Objective： To explore the brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening post-traumatic stress disorder（PTSD）.Methods： According to random number table m...Objective： To explore the brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening post-traumatic stress disorder（PTSD）.Methods： According to random number table method, 60 SD rats were randomly divided into blank group, model group, grabbing group, paroxetine group and acupuncture group. Except for the blank group, all the rats were established into PTSD models through electric shock and incarceration, with model replication for 7 days in total. The rats were given gavage, acupuncture intervention and grabbing fixation 1 h before modeling, with 6 days as 1 course of treatment. Grabbing treatment was performed for 2 courses, with 12 days in total. After modeling, functional near-infrared spectroscopy（fNIRS） system was adopted to collect and record the changes of concentration of Oxy-Hb, Deoxy-Hb and Total-Hb during 3 min in related brain regions of rats in each group after treatment for 5 consecutive days, and the brain function was evaluated.Results： According to the comparison of the time series of blood-oxygen concentration, there were significant differences between model group and blank group as well as grabbing group and blank group（P〈0.01, P〈0.01）, no significant difference was found between model group and grabbing group（P〈0.05）; there were significant differences between paroxetine group and grabbing group as well as acupuncture group and grabbing group（P〈0.05, P〈0.05）, no significant difference was found between paroxetine group and acupuncture group（P〈0.05）.Conclusion： ＂Liver-soothing and mind-regulating＂ acupuncture manipulation has a benign regulatory effect on the blood-oxygen concentration in cerebral cortex of PTSD rats, which may be the important brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening PTSD.展开更多
This study summarizes Prof. Li-xing ZHUANG's experience in treating psycho-cardiological disease, which is characterized by cardiovascular somatic symptoms and emotional abnormalities. Psycho-cardiological disease...This study summarizes Prof. Li-xing ZHUANG's experience in treating psycho-cardiological disease, which is characterized by cardiovascular somatic symptoms and emotional abnormalities. Psycho-cardiological disease is mainly caused by disorders of the brain and heart shen-mind, and related to the dysfunction of zangfu functions. In acupuncture treatment, attention should be paid to “regulation of the heart and brain, and taking zangfu organs in to account at the same time.” Sìshénzhēn (四神针) of JIN’s three-needle, Shéntíng (神庭GV 24) and Yìntáng (印堂GV29) are adopted to regulate the brain, Shénmén (神门HT7) or Nèiguān (内关PC6) are used to regulate the heart shen-mind, Hégǔ (合谷LI4), Tàichōng (太冲LR3), and Sānyīnjiāo (三阴交SP6) are used to regulate zangfu, and the Daoqi Tongjing method is applied to regulate the qi and blood, achieving good effects in the clinical setting.展开更多
基金Supported by Regional fund project of 2014 National Natural Science Foundation of China:814607442013 Gansu Provincial Natural Science Foundation:1308RJZA150~~
文摘Objective： To explore the brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening post-traumatic stress disorder（PTSD）.Methods： According to random number table method, 60 SD rats were randomly divided into blank group, model group, grabbing group, paroxetine group and acupuncture group. Except for the blank group, all the rats were established into PTSD models through electric shock and incarceration, with model replication for 7 days in total. The rats were given gavage, acupuncture intervention and grabbing fixation 1 h before modeling, with 6 days as 1 course of treatment. Grabbing treatment was performed for 2 courses, with 12 days in total. After modeling, functional near-infrared spectroscopy（fNIRS） system was adopted to collect and record the changes of concentration of Oxy-Hb, Deoxy-Hb and Total-Hb during 3 min in related brain regions of rats in each group after treatment for 5 consecutive days, and the brain function was evaluated.Results： According to the comparison of the time series of blood-oxygen concentration, there were significant differences between model group and blank group as well as grabbing group and blank group（P〈0.01, P〈0.01）, no significant difference was found between model group and grabbing group（P〈0.05）; there were significant differences between paroxetine group and grabbing group as well as acupuncture group and grabbing group（P〈0.05, P〈0.05）, no significant difference was found between paroxetine group and acupuncture group（P〈0.05）.Conclusion： ＂Liver-soothing and mind-regulating＂ acupuncture manipulation has a benign regulatory effect on the blood-oxygen concentration in cerebral cortex of PTSD rats, which may be the important brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening PTSD.
基金Supported by the Science and Technology Department of Guangdong Province:2018-5。
文摘This study summarizes Prof. Li-xing ZHUANG's experience in treating psycho-cardiological disease, which is characterized by cardiovascular somatic symptoms and emotional abnormalities. Psycho-cardiological disease is mainly caused by disorders of the brain and heart shen-mind, and related to the dysfunction of zangfu functions. In acupuncture treatment, attention should be paid to “regulation of the heart and brain, and taking zangfu organs in to account at the same time.” Sìshénzhēn (四神针) of JIN’s three-needle, Shéntíng (神庭GV 24) and Yìntáng (印堂GV29) are adopted to regulate the brain, Shénmén (神门HT7) or Nèiguān (内关PC6) are used to regulate the heart shen-mind, Hégǔ (合谷LI4), Tàichōng (太冲LR3), and Sānyīnjiāo (三阴交SP6) are used to regulate zangfu, and the Daoqi Tongjing method is applied to regulate the qi and blood, achieving good effects in the clinical setting.
