To explore construction of novel mimicking biomembrane on biomaterials surfaces, a new polymerizable phosphatidylcholine containing a long monoalkyl chain ended with acryl group （AASOPC） was designed and synthesized...To explore construction of novel mimicking biomembrane on biomaterials surfaces, a new polymerizable phosphatidylcholine containing a long monoalkyl chain ended with acryl group （AASOPC） was designed and synthesized, which was easily derived from the terminal amino group of 9-（2-amino-ethylcarbamoyl）-nonyl-l-phosphatidyl-choline （ASOPC） reacting with acryloyl chloride. The obtained AASOPC was grafted on poly（ethylene terephthalate） （PET） via surface-initiated atom-transfer radical polymerization （SI-ATRP） to form mimicking biomembrane. These modified surface structures of PET were investigated using water contact angle （WAC）, X-ray photoelectron spectroscopy （XPS） and atomic force microscopy （AFM）. The results indicated that the new mimicking phosphatidylcholine biomembrane could be prepared on inert polymer surfaces by using the acryloyl phosphatidylcholine （AASOPC） via surface-initiated atom transfer radical polymerization （SI-ATRP）.展开更多
基金financially supported by the National Natural Science Foundation of China(No.20804025 and 50673063)Program for the New-Century Excellent Talents of Ministry of Education of China(NCET-08-0381)Sichuan Provincial Science Fund for Distinguished Young Scholars(09ZQ026-024)
文摘To explore construction of novel mimicking biomembrane on biomaterials surfaces, a new polymerizable phosphatidylcholine containing a long monoalkyl chain ended with acryl group （AASOPC） was designed and synthesized, which was easily derived from the terminal amino group of 9-（2-amino-ethylcarbamoyl）-nonyl-l-phosphatidyl-choline （ASOPC） reacting with acryloyl chloride. The obtained AASOPC was grafted on poly（ethylene terephthalate） （PET） via surface-initiated atom-transfer radical polymerization （SI-ATRP） to form mimicking biomembrane. These modified surface structures of PET were investigated using water contact angle （WAC）, X-ray photoelectron spectroscopy （XPS） and atomic force microscopy （AFM）. The results indicated that the new mimicking phosphatidylcholine biomembrane could be prepared on inert polymer surfaces by using the acryloyl phosphatidylcholine （AASOPC） via surface-initiated atom transfer radical polymerization （SI-ATRP）.
