BACKGROUND:The incidence of hypertensive intracerebral hemorrhage(HICH)has been increasing during the recent years in low-and middle-income countries.With high mortality and morbidity rates,it brings huge burden to th...BACKGROUND:The incidence of hypertensive intracerebral hemorrhage(HICH)has been increasing during the recent years in low-and middle-income countries.With high mortality and morbidity rates,it brings huge burden to the families.It lacks evidence regarding the application of intracranial pressure(ICP)monitoring in HICH.In the current study,the authors aimed to evaluate whether ICP monitoring could make any difference on the prognosis of HICH patients after minimally invasive surgery.METHODS:A retrospective review of 116 HICH patients admitted to the Second Affiliated Hospital of Zhejiang University School of Medicine,between 2014 and 2016,was performed.The effects of ICP monitoring on 6-month mortality and favorable outcomes were evaluated by univariate and logistic regression analysis.RESULTS:ICP monitors were inserted into 50 patients.Patients with ICP monitoring had a significantly better outcome(P<0.05).The average in-hospital duration in patients with ICP monitoring was shorter than that in the patients without ICP monitoring(16.68 days vs.20.47 days,P<0.05).Mortality rates between ICP monitoring and no ICP monitoring did not differ significantly(16.0%vs.15.1%,P=0.901).On univariate analysis,age,Glasgow Coma Scale(GCS)on admission and presence of ICP monitor were independent predictors of 6-month favorable outcomes.CONCLUSION:ICP monitoring is associated with a better 6-month functional outcome compared with no ICP monitoring.Future study is still needed to confirm our results and elucidate which subgroup of HICH patients will benefit most from the minimally invasive surgical intervention and ICP monitoring.展开更多
目的:探索颅内压(ICP)监测在高血压脑出血(HICH)微创术中及术后治疗中的指导价值和优势。方法:抽取73例HICH的病例,随机分配为对照组和治疗组(ICP监测组)。对照组34例,术中使用立体定向软通道技术对血肿进行穿刺,抽吸术前计算血肿量的1/...目的:探索颅内压(ICP)监测在高血压脑出血(HICH)微创术中及术后治疗中的指导价值和优势。方法:抽取73例HICH的病例,随机分配为对照组和治疗组(ICP监测组)。对照组34例,术中使用立体定向软通道技术对血肿进行穿刺,抽吸术前计算血肿量的1/3～1/2后停止,术后常规血肿腔内注射尿激酶;治疗组39例,血肿穿刺前放置ICP监测,然后对血肿进行控制性抽吸,设定目标ICP为15 mm Hg,达到目标ICP则停止抽吸,术后根据ICP监测数值控制性血肿腔内注射尿激酶2～5万单位等治疗方案。通过对比两组患者术后再出血的发生率、血肿排空时间、平均住院时间等,评判ICP控制在HICH的价值。结果:通过治疗组观察发现,要达到预期治疗效果的ICP,术中抽吸初始血肿量的1/5左右即可;术后再出血:治疗组0例,对照组4例,差异有统计学意义。两组血肿排空用时:治疗组(7.36±2.06)d,对照组(10.00±2.59)d,差异有统计学意义。平均住院时间:治疗组(19.45±5.942)d,对照组(25.52±9.881)d,差异有统计学意义。结论:持续ICP监测联合定向软通道微创手术治疗HICH,改变既往术中经验性抽吸血肿和术后推注药物的观念,提出控制性引流和注药的理念,抽吸初始血肿量的1/5左右(约4～10 m L),即可降低ICP至目标值,还可明显减少术后再出血的发生,缩短病程,减少并发症发生,缩短患者住院时间,并为临床上提供灵敏、客观的指标和依据,提高疗效,减少继发性损伤,改善预后。展开更多
文摘BACKGROUND:The incidence of hypertensive intracerebral hemorrhage(HICH)has been increasing during the recent years in low-and middle-income countries.With high mortality and morbidity rates,it brings huge burden to the families.It lacks evidence regarding the application of intracranial pressure(ICP)monitoring in HICH.In the current study,the authors aimed to evaluate whether ICP monitoring could make any difference on the prognosis of HICH patients after minimally invasive surgery.METHODS:A retrospective review of 116 HICH patients admitted to the Second Affiliated Hospital of Zhejiang University School of Medicine,between 2014 and 2016,was performed.The effects of ICP monitoring on 6-month mortality and favorable outcomes were evaluated by univariate and logistic regression analysis.RESULTS:ICP monitors were inserted into 50 patients.Patients with ICP monitoring had a significantly better outcome(P<0.05).The average in-hospital duration in patients with ICP monitoring was shorter than that in the patients without ICP monitoring(16.68 days vs.20.47 days,P<0.05).Mortality rates between ICP monitoring and no ICP monitoring did not differ significantly(16.0%vs.15.1%,P=0.901).On univariate analysis,age,Glasgow Coma Scale(GCS)on admission and presence of ICP monitor were independent predictors of 6-month favorable outcomes.CONCLUSION:ICP monitoring is associated with a better 6-month functional outcome compared with no ICP monitoring.Future study is still needed to confirm our results and elucidate which subgroup of HICH patients will benefit most from the minimally invasive surgical intervention and ICP monitoring.
文摘目的:探索颅内压(ICP)监测在高血压脑出血(HICH)微创术中及术后治疗中的指导价值和优势。方法:抽取73例HICH的病例,随机分配为对照组和治疗组(ICP监测组)。对照组34例,术中使用立体定向软通道技术对血肿进行穿刺,抽吸术前计算血肿量的1/3～1/2后停止,术后常规血肿腔内注射尿激酶;治疗组39例,血肿穿刺前放置ICP监测,然后对血肿进行控制性抽吸,设定目标ICP为15 mm Hg,达到目标ICP则停止抽吸,术后根据ICP监测数值控制性血肿腔内注射尿激酶2～5万单位等治疗方案。通过对比两组患者术后再出血的发生率、血肿排空时间、平均住院时间等,评判ICP控制在HICH的价值。结果:通过治疗组观察发现,要达到预期治疗效果的ICP,术中抽吸初始血肿量的1/5左右即可;术后再出血:治疗组0例,对照组4例,差异有统计学意义。两组血肿排空用时:治疗组(7.36±2.06)d,对照组(10.00±2.59)d,差异有统计学意义。平均住院时间:治疗组(19.45±5.942)d,对照组(25.52±9.881)d,差异有统计学意义。结论:持续ICP监测联合定向软通道微创手术治疗HICH,改变既往术中经验性抽吸血肿和术后推注药物的观念,提出控制性引流和注药的理念,抽吸初始血肿量的1/5左右(约4～10 m L),即可降低ICP至目标值,还可明显减少术后再出血的发生,缩短病程,减少并发症发生,缩短患者住院时间,并为临床上提供灵敏、客观的指标和依据,提高疗效,减少继发性损伤,改善预后。
