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Study on Synthesis and Deplete Harmful Radical of Cobalt Porphyrins as the Mimic of Enzyme
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作者 LI Zao ying1, ZHANG Yue ning1, LI Cong1, FENG Qing2, XIA Shu zhen2 (1. College of Chemistry and Environment Science, Wuhan University, Wuhan 430072, China 2. Department of Chemistry, Tongji Medical University, Wuhan 430030, China) 《Wuhan University Journal of Natural Sciences》 CAS 2000年第2期214-214,共1页
The four cobalt porphyrins [Co (3, 4, 5 MeO TPP) (1) ; Co (TTP) (2) ; Co (4 CI TPP) (3);Co (4 HSO 3 TPP) (4)] were synthesized and considered as two mimic of superoxide dismutaes (SOD) and catalase (CAT). The ... The four cobalt porphyrins [Co (3, 4, 5 MeO TPP) (1) ; Co (TTP) (2) ; Co (4 CI TPP) (3);Co (4 HSO 3 TPP) (4)] were synthesized and considered as two mimic of superoxide dismutaes (SOD) and catalase (CAT). The catalytic efficiency of them on deplete the harmful radical have been proved using riboflavin methionine photoreduction method in the concentration range of 10 6 ~10 5 mol/L. The catalytic efficiency of them at decomposing H 2O 2 has been performed by spectrophotometer. The percentage of decomposing H 2O 2 while the increasing the concentration of the imitating compounds. The lipid peroxidationproduced in liver homogenatcd of mice was determined by spectrophotometer detecting the content of MDA. 展开更多
关键词 cobalt porphyrin SYNTHESIS superoxide dismutaes CATALASE two functional mimic of enzyme
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