EBI2 is known as a kind of 7TM G protein-coupled receptors, and EBi2 gene is one of the most upregulated genes in Epstein-Barr virus （EBV） -infected lymphocytes. As a constitutively active receptor, EBI2 signals via...EBI2 is known as a kind of 7TM G protein-coupled receptors, and EBi2 gene is one of the most upregulated genes in Epstein-Barr virus （EBV） -infected lymphocytes. As a constitutively active receptor, EBI2 signals via Gai, and TM-II plays an important role in the signal transduct/on process. EBI2 is expressed mainly in mature, B cells and the expression level increases at the early stage of activation; subsequently, B cells are transferred into GC and the expression level is down-regulated. EBI2 can regulate independently and mediate synergistically the migration of B cell towards the extrafollicular areas and GC depending on chemo- kine receptors CXCR5 and CCR7 （EBII）. Differential expression of EBI2 receptor is conducive to accurate migration of B cells at different stages, thereby leading to appropriate irranunologic responses to T-dependent antigens. Recently, two research groups identified a specific oxysteml as the natural ligand for EBL2. Among all the oxysterols, 7α, 25-Dihydrexycholesteml （7a, 25-OHC） is the most effective ligand and activator, and EBI2-Oxysterol signal pathway plays an important role in adaptive immune responses. In addition, EBI2 is also closely related with specific kinds of autoimmune diseases, so it is considered as a negative regulator of the innate immune response in macrophages.展开更多
基金Supported by 2011 Funding Project for Academic Human Resources Development(015000543111509)
文摘EBI2 is known as a kind of 7TM G protein-coupled receptors, and EBi2 gene is one of the most upregulated genes in Epstein-Barr virus （EBV） -infected lymphocytes. As a constitutively active receptor, EBI2 signals via Gai, and TM-II plays an important role in the signal transduct/on process. EBI2 is expressed mainly in mature, B cells and the expression level increases at the early stage of activation; subsequently, B cells are transferred into GC and the expression level is down-regulated. EBI2 can regulate independently and mediate synergistically the migration of B cell towards the extrafollicular areas and GC depending on chemo- kine receptors CXCR5 and CCR7 （EBII）. Differential expression of EBI2 receptor is conducive to accurate migration of B cells at different stages, thereby leading to appropriate irranunologic responses to T-dependent antigens. Recently, two research groups identified a specific oxysteml as the natural ligand for EBL2. Among all the oxysterols, 7α, 25-Dihydrexycholesteml （7a, 25-OHC） is the most effective ligand and activator, and EBI2-Oxysterol signal pathway plays an important role in adaptive immune responses. In addition, EBI2 is also closely related with specific kinds of autoimmune diseases, so it is considered as a negative regulator of the innate immune response in macrophages.
