不够。结论应加强对医学生交流/沟通技能的培养,培养适合现代医学模式的高级医学人才。

626例医院感染病例调查分析

目的了解、掌握医院感染现状,为降低医院感染率提供依据。方法回顾性调查2004年10月-2005年9月住院患者40 554例,医院感染626例。结果2005年医院感染率为1.54%,医院易感人群中以老年患者居多,住院时间越长,发生医院感染的危险性越大,高危感染科室为老年监护室和血液科,感染高发部位为呼吸道,医院感染病种以恶性肿瘤居多,侵入性诊疗技术操作是引起医院感染的因素之一。结论医院感染率偏低,建立医院感染管理监控系统,利用先进统计软件进行辅助监控,从统计规律性的角度发现感染缺陷。